Geoffrey C Kabat

..Aside from exposure to ionizing radiation and benzene, little is known about lifestyle risk factors for chronic myeloid leukemia (CML) in the general population...

..In view of the limited number of cases, we cannot rule out the existence of weak associations of these measures with risk of colorectal cancer...

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..51 (95% CI: 1.27-1.80) for melanoma. Our study provides strong support for a positive association of adult height with risk of certain cancers. The underlying biological mechanisms are not clear but may differ by anatomic site...

..To investigate the association of reproductive factors and hormone therapy, including type of hormone therapy, with risk of thyroid cancer in postmenopausal women...

..Few cohort studies have examined smoking and alcohol consumption in relation to risk of thyroid cancer, and their findings are conflicting...

..The biological mechanism underlying these associations remains to be clarified...

..lowest quartile 0.69, 95% CI 0.49-0.98). Overall, this study provides some evidence of inverse associations of intake of total vitamin A and total vitamin C with the risk of NHL and diffuse lymphoma, respectively...

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..In the present study, we assessed the association of serum levels of eight antioxidant nutrients in relation to risk of colorectal cancer, using repeated measurements...

..To investigate the associations of anthropometric factors and physical activity with risk of thyroid cancer in a large prospective study...

..Obesity is associated with impaired immune function through which it may influence the risk of NHL; other factors reflecting energy homeostasis (height, abdominal adiposity, and physical activity) may also be involved...

..It is unclear whether circulating insulin or glucose levels are associated with increased risk of colorectal cancer. Few prospective studies have examined this question, and only one study had repeated measurements...

..The contribution of menstrual and reproductive factors to risk of ductal carcinoma (DCIS) of the breast is poorly understood...

..The results of this large cohort study provide little support for an association of cigarette smoking with risk of DCIS in postmenopausal women...

..Observational studies have commonly linked higher alcohol consumption with a modest increase in invasive breast cancer risk, but cohort studies have not examined alcohol intake in relation to ductal carcinoma in situ (DCIS)...

..If hormonal pathways are involved in gliomagenesis, this could eventually lead to the design of preventive strategies...

..Although the results of case-control studies have suggested a possible protective effect of fruit and vegetable intake on the risk of endometrial carcinoma, few cohort studies have examined this association...

..The present study provides only limited support for the hypothesis that menstrual/reproductive factors or exogenous hormone use play a role in gliogenesis...

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..Intakes of dietary iron and, in particular, heme iron may increase breast cancer risk because of the prooxidant properties of iron. However, few studies have examined the association of iron and heme-iron intakes with breast cancer risk...

..We examined the association of smoking and alcohol intake with TNBC and estrogen receptor-positive (ER+) breast cancer...

..To assess the association of recreational physical activity and anthropometric factors in relation to risk of ductal carcinoma in situ (DCIS) of the breast...

..Prospective studies have examined the association of serum and plasma carotenoids and micronutrients and breast cancer; however, to date, studies have only assessed exposure at one point in time...

..Analysis of the repeated measurements supported the results of the baseline analysis. These data suggest that elevated serum insulin levels may be a risk factor for postmenopausal breast cancer...

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..This large prospective study with detailed information on meat preparation methods provides no support for a role of meat mutagens in the development of postmenopausal breast cancer...

..These findings suggest that in smokers, BMI is inversely associated with lung cancer risk and that waist circumference is positively associated with risk...

..Results of this large study do not support of a role of a diet characterized by high glycemic index or load in colorectal carcinogenesis in postmenopausal women...

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..31) but the confidence intervals were extremely wide. Our findings raise the possibility that the combination of p53 protein accumulation and the presence of genetic alterations may identify a group at increased risk of breast cancer...

..However, given the lack of a dose-response relationship and the potential for confounding, studies with more complete assessment of exogenous hormone use throughout the life course are needed to clarify this association...

..However, further cohort studies with repeated measurement of iron intake are warranted...

..Such studies are required to prove the causal relationship between moderate iron overload and diabetes risk...

..Our results add to the limited existing evidence that certain reproductive and hormonal factors may be associated with lung cancer risk in women...

..Ultimately, it is important to determine whether iron levels in the breast and iron-induced pathology are higher in women who go on to develop breast cancer compared to women who do not...

..96) or total folate intake (OR, 1.71; 95% CI, 1.08-2.71). From a public heath perspective, it is important to identify risk factors, such as low B vitamin consumption, that may guide an effective prevention strategy against the disease...

..Early age at menarche increases future disease risk. Secular decline in age at menarche has been attributed to body size characteristics, diet, and energy expenditure. Risk factors for puberty have been less frequently explored...

..CONCLUSIONS: The results of this large investigation are consistent with those of most previous studies, and do not support the hypothesis that electric blanket use is associated with increased breast cancer risk...

..In addition to assessing the main effects of specific variants, gene-gene and gene-environment interactions are likely to explain a greater proportion of the variability in breast cancer risk...

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