Aharona Glatman-Freedman

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. pmc Serum therapy for tuberculosis revisited: reappraisal of the role of antibody-mediated immunity against Mycobacterium tuberculosis
    A Glatman-Freedman
    Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Clin Microbiol Rev 11:514-32. 1998
  2. ncbi request reprint The role of antibody-mediated immunity in defense against Mycobacterium tuberculosis: advances toward a novel vaccine strategy
    Aharona Glatman-Freedman
    Division of Infectious Diseases, Department of Pediatrics, Children s Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Tuberculosis (Edinb) 86:191-7. 2006
  3. pmc Antigenic evidence of prevalence and diversity of Mycobacterium tuberculosis arabinomannan
    Aharona Glatman-Freedman
    Department of Pediatrics, Children s Hospital at Montefiore, Albert Einstein College of Medicine, Golding Bldg, Room 702, 1300 Morris Park Ave, Bronx, NY 10461, USA
    J Clin Microbiol 42:3225-31. 2004
  4. ncbi request reprint Advances in antibody-mediated immunity against Mycobacterium tuberculosis: implications for a novel vaccine strategy
    Aharona Glatman-Freedman
    Division of Infectious Diseases, Department of Pediatrics, Children s Hospital at Montefiore, Albert Einstein College of Medicine, Golding Building, Room 702, 1300 Morris Park Ave, Bronx, NY, USA
    FEMS Immunol Med Microbiol 39:9-16. 2003
  5. pmc Clearance and organ distribution of Mycobacterium tuberculosis lipoarabinomannan (LAM) in the presence and absence of LAM-binding immunoglobulin M
    A Glatman-Freedman
    Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Infect Immun 68:335-41. 2000
  6. pmc Monoclonal antibodies to Mycobacterium tuberculosis CDC 1551 reveal subcellular localization of MPT51
    Ban Al-Sayyed
    Division of Pediatric Infectious Diseases, Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Tuberculosis (Edinb) 87:489-97. 2007
  7. pmc Specificity and diversity of antibodies to Mycobacterium tuberculosis arabinomannan
    Josephine Anne D Navoa
    Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York, New York 10461, USA
    Clin Diagn Lab Immunol 10:88-94. 2003
  8. pmc Infection of mice with aerosolized Mycobacterium tuberculosis: use of a nose-only apparatus for delivery of low doses of inocula and design of an ultrasafe facility
    J Reid Schwebach
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Appl Environ Microbiol 68:4646-9. 2002
  9. pmc Glucan is a component of the Mycobacterium tuberculosis surface that is expressed in vitro and in vivo
    J Reid Schwebach
    Department of Microbiology and Immunology, Children s Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Infect Immun 70:2566-75. 2002
  10. ncbi request reprint Immunological options for the treatment of tuberculosis: evaluation of novel therapeutic approaches
    Jacqueline M Achkar
    Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Expert Rev Anti Infect Ther 5:461-74. 2007

Research Grants

  1. STRUCTURE/FUNCTION RELATIONSHIP FOR ANTIBODIES TO M. TUB
    Aharona Glatman Freedman; Fiscal Year: 2003
  2. Novel Approach for Vaccine Development against M.Tb
    Aharona Glatman Freedman; Fiscal Year: 2003

Collaborators

Detail Information

Publications14

  1. pmc Serum therapy for tuberculosis revisited: reappraisal of the role of antibody-mediated immunity against Mycobacterium tuberculosis
    A Glatman-Freedman
    Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Clin Microbiol Rev 11:514-32. 1998
    ..Based on our findings and on what is known in other systems, we propose that the role of antibody-mediated immunity to M. tuberculosis be reexamined, using advanced technology...
  2. ncbi request reprint The role of antibody-mediated immunity in defense against Mycobacterium tuberculosis: advances toward a novel vaccine strategy
    Aharona Glatman-Freedman
    Division of Infectious Diseases, Department of Pediatrics, Children s Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Tuberculosis (Edinb) 86:191-7. 2006
    ..Challenges to the field and an outline of future directions with particular attention to research leading to the development of a novel vaccine strategy, are emphasized...
  3. pmc Antigenic evidence of prevalence and diversity of Mycobacterium tuberculosis arabinomannan
    Aharona Glatman-Freedman
    Department of Pediatrics, Children s Hospital at Montefiore, Albert Einstein College of Medicine, Golding Bldg, Room 702, 1300 Morris Park Ave, Bronx, NY 10461, USA
    J Clin Microbiol 42:3225-31. 2004
    ..tuberculosis strains tested, with differences in epitope distributions of certain strains. In addition, our results suggest that an experimental AM-rEPA vaccine has a moderate effect on the numbers of CFU in organs early after infection...
  4. ncbi request reprint Advances in antibody-mediated immunity against Mycobacterium tuberculosis: implications for a novel vaccine strategy
    Aharona Glatman-Freedman
    Division of Infectious Diseases, Department of Pediatrics, Children s Hospital at Montefiore, Albert Einstein College of Medicine, Golding Building, Room 702, 1300 Morris Park Ave, Bronx, NY, USA
    FEMS Immunol Med Microbiol 39:9-16. 2003
    ..tuberculosis, with particular emphasis on the implications of these findings for a novel vaccine strategy...
  5. pmc Clearance and organ distribution of Mycobacterium tuberculosis lipoarabinomannan (LAM) in the presence and absence of LAM-binding immunoglobulin M
    A Glatman-Freedman
    Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Infect Immun 68:335-41. 2000
    ..The results indicate that serum clearance and organ deposition of LAM in mice are affected by the presence of LAM-binding antibody and suggest a mechanism by which antibody could modify the course of mycobacterial infection...
  6. pmc Monoclonal antibodies to Mycobacterium tuberculosis CDC 1551 reveal subcellular localization of MPT51
    Ban Al-Sayyed
    Division of Pediatric Infectious Diseases, Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Tuberculosis (Edinb) 87:489-97. 2007
    ..This immunogenic protein of unknown function was previously reported only in culture filtrates of M. tuberculosis. Our findings suggest for the first time that this protein is found within the M. tuberculosis cell...
  7. pmc Specificity and diversity of antibodies to Mycobacterium tuberculosis arabinomannan
    Josephine Anne D Navoa
    Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York, New York 10461, USA
    Clin Diagn Lab Immunol 10:88-94. 2003
    ..One MAb and a subset of human antibodies bind AM specifically, suggesting that this polysaccharide is antigenically distinct and is expressed in human infection...
  8. pmc Infection of mice with aerosolized Mycobacterium tuberculosis: use of a nose-only apparatus for delivery of low doses of inocula and design of an ultrasafe facility
    J Reid Schwebach
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Appl Environ Microbiol 68:4646-9. 2002
    ..To maximize safety, we installed a nose-only aerosol apparatus that can reproducibly deliver a low dose (<100 CFU per mouse) of M. tuberculosis in a carefully designed biohazard facility...
  9. pmc Glucan is a component of the Mycobacterium tuberculosis surface that is expressed in vitro and in vivo
    J Reid Schwebach
    Department of Microbiology and Immunology, Children s Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Infect Immun 70:2566-75. 2002
    ..Our results provide a more comprehensive picture of the M. tuberculosis cell envelope and the conditions that allow expression of M. tuberculosis GC...
  10. ncbi request reprint Immunological options for the treatment of tuberculosis: evaluation of novel therapeutic approaches
    Jacqueline M Achkar
    Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Expert Rev Anti Infect Ther 5:461-74. 2007
    ..These immune-based therapies are discussed here with the aim of assessing their potential use as adjuncts to chemotherapy...
  11. pmc Mycobacteria release active membrane vesicles that modulate immune responses in a TLR2-dependent manner in mice
    Rafael Prados-Rosales
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, New York 10461, USA
    J Clin Invest 121:1471-83. 2011
    ..These findings may open up new horizons for understanding the pathogenesis of tuberculosis and developing vaccines...
  12. ncbi request reprint Serologic evidence for regional differences in pediatric cryptococcal infection
    Jennifer Davis
    Department of Pediatrics, Childrens Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Pediatr Infect Dis J 26:549-51. 2007
    ..Our results indicate unrecognized cryptococcal infections are extremely common in Bronx children, but uncommon in children from Dutchess County, NY and the Philippines...
  13. ncbi request reprint Failure of a Mycobacterium tuberculosis DeltaRD1 DeltapanCD double deletion mutant in a neonatal calf aerosol M. bovis challenge model: comparisons to responses elicited by M. bovis bacille Calmette Guerin
    W Ray Waters
    National Animal Disease Center, Agricultural Research Service, US Department of Agriculture, 2300 Dayton Avenue, Ames, IA 50010, USA
    Vaccine 25:7832-40. 2007
    ..The calf sensitization and challenge model provides an informative screen for candidate tuberculosis vaccines before their evaluation in costly non-human, primates...
  14. pmc Do CD1-restricted T cells contribute to antibody-mediated immunity against Mycobacterium tuberculosis?
    Mark L Lang
    Department of Microbiology and Immunology, 632W Borwell Building, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
    Infect Immun 74:803-9. 2006

Research Grants2

  1. STRUCTURE/FUNCTION RELATIONSHIP FOR ANTIBODIES TO M. TUB
    Aharona Glatman Freedman; Fiscal Year: 2003
    ..This study will help us understand the structural characteristics required for useful antibodies to M. tuberculosis. ..
  2. Novel Approach for Vaccine Development against M.Tb
    Aharona Glatman Freedman; Fiscal Year: 2003
    ..2) To isolate mycobacterial arabinomannan fractions and generate candidate vaccines. 3) To determine the protective efficacy of arabinomannan and arabinomannan-protein conjugate vaccine candidates against Mtb infection. ..