Herbert Lachman

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. ncbi request reprint An overview of the genetics of substance use disorders
    H M Lachman
    Albert Einstein College of Medicine, Departments of Medicine and Psychiatry, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Curr Psychiatry Rep 8:133-43. 2006
  2. ncbi request reprint Lack of association of catechol-O-methyltransferase (COMT) functional polymorphism in bipolar affective disorder
    H M Lachman
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Psychiatr Genet 7:13-7. 1997
  3. ncbi request reprint Genomewide suggestive linkage of opioid dependence to chromosome 14q
    Herbert M Lachman
    Division of Basic Research, Department of Psychiatry and Behavioral Sciences, Albert Einstein College of MedicineBronx, NY 10461, USA
    Hum Mol Genet 16:1327-34. 2007
  4. ncbi request reprint Analysis of synapsin III-196 promoter mutation in schizophrenia and bipolar disorder
    Herbert M Lachman
    Department of Psychiatry and Behavioral Sciences, Division of Psychiatry Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Neuropsychobiology 53:57-62. 2006
  5. ncbi request reprint Analysis of polymorphisms in AT-rich domains of neuregulin 1 gene in schizophrenia
    Herbert M Lachman
    Department of Psychiatry, Division of Basic Research, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Am J Med Genet B Neuropsychiatr Genet 141:102-9. 2006
  6. doi request reprint Analysis of protocadherin alpha gene deletion variant in bipolar disorder and schizophrenia
    Herbert M Lachman
    Department of Psychiatry and Behavioral Sciences, Division of Basic Research, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Psychiatr Genet 18:110-5. 2008
  7. ncbi request reprint Association of schizophrenia in African Americans to polymorphism in synapsin III gene
    Herbert M Lachman
    Department of Psychiatry and Behavioral Sciences, Division of Psychiatry Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Psychiatr Genet 15:127-32. 2005
  8. ncbi request reprint Increase in GSK3beta gene copy number variation in bipolar disorder
    Herbert M Lachman
    Department of Psychiatry and Behavioral Sciences, Division of Basic Research, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Med Genet B Neuropsychiatr Genet 144:259-65. 2007
  9. doi request reprint Does COMT val158met affect behavioral phenotypes: yes, no, maybe?
    Herbert M Lachman
    Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, NY, USA
    Neuropsychopharmacology 33:3027-9. 2008
  10. pmc Copy variations in schizophrenia and bipolar disorder
    H M Lachman
    Department of Psychiatry and Behavioral Sciences, Division of Basic Research Albert Einstein College of Medicine, Bronx, New York, USA
    Cytogenet Genome Res 123:27-35. 2008

Research Grants

Collaborators

Detail Information

Publications29

  1. ncbi request reprint An overview of the genetics of substance use disorders
    H M Lachman
    Albert Einstein College of Medicine, Departments of Medicine and Psychiatry, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Curr Psychiatry Rep 8:133-43. 2006
    ..Through a combination of genetic approaches, the variant alleles responsible for interindividual differences in susceptibility to addiction are being uncovered...
  2. ncbi request reprint Lack of association of catechol-O-methyltransferase (COMT) functional polymorphism in bipolar affective disorder
    H M Lachman
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Psychiatr Genet 7:13-7. 1997
    ..We have now screened 63 unrelated patients with BPD for this functional polymorphism. However, no significant association was detected. This suggests that the codon 158 COMT polymorphism is not a susceptibility gene in BPD...
  3. ncbi request reprint Genomewide suggestive linkage of opioid dependence to chromosome 14q
    Herbert M Lachman
    Division of Basic Research, Department of Psychiatry and Behavioral Sciences, Albert Einstein College of MedicineBronx, NY 10461, USA
    Hum Mol Genet 16:1327-34. 2007
    ..05). Our linkage data suggest specific chromosomal loci for future fine-mapping genetic analysis and support the hypothesis that ethnic and gender specific genes underlie addiction susceptibility...
  4. ncbi request reprint Analysis of synapsin III-196 promoter mutation in schizophrenia and bipolar disorder
    Herbert M Lachman
    Department of Psychiatry and Behavioral Sciences, Division of Psychiatry Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Neuropsychobiology 53:57-62. 2006
    ..The -196A allele results in a 6/8 base match to the core recognition octamer sequence for Oct-1, a member of the POU family of transcription factors...
  5. ncbi request reprint Analysis of polymorphisms in AT-rich domains of neuregulin 1 gene in schizophrenia
    Herbert M Lachman
    Department of Psychiatry, Division of Basic Research, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Am J Med Genet B Neuropsychiatr Genet 141:102-9. 2006
    ....
  6. doi request reprint Analysis of protocadherin alpha gene deletion variant in bipolar disorder and schizophrenia
    Herbert M Lachman
    Department of Psychiatry and Behavioral Sciences, Division of Basic Research, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Psychiatr Genet 18:110-5. 2008
    ..A polymorphic copy number variation in this locus, a 16.7-kb deletion affecting PCDH-alpha exons 8-10 (alpha 8-alpha 10 Delta), was analyzed in this study as a potential candidate variant in SZ and BD...
  7. ncbi request reprint Association of schizophrenia in African Americans to polymorphism in synapsin III gene
    Herbert M Lachman
    Department of Psychiatry and Behavioral Sciences, Division of Psychiatry Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Psychiatr Genet 15:127-32. 2005
    ....
  8. ncbi request reprint Increase in GSK3beta gene copy number variation in bipolar disorder
    Herbert M Lachman
    Department of Psychiatry and Behavioral Sciences, Division of Basic Research, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Med Genet B Neuropsychiatr Genet 144:259-65. 2007
    ..002). The finding suggests that GSK3beta may be involved in BD susceptibility in some individuals and that CNVs in this and other candidate genes for psychiatric disorders should be analyzed as causative functional genetic variants...
  9. doi request reprint Does COMT val158met affect behavioral phenotypes: yes, no, maybe?
    Herbert M Lachman
    Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, NY, USA
    Neuropsychopharmacology 33:3027-9. 2008
    ..The studies make important contributions to the growing literature that aim to establish an effect of this functional variant on behavioral phenotypes and treatment response...
  10. pmc Copy variations in schizophrenia and bipolar disorder
    H M Lachman
    Department of Psychiatry and Behavioral Sciences, Division of Basic Research Albert Einstein College of Medicine, Bronx, New York, USA
    Cytogenet Genome Res 123:27-35. 2008
    ..Although the analysis of CNVs in patients with psychiatric disorders is in its infancy, informative new findings have already been made, suggesting that this is a very promising line of research...
  11. ncbi request reprint Association between catechol O-methyltransferase genotype and violence in schizophrenia and schizoaffective disorder
    H M Lachman
    Department of Psychiatry and Medicine, Albert Einstein College of Medicine, Orangeburg, N Y, USA
    Am J Psychiatry 155:835-7. 1998
    ..This study replicates and extends these findings by using more direct measures of violent behavior...
  12. pmc Analysis of a promoter polymorphism in the SMDF neuregulin 1 isoform in Schizophrenia
    Erika Pedrosa
    Division of Basic Research, Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Neuropsychobiology 59:205-12. 2009
    ..Analysis of the SNP database revealed several polymorphisms within the approximate borders of the region immunoprecipitated in our ChIP-chip experiments, one of which is rs7825588...
  13. ncbi request reprint Positive association of schizophrenia to JARID2 gene
    Erika Pedrosa
    Department of Psychiatry, Division of Basic Research, Albert Einstein College of Medicine, Bronx, New York, USA
    Am J Med Genet B Neuropsychiatr Genet 144:45-51. 2007
    ..02; P = 0.008). No other JARID2 marker displayed statistically significant allele and genotype distributions. Our findings suggest that JARID2 should be viewed as a candidate gene for 6p22.3-linked SZ...
  14. pmc Analysis of protocadherin alpha gene enhancer polymorphism in bipolar disorder and schizophrenia
    Erika Pedrosa
    Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, New York 10461, United States
    Schizophr Res 102:210-9. 2008
    ..The findings suggest that the 5q31-linked PCDH locus should be more thoroughly considered as a disease-susceptibility locus in psychiatric disorders...
  15. ncbi request reprint Polymorphism screening of PIK4CA: possible candidate gene for chromosome 22q11-linked psychiatric disorders
    Takuya Saito
    Department of Psychiatry, Division of Psychiatry Research, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Med Genet B Neuropsychiatr Genet 116:77-83. 2003
    ....
  16. ncbi request reprint Catechol O-methyltransferase Val158Met polymorphism in schizophrenia: differential effects of Val and Met alleles on cognitive stability and flexibility
    Karen A Nolan
    Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Am J Psychiatry 161:359-61. 2004
    ..They hypothesized that the Val and Met alleles would be associated with deficits in imitation learning and reversal learning, respectively...
  17. doi request reprint ChIP-chip analysis of neurexins and other candidate genes for addiction and neuropsychiatric disorders
    Erika Pedrosa
    Department of Psychiatry and Behavioral Sciences, Division of Basic Research, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurogenet 24:5-17. 2010
    ..Many established or putative regulatory elements map near-disease-associated SNPs. These regions would be of interest to survey for patient-specific functional variants involved in disease susceptibility...
  18. ncbi request reprint Analysis of SYNJ1, a candidate gene for 21q22 linked bipolar disorder: a replication study
    Pavla Stopkova
    Department of Psychiatry and Behavioral Sciences, Division of Psychiatry Research, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Psychiatry Res 127:157-61. 2004
    ..The combined data from both studies continue to show a trend toward significance for allele 2 homozygotes in BPD...
  19. ncbi request reprint Polymorphism screening of PIP5K2A: a candidate gene for chromosome 10p-linked psychiatric disorders
    Pavla Stopkova
    Department of Psychiatry and Behavioral Sciences, Division of Psychiatry Research, Albert Einstein College of Medicine, New York 10461, USA
    Am J Med Genet B Neuropsychiatr Genet 123:50-8. 2003
    ..These data suggest that the imperfect CT repeat in PIP5K2A intron 9 should be further investigated as a possible candidate allele for 10p12-linked psychiatric disorders...
  20. ncbi request reprint Screening of PIP5K2A promoter region for mutations in bipolar disorder and schizophrenia
    Pavla Stopkova
    Department of Psychiatry and Behavioral Sciences, Division of Psychiatry Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Psychiatr Genet 15:223-7. 2005
    ..To analyze the promoter region of PIP5K2A, a phosphatidylinositol 4-phosphate 5-kinase that maps to 10p in a region linked to both bipolar disorder and schizophrenia...
  21. ncbi request reprint The catechol-O-methyltransferase polymorphism: relations to the tonic-phasic dopamine hypothesis and neuropsychiatric phenotypes
    Robert M Bilder
    Department of Psychiatry, David Geffen School of Medicine and Psychology, UCLA Neuropsychiatric Institute, University of California at Los Angeles, Los Angeles, CA, USA
    Neuropsychopharmacology 29:1943-61. 2004
    ....
  22. pmc Rare NRXN1 promoter variants in patients with schizophrenia
    Abhishek K Shah
    Department of Psychiatry and Behavioral Sciences, Division of Basic Research, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, New York 10461, United States
    Neurosci Lett 475:80-4. 2010
    ..The findings suggest that in addition to chromosomal alterations disrupting the NRXN1alpha promoter, rare point mutations in the region may also be involved in SZ pathogenesis...
  23. ncbi request reprint Analysis of monoamine oxidase A (MAOA) promoter polymorphism in Finnish male alcoholics
    Takuya Saito
    Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Psychiatry Res 109:113-9. 2002
    ..Since MAOA is X-linked, the heterozygotes are probable cases of Klinefelter's syndrome (47,XXY) suggesting that X-chromosome aneuploidy may increase the risk for developing type 2 alcoholism...
  24. ncbi request reprint Catechol-O-methyltransferase and monoamine oxidase-A polymorphisms and treatment response to typical and atypical neuroleptics
    Karen A Nolan
    J Clin Psychopharmacol 26:338-40. 2006
  25. ncbi request reprint Analysis of PIK3C3 promoter variant in African-Americans with schizophrenia
    Takuya Saito
    Schizophr Res 76:361-2. 2005
  26. ncbi request reprint Genetic linkage for schizophrenia?
    Jan Volavka
    Am J Psychiatry 161:1134-5; author reply 1135-6. 2004
  27. ncbi request reprint Identification of PIK3C3 promoter variant associated with bipolar disorder and schizophrenia
    Pavla Stopkova
    Psychiatric Clinic, First Medical Faculty, Charles University, Prague, Czech Republic
    Biol Psychiatry 55:981-8. 2004
    ..One is PIK3C3, a member of the phosphatidylinositide 3-kinase family that maps closely to markers on 18q linked to both BD and SZ in a few studies...
  28. ncbi request reprint Aggressive behavior in schizophrenia is associated with the low enzyme activity COMT polymorphism: a replication study
    Rael D Strous
    Beer Yaakov Mental Health Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Am J Med Genet B Neuropsychiatr Genet 120:29-34. 2003
    ..Our findings provide further support that COMT is a modifying gene that plays a role in determining interindividual variability in the proclivity for outward and self-directed aggressive behavior found in some schizophrenic patients...
  29. ncbi request reprint Analysis of an association between the COMT polymorphism and clinical symptomatology in schizophrenia
    Rael D Strous
    Beer Yaakov Mental Health Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, PO Box 1, Beer Yaakov 70350, Israel
    Neurosci Lett 393:170-3. 2006
    ....

Research Grants8

  1. GENOME-WIDE ANALYSIS FOR ADDICTION SUSCEPTIBILITY GENES
    Herbert Lachman; Fiscal Year: 2005
    ..By the end of the project, which will coincide with the completion of the human genome project, they will be able to analyze all of the specific candidate genes that map to linked markers. ..
  2. Molecular analysis of bipolar and schizophrenia candidate genes
    Herbert Lachman; Fiscal Year: 2007
    ..It is through alterations in gene expression that environmental stressors interact with the brain. ..