Research Topics
Genomes and Genes | Sumanta GoswamiSummaryAffiliation: Albert Einstein College of Medicine Country: USA Publications
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Publications
Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1/epidermal growth factor paracrine loopSumanta Goswami
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Cancer Res 65:5278-83. 2005..Disruption of this loop by blockade of either EGF receptor or CSF-1 receptor signaling is sufficient to inhibit both macrophage and tumor cell migration and invasion...
Cofilin determines the migration behavior and turning frequency of metastatic cancer cellsMazen Sidani
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY 10461, USA
J Cell Biol 179:777-91. 2007..The changes in cell shape, directional migration, and turning frequency were related to the re-localization of Arp2/3 complex to one pole of the cell upon suppression of cofilin expression...- Invasion of human breast cancer cells in vivo requires both paracrine and autocrine loops involving the colony-stimulating factor-1 receptorAntonia Patsialou
Department of Anatomy, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Cancer Res 69:9498-506. 2009..In particular, we show that the autocrine contribution to invasion is specifically amplified in vivo through a tumor microenvironment-induced upregulation of CSF-1R expression via the transforming growth factor-beta1... - Coordinated regulation of pathways for enhanced cell motility and chemotaxis is conserved in rat and mouse mammary tumorsWeigang Wang
Department of Anatomy and Structural Biology and Gruss Lipper Center for Biophotonics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Cancer Res 67:3505-11. 2007.... - The activity status of cofilin is directly related to invasion, intravasation, and metastasis of mammary tumorsWeigang Wang
Department of Anatomy and Structural Biology and 2Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA
J Cell Biol 173:395-404. 2006..LIMK1-mediated decreases or increases in the activity of the cofilin pathway are shown to cause proportional decreases or increases in motility, intravasation, and metastasis of tumor cells... - Mena invasive (MenaINV) promotes multicellular streaming motility and transendothelial migration in a mouse model of breast cancerEvanthia T Roussos
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
J Cell Sci 124:2120-31. 2011.... - Mena invasive (Mena(INV)) and Mena11a isoforms play distinct roles in breast cancer cell cohesion and association with TMEMEvanthia T Roussos
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Clin Exp Metastasis 28:515-27. 2011..They also imply that Mena(INV) expression and TMEM score measure related aspects of a common tumor cell dissemination mechanism and provide new insight into metastatic risk... - Identification and testing of a gene expression signature of invasive carcinoma cells within primary mammary tumorsWeigang Wang
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Cancer Res 64:8585-94. 2004..ZBP1 reexpression also inhibited metastasis from tumors. These experiments support the involvement in metastasis of the pathways identified in invasive cells, which are regulated by ZBP1... - Tumor cells caught in the act of invading: their strategy for enhanced cell motilityWeigang Wang
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Trends Cell Biol 15:138-45. 2005..These results support a "tumor microenvironment invasion model" and provide new target opportunities for cancer therapy... - Differential enhancement of breast cancer cell motility and metastasis by helical and kinase domain mutations of class IA phosphoinositide 3-kinaseHuan Pang
Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Cancer Res 69:8868-76. 2009..Our observations suggest that, when compared with kinase domain mutations in a genetically identical background, expression of helical domain mutants of p110alpha produce a more severe metastatic phenotype... - Identification of invasion specific splice variants of the cytoskeletal protein Mena present in mammary tumor cells during invasion in vivoSumanta Goswami
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine of Yeshiva University, 1300 Morris Park Avenue, Bronx, NY 10461, USA
Clin Exp Metastasis 26:153-9. 2009..The Mena isoform switching pattern described here may provide a new biomarker for the presence of metastatic cancer cells and for prognosis... - Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumorsJeffrey B Wyckoff
Gruss Lipper Center for Biophotonics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Cancer Res 67:2649-56. 2007..These results show that the interaction between macrophages and tumor cells lying in close proximity defines a microenvironment that is directly involved in the intravasation of cancer cells in mammary tumors... - The distinct roles of Ras and Rac in PI 3-kinase-dependent protrusion during EGF-stimulated cell migrationShu Chin Yip
Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
J Cell Sci 120:3138-46. 2007..These data suggest an unappreciated role for Ras during protrusion, and a crucial role for Rac in the stabilization of protrusions required for cell motility... - Apoptosis inhibitor ARC promotes breast tumorigenesis, metastasis, and chemoresistanceChristina M Medina-Ramirez
Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Cancer Res 71:7705-15. 2011..Our results establish that ARC promotes breast carcinogenesis by driving primary tumor growth, invasion, and metastasis as well as by promoting chemoresistance in invasive cells... - Breast cancer cells isolated by chemotaxis from primary tumors show increased survival and resistance to chemotherapySumanta Goswami
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Cancer Res 64:7664-7. 2004..In addition, these results indicate that tumor cells that are chemotactic and migratory in response to epidermal growth factor in the primary tumor have a survival advantage over stationary tumor cells... - The bisecting GlcNAc on N-glycans inhibits growth factor signaling and retards mammary tumor progressionYinghui Song
Department of Cell Biology, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, USA
Cancer Res 70:3361-71. 2010..Thus, the addition of the bisecting GlcNAc to complex N-glycans of mammary tumor cell glycoprotein receptors is a cell autonomous mechanism serving to retard tumor progression by reducing growth factor signaling... - Spectrum and range of oxidative stress responses of human lens epithelial cells to H2O2 insultSumanta Goswami
Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Invest Ophthalmol Vis Sci 44:2084-93. 2003.... - The late endosome is essential for mTORC1 signalingRory J Flinn
Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Mol Biol Cell 21:833-41. 2010....