Sumanta Goswami

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. ncbi request reprint Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1/epidermal growth factor paracrine loop
    Sumanta Goswami
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 65:5278-83. 2005
  2. pmc Cofilin determines the migration behavior and turning frequency of metastatic cancer cells
    Mazen Sidani
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY 10461, USA
    J Cell Biol 179:777-91. 2007
  3. pmc Invasion of human breast cancer cells in vivo requires both paracrine and autocrine loops involving the colony-stimulating factor-1 receptor
    Antonia Patsialou
    Department of Anatomy, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 69:9498-506. 2009
  4. ncbi request reprint Coordinated regulation of pathways for enhanced cell motility and chemotaxis is conserved in rat and mouse mammary tumors
    Weigang Wang
    Department of Anatomy and Structural Biology and Gruss Lipper Center for Biophotonics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Cancer Res 67:3505-11. 2007
  5. pmc The activity status of cofilin is directly related to invasion, intravasation, and metastasis of mammary tumors
    Weigang Wang
    Department of Anatomy and Structural Biology and 2Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Cell Biol 173:395-404. 2006
  6. pmc Mena invasive (MenaINV) promotes multicellular streaming motility and transendothelial migration in a mouse model of breast cancer
    Evanthia T Roussos
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Cell Sci 124:2120-31. 2011
  7. pmc Mena invasive (Mena(INV)) and Mena11a isoforms play distinct roles in breast cancer cell cohesion and association with TMEM
    Evanthia T Roussos
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Clin Exp Metastasis 28:515-27. 2011
  8. ncbi request reprint Identification and testing of a gene expression signature of invasive carcinoma cells within primary mammary tumors
    Weigang Wang
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 64:8585-94. 2004
  9. ncbi request reprint Tumor cells caught in the act of invading: their strategy for enhanced cell motility
    Weigang Wang
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Trends Cell Biol 15:138-45. 2005
  10. pmc Differential enhancement of breast cancer cell motility and metastasis by helical and kinase domain mutations of class IA phosphoinositide 3-kinase
    Huan Pang
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 69:8868-76. 2009

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1/epidermal growth factor paracrine loop
    Sumanta Goswami
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 65:5278-83. 2005
    ..Disruption of this loop by blockade of either EGF receptor or CSF-1 receptor signaling is sufficient to inhibit both macrophage and tumor cell migration and invasion...
  2. pmc Cofilin determines the migration behavior and turning frequency of metastatic cancer cells
    Mazen Sidani
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY 10461, USA
    J Cell Biol 179:777-91. 2007
    ..The changes in cell shape, directional migration, and turning frequency were related to the re-localization of Arp2/3 complex to one pole of the cell upon suppression of cofilin expression...
  3. pmc Invasion of human breast cancer cells in vivo requires both paracrine and autocrine loops involving the colony-stimulating factor-1 receptor
    Antonia Patsialou
    Department of Anatomy, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 69:9498-506. 2009
    ..In particular, we show that the autocrine contribution to invasion is specifically amplified in vivo through a tumor microenvironment-induced upregulation of CSF-1R expression via the transforming growth factor-beta1...
  4. ncbi request reprint Coordinated regulation of pathways for enhanced cell motility and chemotaxis is conserved in rat and mouse mammary tumors
    Weigang Wang
    Department of Anatomy and Structural Biology and Gruss Lipper Center for Biophotonics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Cancer Res 67:3505-11. 2007
    ....
  5. pmc The activity status of cofilin is directly related to invasion, intravasation, and metastasis of mammary tumors
    Weigang Wang
    Department of Anatomy and Structural Biology and 2Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Cell Biol 173:395-404. 2006
    ..LIMK1-mediated decreases or increases in the activity of the cofilin pathway are shown to cause proportional decreases or increases in motility, intravasation, and metastasis of tumor cells...
  6. pmc Mena invasive (MenaINV) promotes multicellular streaming motility and transendothelial migration in a mouse model of breast cancer
    Evanthia T Roussos
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Cell Sci 124:2120-31. 2011
    ....
  7. pmc Mena invasive (Mena(INV)) and Mena11a isoforms play distinct roles in breast cancer cell cohesion and association with TMEM
    Evanthia T Roussos
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Clin Exp Metastasis 28:515-27. 2011
    ..They also imply that Mena(INV) expression and TMEM score measure related aspects of a common tumor cell dissemination mechanism and provide new insight into metastatic risk...
  8. ncbi request reprint Identification and testing of a gene expression signature of invasive carcinoma cells within primary mammary tumors
    Weigang Wang
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 64:8585-94. 2004
    ..ZBP1 reexpression also inhibited metastasis from tumors. These experiments support the involvement in metastasis of the pathways identified in invasive cells, which are regulated by ZBP1...
  9. ncbi request reprint Tumor cells caught in the act of invading: their strategy for enhanced cell motility
    Weigang Wang
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Trends Cell Biol 15:138-45. 2005
    ..These results support a "tumor microenvironment invasion model" and provide new target opportunities for cancer therapy...
  10. pmc Differential enhancement of breast cancer cell motility and metastasis by helical and kinase domain mutations of class IA phosphoinositide 3-kinase
    Huan Pang
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 69:8868-76. 2009
    ..Our observations suggest that, when compared with kinase domain mutations in a genetically identical background, expression of helical domain mutants of p110alpha produce a more severe metastatic phenotype...
  11. pmc Identification of invasion specific splice variants of the cytoskeletal protein Mena present in mammary tumor cells during invasion in vivo
    Sumanta Goswami
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine of Yeshiva University, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Clin Exp Metastasis 26:153-9. 2009
    ..The Mena isoform switching pattern described here may provide a new biomarker for the presence of metastatic cancer cells and for prognosis...
  12. ncbi request reprint Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors
    Jeffrey B Wyckoff
    Gruss Lipper Center for Biophotonics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 67:2649-56. 2007
    ..These results show that the interaction between macrophages and tumor cells lying in close proximity defines a microenvironment that is directly involved in the intravasation of cancer cells in mammary tumors...
  13. ncbi request reprint The distinct roles of Ras and Rac in PI 3-kinase-dependent protrusion during EGF-stimulated cell migration
    Shu Chin Yip
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Cell Sci 120:3138-46. 2007
    ..These data suggest an unappreciated role for Ras during protrusion, and a crucial role for Rac in the stabilization of protrusions required for cell motility...
  14. pmc Apoptosis inhibitor ARC promotes breast tumorigenesis, metastasis, and chemoresistance
    Christina M Medina-Ramirez
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 71:7705-15. 2011
    ..Our results establish that ARC promotes breast carcinogenesis by driving primary tumor growth, invasion, and metastasis as well as by promoting chemoresistance in invasive cells...
  15. ncbi request reprint Breast cancer cells isolated by chemotaxis from primary tumors show increased survival and resistance to chemotherapy
    Sumanta Goswami
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 64:7664-7. 2004
    ..In addition, these results indicate that tumor cells that are chemotactic and migratory in response to epidermal growth factor in the primary tumor have a survival advantage over stationary tumor cells...
  16. pmc The bisecting GlcNAc on N-glycans inhibits growth factor signaling and retards mammary tumor progression
    Yinghui Song
    Department of Cell Biology, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, USA
    Cancer Res 70:3361-71. 2010
    ..Thus, the addition of the bisecting GlcNAc to complex N-glycans of mammary tumor cell glycoprotein receptors is a cell autonomous mechanism serving to retard tumor progression by reducing growth factor signaling...
  17. pmc Spectrum and range of oxidative stress responses of human lens epithelial cells to H2O2 insult
    Sumanta Goswami
    Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Invest Ophthalmol Vis Sci 44:2084-93. 2003
    ..Oxidative stress (OS) is believed to be a major contributor to age-related cataract and other age-related diseases...
  18. pmc The late endosome is essential for mTORC1 signaling
    Rory J Flinn
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Mol Biol Cell 21:833-41. 2010
    ....