Rachel Hazan

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. ncbi Cadherin switch in tumor progression
    Rachel B Hazan
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Ann N Y Acad Sci 1014:155-63. 2004
  2. ncbi N-cadherin expression in breast cancer: correlation with an aggressive histologic variant--invasive micropapillary carcinoma
    Chandandeep Nagi
    Department of Pathology, Mount Sinai School of Medicine, New York, NY, USA
    Breast Cancer Res Treat 94:225-35. 2005
  3. ncbi Differential cadherin expression: potential markers for epithelial to mesenchymal transformation during tumor progression
    Georgia Agiostratidou
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Mammary Gland Biol Neoplasia 12:127-33. 2007
  4. ncbi Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion
    Terence M Williams
    Department of Molecular Pharmacology and Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 279:51630-46. 2004
  5. ncbi N-cadherin signaling potentiates mammary tumor metastasis via enhanced extracellular signal-regulated kinase activation
    James Hulit
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA
    Cancer Res 67:3106-16. 2007
  6. ncbi Loss of retinal cadherin facilitates mammary tumor progression and metastasis
    Georgia Agiostratidou
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Cancer Res 69:5030-8. 2009
  7. ncbi A signaling pathway leading to metastasis is controlled by N-cadherin and the FGF receptor
    Kimita Suyama
    Derald H Ruttenberg Cancer Center, The Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Cancer Cell 2:301-14. 2002

Research Grants

  1. R-Cadherin in Breast Cancer Suppression
    Rachel B Hazan; Fiscal Year: 2010
  2. EMT, Extravasation and metastasis by N-Cadherin signaling
    Rachel B Hazan; Fiscal Year: 2010
  3. Mechanisms of N-Cadherin Mediated Breast CA Metastasis
    Rachel Hazan; Fiscal Year: 2005
  4. EMT, Extravasation and metastasis by N-Cadherin signaling
    Rachel B Hazan; Fiscal Year: 2010

Collaborators

  • Georgia Agiostratidou
  • James Hulit
  • Kimita Suyama
  • Rinat Keren
  • Terence M Williams
  • Greg R Phillips
  • Su Chung
  • Maomi Li
  • Ines Badano
  • Michael P Lisanti
  • Chandandeep Nagi
  • Mitchell Guttman
  • Binzhi Qian
  • Olivier Loudig
  • Joseph Locker
  • Eliseo Eugenin
  • Amy Anzovino
  • Boumediene Bouzahzah
  • Weisong Shan
  • Karen Knudsen
  • Xinyuan Dong
  • Aymara Triana
  • Ira J Bleiweiss
  • Rui Qiao
  • Shabnam Jaffer
  • James Godbold
  • John Hutchinson
  • Freddy Medina
  • Neeru G Chopra
  • Richard G Pestell
  • William J Muller
  • Philipp E Scherer
  • Irina Shapiro

Detail Information

Publications7

  1. ncbi Cadherin switch in tumor progression
    Rachel B Hazan
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Ann N Y Acad Sci 1014:155-63. 2004
    ..Here, we summarize the various aspects of the E- to N-cadherin switching in epithelial carcinomas and its potential impact on metastatic progression...
  2. ncbi N-cadherin expression in breast cancer: correlation with an aggressive histologic variant--invasive micropapillary carcinoma
    Chandandeep Nagi
    Department of Pathology, Mount Sinai School of Medicine, New York, NY, USA
    Breast Cancer Res Treat 94:225-35. 2005
    ..005), whereas such changes were not significant in the non-MPAP group (p = 0.10). Thus, N-cadherin is associated with tumor aggressiveness and metastatic potential and may contribute to tumor progression...
  3. ncbi Differential cadherin expression: potential markers for epithelial to mesenchymal transformation during tumor progression
    Georgia Agiostratidou
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Mammary Gland Biol Neoplasia 12:127-33. 2007
    ..Double labeling of individual tumors with specific E- and N-cadherin antibodies suggests that EMT can occur heterogeneously and/or transiently within an invasive tumor...
  4. ncbi Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion
    Terence M Williams
    Department of Molecular Pharmacology and Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 279:51630-46. 2004
    ..These results demonstrate, for the first time, that caveolin-1 is a potent suppressor of mammary tumor growth and metastasis using novel in vivo animal model approaches...
  5. ncbi N-cadherin signaling potentiates mammary tumor metastasis via enhanced extracellular signal-regulated kinase activation
    James Hulit
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA
    Cancer Res 67:3106-16. 2007
    ..Thus, de novo expression of N-cadherin in mammary ducts enhances metastasis of breast tumors via enhanced ERK signaling...
  6. ncbi Loss of retinal cadherin facilitates mammary tumor progression and metastasis
    Georgia Agiostratidou
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Cancer Res 69:5030-8. 2009
    ..The data suggest that R-cad is an adhesion molecule of the mammary epithelium, which acts as a critical regulator of the normal phenotype. As a result, R-cad loss contributes to epithelial suppression and metastatic progression...
  7. ncbi A signaling pathway leading to metastasis is controlled by N-cadherin and the FGF receptor
    Kimita Suyama
    Derald H Ruttenberg Cancer Center, The Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Cancer Cell 2:301-14. 2002
    ..These results suggest that protection of the FGFR-1 from ligand-induced downregulation by N-cadherin enhances receptor signaling and provides a mechanism by which tumor cells can acquire metastatic properties...

Research Grants10

  1. R-Cadherin in Breast Cancer Suppression
    Rachel B Hazan; Fiscal Year: 2010
    ..We believe these studies have the potential to broaden our understanding of mechanisms that regulate breast cancer progression and have thus the potential to provide insights into therapeutic application. ..
  2. EMT, Extravasation and metastasis by N-Cadherin signaling
    Rachel B Hazan; Fiscal Year: 2010
    ..We will rule out the role of N-cadherin adhesion in this process. We believe these studies will broaden our understanding of mechanisms that regulate breast cancer metastasis and will provide insights into therapeutic application. ..
  3. Mechanisms of N-Cadherin Mediated Breast CA Metastasis
    Rachel Hazan; Fiscal Year: 2005
    ..abstract_text> ..
  4. EMT, Extravasation and metastasis by N-Cadherin signaling
    Rachel B Hazan; Fiscal Year: 2010
    ..We will rule out the role of N-cadherin adhesion in this process. We believe these studies will broaden our understanding of mechanisms that regulate breast cancer metastasis and will provide insights into therapeutic application. ..