Fernando Macian

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. ncbi request reprint NFAT proteins: key regulators of T-cell development and function
    Fernando Macian
    Albert Einstein College of Medicine, Department of Pathology, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Nat Rev Immunol 5:472-84. 2005
  2. pmc Interleukin 2 gene transcription is regulated by Ikaros-induced changes in histone acetylation in anergic T cells
    Sanmay Bandyopadhyay
    Albert Einstein College of Medicine, Department of Pathology, Bronx, NY 10461, USA
    Blood 109:2878-86. 2007
  3. pmc Macroautophagy regulates energy metabolism during effector T cell activation
    Vanessa M Hubbard
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 185:7349-57. 2010
  4. pmc Transcriptional complexes formed by NFAT dimers regulate the induction of T cell tolerance
    Noemi Soto-Nieves
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Exp Med 206:867-76. 2009
  5. ncbi request reprint Transcriptional mechanisms underlying lymphocyte tolerance
    Fernando Macian
    Center for Blood Research, Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Cell 109:719-31. 2002
  6. pmc Tle4 regulates epigenetic silencing of gamma interferon expression during effector T helper cell tolerance
    Sanmay Bandyopadhyay
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA
    Mol Cell Biol 34:233-45. 2014
  7. pmc Helios induces epigenetic silencing of IL2 gene expression in regulatory T cells
    Ian Baine
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 190:1008-16. 2013
  8. ncbi request reprint A molecular dissection of lymphocyte unresponsiveness induced by sustained calcium signalling
    Vigo Heissmeyer
    Department of Pathology, Harvard Medical School, CBR Institute for Biomedical Research, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Novartis Found Symp 267:165-74; discussion 174-9. 2005
  9. pmc Transcriptional regulation of T cell tolerance
    Sanmay Bandyopadhyay
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Semin Immunol 19:180-7. 2007
  10. pmc The lipid kinase PI4KIIIβ preserves lysosomal identity
    Sunandini Sridhar
    Department of Development and Molecular Biology, Bronx, NY 10461, USA
    EMBO J 32:324-39. 2013

Collaborators

Detail Information

Publications29

  1. ncbi request reprint NFAT proteins: key regulators of T-cell development and function
    Fernando Macian
    Albert Einstein College of Medicine, Department of Pathology, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Nat Rev Immunol 5:472-84. 2005
    ..This Review focuses on the recent advances in our understanding of the regulation, mechanism of action and functions of NFAT proteins in T cells...
  2. pmc Interleukin 2 gene transcription is regulated by Ikaros-induced changes in histone acetylation in anergic T cells
    Sanmay Bandyopadhyay
    Albert Einstein College of Medicine, Department of Pathology, Bronx, NY 10461, USA
    Blood 109:2878-86. 2007
    ..We propose a model in which tolerizing stimuli induce epigenetic changes on the interleukin 2 locus that are responsible for the stable inhibition of the expression of this cytokine in anergic T cells...
  3. pmc Macroautophagy regulates energy metabolism during effector T cell activation
    Vanessa M Hubbard
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 185:7349-57. 2010
    ..These results suggest that macroautophagy is an actively regulated process in T cells that can be induced in response to TCR engagement to accommodate the bioenergetic requirements of activated T cells...
  4. pmc Transcriptional complexes formed by NFAT dimers regulate the induction of T cell tolerance
    Noemi Soto-Nieves
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Exp Med 206:867-76. 2009
    ..These data also establish a basis for the design of immunomodulatory strategies that specifically target each type of complex...
  5. ncbi request reprint Transcriptional mechanisms underlying lymphocyte tolerance
    Fernando Macian
    Center for Blood Research, Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Cell 109:719-31. 2002
    ..Thus, in the absence of AP-1, NFAT imposes a genetic program of lymphocyte anergy that counters the program of productive activation mediated by the cooperative NFAT:AP-1 complex...
  6. pmc Tle4 regulates epigenetic silencing of gamma interferon expression during effector T helper cell tolerance
    Sanmay Bandyopadhyay
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA
    Mol Cell Biol 34:233-45. 2014
    ....
  7. pmc Helios induces epigenetic silencing of IL2 gene expression in regulatory T cells
    Ian Baine
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 190:1008-16. 2013
    ..Interestingly, the loss of Helios in Tregs also causes a decrease in suppressive capacity. Our results identify Helios as a key regulator of Il2 expression in Tregs, contributing to the maintenance of the anergic phenotype...
  8. ncbi request reprint A molecular dissection of lymphocyte unresponsiveness induced by sustained calcium signalling
    Vigo Heissmeyer
    Department of Pathology, Harvard Medical School, CBR Institute for Biomedical Research, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Novartis Found Symp 267:165-74; discussion 174-9. 2005
    ..Thus Ca(2+)-calcineurin-NFAT signalling links gene transcription to a multi-step programme that leads to impaired signal transduction in anergic T cells...
  9. pmc Transcriptional regulation of T cell tolerance
    Sanmay Bandyopadhyay
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Semin Immunol 19:180-7. 2007
    ....
  10. pmc The lipid kinase PI4KIIIβ preserves lysosomal identity
    Sunandini Sridhar
    Department of Development and Molecular Biology, Bronx, NY 10461, USA
    EMBO J 32:324-39. 2013
    ....
  11. pmc IL-2 signaling prevents T cell anergy by inhibiting the expression of anergy-inducing genes
    Myrianne Dure
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Mol Immunol 46:999-1006. 2009
    ....
  12. pmc Autophagy and disease: always two sides to a problem
    Sunandini Sridhar
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Pathol 226:255-73. 2012
    ....
  13. pmc Suppression of inflammatory responses during myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis is regulated by AKT3 signaling
    Vladislav Tsiperson
    Department of Pathology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10461, USA
    J Immunol 190:1528-39. 2013
    ..These results indicate that AKT3 signaling contributes to the protection of mice against EAE...
  14. pmc Targeted cleavage of signaling proteins by caspase 3 inhibits T cell receptor signaling in anergic T cells
    Irene Puga
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Immunity 29:193-204. 2008
    ..Our results identify a role for caspase 3 in nonapoptotic T cells and support that caspase 3-dependent proteolytic inactivation of signaling proteins is essential to maintain T cell tolerance...
  15. ncbi request reprint T-cell anergy
    Fernando Macian
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Curr Opin Immunol 16:209-16. 2004
    ..These studies have helped clarify the nature of the signals that induce tolerance, the cells able to deliver them and the molecular processes that underlie the unresponsive state...
  16. doi request reprint Regulation of T-cell tolerance by calcium/NFAT signaling
    Ian Baine
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Immunol Rev 231:225-40. 2009
    ..The proteins encoded by those genes are required to impose a state of functional unresponsiveness through different mechanisms that include downregulation of T-cell receptor signaling and inhibition of cytokine transcription...
  17. pmc Silencing of the Il2 gene transcription is regulated by epigenetic changes in anergic T cells
    Sanmay Bandyopadhyay
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Eur J Immunol 42:2471-83. 2012
    ..This mechanism may account for the stable nature of the inhibition of IL-2 production in anergic cells...
  18. pmc Age-related oxidative stress compromises endosomal proteostasis
    Elvira S Cannizzo
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Cell Rep 2:136-49. 2012
    ..These findings underscore a previously unrecognized negative effect of age-dependent changes in cellular proteostasis on the immune response...
  19. pmc Chaperone-mediated autophagy is required for tumor growth
    Maria Kon
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Sci Transl Med 3:109ra117. 2011
    ..The fact that similar manipulations of CMA also reduce tumor growth of two different melanoma cell lines suggests that targeting this autophagic pathway may have broad antitumorigenic potential...
  20. doi request reprint Selective autophagy in the maintenance of cellular homeostasis in aging organisms
    Vanessa M Hubbard
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA
    Biogerontology 13:21-35. 2012
    ..We comment on the contribution of an adequate autophagic function to longevity, and the negative impact on health-span of the age-dependent decline in autophagic function...
  21. pmc Regulation of transcription factor NFAT by ADP-ribosylation
    Opeyemi A Olabisi
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Mol Cell Biol 28:2860-71. 2008
    ..These results also imply that, similar to the effect of calcineurin inhibition, PARP-1 inhibition may be beneficial in modulating immune functions...
  22. pmc NFAT1 supports tumor-induced anergy of CD4(+) T cells
    Brian T Abe
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 72:4642-51. 2012
    ..By illustrating the dependence of tumor-induced CD4+ T-cell anergy on NFAT1, our findings open the possibility of targeting this transcription factor to improve the efficacy of cancer immunotherapy or immunochemotherapy...
  23. ncbi request reprint TID1, a mammalian homologue of the drosophila tumor suppressor lethal(2) tumorous imaginal discs, regulates activation-induced cell death in Th2 cells
    Josh Syken
    Department of Pathology, Harvard Medical School, 200 Longwood Avenue, D2 544A, Boston, MA 02115 5701, USA
    Oncogene 22:4636-41. 2003
    ..Hence, the accumulation of Tid-1S in Th2 cells following activation represents a novel mechanism that may contribute to the induction of apoptosis resistance during the activation of Th2 cells...
  24. pmc Induction and stability of the anergic phenotype in T cells
    Rut Valdor
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA
    Semin Immunol 25:313-20. 2013
    ....
  25. pmc Autophagy and the regulation of the immune response
    Rut Valdor
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA
    Pharmacol Res 66:475-83. 2012
    ..Here, we review the recent advances that have allowed us to better understand why autophagy is a crucial process in the regulation of the innate and adaptive immune responses...
  26. pmc Autophagy, nutrition and immunology
    Ana Maria Cuervo
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Mol Aspects Med 33:2-13. 2012
    ..We describe their direct effect on autophagy and discuss how the autophagic reaction to these stimuli allows cells to accommodate the requirements of the cellular response to stress, including those specific to the immune responses...
  27. pmc A photoconvertible fluorescent reporter to track chaperone-mediated autophagy
    Hiroshi Koga
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Nat Commun 2:386. 2011
    ..Using this reporter, we find that levels of basal and inducible CMA activity are cell-type dependent, and we have identified an upregulation of this pathway in response to the catalytic inhibition of the proteasome...
  28. pmc Loss of the receptor tyrosine kinase Axl leads to enhanced inflammation in the CNS and delayed removal of myelin debris during experimental autoimmune encephalomyelitis
    Jason G Weinger
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    J Neuroinflammation 8:49. 2011
    ..To test for this, we studied the susceptibility of Axl-/- mice to experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis...
  29. ncbi request reprint T(H) cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes
    Orly Avni
    The Center for Blood Research and the Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Nat Immunol 3:643-51. 2002
    ....