Barbara Heerdt

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. ncbi Dissociation of staurosporine-induced apoptosis from G2-M arrest in SW620 human colonic carcinoma cells: initiation of the apoptotic cascade is associated with elevation of the mitochondrial membrane potential (deltapsim)
    B G Heerdt
    Department of Oncology, Albert Einstein Cancer Center, Montefiore Medical Center, Bronx, New York 10467, USA
    Cancer Res 60:6704-13. 2000
  2. ncbi Growth properties of colonic tumor cells are a function of the intrinsic mitochondrial membrane potential
    Barbara G Heerdt
    Department of Oncology, Albert Einstein Cancer Center, Montefiore Medical Center, 111 East 210th Street, Bronx, NY 10467, USA
    Cancer Res 66:1591-6. 2006
  3. ncbi The intrinsic mitochondrial membrane potential of colonic carcinoma cells is linked to the probability of tumor progression
    Barbara G Heerdt
    Department of Oncology, Albert Einstein Cancer Center, Montefiore Medical Center, Bronx, New York 10467, USA
    Cancer Res 65:9861-7. 2005
  4. ncbi The intrinsic mitochondrial membrane potential (Deltapsim) is associated with steady-state mitochondrial activity and the extent to which colonic epithelial cells undergo butyrate-mediated growth arrest and apoptosis
    Barbara G Heerdt
    Department of Oncology, Albert Einstein Cancer Center, Montefiore Medical Center, 111 East 210th Street, Bronx, NY 10467, USA
    Cancer Res 63:6311-9. 2003
  5. ncbi TR3/Nur77 in colon cancer cell apoptosis
    Andrew J Wilson
    Department of Oncology, Albert Einstein Cancer Center, Montefiore Medical Center, Bronx, New York 10467, USA
    Cancer Res 63:5401-7. 2003
  6. ncbi Gene expression profiling of intestinal epithelial cell maturation along the crypt-villus axis
    John M Mariadason
    Montefiore Medical Cente, Albert Einstein Cancer Center, Bronx, New Yorrk 10467, USA
    Gastroenterology 128:1081-8. 2005
  7. ncbi Environment-gene interactions in intestinal cancer
    Leonard H Augenlicht
    Department of Oncology, Albert Einstein Cancer Center, Montefiore Hospital, 111 East 210th Street, Bronx, NY 10467, USA
    Eur J Cancer Prev 11:S12-7. 2002
  8. ncbi Short chain fatty acids and colon cancer
    Leonard H Augenlicht
    Department of Oncology, Albert Einstein Cancer Center, Montefiore Medical Center, Bronx, NY 10467, USA
    J Nutr 132:3804S-3808S. 2002
  9. ncbi Application of gene expression profiling to colon cell maturation, transformation and chemoprevention
    Leonard H Augenlicht
    Albert Einstein Cancer Center, Bronx, NY, USA
    J Nutr 133:2410S-2416S. 2003
  10. pmc Apoptotic sensitivity of colon cancer cells to histone deacetylase inhibitors is mediated by an Sp1/Sp3-activated transcriptional program involving immediate-early gene induction
    Andrew J Wilson
    Department of Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York, USA
    Cancer Res 70:609-20. 2010

Research Grants

  1. MITOCHONDRIA AND APOPTOSIS OF MAMMARY EPITHELIAL CELLS
    Barbara Heerdt; Fiscal Year: 2001
  2. Colon Cancer and Mitochondria
    Barbara Heerdt; Fiscal Year: 2006
  3. Short chain fatty acid metabolism and colonic tumorigenesis
    Barbara Heerdt; Fiscal Year: 2008

Detail Information

Publications10

  1. ncbi Dissociation of staurosporine-induced apoptosis from G2-M arrest in SW620 human colonic carcinoma cells: initiation of the apoptotic cascade is associated with elevation of the mitochondrial membrane potential (deltapsim)
    B G Heerdt
    Department of Oncology, Albert Einstein Cancer Center, Montefiore Medical Center, Bronx, New York 10467, USA
    Cancer Res 60:6704-13. 2000
    ....
  2. ncbi Growth properties of colonic tumor cells are a function of the intrinsic mitochondrial membrane potential
    Barbara G Heerdt
    Department of Oncology, Albert Einstein Cancer Center, Montefiore Medical Center, 111 East 210th Street, Bronx, NY 10467, USA
    Cancer Res 66:1591-6. 2006
    ..Combined with our previous work, these data implicate the intrinsic Deltapsim of colonic carcinoma cells in determining the probability of tumor expansion and progression...
  3. ncbi The intrinsic mitochondrial membrane potential of colonic carcinoma cells is linked to the probability of tumor progression
    Barbara G Heerdt
    Department of Oncology, Albert Einstein Cancer Center, Montefiore Medical Center, Bronx, New York 10467, USA
    Cancer Res 65:9861-7. 2005
    ..Therefore, these data establish that the probability for tumor development and progression is linked to stable differences in the intrinsic Deltapsim of colonic epithelial cells...
  4. ncbi The intrinsic mitochondrial membrane potential (Deltapsim) is associated with steady-state mitochondrial activity and the extent to which colonic epithelial cells undergo butyrate-mediated growth arrest and apoptosis
    Barbara G Heerdt
    Department of Oncology, Albert Einstein Cancer Center, Montefiore Medical Center, 111 East 210th Street, Bronx, NY 10467, USA
    Cancer Res 63:6311-9. 2003
    ....
  5. ncbi TR3/Nur77 in colon cancer cell apoptosis
    Andrew J Wilson
    Department of Oncology, Albert Einstein Cancer Center, Montefiore Medical Center, Bronx, New York 10467, USA
    Cancer Res 63:5401-7. 2003
    ..Therefore, TR3 translocation from the nucleus may initiate the apoptotic cascade in colon cancer cells by stimulating other cytosolic proapoptotic molecules to associate with mitochondria...
  6. ncbi Gene expression profiling of intestinal epithelial cell maturation along the crypt-villus axis
    John M Mariadason
    Montefiore Medical Cente, Albert Einstein Cancer Center, Bronx, New Yorrk 10467, USA
    Gastroenterology 128:1081-8. 2005
    ..To define the genetic reprogramming that drives intestinal epithelial cell maturation along the crypt-villus axis, enterocytes were sequentially isolated from the villus tip to the crypts of mouse small intestine...
  7. ncbi Environment-gene interactions in intestinal cancer
    Leonard H Augenlicht
    Department of Oncology, Albert Einstein Cancer Center, Montefiore Hospital, 111 East 210th Street, Bronx, NY 10467, USA
    Eur J Cancer Prev 11:S12-7. 2002
    ..This renders the cells competent to efficiently utilize factors in the intestinal lumen in normal metabolic and signaling pathways that contribute to homeostasis...
  8. ncbi Short chain fatty acids and colon cancer
    Leonard H Augenlicht
    Department of Oncology, Albert Einstein Cancer Center, Montefiore Medical Center, Bronx, NY 10467, USA
    J Nutr 132:3804S-3808S. 2002
    ....
  9. ncbi Application of gene expression profiling to colon cell maturation, transformation and chemoprevention
    Leonard H Augenlicht
    Albert Einstein Cancer Center, Bronx, NY, USA
    J Nutr 133:2410S-2416S. 2003
    ....
  10. pmc Apoptotic sensitivity of colon cancer cells to histone deacetylase inhibitors is mediated by an Sp1/Sp3-activated transcriptional program involving immediate-early gene induction
    Andrew J Wilson
    Department of Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York, USA
    Cancer Res 70:609-20. 2010
    ..Our findings link HDACi-induced apoptosis to activation of a Spl/Sp3-mediated response that involves derepression of a transcriptional network basally repressed in colon cancer...

Research Grants3

  1. MITOCHONDRIA AND APOPTOSIS OF MAMMARY EPITHELIAL CELLS
    Barbara Heerdt; Fiscal Year: 2001
    ..abstract_text> ..
  2. Colon Cancer and Mitochondria
    Barbara Heerdt; Fiscal Year: 2006
    ..abstract_text> ..
  3. Short chain fatty acid metabolism and colonic tumorigenesis
    Barbara Heerdt; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..