Genomes and Genes
Affiliation: Albert Einstein College of Medicine
- Imaging sites of N-wasp activity in lamellipodia and invadopodia of carcinoma cellsMike Lorenz
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
Curr Biol 14:697-703. 2004..This is the first time that the activity of full-length N-WASP has been visualized in vivo, and this has lead to new insights for N-WASP function...
- Molecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2/3 complex pathway and cofilinHideki Yamaguchi
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
J Cell Biol 168:441-52. 2005..These results indicate that EGF receptor signaling regulates invadopodium formation through the N-WASP-Arp2/3 pathway and cofilin is necessary for the stabilization and maturation of invadopodia...
- RhoA/ROCK-mediated switching between Cdc42- and Rac1-dependent protrusion in MTLn3 carcinoma cellsMirvat El-Sibai
Department of Molecular Pharmacology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
Exp Cell Res 314:1540-52. 2008..These data describe a novel role for Rho in coordinating signaling by Rac and Cdc42...
- ZBP1 enhances cell polarity and reduces chemotaxisKyle Lapidus
Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461 1975, USA
J Cell Sci 120:3173-8. 2007..We found that ZBP1 expression actually reduced tumor cell motility and chemotaxis, presumably mediating their decreased metastatic potential by reducing their ability to respond to signals necessary for invasion...
- Measurement of barbed ends, actin polymerization, and motility in live carcinoma cells after growth factor stimulationMike Lorenz
Albert Einstein College of Medicine, Department of Anatomy and Structural Biology, Bronx, NY 10461, USA
Cell Motil Cytoskeleton 57:207-17. 2004..This assay has a high potential for applications where rapid changes in the dynamic filament population are to be measured...
- Spatial regulation of beta-actin translation by Src-dependent phosphorylation of ZBP1Stefan Huttelmaier
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
Nature 438:512-5. 2005..These sequential events provide both temporal and spatial control over beta-actin mRNA translation, which is important for cell migration and neurite outgrowth...
- The mechanism of CSF-1-induced Wiskott-Aldrich syndrome protein activation in vivo: a role for phosphatidylinositol 3-kinase and Cdc42Michael Cammer
Department of Anatomy, Albert Einstein College of Medicine, Yeshiva University, Bronx, New York 10461, USA
J Biol Chem 284:23302-11. 2009..However, although tyrosine phosphorylation of WASP has been proposed to stimulate WASP activity, we found no evidence to indicate that this occurs in vivo...
- Distance determination in protein-DNA complexes using fluorescence resonance energy transferMike Lorenz
Optical Technology Development, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
Methods Mol Biol 335:243-55. 2006..Advances in the preparation of dye-labeled nucleic acid molecules and modern techniques like the measurement of FRET in vivo lead to an increased importance of FRET studies in structural and molecular biology...
- A peptide motif in Raver1 mediates splicing repression by interaction with the PTB RRM2 domainAlexis P Rideau
Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, CB2 1GA, UK
Nat Struct Mol Biol 13:839-48. 2006..The requirement for the PTB-Raver1 interaction that we have characterized may serve to bring the additional repressor regions of both proteins into a configuration that allows them to synergistically effect exon skipping...