Jean M Hebert
Affiliation: Albert Einstein College of Medicine
Nandi S, Gutin G, Blackwood C, Kamatkar N, Lee K, Fishell G, et al
. FGF-Dependent, Context-Driven Role for FRS Adapters in the Early Telencephalon. J Neurosci. 2017;37:5690-5698 pubmed publisher
..Differential engagement of FRS and non-FRS intracellular adapters downstream of FGFRs could therefore in principle explain how FGFs play several distinct roles in other developing tissues and developmental stages. ..
Kang W, HÃ©bert J. FGF Signaling Is Necessary for Neurogenesis in Young Mice and Sufficient to Reverse Its Decline in Old Mice. J Neurosci. 2015;35:10217-23 pubmed publisher
..Moreover, in older mice, increasing FGF signaling is sufficient to reverse the decline in neuron production to levels found in young adults, providing a potential means of reversing age-related hippocampal deficits. ..
Hebert J, Vijg J. Cell Replacement to Reverse Brain Aging: Challenges, Pitfalls, and Opportunities. Trends Neurosci. 2018;41:267-279 pubmed publisher
..We outline the primary challenges for brain cell replacement, and key areas that require further investigation. ..
Nandi S, Alviña K, Lituma P, Castillo P, Hebert J. Neurotrophin and FGF Signaling Adapter Proteins, FRS2 and FRS3, Regulate Dentate Granule Cell Maturation and Excitatory Synaptogenesis. Neuroscience. 2018;369:192-201 pubmed publisher
..These observations reveal roles for FRS adapters in DGC maturation and synaptogenesis and suggest that FRS proteins may act as an important node for FGF and neurotrophin signaling in postnatal hippocampal development. ..