Research Topics
Species | Aristea S GalanopoulouSummaryAffiliation: Albert Einstein College of Medicine Country: USA Publications
Research Grants
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Detail Information
Publications
Under what circumstances can seizures produce hippocampal injury: evidence for age-specific effectsAristea S Galanopoulou
Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Dev Neurosci 24:355-63. 2002..The key point is to identify the significance of these changes and design age-appropriate preventative treatments...- Sex-specific KCC2 expression and GABA(A) receptor function in rat substantia nigraAristea S Galanopoulou
Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Exp Neurol 183:628-37. 2003..Consequently, GABA(A) receptor activation selectively upregulates the expression of calcium-regulated genes, such as KCC2, in male SNR, promoting the sexual differentiation of the SNR... 
Dissociated gender-specific effects of recurrent seizures on GABA signaling in CA1 pyramidal neurons: role of GABA(A) receptorsAristea S Galanopoulou
Saul R Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Neurosci 28:1557-67. 2008..These effects differ from the consequences of severe stress...
GABA(A) receptors in normal development and seizures: friends or foes?Aristea S Galanopoulou
Albert Einstein College of Medicine, Saul R Korey Department of Neurology and Dominick P Purpura, Department of Neuroscience, Bronx NY, USA
Curr Neuropharmacol 6:1-20. 2008..Finally, the implications of these changes for the treatment of certain forms of medically refractory epilepsies and status epilepticus will be discussed...- The epileptic hypothesis: developmentally related arguments based on animal modelsAristea S Galanopoulou
Saul R Korey Department of Neurology, Laboratory of Developmental Epilepsy, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, U S A
Epilepsia 50:37-42. 2009..Of special importance is the developmental age when the epileptic disorder manifests, because it may dictate outcome but also may be a deciding factor in selecting appropriate therapies... - Role of sex hormones in the sexually dimorphic expression of KCC2 in rat substantia nigraAristea S Galanopoulou
Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Exp Neurol 184:1003-9. 2003..Estradiol therefore downregulates KCC2 mRNA in male PN15 SNR, by interacting with the GABA(A) receptor and L-VSCC signaling pathway... - GABA receptors as broadcasters of sexually differentiating signals in the brainAristea S Galanopoulou
Department of Neurology and Neuroscience, Albert Einstein College of Medicine, Bronx, New York, USA
Epilepsia 46:107-12. 2005..As a result, they have the potency of causing long-term changes in the function of the SNR in the control of seizures, movement, and the susceptibility to and course of epilepsy and movement disorders... - Sex- and cell-type-specific patterns of GABAA receptor and estradiol-mediated signaling in the immature rat substantia nigraAristea S Galanopoulou
Department of Neurology and Einstein Montefiore Comprehensive Epilepsy Center, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Kennedy Center Rm 311, Bronx, NY 10461, USA
Eur J Neurosci 23:2423-30. 2006.... - Seizures in the developing brainJANA VELISKOVA
Department of Neurology, Montofiore Einstein Epilepsy Management Center, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York 10461, USA
Epilepsia 45:6-12. 2004..By contrast, female SNR does not contain any region that mediates muscimol-related proconvulsant effects. As with the adult, immature female rats do not develop a proconvulsant SNR region at any age... - Developmental patterns in the regulation of chloride homeostasis and GABA(A) receptor signaling by seizuresAristea S Galanopoulou
Albert Einstein College of Medicine, Department of Neurology and Neuroscience, Bronx, New York, USA
Epilepsia 48:14-8. 2007..The contrasting patterns of regulation of KCC2 by seizures in mature and immature neurons may be one of the age-related factors that protect the neonatal brain against the development of epilepsy... - Age-dependent consequences of status epilepticus: animal modelsMorris H Scantlebury
Korey Department of Neurology, Albert Einstein College of Medicine, Pelham Parkway South, Kennedy Center, Bronx, NY, USA
Epilepsia 48:75-82. 2007..Better understanding of the pathophysiologic mechanisms underlying the age-specific alterations to the brain induced by SE will lead to the development of novel and effective strategies to improve the deleterious consequences... - A model of symptomatic infantile spasms syndromeMorris H Scantlebury
Saul R Korey Department of Neurology, Laboratory of Developmental Neurology, and Montefiore Einstein Epilepsy Management Center, USA
Neurobiol Dis 37:604-12. 2010..Adrenocorticotropic hormone (ACTH) did not affect spasms. Vigabatrin transiently suppressed spasms at P5. This new model of SIS will be useful to study the neurobiology and treatment of SIS, including those that are refractory to ACTH... - Modeling new therapies for infantile spasmsLenka Chudomelova
Saul R Korey Department of Neurology and Montefiore Einstein Epilepsy Management Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Epilepsia 51:27-33. 2010.... - Sex-dependent maturation of GABAA receptor-mediated synaptic events in rat substantia nigra reticulataAndreas Kyrozis
Department of Neurology, Albert Einstein College of Medicine, Bronx, 1410 Pelham Parkway South, Kennedy Center Rm 313, Bronx, NY 10461, USA
Neurosci Lett 398:1-5. 2006..The switch occurred in males around postnatal day (PN) 17 and in females around PN10. This sex dimorphism may play a role in several other recognized sex differences in the development of SNR and in its regulatory role in seizures... - Estradiol reduces seizure-induced hippocampal injury in ovariectomized female but not in male ratsAristea S Galanopoulou
Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA
Neurosci Lett 342:201-5. 2003..In males, estradiol increased the total damage score. These findings suggest that the effects of estradiol on seizure threshold and damage may be altered by sex-related differences in the hormonal environment... - Mutations affecting GABAergic signaling in seizures and epilepsyAristea S Galanopoulou
Saul R Korey Department of Neurology and Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Kennedy Center Room 306, Bronx, NY 10461, USA
Pflugers Arch 460:505-23. 2010.... - In search of epilepsy biomarkers in the immature brain: goals, challenges and strategiesAristea S Galanopoulou
Saul R Korey Department of Neurology, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Kennedy Center, Room 306, Bronx, NY 10461, USA
Biomark Med 5:615-28. 2011.... - A pulse rapamycin therapy for infantile spasms and associated cognitive declineEmmanuel Raffo
Saul R Korey Department of Neurology, Albert Einstein College of Medicine, Bronx NY 10461, USA
Neurobiol Dis 43:322-9. 2011..Furthermore, a high-dose, pulse rapamycin treatment is a promising, well tolerated and disease-modifying new therapy for infantile spasms, including those refractory to ACTH... - Identification of new epilepsy treatments: issues in preclinical methodologyAristea S Galanopoulou
Laboratory of Developmental Epilepsy, Saul R Korey Department of Neurology, Dominick P Purpura Department of Neuroscience, Montefiore Einstein Epilepsy Management Center, Albert Einstein College of Medicine, Bronx, NY, USA
Epilepsia 53:571-82. 2012.... - Epilepsy and epileptic syndromeTomonori Ono
Saul R Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA
Adv Exp Med Biol 724:99-113. 2012.... - Developmental aspects of the basal ganglia and therapeutic perspectivesJANA VELISKOVA
Deptartment of Neurology, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA
Epileptic Disord 4:S73-82. 2002..Better understanding of the influence of the endocrine system on brain development and neuronal activity may provide new insight into the treatment of age- and sex-dependent seizure disorders... - Altered GABA signaling in early life epilepsiesStephen W Briggs
Saul R Korey Department of Neurology, Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Kennedy Center Rm 306, Bronx, NY 10461, USA
Neural Plast 2011:527605. 2011..However, more needs to be known so as to develop therapies capable of stopping seizures while preserving the age- and sex-appropriate development of the brain... - Carisbamate acutely suppresses spasms in a rat model of symptomatic infantile spasmsTomonori Ono
Saul R Korey Department of Neurology, Laboratory of Developmental Epilepsy, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Epilepsia 52:1678-84. 2011..We tested the efficacy of carisbamate, a novel neurotherapeutic drug, to suppress spasms in the multiple-hit rat model of SIS, and compared it with phenytoin to determine if its effect is via sodium-channel blockade... - Sexually dimorphic expression of KCC2 and GABA functionAristea S Galanopoulou
Albert Einstein College of Medicine, Saul R Korey Department of Neurology, Bronx, NY, USA
Epilepsy Res 80:99-113. 2008..It is important therefore to study separately the effects of these factors not only on the course of epilepsy but also design new treatments that may not necessarily disturb the gender-appropriate brain development... - Finding a better drug for epilepsy: the mTOR pathway as an antiepileptogenic targetAristea S Galanopoulou
Saul R Korey Department of Neurology, Dominick P Purpura Department of Neuroscience, Laboratory of Developmental Epilepsy, Montefiore Einstein Epilepsy Management Center, Albert Einstein College of Medicine, Bronx, New York, USA
Epilepsia 53:1119-30. 2012..The use of mTOR inhibitors can reverse some of these epileptogenic processes, although their effects depend upon the timing and dose of administration as well as the model used...
Research Grants
- Sexual dimorphism in seizure control is KCC2 mediatedARISTEA GALANOPOULOU; Fiscal Year: 2007..Albert Einstein College of Medicine will offer the necessary mentoring, laboratory space, equipment and training opportunities to achieve these goals. ..