Research Topics
Species | R HoltzerSummaryAffiliation: Albert Einstein College of Medicine Country: USA Publications
Research Grants
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Detail Information
Publications
Age effects on load-dependent brain activations in working memory for novel materialRoee Holtzer
Ferkauf Graduate School of Psychology, Yeshiva University, NY, USA
Brain Res 1249:148-61. 2009..Delineating how these theories work in concert can increase knowledge of age-related effects on working memory...- The relationship between specific cognitive functions and falls in agingRoee Holtzer
Ferkauf Graduate School of Psychology, Albert Einstein College of Medicine, Yeshiva University, NY 10461, USA
Neuropsychology 21:540-8. 2007..Memory was not associated with either single or recurrent falls. These findings are relevant to risk assessment and prevention of falls and point to possible shared neural substrates of cognitive and motor function... 
Cognitive processes related to gait velocity: results from the Einstein Aging StudyRoee Holtzer
Yeshiva University, Bronx, NY 10461, USA
Neuropsychology 20:215-23. 2006..These findings suggest that gait velocity and cognitive function may have both shared and independent brain substrates. Future studies should explore gait velocity and cognitive function as predictors of dementia and falls...- Extending the administration time of the letter fluency test increases sensitivity to cognitive status in agingRoee Holtzer
Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, Bronx, New York 10461, USA
Exp Aging Res 35:317-26. 2009..Finally, discriminant function analyses revealed that extending the letter fluency trials to 2 minutes increased discrimination between the control and cognitive impairment groups... - Differential effects of COMT on gait and executive control in agingR Holtzer
Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10461, United States
Neurobiol Aging 31:523-31. 2010..These findings suggest a differential effect in relating the Val(158)Met polymorphism to gait and to cognitive function while supporting the previously described sexual dimorphism in the phenotypic expressions of COMT... - Robust norms for selected neuropsychological tests in older adultsRoee Holtzer
Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10461, USA
Arch Clin Neuropsychol 23:531-41. 2008..We suggest that longitudinal robust norms may help mitigate the limitations inherent in cross-sectional normative samples... - Within-person across-neuropsychological test variability and incident dementiaRoee Holtzer
Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10461, USA
JAMA 300:823-30. 2008..Neuropsychological tests are used to predict and diagnose dementia. However, to our knowledge, no studies to date have examined whether within-person across-neuropsychological test variability predicts dementia... - The relationship between subjective reports of fatigue and executive control in multiple sclerosisR Holtzer
Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, Bronx, New York 10461, USA
J Neurol Sci 281:46-50. 2009..The present study provided first behavioral evidence that fatigue and executive control are uniquely related in MS... - Predicting age-related dual-task effects with individual differences on neuropsychological testsRoee Holtzer
Cognitive Neuroscience Division of the Taub Institute, Columbia University College of Physicians and Surgeons, New York, NY, USA
Neuropsychology 19:18-27. 2005..The authors conclude that compromised central executive may underlie age-related decline in dual-task performance... - Egocentric and exocentric navigation skills in older adultsAmy E Sanders
Albert Einstein College of Medicine, Bronx, NY 10461, USA
J Gerontol A Biol Sci Med Sci 63:1356-63. 2008..Our objective was to develop tests of navigation and study their cognitive correlates in nondemented older adults... - Self-reported difficulty in climbing up or down stairs in nondisabled elderlyJoe Verghese
Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10461, USA
Arch Phys Med Rehabil 89:100-4. 2008..To examine clinical and functional correlates of self-reported difficulty in climbing up or climbing down stairs in older adults... - Quantitative gait dysfunction and risk of cognitive decline and dementiaJoe Verghese
Department of Neurology, Albert Einstein College of Medicine, 1165 Morris Park Avenue, Room 338, Bronx, New York 10461, USA
J Neurol Neurosurg Psychiatry 78:929-35. 2007..Identifying quantitative gait markers of preclinical dementia may lead to new insights into early disease stages, improve diagnostic assessments and identify new preventive strategies... - Walking while talking: effect of task prioritization in the elderlyJoe Verghese
Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY, USA
Arch Phys Med Rehabil 88:50-3. 2007..To examine the effect of 2 instructions on the same walking while talking (WWT) task on task prioritization by nondisabled subjects... - Quantitative gait markers and incident fall risk in older adultsJoe Verghese
MBBS, Einstein Aging Study, Albert Einstein College of Medicine, Yeshiva University, 1165 Morris Park Avenue, Room 338, Bronx, NY 10461, USA
J Gerontol A Biol Sci Med Sci 64:896-901. 2009..Identifying quantitative gait markers of falls in older adults may improve diagnostic assessments and suggest novel intervention targets... 
Effect of cognitive remediation on gait in sedentary seniorsJoe Verghese
Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, 1165 Morris Park Avenue, Bronx, NY 10461, USA
J Gerontol A Biol Sci Med Sci 65:1338-43. 2010..However, cognitive remediation as a strategy to improve mobility has not been investigated...- Gait dysfunction in mild cognitive impairment syndromesJoe Verghese
Department of Neurology, Einstein Aging Study, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Am Geriatr Soc 56:1244-51. 2008..To conduct a systematic clinical and quantitative assessment of gait in older adults with mild cognitive impairment (MCI) syndromes... - Ictal mnemestic aura and verbal memory functionAaron C Vederman
New York University Comprehensive Epilepsy Center, New York, NY, USA
Epilepsy Behav 17:474-7. 2010..Mnemestic auras were associated with clinical indices of illness, suggesting that the presence of these auras may be regarded as a risk factor for greater chronicity and severity in epilepsy... - Homocysteine and mobility in older adultsLydia Rolita
Department of General Internal Medicine, New York University School of Medicine, New York, New York 10461, USA
J Am Geriatr Soc 58:545-50. 2010..To determine the influence of homocysteine on mobility decline in older adults... - Conventional and robust quantitative gait norms in community-dwelling older adultsMooyeon Oh-Park
Department of Physical Medicine and Rehabilitation, Albert Einstein College of Medicine, Bronx, New York, USA
J Am Geriatr Soc 58:1512-8. 2010..To develop and compare norms for widely used gait parameters in adults aged 70 and older using cross-sectional (conventional) and longitudinal (robust) approaches accounting for important confounders such as disease effects on gait... - A common neural network for cognitive reserve in verbal and object working memory in young but not oldYaakov Stern
Cognitive Neuroscience Division of the Taub Institute, NY, USA
Cereb Cortex 18:959-67. 2008..This spatial pattern could represent a general neural instantiation of CR that is affected by the aging process... - Depressive symptoms in Alzheimer's disease: natural course and temporal relation to function and cognitive statusRoee Holtzer
Cognitive Neuroscience Division, Taub Institute, G.H. Gertrude Sergievsky Center and Department of Neurology, College of Physicians and Surgeons, Columbia University Medical Center, New York, New York 10032, USA
J Am Geriatr Soc 53:2083-9. 2005..Examination of the temporal relationship between depressive symptoms and risk factors suggests that decline in function but not in cognition precedes the first episode of depressive symptoms in patients with probable AD... - The sensitivity of dual-task performance to cognitive status in agingRoee Holtzer
Cognitive Neuroscience Division of the Taub Institute, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
J Int Neuropsychol Soc 10:230-8. 2004..jins, 2004, 10, 230-238.).. - The rate of cognitive decline and risk of reaching clinical milestones in Alzheimer diseaseRoee Holtzer
Sergievsky Center, Columbia University College of Physicians and Surgeons, 630 W. 168th Street, New York, NY 10032, USA
Arch Neurol 60:1137-42. 2003..Analyses controlled for age, sex, education, and baseline mMMSE scores. CONCLUSION: A fast rate of cognitive decline was associated with increasing risk of reaching clinical milestones in AD... - Psychopathological features in Alzheimer's disease: course and relationship with cognitive statusRoee Holtzer
Sergievsky Center, New York, New York 10032, USA
J Am Geriatr Soc 51:953-60. 2003..These findings provide important information to clinicians and caregivers regarding the course, predictability, and possible treatment of psychopathological behaviors in patients with probable AD... - Relation of quantitative indexes of concurrent alpha-synuclein abnormalities to clinical outcome in autopsy-proven Alzheimer diseaseRoee Holtzer
Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Arch Neurol 63:226-30. 2006..There was no relation between quantitative neuropathologic indexes of LB abnormalities and clinical outcome. CONCLUSION: The variability of clinical features in AD was not related to the presence or degree of LB abnormalities... - Age-related differences in executive control of working memoryRoee Holtzer
Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Mem Cognit 32:1333-45. 2004..The degree of temporal overlap between individual tasks and the sensitivity of specific memory operations to interference should be considered, as well...
Research Grants
- Predictors of Gait and Falls in Aging: Linking Cognitive Control to GenesRoee Holtzer; Fiscal Year: 2007..We believe that this theory driven application will provide valuable insights into risk assessment, as well as rehabilitative and pharmacological interventions for individuals at risk of decline in gait and falls. ..