Antonio Iavarone

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. ncbi request reprint Id2 is critical for cellular proliferation and is the oncogenic effector of N-myc in human neuroblastoma
    Anna Lasorella
    Department of Neurology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 62:301-6. 2002
  2. ncbi request reprint Id2 drives differentiation and suppresses tumor formation in the intestinal epithelium
    Robert G Russell
    Lombardi Cancer Center, Department of Oncology, Georgetown University, Washington, D C, USA
    Cancer Res 64:7220-5. 2004
  3. ncbi request reprint Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages
    Antonio Iavarone
    Institute for Cancer Genetics, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Nature 432:1040-5. 2004
  4. pmc Id2 mediates tumor initiation, proliferation, and angiogenesis in Rb mutant mice
    Anna Lasorella
    Institute for Cancer Genetics, Columbia University, 1150 St Nicholas Avenue, New York, NY 10032, USA
    Mol Cell Biol 25:3563-74. 2005
  5. pmc The protein ENH is a cytoplasmic sequestration factor for Id2 in normal and tumor cells from the nervous system
    Anna Lasorella
    Institute for Cancer Genetics, Department of Pathology, Pediatrics, and Neurology, Columbia University Medical Center, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 103:4976-81. 2006
  6. pmc Control of chromosome stability by the beta-TrCP-REST-Mad2 axis
    Daniele Guardavaccaro
    Department of Pathology, NYU Cancer Institute, New York University School of Medicine, 550 First Avenue, MSB 599, New York, New York 10016, USA
    Nature 452:365-9. 2008
  7. ncbi request reprint Degradation of Id2 by the anaphase-promoting complex couples cell cycle exit and axonal growth
    Anna Lasorella
    Institute for Cancer Genetics, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Nature 442:471-4. 2006
  8. pmc E Proteins and Id2 converge on p57Kip2 to regulate cell cycle in neural cells
    Gerson Rothschild
    Institute for Cancer Genetics, 1150 St Nicholas Ave, Columbia University, New York, NY 10032, USA
    Mol Cell Biol 26:4351-61. 2006
  9. ncbi request reprint Id family of helix-loop-helix proteins in cancer
    Jonathan Perk
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue Box 241, New York 10021, USA
    Nat Rev Cancer 5:603-14. 2005
  10. ncbi request reprint Xenopus Id3 is required downstream of Myc for the formation of multipotent neural crest progenitor cells
    William Light
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208, USA
    Development 132:1831-41. 2005

Collaborators

  • Yoshifumi Yokota
  • Alberto Donfrancesco
  • ROBERT I BENEZRA
  • Anna Lasorella
  • Daniele Guardavaccaro
  • Gerson Rothschild
  • Xudong Zhao
  • Michele Pagano
  • Robert G Russell
  • William Light
  • Jonathan Perk
  • David Frescas
  • Eva Hernando
  • Sandy Chang
  • Richeng Jiang
  • Francois Guillemot
  • Angelo Peschiaroli
  • N Valerio Dorrello
  • Asha S Multani
  • Julian Ik Tsen Heng
  • Timothy Cardozo
  • Judith Stegmuller
  • Azad Bonni
  • Guangchao Liu
  • Maria S Carro
  • Luis de la Torre-Ubieta
  • Carole LaBonne
  • Ann E Vernon
  • Luis E Dettin
  • Carlo Dominici
  • Renata Boldrini
  • Alessandro Inserra

Detail Information

Publications12

  1. ncbi request reprint Id2 is critical for cellular proliferation and is the oncogenic effector of N-myc in human neuroblastoma
    Anna Lasorella
    Department of Neurology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 62:301-6. 2002
    ..We suggest that Id2 overexpression may be a better prognostic indicator than N-myc gene amplification in neuroblastoma. Thus, disrupting Id2 function may lead to new and useful therapeutic strategies for cancer patients...
  2. ncbi request reprint Id2 drives differentiation and suppresses tumor formation in the intestinal epithelium
    Robert G Russell
    Lombardi Cancer Center, Department of Oncology, Georgetown University, Washington, D C, USA
    Cancer Res 64:7220-5. 2004
    ..Thus, our data are the first to establish a direct requirement of basic helix-loop-helix inhibitors in driving differentiation and define an unexpected role for the retinoblastoma-binding protein Id2 in preventing tumor formation...
  3. ncbi request reprint Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages
    Antonio Iavarone
    Institute for Cancer Genetics, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Nature 432:1040-5. 2004
    ..1, a master regulator of macrophage differentiation. Thus, Rb has a cell autonomous function in fetal liver macrophages, and restrains Id2 in these cells in order to implement definitive erythropoiesis...
  4. pmc Id2 mediates tumor initiation, proliferation, and angiogenesis in Rb mutant mice
    Anna Lasorella
    Institute for Cancer Genetics, Columbia University, 1150 St Nicholas Avenue, New York, NY 10032, USA
    Mol Cell Biol 25:3563-74. 2005
    ..In human neuroblastoma, the N-Myc-driven expression of Id2 is sufficient and necessary for expression of VEGF. These results establish that aberrant Id2 activity directs initiation and progression of embryonal cancer...
  5. pmc The protein ENH is a cytoplasmic sequestration factor for Id2 in normal and tumor cells from the nervous system
    Anna Lasorella
    Institute for Cancer Genetics, Department of Pathology, Pediatrics, and Neurology, Columbia University Medical Center, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 103:4976-81. 2006
    ..These data indicate that ENH contributes to differentiation of the nervous system through cytoplasmic sequestration of Id2. They also suggest that ENH is a restraining factor of the oncogenic activity of Id proteins in neural tumors...
  6. pmc Control of chromosome stability by the beta-TrCP-REST-Mad2 axis
    Daniele Guardavaccaro
    Department of Pathology, NYU Cancer Institute, New York University School of Medicine, 550 First Avenue, MSB 599, New York, New York 10016, USA
    Nature 452:365-9. 2008
    ..The high levels of REST or its truncated variants found in certain human tumours may contribute to cellular transformation by promoting genomic instability...
  7. ncbi request reprint Degradation of Id2 by the anaphase-promoting complex couples cell cycle exit and axonal growth
    Anna Lasorella
    Institute for Cancer Genetics, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Nature 442:471-4. 2006
    ..These findings indicate that deregulated Id activity might be useful to reprogramme quiescent neurons into the axonal growth mode...
  8. pmc E Proteins and Id2 converge on p57Kip2 to regulate cell cycle in neural cells
    Gerson Rothschild
    Institute for Cancer Genetics, 1150 St Nicholas Ave, Columbia University, New York, NY 10032, USA
    Mol Cell Biol 26:4351-61. 2006
    ....
  9. ncbi request reprint Id family of helix-loop-helix proteins in cancer
    Jonathan Perk
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue Box 241, New York 10021, USA
    Nat Rev Cancer 5:603-14. 2005
    ....
  10. ncbi request reprint Xenopus Id3 is required downstream of Myc for the formation of multipotent neural crest progenitor cells
    William Light
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208, USA
    Development 132:1831-41. 2005
    ..These results shed new light on the mechanisms governing the formation and maintenance of a developmentally and clinically important cell population...
  11. ncbi request reprint Id proteins in neural cancer
    Antonio Iavarone
    Department of Pathology, Institute for Cancer Genetics, College of Physicians and Surgeons, Columbia University, 1150 St Nicholas Avenue, 10032 New York, USA
    Cancer Lett 204:189-96. 2004
    ..Future work will be required to fully elucidate the molecular networks engaged by Id proteins to contribute to the essential hallmarks of neural cancer...
  12. pmc The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein
    Xudong Zhao
    Institute for Cancer Genetics, Columbia University Medical Center, New York, New York 10032, USA
    Nat Cell Biol 10:643-53. 2008
    ..These findings indicate that Huwe1 links destruction of N-Myc to the quiescent state that complements differentiation in the neural tissue...