John M Greally

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. ncbi request reprint A stain upon the silence: genes escaping X inactivation
    Carolyn J Brown
    Department of Medical Genetics, University of British Columbia, 6174 University Blvd, Vancouver, British Columbia, Canada V6T 1Z3
    Trends Genet 19:432-8. 2003
  2. pmc Convergent and divergent evolution of genomic imprinting in the marsupial Monodelphis domestica
    Radhika Das
    Department of Radiation Oncology, Duke University Medical Center, Box 3433, Durham, NC 27710, USA
    BMC Genomics 13:394. 2012
  3. pmc Genetic mapping of putative Chrna7 and Luzp2 neuronal transcriptional enhancers due to impact of a transgene-insertion and 6.8 Mb deletion in a mouse model of Prader-Willi and Angelman syndromes
    Mihaela Stefan
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    BMC Genomics 6:157. 2005
  4. pmc Short interspersed transposable elements (SINEs) are excluded from imprinted regions in the human genome
    John M Greally
    Department of Medicine Hematology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Ullmann 925, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 99:327-32. 2002
  5. pmc An integrative genomic and epigenomic approach for the study of transcriptional regulation
    Maria E Figueroa
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 3:e1882. 2008
  6. doi request reprint The Wasp System: an open source environment for managing and analyzing genomic data
    Andrew S McLellan
    Center for Epigenomics and Division of Computational Genetics, Department of Genetics, Albert Einstein College of Medicine, 1301 Morris Park Avenue, Bronx, NY 10461, USA
    Genomics 100:345-51. 2012
  7. doi request reprint Methylome profiling reveals distinct alterations in phenotypic and mutational subgroups of myeloproliferative neoplasms
    Sangeeta Nischal
    Authors Affiliations Albert Einstein College of Medicine, Bronx, New York Mayo Clinic, Rochester, Minnesota Johns Hopkins School of Medicine, Baltimore, Maryland Cleveland Clinic, Cleveland, Ohio and Weill Cornell Medical School, New York, New York
    Cancer Res 73:1076-85. 2013
  8. doi request reprint An analytical pipeline for genomic representations used for cytosine methylation studies
    Reid F Thompson
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Bioinformatics 24:1161-7. 2008
  9. pmc Late-replicating heterochromatin is characterized by decreased cytosine methylation in the human genome
    Masako Suzuki
    Department of Genetics Computational Genetics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Genome Res 21:1833-40. 2011
  10. pmc High-resolution genome-wide cytosine methylation profiling with simultaneous copy number analysis and optimization for limited cell numbers
    Mayumi Oda
    Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, USA
    Nucleic Acids Res 37:3829-39. 2009

Research Grants

Detail Information

Publications50

  1. ncbi request reprint A stain upon the silence: genes escaping X inactivation
    Carolyn J Brown
    Department of Medical Genetics, University of British Columbia, 6174 University Blvd, Vancouver, British Columbia, Canada V6T 1Z3
    Trends Genet 19:432-8. 2003
    ..We discuss the impact of the evolutionary history of the X (and Y) chromosome, and the bioinformatic approaches that promise to provide new insights into the genomic architecture of genes or regions that escape X-chromosome inactivation...
  2. pmc Convergent and divergent evolution of genomic imprinting in the marsupial Monodelphis domestica
    Radhika Das
    Department of Radiation Oncology, Duke University Medical Center, Box 3433, Durham, NC 27710, USA
    BMC Genomics 13:394. 2012
    ..It is postulated to have evolved in placental mammals to modulate intrauterine resource allocation to the offspring. In this study, we determined the imprint status of metatherian orthologues of eutherian imprinted genes...
  3. pmc Genetic mapping of putative Chrna7 and Luzp2 neuronal transcriptional enhancers due to impact of a transgene-insertion and 6.8 Mb deletion in a mouse model of Prader-Willi and Angelman syndromes
    Mihaela Stefan
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    BMC Genomics 6:157. 2005
    ..In this study, we define the deletion endpoints and examine the impact on expression of flanking genes...
  4. pmc Short interspersed transposable elements (SINEs) are excluded from imprinted regions in the human genome
    John M Greally
    Department of Medicine Hematology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Ullmann 925, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 99:327-32. 2002
    ..Methylation-induced silencing could lead to deleterious consequences at imprinted loci, where inactivation of one allele is already established, and expression is often essential for embryonic growth and survival...
  5. pmc An integrative genomic and epigenomic approach for the study of transcriptional regulation
    Maria E Figueroa
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 3:e1882. 2008
    ..Integrative epigenomic studies are thus feasible using clinical samples and provide superior detection of aberrant transcriptional programming than single-platform microarray studies...
  6. doi request reprint The Wasp System: an open source environment for managing and analyzing genomic data
    Andrew S McLellan
    Center for Epigenomics and Division of Computational Genetics, Department of Genetics, Albert Einstein College of Medicine, 1301 Morris Park Avenue, Bronx, NY 10461, USA
    Genomics 100:345-51. 2012
    ..Here we describe the current implementation and development of the Wasp System and the roadmap for its community development...
  7. doi request reprint Methylome profiling reveals distinct alterations in phenotypic and mutational subgroups of myeloproliferative neoplasms
    Sangeeta Nischal
    Authors Affiliations Albert Einstein College of Medicine, Bronx, New York Mayo Clinic, Rochester, Minnesota Johns Hopkins School of Medicine, Baltimore, Maryland Cleveland Clinic, Cleveland, Ohio and Weill Cornell Medical School, New York, New York
    Cancer Res 73:1076-85. 2013
    ..These results show epigenetic differences between PMF and polycythemia vera/essential thrombocytosis and reveal methylomic signatures of ASXL1 and TET2 mutations. Cancer Res; 73(3); 1076-85. ©2012 AACR...
  8. doi request reprint An analytical pipeline for genomic representations used for cytosine methylation studies
    Reid F Thompson
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Bioinformatics 24:1161-7. 2008
    ..Here we describe all of the components of the pipeline, which can also be applied to data derived from other assays based on genomic representations...
  9. pmc Late-replicating heterochromatin is characterized by decreased cytosine methylation in the human genome
    Masako Suzuki
    Department of Genetics Computational Genetics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Genome Res 21:1833-40. 2011
    ....
  10. pmc High-resolution genome-wide cytosine methylation profiling with simultaneous copy number analysis and optimization for limited cell numbers
    Mayumi Oda
    Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, USA
    Nucleic Acids Res 37:3829-39. 2009
    ....
  11. doi request reprint Genome-wide determination of DNA methylation by Hpa II tiny fragment enrichment by ligation-mediated PCR (HELP) for the study of acute leukemias
    Maria E Figueroa
    Department of Medicine and Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Ave, Ullmann 911, Bronx, NY 10461, USA
    Methods Mol Biol 538:395-407. 2009
    ..The HELP assay allows methylation levels throughout the genome to be accurately determined so that the epigenetic state of leukemia cells can be identified, compared, and contrasted...
  12. pmc Tissue-specific dysregulation of DNA methylation in aging
    Reid F Thompson
    Departments of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA
    Aging Cell 9:506-18. 2010
    ..We conclude that different patterns of epigenetic dysregulation occur in each tissue over time and may cause some of the physiological changes associated with normal aging...
  13. doi request reprint The HELP assay
    Mayumi Oda
    Departments of Medicine Hematology and Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY, USA
    Methods Mol Biol 507:77-87. 2009
    ....
  14. ncbi request reprint The Einstein Genome Gateway using WASP - a high throughput multi-layered life sciences portal for XSEDE
    Aaron Golden
    Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Stud Health Technol Inform 175:182-91. 2012
    ..In this paper we discuss the existing WASP system, its proposed middleware role, and its planned interaction with XSEDE to form the Einstein Genome Gateway...
  15. pmc Experimental intrauterine growth restriction induces alterations in DNA methylation and gene expression in pancreatic islets of rats
    Reid F Thompson
    Departments of Genetics Computational Genetics, Albert Einstein College of Medicine, Bronx, New York, New York 10461, USA
    J Biol Chem 285:15111-8. 2010
    ..These results demonstrate that epigenetic dysregulation is a strong candidate for propagating the cellular memory of intrauterine events, causing changes in expression of nearby genes and long term susceptibility to type 2 diabetes...
  16. doi request reprint Automated computational analysis of genome-wide DNA methylation profiling data from HELP-tagging assays
    Qiang Jing
    Departments of Genetics Computational Genetics and Center for Epigenomics, Albert Einstein College of Medicine, 1301 Morris Park Avenue, Bronx, NY, USA
    Methods Mol Biol 815:79-87. 2012
    ..HELP-tagging analysis results are supplied in standard file formats (BED and WIG) that can be readily examined on the UCSC genome browser...
  17. doi request reprint CG dinucleotide periodicities recognized by the Dnmt3a-Dnmt3L complex are distinctive at retroelements and imprinted domains
    Jacob L Glass
    Department of Genetics Computational Genetics, Albert Einstein College of Medicine, 1301 Morris Park Avenue, Bronx, NY 10461, USA
    Mamm Genome 20:633-43. 2009
    ..We conclude that CG dinucleotide periodicity helps to explain some but not all of the relative sequence specificity of mutations of Dnmt3a or Dnmt3L in the establishment of germline cytosine methylation patterns...
  18. pmc Cytosine methylation dysregulation in neonates following intrauterine growth restriction
    Francine Einstein
    Department of Obstetrics, Gynecology and Women s Health, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 5:e8887. 2010
    ....
  19. doi request reprint Introduction to epigenomics and epigenome-wide analysis
    Melissa J Fazzari
    Division of Biostatistics, Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA
    Methods Mol Biol 620:243-65. 2010
    ..We will conclude this chapter by identifying issues in building methylation-based models for prediction and potential directions of further statistical research in epigenetics...
  20. doi request reprint The Einstein Center for Epigenomics: studying the role of epigenomic dysregulation in human disease
    Andrew S McLellan
    Price Center for Genetics and Translational Medicine, Albert Einstein College of Medicine, 1301 Morris Park Avenue, Bronx, NY 10461, USA
    Epigenomics 1:33-8. 2009
    ..As a result, several avenues of research are now expanding, with cancer epigenomics being complemented by studies of the epigenomics of infectious disease and a neuroepigenomics program...
  21. pmc Experimental approaches to the study of epigenomic dysregulation in ageing
    Reid F Thompson
    Department of Genetics and Center for Epigenomics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Exp Gerontol 45:255-68. 2010
    ..We describe how such experiments are currently performed, their limitations technically and analytically and their application to ageing research...
  22. pmc DNA methylation profiling using HpaII tiny fragment enrichment by ligation-mediated PCR (HELP)
    Masako Suzuki
    Center for Epigenomics and Division of Computational Genetics, Department of Genetics, Albert Einstein College of Medicine, 1301 Morris Park Avenue, Bronx, NY 10461, USA
    Methods 52:218-22. 2010
    ..Here we describe the assay, its relative strengths and weaknesses, and the transition of the assay from a microarray to massively-parallel sequencing-based foundation...
  23. pmc Optimized design and data analysis of tag-based cytosine methylation assays
    Masako Suzuki
    Department of Genetics Computational Genetics, Center for Epigenomics, Albert Einstein College of Medicine, 1301 Morris Park Avenue, Bronx, NY 10461, USA
    Genome Biol 11:R36. 2010
    ..8 million loci in the human genome. This HELP-tagging assay is not sensitive to sequence polymorphism or base composition and allows exploration of both CG-rich and depleted genomic contexts...
  24. doi request reprint DNA methylation changes in murine breast adenocarcinomas allow the identification of candidate genes for human breast carcinogenesis
    Deanna Acosta
    Department of Genetics, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY 10461, USA
    Mamm Genome 22:249-59. 2011
    ..Based on these studies, we present a model in which comparative epigenetic techniques can be used to identify novel candidate genes important for human breast tumorigenesis, in both primary and metastatic tumors...
  25. pmc Toxoplasma gondii and Cryptosporidium parvum lack detectable DNA cytosine methylation
    Mathieu Gissot
    Albert Einstein College of Medicine, Ullmann 1225, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Eukaryot Cell 7:537-40. 2008
    ..To assess the presence of cytosine methylation of Toxoplasma gondii and Cryptosporidium parvum DNA, we used mass spectrometry analysis and confirmed that these organisms lack detectable methylcytosine in their DNA...
  26. doi request reprint Genome-wide DNA methylation analysis using massively parallel sequencing technologies
    Masako Suzuki
    Center for Epigenomics, Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Semin Hematol 50:70-7. 2013
    ..We will also describe recently discovered DNA modifications, and the protocols to detect these modifications...
  27. pmc Stem and progenitor cells in myelodysplastic syndromes show aberrant stage-specific expansion and harbor genetic and epigenetic alterations
    Britta Will
    Albert Einstein College of Medicine, Bronx, NY, USA
    Blood 120:2076-86. 2012
    ..This study demonstrates that stem and progenitor cells in MDS are characterized by stage-specific expansions and contain epigenetic and genetic alterations...
  28. pmc Comparative isoschizomer profiling of cytosine methylation: the HELP assay
    Batbayar Khulan
    Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Genome Res 16:1046-55. 2006
    ..The HELP assay is robust, quantitative, and accurate and is providing new insights into the distribution and dynamic nature of cytosine methylation in the genome...
  29. pmc A pipeline for the quantitative analysis of CG dinucleotide methylation using mass spectrometry
    Reid F Thompson
    Department of Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Bioinformatics 25:2164-70. 2009
    ..The tools in this package include bisulphite conversion efficiency calculation, sequence polymorphism flagging and visualization tools that combine multiple experimental replicates and create tracks for genome browser viewing...
  30. doi request reprint DNA methylation alterations in multiple myeloma as a model for epigenetic changes in cancer
    Amy Sharma
    Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Wiley Interdiscip Rev Syst Biol Med 2:654-69. 2010
    ..We have thus focused on DNA methylation changes in the pathogenesis of multiple myeloma, which promises to become an excellent model for systems biological studies of epigenomic dysregulation in human disease...
  31. pmc Repressor element-1 silencing transcription factor (REST)-dependent epigenetic remodeling is critical to ischemia-induced neuronal death
    Kyung Min Noh
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, New York, NY 10461, USA
    Proc Natl Acad Sci U S A 109:E962-71. 2012
    ....
  32. pmc Aberrant epigenetic and genetic marks are seen in myelodysplastic leukocytes and reveal Dock4 as a candidate pathogenic gene on chromosome 7q
    Li Zhou
    Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 286:25211-23. 2011
    ..These findings reveal widespread novel epigenetic alterations in myelodysplastic leukocytes and implicate DOCK4 as a pathogenic gene located on the 7q chromosomal region...
  33. pmc Epigenomic modifications predict active promoters and gene structure in Toxoplasma gondii
    Mathieu Gissot
    Department of Medicine Infectious Diseases, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS Pathog 3:e77. 2007
    ..In addition, with its compact genome, genetic tractability, and discrete life cycle stages, T. gondii provides an important new model to study the evolutionarily conserved components of the histone code...
  34. pmc CG dinucleotide clustering is a species-specific property of the genome
    Jacob L Glass
    Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA, Division of Hematology Oncology, University of Kentucky, Markey Cancer Center, 800 Rose Street, Lexington KY 40536, USA
    Nucleic Acids Res 35:6798-807. 2007
    ..Finally, our approach is able to identify methylating genomes (such as Takifugu rubripes) that lack CG clustering entirely, in which it is inappropriate to annotate CpG islands or CG clusters...
  35. ncbi request reprint Epigenomics: beyond CpG islands
    Melissa J Fazzari
    Department of Epidemiology and Social Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Nat Rev Genet 5:446-55. 2004
  36. pmc Transcriptional signature with differential expression of BCL6 target genes accurately identifies BCL6-dependent diffuse large B cell lymphomas
    Jose M Polo
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 104:3207-12. 2007
    ..More broadly, these data show how genome-wide identification of direct target genes can identify tumors dependent on oncogenic transcription factors and amenable to targeted therapeutics...
  37. pmc Phase II trial of the histone deacetylase inhibitor romidepsin in patients with recurrent/metastatic head and neck cancer
    Missak Haigentz
    Division of Oncology, Department of Medicine, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY 10467, USA
    Oral Oncol 48:1281-8. 2012
    ..Inhibition of histone deacetylases (HDACs) represents a novel therapeutic approach warranting additional investigation in solid tumors...
  38. pmc Differential epigenome-wide DNA methylation patterns in childhood obesity-associated asthma
    Deepa Rastogi
    Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, USA
    Sci Rep 3:2164. 2013
    ..These findings suggest that dysregulated DNA methylation is associated with non-atopic inflammation observed in pediatric obesity-associated asthma. ..
  39. pmc Mammalian linker-histone subtypes differentially affect gene expression in vivo
    Raouf Alami
    Department of Medicine, Division of Hematology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 100:5920-5. 2003
    ....
  40. ncbi request reprint Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences
    Tarjei S Mikkelsen
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 447:167-77. 2007
    ..A substantial proportion of these eutherian-specific CNEs arose from sequence inserted by transposable elements, pointing to transposons as a major creative force in the evolution of mammalian gene regulation...
  41. ncbi request reprint Genomics: Encyclopaedia of humble DNA
    John M Greally
    Nature 447:782-3. 2007
  42. ncbi request reprint Epigenetics: perceptive enzymes
    Anne C Ferguson-Smith
    Nature 449:148-9. 2007
  43. ncbi request reprint Cell type-specific methylation profiles occurring disproportionately in CpG-less regions that delineate developmental similarity
    Hideki Sakamoto
    Cellular Biochemistry, Animal Resource Sciences Veterinary Medical Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113 8657, Japan
    Genes Cells 12:1123-32. 2007
    ..The finding indicates the power of NotI methylation profiles in evaluating the relatedness of different cell types...
  44. ncbi request reprint Genome-wide and locus-specific DNA hypomethylation in G9a deficient mouse embryonic stem cells
    Kohta Ikegami
    Laboratory of Cellular Biochemistry, Department of Animal Resource Sciences and Veterinary Medical Sciences, The University of Tokyo, Tokyo 113 8657, Japan
    Genes Cells 12:1-11. 2007
    ..Chromatin immunoprecipitation (ChIP) confirmed these loci to be targets of G9a, with decreased H3-K9 and/or -K27 dimethylation in the G9a(-/-) cells. These data indicate that G9a site-selectively contributes to DNA methylation...
  45. ncbi request reprint A new class of tissue-specifically methylated regions involving entire CpG islands in the mouse
    Masako Suzuki
    Laboratory of Cellular Biochemistry, Veterinary Medical Sciences Animal Resource Sciences, The University of Tokyo, Tokyo 113 8657, Japan
    Genes Cells 12:1305-14. 2007
    ..T-DMRs at CpG islands are functionally important gene regulatory elements that may now be categorized into two classes: T-DMRs involving a subregion of the CpG island and those that occupy the whole CpG island...
  46. ncbi request reprint The potential role of epigenomic dysregulation in complex human disease
    Eli Hatchwell
    Department of Pathology, SUNY at Stony Brook, HSC T8, Room 053, Stony Brook, NY 11794 8088, USA
    Trends Genet 23:588-95. 2007
    ....
  47. doi request reprint Kaiso contributes to DNA methylation-dependent silencing of tumor suppressor genes in colon cancer cell lines
    Eloisi C Lopes
    Department of Molecular Pharmacology and Chemistry, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Cancer Res 68:7258-63. 2008
    ..Because Kaiso inactivation sensitized colon cancer cell lines to chemotherapy, it is possible that therapeutic targeting of Kaiso could improve the efficacy of current treatment regimens...
  48. ncbi request reprint Identification of a candidate regulatory region in the human CD8 gene complex by colocalization of DNase I hypersensitive sites and matrix attachment regions which bind SATB1 and GATA-3
    Lynda J Kieffer
    Department of Laboratory Medicine and Department of Genetics and Section of Immunobiology, Yale University, New Haven, CT 06520, USA
    J Immunol 168:3915-22. 2002
    ..This clustering of DNase HS sites and MARs capable of binding SATB1 and GATA-3 at the 3' end of the CD8B gene suggests that this region is an epigenetic regulator of CD8 expression...
  49. pmc Homez, a homeobox leucine zipper gene specific to the vertebrate lineage
    Dashzeveg Bayarsaihan
    Department of Molecular, Cellular, and Developmental Biology, Yale University, 266 Whitney Avenue, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 100:10358-63. 2003
    ..We apply a duplication-degeneration-complementation model to explain how this family of genes has evolved...

Research Grants12

  1. Spectral imaging and flourescence microscopy system
    John Greally; Fiscal Year: 2003
    ..The College, for its part, is supporting\ this application with a strong commitment to both facilities and to the infrastructure required for the equipment and the FISH facility. ..
  2. Massively-parallel sequencing technology for the epigenome
    John Greally; Fiscal Year: 2009
    ..As sequencing technology continues to advance, the insights gained from this project will allow their adoption for epigenomic identification of functional elements. ..
  3. Massively-parallel sequencing technology for the epigenome
    John Greally; Fiscal Year: 2007
    ..As sequencing technology continues to advance, the insights gained from this project will allow their adoption for epigenomic identification of functional elements. ..
  4. Epigenomic influences of diet on intestinal neoplasia
    John Greally; Fiscal Year: 2007
    ..The study will be the first genome-wide study of cytosine methylation to see whether diet-induced changes represent an intermediate stage in the development of cancer. ..
  5. Genomic analysis of mammalian imprinted loci
    John Greally; Fiscal Year: 2007
    ....
  6. Genome-wide cytosine methylation analysis
    John Greally; Fiscal Year: 2005
    ..We will make the developed assay broadly available to this institution's Cancer Center researchers through our fluorescence in situ hybridisation (FISH) core facility, for which the P.I. is scientific director. ..
  7. In vivo imaging of X inactivation
    Matthew Levy; Fiscal Year: 2010
    ....