Dhananjay Kaul

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. ncbi request reprint Rate of deoxygenation modulates rheologic behavior of sickle red blood cells at a given mean corpuscular hemoglobin concentration
    D K Kaul
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Clin Hemorheol Microcirc 21:125-35. 1999
  2. pmc Sickle red cell-endothelium interactions
    Dhananjay K Kaul
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Microcirculation 16:97-111. 2009
  3. doi request reprint Sickle red cell adhesion: many issues and some answers
    D K Kaul
    Department of Medicine, Ullmann 917, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Transfus Clin Biol 15:51-5. 2008
  4. pmc Arginine therapy of transgenic-knockout sickle mice improves microvascular function by reducing non-nitric oxide vasodilators, hemolysis, and oxidative stress
    Dhananjay K Kaul
    Dept of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Am J Physiol Heart Circ Physiol 295:H39-47. 2008
  5. ncbi request reprint Peptides based on alphaV-binding domains of erythrocyte ICAM-4 inhibit sickle red cell-endothelial interactions and vaso-occlusion in the microcirculation
    Dhananjay K Kaul
    Dept of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Am J Physiol Cell Physiol 291:C922-30. 2006
  6. ncbi request reprint Inhibition of sickle red cell adhesion and vasoocclusion in the microcirculation by antioxidants
    Dhananjay K Kaul
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Am J Physiol Heart Circ Physiol 291:H167-75. 2006
  7. pmc Effect of fetal hemoglobin on microvascular regulation in sickle transgenic-knockout mice
    Dhananjay K Kaul
    Division of Hematology, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Clin Invest 114:1136-45. 2004
  8. ncbi request reprint In vivo studies of sickle red blood cells
    Dhananjay K Kaul
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Microcirculation 11:153-65. 2004
  9. ncbi request reprint Anti-inflammatory therapy ameliorates leukocyte adhesion and microvascular flow abnormalities in transgenic sickle mice
    Dhananjay K Kaul
    Division of Hematology, Department of Medicine, Albert Einstein College of Medicine, Rm U 917, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Am J Physiol Heart Circ Physiol 287:H293-301. 2004
  10. ncbi request reprint Monoclonal antibodies to alphaVbeta3 (7E3 and LM609) inhibit sickle red blood cell-endothelium interactions induced by platelet-activating factor
    D K Kaul
    Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461, USA
    Blood 95:368-74. 2000

Research Grants

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Rate of deoxygenation modulates rheologic behavior of sickle red blood cells at a given mean corpuscular hemoglobin concentration
    D K Kaul
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Clin Hemorheol Microcirc 21:125-35. 1999
    ..Thus, both MCHC and the deoxygenation rate may contribute to microcirculatory flow behavior of SS RBCs...
  2. pmc Sickle red cell-endothelium interactions
    Dhananjay K Kaul
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Microcirculation 16:97-111. 2009
    ....
  3. doi request reprint Sickle red cell adhesion: many issues and some answers
    D K Kaul
    Department of Medicine, Ullmann 917, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Transfus Clin Biol 15:51-5. 2008
    ..This review briefly analyzes these issues...
  4. pmc Arginine therapy of transgenic-knockout sickle mice improves microvascular function by reducing non-nitric oxide vasodilators, hemolysis, and oxidative stress
    Dhananjay K Kaul
    Dept of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Am J Physiol Heart Circ Physiol 295:H39-47. 2008
    ..These results provide a strong rationale for therapeutic use of arginine in sickle cell disease and other hemolytic diseases...
  5. ncbi request reprint Peptides based on alphaV-binding domains of erythrocyte ICAM-4 inhibit sickle red cell-endothelial interactions and vaso-occlusion in the microcirculation
    Dhananjay K Kaul
    Dept of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Am J Physiol Cell Physiol 291:C922-30. 2006
    ..Thus peptides or small molecule mimetics of ICAM-4 may have therapeutic potential...
  6. ncbi request reprint Inhibition of sickle red cell adhesion and vasoocclusion in the microcirculation by antioxidants
    Dhananjay K Kaul
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Am J Physiol Heart Circ Physiol 291:H167-75. 2006
    ..Thus SS red cell adhesion and related vasoocclusion may be ameliorated by antioxidant therapy with a stable and long-acting molecule (e.g., PNA)...
  7. pmc Effect of fetal hemoglobin on microvascular regulation in sickle transgenic-knockout mice
    Dhananjay K Kaul
    Division of Hematology, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Clin Invest 114:1136-45. 2004
    ..Furthermore, BERK + gamma mice show normalization of vessel diameters, and eNOS and COX-2 expression. These results demonstrate a strong relationship between sickling and microvascular function in sickle cell disease...
  8. ncbi request reprint In vivo studies of sickle red blood cells
    Dhananjay K Kaul
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Microcirculation 11:153-65. 2004
    ..An updated version of this 2-step model is presented. The multifactorial nature of sickle red cell adhesion needs to be considered in designing antiadhesive therapy in vivo...
  9. ncbi request reprint Anti-inflammatory therapy ameliorates leukocyte adhesion and microvascular flow abnormalities in transgenic sickle mice
    Dhananjay K Kaul
    Division of Hematology, Department of Medicine, Albert Einstein College of Medicine, Rm U 917, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Am J Physiol Heart Circ Physiol 287:H293-301. 2004
    ..Thus targeting oxidant generation and/or NF-kappaB activation may constitute promising therapeutic approaches in sickle cell disease...
  10. ncbi request reprint Monoclonal antibodies to alphaVbeta3 (7E3 and LM609) inhibit sickle red blood cell-endothelium interactions induced by platelet-activating factor
    D K Kaul
    Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461, USA
    Blood 95:368-74. 2000
    ..Thus, blockade of alphaVbeta3 may constitute a potential therapeutic approach to prevent SS RBC-endothelium interactions under flow conditions. (Blood. 2000;95:368-374)..
  11. ncbi request reprint Ameliorating effects of fluorocarbon emulsion on sickle red blood cell-induced obstruction in an ex vivo vasculature
    D K Kaul
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Blood 98:3128-31. 2001
    ..Thus, oxygenated PFE is capable of reducing SS RBC-induced vaso-occlusion, and further development of this approach is advisable...
  12. ncbi request reprint Impaired nitric oxide-mediated vasodilation in transgenic sickle mouse
    D K Kaul
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Am J Physiol Heart Circ Physiol 278:H1799-806. 2000
    ..Although the increased NOS/NO activity may compensate for flow abnormalities, it may also cause pathophysiological alterations in vascular tone...
  13. pmc Hypoxia/reoxygenation causes inflammatory response in transgenic sickle mice but not in normal mice
    D K Kaul
    Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Clin Invest 106:411-20. 2000
    ..These findings suggest that leukocyte-endothelium interaction contribute to vasoocclusive events in the sickle mice and perhaps in human sickle disease...
  14. pmc Antisickling property of fetal hemoglobin enhances nitric oxide bioavailability and ameliorates organ oxidative stress in transgenic-knockout sickle mice
    Trisha Dasgupta
    Dept of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Am J Physiol Regul Integr Comp Physiol 298:R394-402. 2010
    ..These results show that the protective effect of HbF is mediated primarily by decreasing intravascular sickling resulting in decreased oxidative stress and increased NO bioavailability...
  15. pmc Protective effect of arginine on oxidative stress in transgenic sickle mouse models
    Trisha Dasgupta
    Department of Medicine, Room U 917, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Free Radic Biol Med 41:1771-80. 2006
    ..Thus, the attenuating effect of arginine on oxidative stress in SCD mice suggests its potential application in the management of this disease...
  16. ncbi request reprint The endothelial biology of sickle cell disease: inflammation and a chronic vasculopathy
    Robert P Hebbel
    Vascular Biology Center and Division of Hematology Oncology Transplantation, Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Microcirculation 11:129-51. 2004
    ..Sickle cell anemia is truly an endothelial disease, and it is likely that genetic differences in endothelial function help govern its astonishing phenotypic diversity...
  17. ncbi request reprint Robust vascular protective effect of hydroxamic acid derivatives in a sickle mouse model of inflammation
    Dhananjay K Kaul
    Department of Medicine, Albert Einstein College of Medicine, New York, Bronx, USA
    Microcirculation 13:489-97. 2006
    ..Similar findings characterize the sickle transgenic mouse, which therefore provides a clinically relevant inflammation model...
  18. ncbi request reprint Differential gene expression in the kidney of sickle cell transgenic mice: upregulated genes
    Anne C Rybicki
    Department of Medicine, Division of Hematology, Albert Einstein College of Medicine Montefiore Medical Center, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Blood Cells Mol Dis 31:370-80. 2003
    ..We conclude that microarray technology is a powerful tool to identify genes involved in renal disease in sickle cell anemia and that the identification of various metabolic pathways may open new avenues for therapeutic interventions...
  19. ncbi request reprint Small-molecule cyclic alpha V beta 3 antagonists inhibit sickle red cell adhesion to vascular endothelium and vasoocclusion
    Eileen M Finnegan
    Department of Chemical Engineering, Northeastern University, Boston, MA, USA
    Am J Physiol Heart Circ Physiol 293:H1038-45. 2007
    ..Because of their metabolic stability, the use of these cyclic alpha V beta 3 antagonists may constitute a novel therapeutic strategy to block SS RBC adhesion and associated vasoocclusion under flow conditions...

Research Grants5

  1. Rheologic & Vascular Modulators in Sickle Vasoocclusion
    Dhananjay Kaul; Fiscal Year: 2006
    ..These studies are expected to elucidate new mechanisms with relevance to human sickle cell disease and with potential therapeutic implications. ..
  2. Rheologic and Vascular Modulators in Sickle Vaso-occlusion
    Dhananjay Kaul; Fiscal Year: 2009
    ..The proposed exploratory studies will focus on the role HIF-11 and NO in SCD. A better understanding of the role of in HIF-11 and NO and their interactions will allow us to design future studies with therapeutic implications. ..