Marla J Keller

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. pmc Phase I randomized safety study of twice daily dosing of acidform vaginal gel: candidate antimicrobial contraceptive
    Marla J Keller
    Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, United States of America
    PLoS ONE 7:e46901. 2012
  2. pmc Safety and pharmacokinetics of aciclovir in women following release from a silicone elastomer vaginal ring
    M J Keller
    Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Antimicrob Chemother 67:2005-12. 2012
  3. pmc Risk of cervical precancer and cancer among HIV-infected women with normal cervical cytology and no evidence of oncogenic HPV infection
    Marla J Keller
    Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Ave, Mazer Bldg, Room 512, Bronx, NY 10461, USA
    JAMA 308:362-9. 2012
  4. pmc A randomized trial to assess anti-HIV activity in female genital tract secretions and soluble mucosal immunity following application of 1% tenofovir gel
    Marla J Keller
    Department of Medicine, Albert Einstein College of Medicine, New York, New York, United States of America
    PLoS ONE 6:e16475. 2011
  5. pmc Susceptibility to genital herpes as a biomarker predictive of increased HIV risk: expansion of a murine model of microbicide safety
    Sarah S Wilson
    Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, USA
    Antivir Ther 14:1113-24. 2009
  6. ncbi request reprint ACIDFORM inactivates herpes simplex virus and prevents genital herpes in a mouse model: optimal candidate for microbicide combinations
    Ana C G Tuyama
    Division of Infectious Disease, Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Infect Dis 194:795-803. 2006
  7. ncbi request reprint PRO 2000 elicits a decline in genital tract immune mediators without compromising intrinsic antimicrobial activity
    Marla J Keller
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    AIDS 21:467-76. 2007
  8. ncbi request reprint PRO 2000 gel inhibits HIV and herpes simplex virus infection following vaginal application: a double-blind placebo-controlled trial
    Marla J Keller
    Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Infect Dis 193:27-35. 2006
  9. pmc Disruption of tight junctions by cellulose sulfate facilitates HIV infection: model of microbicide safety
    Pedro M M Mesquita
    Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Infect Dis 200:599-608. 2009
  10. pmc Plasma and mucosal HIV viral loads are associated with genital tract inflammation in HIV-infected women
    Betsy C Herold
    Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Acquir Immune Defic Syndr 63:485-93. 2013

Collaborators

Detail Information

Publications37

  1. pmc Phase I randomized safety study of twice daily dosing of acidform vaginal gel: candidate antimicrobial contraceptive
    Marla J Keller
    Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, United States of America
    PLoS ONE 7:e46901. 2012
    ..This study was designed to evaluate the safety of vaginal dosing and effects of Acidform on mucosal immune mediators, antimicrobial properties of genital secretions, and vaginal microbiota...
  2. pmc Safety and pharmacokinetics of aciclovir in women following release from a silicone elastomer vaginal ring
    M J Keller
    Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Antimicrob Chemother 67:2005-12. 2012
    ..Intravaginal ring (IVR) delivery of aciclovir may provide pre-exposure prophylaxis against HSV acquisition...
  3. pmc Risk of cervical precancer and cancer among HIV-infected women with normal cervical cytology and no evidence of oncogenic HPV infection
    Marla J Keller
    Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Ave, Mazer Bldg, Room 512, Bronx, NY 10461, USA
    JAMA 308:362-9. 2012
    ..Whether a 3-year or 5-year screening interval could be used in HIV-infected women who are cytologically normal and oncogenic HPV-negative is unknown...
  4. pmc A randomized trial to assess anti-HIV activity in female genital tract secretions and soluble mucosal immunity following application of 1% tenofovir gel
    Marla J Keller
    Department of Medicine, Albert Einstein College of Medicine, New York, New York, United States of America
    PLoS ONE 6:e16475. 2011
    ....
  5. pmc Susceptibility to genital herpes as a biomarker predictive of increased HIV risk: expansion of a murine model of microbicide safety
    Sarah S Wilson
    Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, USA
    Antivir Ther 14:1113-24. 2009
    ....
  6. ncbi request reprint ACIDFORM inactivates herpes simplex virus and prevents genital herpes in a mouse model: optimal candidate for microbicide combinations
    Ana C G Tuyama
    Division of Infectious Disease, Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Infect Dis 194:795-803. 2006
    ..These findings suggest that ACIDFORM offers considerable protection against HSV and may be an optimal candidate for developing combination microbicides...
  7. ncbi request reprint PRO 2000 elicits a decline in genital tract immune mediators without compromising intrinsic antimicrobial activity
    Marla J Keller
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    AIDS 21:467-76. 2007
    ..The objective of this study was to examine the effect of 14 daily applications of 0.5% PRO 2000 or placebo gel on mediators of mucosal immunity and intrinsic antimicrobial activity...
  8. ncbi request reprint PRO 2000 gel inhibits HIV and herpes simplex virus infection following vaginal application: a double-blind placebo-controlled trial
    Marla J Keller
    Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Infect Dis 193:27-35. 2006
    ..This study was designed to determine the antiviral activity in cervicovaginal lavage (CVL) samples collected after intravaginal application of 0.5% PRO 2000 gel (Indevus)...
  9. pmc Disruption of tight junctions by cellulose sulfate facilitates HIV infection: model of microbicide safety
    Pedro M M Mesquita
    Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Infect Dis 200:599-608. 2009
    ..The lack of biomarkers that are predictive of safety is a critical gap in the development of microbicides. The present experiments were designed to evaluate the predictive value of in vitro models of microbicide safety...
  10. pmc Plasma and mucosal HIV viral loads are associated with genital tract inflammation in HIV-infected women
    Betsy C Herold
    Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Acquir Immune Defic Syndr 63:485-93. 2013
    ....
  11. pmc Altered biomarkers of mucosal immunity and reduced vaginal Lactobacillus concentrations in sexually active female adolescents
    Rebecca Pellett Madan
    Department of Pediatrics, Albert Einstein College of Medicine, New York, New York, United States of America
    PLoS ONE 7:e40415. 2012
    ..coli), but prior studies have not investigated this endogenous antimicrobial activity or its mediators in adolescent females...
  12. pmc Changes in the soluble mucosal immune environment during genital herpes outbreaks
    Marla J Keller
    Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA
    J Acquir Immune Defic Syndr 61:194-202. 2012
    ..We hypothesize that the anti-HSV activity may prevent the spread of virus from the more commonly affected sites, such as the external genitalia, to the upper genital tract...
  13. ncbi request reprint Seminal plasma reduces the effectiveness of topical polyanionic microbicides
    Sarju Patel
    Department of Pediatrics, Mount Sinai School of Medicine, New York, NY, USA
    J Infect Dis 196:1394-402. 2007
    ..0007, log rank test). If these findings are reflective of what occurs in humans, modifications to microbicides to ensure that they retain activity in the presence of seminal plasma are indicated...
  14. doi request reprint Female genital tract secretions inhibit herpes simplex virus infection: correlation with soluble mucosal immune mediators and impact of hormonal contraception
    Gail F Shust
    Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY 10467, USA
    Am J Reprod Immunol 63:110-9. 2010
    ..Female genital tract secretions inhibit herpes simplex virus (HSV) infection, however, the intra- and inter-subject variability, contribution of specific mediators, and impact of reproductive hormones have not been defined...
  15. pmc Postcoital bioavailability and antiviral activity of 0.5% PRO 2000 gel: implications for future microbicide clinical trials
    Marla J Keller
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA
    PLoS ONE 5:e8781. 2010
    ..This study compared the biological activity and concentration of PRO 2000 in cervicovaginal lavage (CVL) collected in the absence or following coitus...
  16. ncbi request reprint Amphipathic DNA polymers are candidate vaginal microbicides and block herpes simplex virus binding, entry and viral gene expression
    Esmeralda M Guzman
    Department of Pediatrics and Medicine, Mount Sinai School of Medicine, New York, USA
    Antivir Ther 12:1147-56. 2007
    ..This current study was conducted to explore the anti-herpes simplex virus (HSV) activity of the same panel of compounds and to determine their mechanism of activity...
  17. ncbi request reprint Human alpha- and beta-defensins block multiple steps in herpes simplex virus infection
    Ehsan Hazrati
    Department of Pediatrics, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029, USA
    J Immunol 177:8658-66. 2006
    ..These findings demonstrate that HDs act at multiple steps in the HSV life cycle and support the development of defensins or defensin-like peptides as microbicides...
  18. pmc Candidate sulfonated and sulfated topical microbicides: comparison of anti-human immunodeficiency virus activities and mechanisms of action
    Irini A Scordi-Bello
    Department of Medicine, Mount Sinai School of Medicine, Box 1090, New York, NY 10029, USA
    Antimicrob Agents Chemother 49:3607-15. 2005
    ..When mixed with cervicovaginal lavage fluid, SPs maintain inhibitory activity at concentrations achievable in formulations...
  19. ncbi request reprint Cervicovaginal secretions contribute to innate resistance to herpes simplex virus infection
    Minnie John
    Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Infect Dis 192:1731-40. 2005
    ..In contrast, all 15 mice challenged with untreated HSV-2 died. These findings are evidence that cervicovaginal secretions contribute to innate resistance to HSV-2 and identify defensins as contributors to this activity...
  20. ncbi request reprint Use of the dye stain assay and ultraviolet light test for assessing vaginal insertion of placebo-filled applicators before and after sex
    Marla J Keller
    From the Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY The Population Council, New York, NY Albert Einstein Cancer Center, Bronx, NY and National Cancer Institute, National Institutes of Health, Bethesda, MD
    Sex Transm Dis 40:939-43. 2013
    ..This study was designed to determine if semen or presex gel dosing impacts the sensitivity and specificity of a dye stain assay (DSA) for measuring vaginal insertion of placebo-filled applicators with BAT-24 dosing...
  21. ncbi request reprint Evaluation of 3 approaches for assessing adherence to vaginal gel application in clinical trials
    Ariane van der Straten
    From the Women s Global Health Imperative, RTI International, San Francisco, CA Center for AIDS Prevention Studies CAPS Department of Medicine, UCSF, San Francisco, CA The Population Council, New York, NY Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY and Albert Einstein Cancer Center, Bronx, NY
    Sex Transm Dis 40:950-6. 2013
    ..Accurate measurement of adherence to product use is an ongoing challenge in microbicide trials...
  22. doi request reprint Understanding basic mechanisms and optimizing assays to evaluate the efficacy of vaginal microbicides
    Marla J Keller
    Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Sex Transm Dis 36:S92-5. 2009
    ....
  23. ncbi request reprint Assessment of adherence to product dosing in a pilot microbicide study
    Kathleen Hogarty
    Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1090, New York, NY 10029, USA
    Sex Transm Dis 34:1000-3. 2007
    ..To determine whether applicator staining could be incorporated into a microbicide study as a marker of adherence...
  24. pmc Molecular umbrellas: a novel class of candidate topical microbicides to prevent human immunodeficiency virus and herpes simplex virus infections
    Rebecca Pellett Madan
    Department of Pediatrics, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    J Virol 81:7636-46. 2007
    ....
  25. ncbi request reprint A comprehensive murine model to evaluate topical vaginal microbicides: mucosal inflammation and susceptibility to genital herpes as surrogate markers of safety
    Benjamin T Galen
    Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Infect Dis 195:1332-9. 2007
    ..These findings suggest that PRO 2000 has little deleterious effect on mucosal immunity and, if validated by clinical experiences, support the inclusion of this model in the preclinical evaluation of future candidate microbicides...
  26. ncbi request reprint Role of mucosal immunity in preventing genital herpes infection
    Veronica MasCasullo
    Department of Pediatrics, Mount Sinai School of Medicine, New York, New York 10029, USA
    Viral Immunol 18:595-606. 2005
    ..Understanding how each of these components contribute to innate immunity, mechanisms of antiviral activity, and whether the virus has evolved strategies to evade their effects may lead to the development of novel vaginal microbicides...
  27. pmc Lactobacillus proteins are associated with the bactericidal activity against E. coli of female genital tract secretions
    Sabah Kalyoussef
    Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 7:e49506. 2012
    ..Female genital tract secretions are bactericidal for Escherichia (E.) coli ex vivo. However, the intersubject variability and molecules that contribute to this activity have not been defined...
  28. pmc Female genital tract secretions and semen impact the development of microbicides for the prevention of HIV and other sexually transmitted infections
    Betsy C Herold
    Department of Pediatrics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10467, USA
    Am J Reprod Immunol 65:325-33. 2011
    ....
  29. ncbi request reprint Prioritizing prevention of HIV and sexually transmitted infections: first-generation vaginal microbicides
    Rebecca Pellett Madan
    Departments of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Curr Opin Infect Dis 19:49-54. 2006
    ..The microbicides discussed in this review may provide a new opportunity for decreasing the spread of HIV and other sexually transmitted infections...
  30. ncbi request reprint Topical microbicides for the prevention of genital herpes infection
    Marla J Keller
    Departments of Medicine and Pediatrics, Division of Infectious Diseases, Mount Sinai School of Medicine, New York, NY, USA
    J Antimicrob Chemother 55:420-3. 2005
    ..A more vigorous evaluation of the safety of these and other candidate topical microbicides in development should include assessment of the impact of repeated application on innate host defences in the genital tract...
  31. ncbi request reprint Impact of microbicides and sexually transmitted infections on mucosal immunity in the female genital tract
    Marla J Keller
    Division of Infectious Disease, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Am J Reprod Immunol 56:356-63. 2006
    ..This will require a greater understanding of the mediators of mucosal immunity in the female genital tract...
  32. pmc Candidate microbicide PPCM blocks human immunodeficiency virus type 1 infection in cell and tissue cultures and prevents genital herpes in a murine model
    Pedro M M Mesquita
    Department of Cellular and Molecular Medicine, St George s University of London, London, United Kingdom
    J Virol 82:6576-84. 2008
    ....
  33. pmc Candidate topical microbicides bind herpes simplex virus glycoprotein B and prevent viral entry and cell-to-cell spread
    Natalia Cheshenko
    Department of Pediatrics, Mount Sinai School of Medicine, 1 Gustave L Levy Place, Box 1657, New York, NY 10029, USA
    Antimicrob Agents Chemother 48:2025-36. 2004
    ..These studies support further development and rigorous evaluation of these candidate microbicides...
  34. pmc Topical prophylaxis for HIV prevention in women: becoming a reality
    Natasha A Verma
    Department of Pediatrics, Division of Infectious Diseases, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Forchheimer Building, Room 702, Bronx, NY 10461, USA
    Curr HIV/AIDS Rep 8:104-13. 2011
    ....
  35. pmc Association of regional body composition with bone mineral density in HIV-infected and HIV-uninfected women: women's interagency HIV study
    Anjali Sharma
    Department of Medicine, State University of New York Downstate Medical Center, Brooklyn, NY 11205, USA
    J Acquir Immune Defic Syndr 61:469-76. 2012
    ..To understand how regional body composition affects bone mineral density (BMD) in HIV-infected and HIV-uninfected women...
  36. pmc Elevated osteoprotegerin is associated with abnormal ankle brachial indices in patients infected with HIV: a cross-sectional study
    James J Jang
    Zena and Michael A Wiener Cardiovascular Institute and Marie Jose├Če and Henry R Kravis Center for Cardiovascular Health, Mount Sinai School of Medicine, New York, New York, USA
    J Int AIDS Soc 13:12. 2010
    ..The objective of this study was to determine whether PAD is prevalent in an HIV-infected population, and to identify an association with HIV-specific and traditional cardiovascular risk factors, as well as levels of osteoprotegerin...
  37. ncbi request reprint Rigorous pre-clinical evaluation of topical microbicides to prevent transmission of human immunodeficiency virus
    Marla J Keller
    Department of Medicine, Division of Infectious Disease, Box 1657, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    J Antimicrob Chemother 51:1099-102. 2003