Wei Gu

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. ncbi request reprint Mammalian SIRT1 represses forkhead transcription factors
    Maria Carla Motta
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 116:551-63. 2004
  2. ncbi request reprint ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor
    Delin Chen
    Institute for Cancer Genetics, Department of Pathology, College of Physicians and Surgeons, Columbia University, 1150 St Nicholas Avenue, New York, New York 10032
    Cell 121:1071-83. 2005
  3. pmc Blocking beta-catenin binding to the ZBP1 promoter represses ZBP1 expression, leading to increased proliferation and migration of metastatic breast-cancer cells
    Wei Gu
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Cell Sci 122:1895-905. 2009
  4. pmc Feedback regulation between zipcode binding protein 1 and beta-catenin mRNAs in breast cancer cells
    Wei Gu
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Mol Cell Biol 28:4963-74. 2008
  5. pmc ZBP2 facilitates binding of ZBP1 to beta-actin mRNA during transcription
    Feng Pan
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Mol Cell Biol 27:8340-51. 2007
  6. pmc Translation of ASH1 mRNA is repressed by Puf6p-Fun12p/eIF5B interaction and released by CK2 phosphorylation
    Yingfeng Deng
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Genes Dev 22:1037-50. 2008
  7. pmc A new yeast PUF family protein, Puf6p, represses ASH1 mRNA translation and is required for its localization
    Wei Gu
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Genes Dev 18:1452-65. 2004
  8. pmc A predominantly nuclear protein affecting cytoplasmic localization of beta-actin mRNA in fibroblasts and neurons
    Wei Gu
    Department of Anatomy, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Cell Biol 156:41-51. 2002
  9. ncbi request reprint RNA asymmetric distribution and daughter/mother differentiation in yeast
    Xavier Darzacq
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Curr Opin Microbiol 6:614-20. 2003
  10. ncbi request reprint Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function
    Delin Chen
    Institute for Cancer Genetics, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 278:13595-8. 2003

Collaborators

Detail Information

Publications51

  1. ncbi request reprint Mammalian SIRT1 represses forkhead transcription factors
    Maria Carla Motta
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 116:551-63. 2004
    ..We speculate how down-regulating these two classes of damage-responsive mammalian factors may favor long lifespan under certain environmental conditions, such as calorie restriction...
  2. ncbi request reprint ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor
    Delin Chen
    Institute for Cancer Genetics, Department of Pathology, College of Physicians and Surgeons, Columbia University, 1150 St Nicholas Avenue, New York, New York 10032
    Cell 121:1071-83. 2005
    ..As such, ARF-BP1 may serve as a potential target for therapeutic intervention in tumors regardless of p53 status...
  3. pmc Blocking beta-catenin binding to the ZBP1 promoter represses ZBP1 expression, leading to increased proliferation and migration of metastatic breast-cancer cells
    Wei Gu
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Cell Sci 122:1895-905. 2009
    ..These data suggest that repression of ZBP1 deregulates its associated mRNAs, leading to the phenotypic changes of breast cancers...
  4. pmc Feedback regulation between zipcode binding protein 1 and beta-catenin mRNAs in breast cancer cells
    Wei Gu
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Mol Cell Biol 28:4963-74. 2008
    ..beta-Catenin mediates the transcription of the ZBP1 gene, while ZBP1 promotes the stability of beta-catenin mRNA...
  5. pmc ZBP2 facilitates binding of ZBP1 to beta-actin mRNA during transcription
    Feng Pan
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Mol Cell Biol 27:8340-51. 2007
    ..ZBP1 then associates with the RNA throughout the nuclear export and cytoplasmic localization process...
  6. pmc Translation of ASH1 mRNA is repressed by Puf6p-Fun12p/eIF5B interaction and released by CK2 phosphorylation
    Yingfeng Deng
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Genes Dev 22:1037-50. 2008
    ....
  7. pmc A new yeast PUF family protein, Puf6p, represses ASH1 mRNA translation and is required for its localization
    Wei Gu
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Genes Dev 18:1452-65. 2004
    ..We propose that Puf6p is a protein that functions in the translational control of ASH1 mRNA, and this translational inhibition is necessary before localization can proceed...
  8. pmc A predominantly nuclear protein affecting cytoplasmic localization of beta-actin mRNA in fibroblasts and neurons
    Wei Gu
    Department of Anatomy, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Cell Biol 156:41-51. 2002
    ..These data suggest that ZBP2, although predominantly a nuclear protein, has a role in the cytoplasmic localization of beta-actin mRNA...
  9. ncbi request reprint RNA asymmetric distribution and daughter/mother differentiation in yeast
    Xavier Darzacq
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Curr Opin Microbiol 6:614-20. 2003
    ..Recent insights have revealed a role for translation that might have a key function in the regulation of Ash1 protein sorting...
  10. ncbi request reprint Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function
    Delin Chen
    Institute for Cancer Genetics, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 278:13595-8. 2003
    ..These results have significant implications regarding the molecular mechanism by which p53 is activated by HIF-1 alpha in response to hypoxia...
  11. ncbi request reprint Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage
    Chuangui Wang
    Molecular Oncology Program, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Nat Cell Biol 8:1025-31. 2006
    ..These results reveal a mutual regulation between E2F1 and SirT1 that affects cellular sensitivity to DNA damage...
  12. ncbi request reprint Acetylation inactivates the transcriptional repressor BCL6
    Oksana R Bereshchenko
    Institute for Cancer Genetics and the Department of Pathology, Columbia University, New York, New York 10032, USA
    Nat Genet 32:606-13. 2002
    ..Furthermore, these findings provide a new mechanism by which acetylation can promote transcription not only by modifying histones and activating transcriptional activators, but also by inhibiting transcriptional repressors...
  13. pmc Acetylation is indispensable for p53 activation
    Yi Tang
    Institute for Cancer Genetics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Cell 133:612-26. 2008
    ..Our study identifies p53 acetylation as an indispensable event that destabilizes the p53-Mdm2 interaction and enables the p53-mediated stress response...
  14. pmc Hormonal control of androgen receptor function through SIRT1
    Maofu Fu
    Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Mol Cell Biol 26:8122-35. 2006
    ..DHT-induced prostate cancer cellular contact-independent growth is also blocked by SIRT1, providing a direct functional link between the AR, which is a critical determinant of progression of human prostate cancer, and the sirtuins...
  15. ncbi request reprint p53 aerobics: the major tumor suppressor fuels your workout
    Jan Philipp Kruse
    Institute for Cancer Genetics, and Department of Pathology, College of Physicians and Surgeons, Columbia University, 1150 St Nicholas Ave, New York, New York 10032, USA
    Cell Metab 4:1-3. 2006
    ..2006). Loss of p53 results in decreased oxygen consumption and aerobic respiration and promotes a switch to glycolysis, thereby reducing endurance during physical exercise...
  16. ncbi request reprint Mechanisms for human cytomegalovirus-induced cytoplasmic p53 sequestration in endothelial cells
    Budi Utama
    Division of Cardiothoracic Surgery, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    J Cell Sci 119:2457-67. 2006
    ..The HCMV-induced changes in p53 dynamics could contribute to endothelial dysfunction...
  17. ncbi request reprint [Establishment of a multidrug-resistant cell line BEL-7402/5-FU of human hepatocellular carcinoma and its biological characteristics]
    Wei Gu
    Department of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
    Zhong Xi Yi Jie He Xue Bao 4:265-70. 2006
    ..To establish a multidrug-resistant cell line BEL-7402/5-FU of hepatocellular carcinoma (HCC)...
  18. pmc Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway
    Min Hu
    Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA
    PLoS Biol 4:e27. 2006
    ..These results, together with the structure of a combined substrate-binding-and-deubiquitylation domain of HAUSP, provide important insights into regulation of the p53-MDM2 pathway by HAUSP...
  19. ncbi request reprint Growth arrest and apoptosis of the human hepatocellular carcinoma cell line BEL-7402 induced by melittin
    Bai Li
    Department of Traditional Chinese Medicine, Second Military Medical University, Changhai Hospital, China
    Onkologie 29:367-71. 2006
    ....
  20. pmc FBXO11 promotes the Neddylation of p53 and inhibits its transcriptional activity
    Wassim M Abida
    Institute for Cancer Genetics and the Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 282:1797-804. 2007
    ..Our study provides an example of an F-box protein acting as an adaptor protein that can mediate the neddylation of a non-cullin substrate...
  21. ncbi request reprint Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis
    Yi Tang
    Institute for Cancer Genetics, Surgeons, Columbia University, 1150 St Nicholas Ave, New York, New York 10032, USA
    Mol Cell 24:827-39. 2006
    ....
  22. ncbi request reprint [Inhibition action of bufalin on human transplanted hepatocellular tumor and its effects on expressions of Bcl-2 and Bax proteins in nude mice]
    Wei Gu
    Department of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
    Zhong Xi Yi Jie He Xue Bao 5:155-9. 2007
    ..To investigate the anti-tumor effect of bufalin and its regulation on Bcl-2 and Bax proteins in orthotopically transplanted tumor of human hepatocellular carcinoma in nude mice...
  23. pmc Mechanistic studies of MDM2-mediated ubiquitination in p53 regulation
    Christopher L Brooks
    Institute for Cancer Genetics, and Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 282:22804-15. 2007
    ..Ubiquitination-mediated repression of p53 by Mdm2 acts at least, in part, through inhibiting the sequence-specific DNA binding activity. Thus, our results have important implications regarding the mechanisms by which Mdm2 acts on p53...
  24. pmc Functional significance of gene polymorphisms in the promoter of myeloid differentiation-2
    Wei Gu
    State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Chongqing, China
    Ann Surg 246:151-8. 2007
    ..To investigate the functional significance of the reported single nucleotide polymorphisms (SNPs) in the promoter of the myeloid differentiation-2 (MD-2) gene...
  25. ncbi request reprint Non-transcriptional control of DNA replication by c-Myc
    David Dominguez-Sola
    Institute for Cancer Genetics, Department of Genetics and Development and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York 10032, USA
    Nature 448:445-51. 2007
    ..These findings identify a critical function of c-Myc in DNA replication and suggest a novel mechanism for its normal and oncogenic functions...
  26. doi request reprint Mechanism of fast peptide recognition by SH3 domains
    Mazen Ahmad
    Zentrum fur Bioinformatik, Universitat des Saarlandes, 66041 Saarbrucken, Germany
    Angew Chem Int Ed Engl 47:7626-30. 2008
  27. doi request reprint Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation
    Kai Li
    Department of Cancer Biology and the Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 283:7590-8. 2008
    ..Down-regulation of SIRT1 reduces WRN translocation from nucleoplasm to nucleoli after DNA damage. These results suggest that SIRT1 regulates WRN-mediated cellular responses to DNA damage through deacetylation of WRN...
  28. pmc Negative regulation of the deacetylase SIRT1 by DBC1
    Wenhui Zhao
    Institute for Cancer Genetics, and Department of Pathology College of Physicians and Surgeons, Columbia University, 1130 St Nicholas Avenue, New York, New York 10032, USA
    Nature 451:587-90. 2008
    ..Notably, these effects can be reversed in cells by concomitant knockdown of endogenous SIRT1. Our study demonstrates that DBC1 promotes p53-mediated apoptosis through specific inhibition of SIRT1...
  29. ncbi request reprint Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses
    Wen Yong Chen
    Cancer Biology Program, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University, Baltimore, Maryland 21231, USA
    Cell 123:437-48. 2005
    ....
  30. ncbi request reprint Dynamical binding of proline-rich peptides to their recognition domains
    Wei Gu
    Zentrum fur Bioinformatik, Universitat des Saarlandes, D 66041 Saarbrucken, Germany
    Biochim Biophys Acta 1754:232-8. 2005
    ..Furthermore, we give an outlook of the systems in the context of systems biology...
  31. ncbi request reprint [The induced apoptosis of recombinant adenovirus carrying melittin gene for hepatocellular carcinoma cell]
    Bai Li
    Department of Chinese Traditional Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
    Zhonghua Gan Zang Bing Za Zhi 12:453-5. 2004
    ..To observe the induced apoptosis of recombinant adenovirus carrying melittin gene (Ad-rAFP-Mel) for hepatocellular carcinoma cell line (BEL-7402)...
  32. ncbi request reprint A dynamic role of HAUSP in the p53-Mdm2 pathway
    Muyang Li
    Institute for Cancer Genetics and Department of Pathology, College of Physicians and Surgeons, Columbia University, 1150 St Nicholas Avenue, New York, NY 10032, USA
    Mol Cell 13:879-86. 2004
    ..This study provides an example of an ubiquitin ligase (Mdm2) that is directly regulated by a deubiquitinase (HAUSP) and also reveals a dynamic role of HAUSP in the p53-Mdm2 pathway...
  33. pmc Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo
    Jianyuan Luo
    Institute for Cancer Genetics and Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 101:2259-64. 2004
    ..Thus, our results clarify some of the confusion surrounding acetylation-mediated effects on p53 binding to DNA and suggest that acetylation of p53 in vivo may contribute, at least in part, to its transcriptional activation functions...
  34. ncbi request reprint Monoubiquitination: the signal for p53 nuclear export?
    Christopher L Brooks
    Institute for Cancer Genetics, and Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Cell Cycle 3:436-8. 2004
    ..Our findings demonstrate monoubiquitin-mediated protein trafficking can be expanded to nuclear-cytoplasmic shuttling, and also imply similar scenarios may apply to other cellular factors...
  35. ncbi request reprint The prolactin-releasing peptide receptor (GPR10) regulates body weight homeostasis in mice
    Wei Gu
    Millennium Pharmaceuticals, Inc, MA 02139, USA
    J Mol Neurosci 22:93-103. 2004
    ..GPR10 knockout mice will also prove useful for investigating other proposed activities for PrRP...
  36. ncbi request reprint Mono- versus polyubiquitination: differential control of p53 fate by Mdm2
    Muyang Li
    Institute for Cancer Genetics and Department of Pathology, College of Physicians and Surgeons, Columbia University, 1150 St Nicholas Avenue, New York, NY 10032, USA
    Science 302:1972-5. 2003
    ..These results clarify the nature of ubiquitination-mediated p53 regulation and suggest that distinct mechanisms regulate p53 function in accordance with the levels of Mdm2 activity...
  37. ncbi request reprint PARC: a potential target for cancer therapy
    Anatoly Y Nikolaev
    Institute for Cancer Genetics and Department of Pathology, College of Physicians and Surgeons, Columbia University, 1150 St Nicholas Avenue, New York, NY 10032, USA
    Cell Cycle 2:169-71. 2003
  38. ncbi request reprint Parc: a cytoplasmic anchor for p53
    Anatoly Y Nikolaev
    Institute for Cancer Genetics and Department of Pathology, College of Physicians and Surgeons, Columbia University, 1150 St Nicholas Avenue, New York, NY 10032, USA
    Cell 112:29-40. 2003
    ..These results reveal that Parc is a critical regulator in controlling p53 subcellular localization and subsequent function...
  39. ncbi request reprint Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde
    Min Hu
    Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, Princeton, NJ 08544, USA
    Cell 111:1041-54. 2002
    ..Binding by ubiquitin aldehyde induces a drastic conformational change in the active site that realigns the catalytic triad residues for catalysis...
  40. ncbi request reprint [Establishment and biological characteristics of orthotopic transplantation tumor model of hepatocellular carcinoma in mice]
    Ke Qi Han
    Department of Tranditional Chinese Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
    Zhong Xi Yi Jie He Xue Bao 2:372-4. 2004
    ..To study the feasibility of the establishment of the orthotopic transplantation tumor model of hepatocellular carcinoma in mice and its tumor biological characteristics...
  41. ncbi request reprint Identification of a novel BRMS1-homologue protein p40 as a component of the mSin3A/p33(ING1b)/HDAC1 deacetylase complex
    Anatoly Y Nikolaev
    Department of Pathology, Institute for Cancer Genetics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Biochem Biophys Res Commun 323:1216-22. 2004
    ..Thus, our data indicate that p40 may be critically involved in transcription repression of cell growth-associated gene expression by recruiting the HDAC1 deacetylase complex...
  42. ncbi request reprint FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction
    Yukari Ido Kitamura
    Naomi Berrie Diabetes Center, Department of Medicine, Columbia University, New York, New York 10032, USA
    Cell Metab 2:153-63. 2005
    ..The findings provide a mechanism linking glucose- and growth factor receptor-activated pathways to protect beta cells against oxidative damage via FoxO proteins...
  43. pmc Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity
    Lijin Feng
    Section of Molecular Biology, Division of Biological Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0322, USA
    Mol Cell Biol 25:5389-95. 2005
    ....
  44. ncbi request reprint Alternative binding modes of proline-rich peptides binding to the GYF domain
    Wei Gu
    Zentrum fur Bioinformatik, Universitat des Saarlandes, D 66041 Saarbrucken, Germany
    Biochemistry 44:6404-15. 2005
    ..Possible functional implications of this altered conformation of the bound ligand are discussed in the light of our experimental and theoretical results...
  45. ncbi request reprint Cyclophilin A binds to linear peptide motifs containing a consensus that is present in many human proteins
    Kirill Piotukh
    Protein Engineering Group, Freie Universität Berlin and Forschungsinstitut für Molekulare Pharmakologie, Robert Rossle Strasse 10, 13125 Berlin, Germany
    J Biol Chem 280:23668-74. 2005
    ..These sequences represent putative target sites for binding of CypA to intracellular proteins...
  46. ncbi request reprint [Characterization of biologic behaviors and cDNA expression of articular chondrocytes in spondyloepiphyseal dysplasia tarda with progressive arthropathy]
    Hou De Zhou
    Institute of Endocrinology and Metabolism, The Second Xiangya Hospital of Central South University, Changsha 410011, China
    Zhonghua Nei Ke Za Zhi 44:16-21. 2005
    ..The present study characterized the biologic behaviors and cDNA differential expression profile of articular chondrocytes in SEDT-PA...
  47. ncbi request reprint Molecular dynamics simulation of truncated bovine adrenodoxin
    Saurabh Kumar Shakya
    Center for Bioinformatics, Saarland University, D 66041 Saarbrucken, Germany
    Biopolymers 78:9-20. 2005
    ..This points to an intrinsic property of reduced Adx that drives dissociation...
  48. ncbi request reprint Integration of the hepatitis B virus X fragment in hepatocellular carcinoma and its effects on the expression of multiple molecules: a key to the cell cycle and apoptosis
    Zhihai Peng
    Department of General Surgery, Shanghai Jiaotong University Affiliated Shanghai First People s Hospital, Shanghai 200080, P R China
    Int J Oncol 26:467-73. 2005
    ..015). HBx integration and altered expression of genes is a key to apoptosis and may play important roles in HBV-induced hepatocarcinogenesis...
  49. ncbi request reprint SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1
    Toula Bouras
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, 3970 Reservoir Rd, Washington, DC 20057, USA
    J Biol Chem 280:10264-76. 2005
    ..Because p300 is a limiting transcriptional cofactor, deacetylation and repression of p300 by SIRT1 may serve an important integration point during metabolism and cellular differentiation...
  50. ncbi request reprint [Anti-hepatocarcinoma effect of recombinant adenovirus carrying melittin gene]
    Chang Quan Ling
    Department of Chinese Traditional Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
    Zhonghua Gan Zang Bing Za Zhi 12:741-4. 2004
    ..To find a new method of treating hepatocellular carcinoma with melittin by way of using the melittin gene...
  51. ncbi request reprint Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization
    Muyang Li
    Institute for Cancer Genetics, and Department of Pathology, College of Physicians and Surgeons, Columbia University, 1150 St Nicholas Avenue, New York, New York 10032, USA
    Nature 416:648-53. 2002
    ..These findings reveal an important mechanism by which p53 can be stabilized by direct deubiquitination and also imply that HAUSP might function as a tumour suppressor in vivo through the stabilization of p53...