Derek M Huffman

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. pmc Aging per se increases the susceptibility to free fatty acid-induced insulin resistance
    Francine H Einstein
    Department of Obstetrics and Gynecology and Women s Health at Montefiore Medical Center, Bronx, New York, USA
    J Gerontol A Biol Sci Med Sci 65:800-8. 2010
  2. doi request reprint Exercise as a calorie restriction mimetic: implications for improving healthy aging and longevity
    Derek M Huffman
    Department of Medicine and Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Interdiscip Top Gerontol 37:157-74. 2010
  3. pmc Abdominal obesity, independent from caloric intake, accounts for the development of intestinal tumors in Apc(1638N/+) female mice
    Derek M Huffman
    Department of Medicine, Division of Endocrinology, Institute for Aging Research, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Golding Building Room 502, Bronx, NY 10461, USA
    Cancer Prev Res (Phila) 6:177-87. 2013
  4. pmc Humanin: a novel central regulator of peripheral insulin action
    Radhika H Muzumdar
    Department of Pediatrics, Children s Hospital at Montefiore, Institute for Aging Research, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, NY, USA
    PLoS ONE 4:e6334. 2009
  5. pmc Distinguishing between longevity and buffered-deleterious genotypes for exceptional human longevity: the case of the MTP gene
    Derek M Huffman
    Department of Medicine, The Albert Einstein College of Medicine of Yeshiva University, New York, NY, USA
    J Gerontol A Biol Sci Med Sci 67:1153-60. 2012
  6. pmc The critical role of metabolic pathways in aging
    Nir Barzilai
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA
    Diabetes 61:1315-22. 2012
  7. pmc Enhanced activation of a "nutrient-sensing" pathway with age contributes to insulin resistance
    Francine H Einstein
    Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461, USA
    FASEB J 22:3450-7. 2008
  8. pmc Evolution in health and medicine Sackler colloquium: Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians
    Gil Atzmon
    Department of Medicine and Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 107:1710-7. 2010
  9. pmc Role of visceral adipose tissue in aging
    Derek M Huffman
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Biochim Biophys Acta 1790:1117-23. 2009
  10. doi request reprint Contribution of adipose tissue to health span and longevity
    Derek M Huffman
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Interdiscip Top Gerontol 37:1-19. 2010

Detail Information

Publications11

  1. pmc Aging per se increases the susceptibility to free fatty acid-induced insulin resistance
    Francine H Einstein
    Department of Obstetrics and Gynecology and Women s Health at Montefiore Medical Center, Bronx, New York, USA
    J Gerontol A Biol Sci Med Sci 65:800-8. 2010
    ..Thus, aging per se increases the inflammatory response to excess nutrients and vulnerability to FFA-induced insulin resistance with aging...
  2. doi request reprint Exercise as a calorie restriction mimetic: implications for improving healthy aging and longevity
    Derek M Huffman
    Department of Medicine and Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Interdiscip Top Gerontol 37:157-74. 2010
    ..Therefore, in rodents, the ability of CR to slow aging is apparently more dependent on decreasing nutrient flux, rather than changes in energy balance and body composition...
  3. pmc Abdominal obesity, independent from caloric intake, accounts for the development of intestinal tumors in Apc(1638N/+) female mice
    Derek M Huffman
    Department of Medicine, Division of Endocrinology, Institute for Aging Research, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Golding Building Room 502, Bronx, NY 10461, USA
    Cancer Prev Res (Phila) 6:177-87. 2013
    ..Furthermore, these data emphasize that strategies designed to deplete visceral fat stores in humans should be considered in the prevention of intestinal cancer. Cancer Prev Res; 6(3); 177-87. ©2012 AACR...
  4. pmc Humanin: a novel central regulator of peripheral insulin action
    Radhika H Muzumdar
    Department of Pediatrics, Children s Hospital at Montefiore, Institute for Aging Research, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, NY, USA
    PLoS ONE 4:e6334. 2009
    ..A novel mitochondria-associated peptide, Humanin (HN), has a neuroprotective role against AD-related neurotoxicity. Considering the association between insulin resistance and AD, we investigated if HN influences insulin sensitivity...
  5. pmc Distinguishing between longevity and buffered-deleterious genotypes for exceptional human longevity: the case of the MTP gene
    Derek M Huffman
    Department of Medicine, The Albert Einstein College of Medicine of Yeshiva University, New York, NY, USA
    J Gerontol A Biol Sci Med Sci 67:1153-60. 2012
    ..05). Thus, we conclude that MTP CC is a buffered-deleterious genotype and that assessing genotype frequency across aging is essential for discerning longevity from buffered-deleterious genotypes...
  6. pmc The critical role of metabolic pathways in aging
    Nir Barzilai
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA
    Diabetes 61:1315-22. 2012
    ..Although life span has been the major outcome of interest in the laboratory, a special focus is made in this study on healthspan, as improved quality of life is the goal when translated to humans...
  7. pmc Enhanced activation of a "nutrient-sensing" pathway with age contributes to insulin resistance
    Francine H Einstein
    Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461, USA
    FASEB J 22:3450-7. 2008
    ..These results suggest that altered nutrient sensing by HBP with age may be the link among nutrients, insulin resistance, and age-related diabetes...
  8. pmc Evolution in health and medicine Sackler colloquium: Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians
    Gil Atzmon
    Department of Medicine and Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 107:1710-7. 2010
    ..Thus, variations in human telomerase gene that are associated with better maintenance of telomere length may confer healthy aging and exceptional longevity in humans...
  9. pmc Role of visceral adipose tissue in aging
    Derek M Huffman
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Biochim Biophys Acta 1790:1117-23. 2009
    ..Visceral fat (VF) accretion is a hallmark of aging in humans. Epidemiologic studies have implicated abdominal obesity as a major risk factor for insulin resistance, type 2 diabetes, cardiovascular disease, metabolic syndrome and death...
  10. doi request reprint Contribution of adipose tissue to health span and longevity
    Derek M Huffman
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Interdiscip Top Gerontol 37:1-19. 2010
    ..Treatments targeting the prevention of fat accrual in these harmful depots should be considered as a primary target for improving human health span and longevity...
  11. pmc Visceral adipose tissue modulates mammalian longevity
    Radhika Muzumdar
    Institute for Aging Research, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA
    Aging Cell 7:438-40. 2008
    ..13). Taken together, these observations provide the most direct evidence to date that a reduction in fat mass, specifically VF, may be one of the possible underlying mechanisms of the anti-aging effect of CR...