Noboru Hiroi

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. ncbi Constitutional mechanisms of vulnerability and resilience to nicotine dependence
    N Hiroi
    Department of Psychiatry and Behavioral Sciences, Laboratory of Molecular Psychobiology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Mol Psychiatry 14:653-67. 2009
  2. ncbi Genetic susceptibility to substance dependence
    N Hiroi
    Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Mol Psychiatry 10:336-44. 2005
  3. ncbi A 200-kb region of human chromosome 22q11.2 confers antipsychotic-responsive behavioral abnormalities in mice
    Noboru Hiroi
    Laboratory of Molecular Psychobiology, Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 102:19132-7. 2005
  4. ncbi Pleiotropic impact of constitutive fosB inactivation on nicotine-induced behavioral alterations and stress-related traits in mice
    Hongwen Zhu
    Laboratory of Molecular Psychobiology, Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Hum Mol Genet 16:820-36. 2007
  5. ncbi Over-expression of a human chromosome 22q11.2 segment including TXNRD2, COMT and ARVCF developmentally affects incentive learning and working memory in mice
    Go Suzuki
    Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Hum Mol Genet 18:3914-25. 2009
  6. ncbi Monoamine oxidase A knockout mice exhibit impaired nicotine preference but normal responses to novel stimuli
    Soh Agatsuma
    Laboratory of Molecular Psychobiology, Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Hum Mol Genet 15:2721-31. 2006
  7. ncbi Tbx1: identification of a 22q11.2 gene as a risk factor for autism spectrum disorder in a mouse model
    Takeshi Hiramoto
    Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Hum Mol Genet 20:4775-85. 2011
  8. ncbi Alterations of social interaction through genetic and environmental manipulation of the 22q11.2 gene Sept5 in the mouse brain
    Kathryn M Harper
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Hum Mol Genet 21:3489-99. 2012
  9. ncbi Transgenic expression of ZBP1 in neurons suppresses cocaine-associated conditioning
    Kyle A B Lapidus
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461 1975, USA
    Learn Mem 19:35-42. 2012
  10. ncbi DARPP-32 phosphorylation opposes the behavioral effects of nicotine
    Hongwen Zhu
    Laboratory of Molecular Psychobiology, Albert Einstein College of Medicine, Bronx, NY, USA
    Biol Psychiatry 58:981-9. 2005

Research Grants

  1. INTRACELLULAR MOLECULES OF NICOTINE ADDICTION
    Noboru Hiroi; Fiscal Year: 2004
  2. Molecular Mechanisms of Nicotine Addiction and Extinction
    Noboru Hiroi; Fiscal Year: 2007

Collaborators

Detail Information

Publications18

  1. ncbi Constitutional mechanisms of vulnerability and resilience to nicotine dependence
    N Hiroi
    Department of Psychiatry and Behavioral Sciences, Laboratory of Molecular Psychobiology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Mol Psychiatry 14:653-67. 2009
    ..This perspective suggests that the identification of the molecular bases of such pre-existing behavioral traits will contribute to the development of effective methods for reducing smoking dependence and for helping smokers to quit...
  2. ncbi Genetic susceptibility to substance dependence
    N Hiroi
    Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Mol Psychiatry 10:336-44. 2005
    ..Identification of the specific genes involved in these processes would help to identify individuals that are vulnerable to dependence/addiction and to devise novel treatment strategies...
  3. ncbi A 200-kb region of human chromosome 22q11.2 confers antipsychotic-responsive behavioral abnormalities in mice
    Noboru Hiroi
    Laboratory of Molecular Psychobiology, Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 102:19132-7. 2005
    ..Our results show that the approximately 200-kb region of 22q11.2 contains a gene(s) responsible for behavioral abnormalities and suggest that distinct genetic components within 22q11.2 mediate physical and behavioral abnormalities...
  4. ncbi Pleiotropic impact of constitutive fosB inactivation on nicotine-induced behavioral alterations and stress-related traits in mice
    Hongwen Zhu
    Laboratory of Molecular Psychobiology, Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Hum Mol Genet 16:820-36. 2007
    ..Our results suggest that the constitutive absence of fosB has a pleiotropic influence on the behavioral effects of repeated or prolonged nicotine administration and on stress-related behavioral traits in mice...
  5. ncbi Over-expression of a human chromosome 22q11.2 segment including TXNRD2, COMT and ARVCF developmentally affects incentive learning and working memory in mice
    Go Suzuki
    Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Hum Mol Genet 18:3914-25. 2009
    ..High copy numbers of this 22q11.2 segment might contribute to a highly selective set of phenotypes in learning and cognition during development...
  6. ncbi Monoamine oxidase A knockout mice exhibit impaired nicotine preference but normal responses to novel stimuli
    Soh Agatsuma
    Laboratory of Molecular Psychobiology, Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Hum Mol Genet 15:2721-31. 2006
    ..Constitutive MAOA activity levels are likely to contribute to the vulnerability or resiliency to nicotine addiction by altering the rewarding effects of nicotine...
  7. ncbi Tbx1: identification of a 22q11.2 gene as a risk factor for autism spectrum disorder in a mouse model
    Takeshi Hiramoto
    Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Hum Mol Genet 20:4775-85. 2011
    ..Taken together, our data suggest that Tbx1 is a gene responsible for the phenotypes of 22q11.2 hemizygosity-associated ASD possibly through its role in diverse cell types, including postnatally and prenatally generated neurons...
  8. ncbi Alterations of social interaction through genetic and environmental manipulation of the 22q11.2 gene Sept5 in the mouse brain
    Kathryn M Harper
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Hum Mol Genet 21:3489-99. 2012
    ..2-associated schizophrenia and ASD can be genetically and environmentally modified by altering this 22q11.2 gene...
  9. ncbi Transgenic expression of ZBP1 in neurons suppresses cocaine-associated conditioning
    Kyle A B Lapidus
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461 1975, USA
    Learn Mem 19:35-42. 2012
    ..These data suggest that RNA-binding proteins can be used as a tool to identify the post-transcriptional regulation of gene expression in the establishment and function of neural circuits involved in addiction behaviors...
  10. ncbi DARPP-32 phosphorylation opposes the behavioral effects of nicotine
    Hongwen Zhu
    Laboratory of Molecular Psychobiology, Albert Einstein College of Medicine, Bronx, NY, USA
    Biol Psychiatry 58:981-9. 2005
    ....
  11. ncbi [Genetic basis of drug dependence and comorbid behavioral traits]
    Soh Agatsuma
    Laboratory of Molecular Psychobiology, Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Nihon Shinkei Seishin Yakurigaku Zasshi 24:137-45. 2004
    ..However, MAO-B influences a behavioral response to novelty without affecting nicotine dependence susceptibility. The mechanisms by which genes influence dependence susceptibility and comorbid behavioral traits are likely to be complex...
  12. ncbi Deconstructing craving: dissociable cortical control of cue reactivity in nicotine addiction
    Daniel Scott
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Biol Psychiatry 69:1052-9. 2011
    ..Moreover, it remains unclear whether the simultaneous activation of these cortical regions reflects coordinated functional connectivity or parallel processing...
  13. ncbi Emergence of dormant conditioned incentive approach by conditioned withdrawal in nicotine addiction
    Daniel Scott
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Biol Psychiatry 68:726-32. 2010
    ..The process by which withdrawal affects nicotine seeking is poorly understood...
  14. ncbi Sept5 deficiency exerts pleiotropic influence on affective behaviors and cognitive functions in mice
    Go Suzuki
    Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Hum Mol Genet 18:1652-60. 2009
    ..These data suggest that Sept5 deficiency exerts pleiotropic effects on a select set of affective behaviors and cognitive processes and that genetic backgrounds could provide an epistatic influence on phenotypic expression...
  15. ncbi N-methyl-D-aspartic acid receptors on striatal neurons are essential for cocaine cue reactivity in mice
    Soh Agatsuma
    Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Biol Psychiatry 67:778-80. 2010
    ..Although glutamatergic neurotransmission has been implicated in this effect of cocaine, the precise subtype and localization in the brain of the glutamatergic receptor critical for cocaine cue reactivity is not well-understood...
  16. ncbi [Chromosome 22q11 and schizophrenia]
    Soh Agatsuma
    Laboratory of Molecular Psychobiology, Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Nihon Shinkei Seishin Yakurigaku Zasshi 25:79-84. 2005
    ..As VCFS/DGS is likely to represent a genetic subtype of schizophrenia, pinpointing the genetic basis for this specific subtype will contribute to a better understanding of this neuropsychiatric disorder...
  17. ncbi MAO-B knockout mice exhibit deficient habituation of locomotor activity but normal nicotine intake
    M Lee
    Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Morris Park Avenue, Bronx, NY 10461, USA
    Genes Brain Behav 3:216-27. 2004
    ..The data suggest that the absence of MAO-B impairs the ability of mice to habituate in the inescapable environment, but does not alter their nicotine intake...
  18. ncbi Chronic treatment with atypical neuroleptics induces striosomal FosB/DeltaFosB expression in rats
    Cristina Grande
    Cajal Institute (CG, ABM, OO, RM, , Madrid, Spain
    Biol Psychiatry 55:457-63. 2004
    ..Expression of FosB/DeltaFosB in the matrix may contribute to parkinsonism of typical neuroleptics...

Research Grants9

  1. INTRACELLULAR MOLECULES OF NICOTINE ADDICTION
    Noboru Hiroi; Fiscal Year: 2004
    ..If these molecules turn out to be important for vulnerability to nicotine addiction, this mouse study will provide a solid basis for genetic analysis of human addiction vulnerability. ..
  2. Molecular Mechanisms of Nicotine Addiction and Extinction
    Noboru Hiroi; Fiscal Year: 2007
    ..The proposed studies are designed to fill in this knowledge gap. ..