Aristea S Galanopoulou

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. ncbi request reprint Under what circumstances can seizures produce hippocampal injury: evidence for age-specific effects
    Aristea S Galanopoulou
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Dev Neurosci 24:355-63. 2002
  2. ncbi request reprint Sex-specific KCC2 expression and GABA(A) receptor function in rat substantia nigra
    Aristea S Galanopoulou
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Exp Neurol 183:628-37. 2003
  3. doi request reprint Dissociated gender-specific effects of recurrent seizures on GABA signaling in CA1 pyramidal neurons: role of GABA(A) receptors
    Aristea S Galanopoulou
    Saul R Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 28:1557-67. 2008
  4. pmc GABA(A) receptors in normal development and seizures: friends or foes?
    Aristea S Galanopoulou
    Albert Einstein College of Medicine, Saul R Korey Department of Neurology and Dominick P Purpura, Department of Neuroscience, Bronx NY, USA
    Curr Neuropharmacol 6:1-20. 2008
  5. pmc The epileptic hypothesis: developmentally related arguments based on animal models
    Aristea S Galanopoulou
    Saul R Korey Department of Neurology, Laboratory of Developmental Epilepsy, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, U S A
    Epilepsia 50:37-42. 2009
  6. ncbi request reprint Role of sex hormones in the sexually dimorphic expression of KCC2 in rat substantia nigra
    Aristea S Galanopoulou
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Exp Neurol 184:1003-9. 2003
  7. pmc GABA receptors as broadcasters of sexually differentiating signals in the brain
    Aristea S Galanopoulou
    Department of Neurology and Neuroscience, Albert Einstein College of Medicine, Bronx, New York, USA
    Epilepsia 46:107-12. 2005
  8. ncbi request reprint Sex- and cell-type-specific patterns of GABAA receptor and estradiol-mediated signaling in the immature rat substantia nigra
    Aristea S Galanopoulou
    Department of Neurology and Einstein Montefiore Comprehensive Epilepsy Center, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Kennedy Center Rm 311, Bronx, NY 10461, USA
    Eur J Neurosci 23:2423-30. 2006
  9. ncbi request reprint Seizures in the developing brain
    JANA VELISKOVA
    Department of Neurology, Montofiore Einstein Epilepsy Management Center, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York 10461, USA
    Epilepsia 45:6-12. 2004
  10. ncbi request reprint Developmental patterns in the regulation of chloride homeostasis and GABA(A) receptor signaling by seizures
    Aristea S Galanopoulou
    Albert Einstein College of Medicine, Department of Neurology and Neuroscience, Bronx, New York, USA
    Epilepsia 48:14-8. 2007

Research Grants

  1. Sexual dimorphism in seizure control is KCC2 mediated
    ARISTEA GALANOPOULOU; Fiscal Year: 2007

Detail Information

Publications29

  1. ncbi request reprint Under what circumstances can seizures produce hippocampal injury: evidence for age-specific effects
    Aristea S Galanopoulou
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Dev Neurosci 24:355-63. 2002
    ..The key point is to identify the significance of these changes and design age-appropriate preventative treatments...
  2. ncbi request reprint Sex-specific KCC2 expression and GABA(A) receptor function in rat substantia nigra
    Aristea S Galanopoulou
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Exp Neurol 183:628-37. 2003
    ..Consequently, GABA(A) receptor activation selectively upregulates the expression of calcium-regulated genes, such as KCC2, in male SNR, promoting the sexual differentiation of the SNR...
  3. doi request reprint Dissociated gender-specific effects of recurrent seizures on GABA signaling in CA1 pyramidal neurons: role of GABA(A) receptors
    Aristea S Galanopoulou
    Saul R Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 28:1557-67. 2008
    ..These effects differ from the consequences of severe stress...
  4. pmc GABA(A) receptors in normal development and seizures: friends or foes?
    Aristea S Galanopoulou
    Albert Einstein College of Medicine, Saul R Korey Department of Neurology and Dominick P Purpura, Department of Neuroscience, Bronx NY, USA
    Curr Neuropharmacol 6:1-20. 2008
    ..Finally, the implications of these changes for the treatment of certain forms of medically refractory epilepsies and status epilepticus will be discussed...
  5. pmc The epileptic hypothesis: developmentally related arguments based on animal models
    Aristea S Galanopoulou
    Saul R Korey Department of Neurology, Laboratory of Developmental Epilepsy, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, U S A
    Epilepsia 50:37-42. 2009
    ..Of special importance is the developmental age when the epileptic disorder manifests, because it may dictate outcome but also may be a deciding factor in selecting appropriate therapies...
  6. ncbi request reprint Role of sex hormones in the sexually dimorphic expression of KCC2 in rat substantia nigra
    Aristea S Galanopoulou
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Exp Neurol 184:1003-9. 2003
    ..Estradiol therefore downregulates KCC2 mRNA in male PN15 SNR, by interacting with the GABA(A) receptor and L-VSCC signaling pathway...
  7. pmc GABA receptors as broadcasters of sexually differentiating signals in the brain
    Aristea S Galanopoulou
    Department of Neurology and Neuroscience, Albert Einstein College of Medicine, Bronx, New York, USA
    Epilepsia 46:107-12. 2005
    ..As a result, they have the potency of causing long-term changes in the function of the SNR in the control of seizures, movement, and the susceptibility to and course of epilepsy and movement disorders...
  8. ncbi request reprint Sex- and cell-type-specific patterns of GABAA receptor and estradiol-mediated signaling in the immature rat substantia nigra
    Aristea S Galanopoulou
    Department of Neurology and Einstein Montefiore Comprehensive Epilepsy Center, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Kennedy Center Rm 311, Bronx, NY 10461, USA
    Eur J Neurosci 23:2423-30. 2006
    ....
  9. ncbi request reprint Seizures in the developing brain
    JANA VELISKOVA
    Department of Neurology, Montofiore Einstein Epilepsy Management Center, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York 10461, USA
    Epilepsia 45:6-12. 2004
    ..By contrast, female SNR does not contain any region that mediates muscimol-related proconvulsant effects. As with the adult, immature female rats do not develop a proconvulsant SNR region at any age...
  10. ncbi request reprint Developmental patterns in the regulation of chloride homeostasis and GABA(A) receptor signaling by seizures
    Aristea S Galanopoulou
    Albert Einstein College of Medicine, Department of Neurology and Neuroscience, Bronx, New York, USA
    Epilepsia 48:14-8. 2007
    ..The contrasting patterns of regulation of KCC2 by seizures in mature and immature neurons may be one of the age-related factors that protect the neonatal brain against the development of epilepsy...
  11. ncbi request reprint Age-dependent consequences of status epilepticus: animal models
    Morris H Scantlebury
    Korey Department of Neurology, Albert Einstein College of Medicine, Pelham Parkway South, Kennedy Center, Bronx, NY, USA
    Epilepsia 48:75-82. 2007
    ..Better understanding of the pathophysiologic mechanisms underlying the age-specific alterations to the brain induced by SE will lead to the development of novel and effective strategies to improve the deleterious consequences...
  12. pmc A model of symptomatic infantile spasms syndrome
    Morris H Scantlebury
    Saul R Korey Department of Neurology, Laboratory of Developmental Neurology, and Montefiore Einstein Epilepsy Management Center, USA
    Neurobiol Dis 37:604-12. 2010
    ..Adrenocorticotropic hormone (ACTH) did not affect spasms. Vigabatrin transiently suppressed spasms at P5. This new model of SIS will be useful to study the neurobiology and treatment of SIS, including those that are refractory to ACTH...
  13. pmc Modeling new therapies for infantile spasms
    Lenka Chudomelova
    Saul R Korey Department of Neurology and Montefiore Einstein Epilepsy Management Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Epilepsia 51:27-33. 2010
    ....
  14. pmc Epilepsy therapy development: technical and methodologic issues in studies with animal models
    Aristea S Galanopoulou
    Laboratory of Developmental Epilepsy, Saul R Korey Department of Neurology, Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Epilepsia 54:13-23. 2013
    ..We propose several infrastructure initiatives to overcome these barriers. ..
  15. pmc Mutations affecting GABAergic signaling in seizures and epilepsy
    Aristea S Galanopoulou
    Saul R Korey Department of Neurology and Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Kennedy Center Room 306, Bronx, NY 10461, USA
    Pflugers Arch 460:505-23. 2010
    ....
  16. ncbi request reprint Sex-dependent maturation of GABAA receptor-mediated synaptic events in rat substantia nigra reticulata
    Andreas Kyrozis
    Department of Neurology, Albert Einstein College of Medicine, Bronx, 1410 Pelham Parkway South, Kennedy Center Rm 313, Bronx, NY 10461, USA
    Neurosci Lett 398:1-5. 2006
    ..The switch occurred in males around postnatal day (PN) 17 and in females around PN10. This sex dimorphism may play a role in several other recognized sex differences in the development of SNR and in its regulatory role in seizures...
  17. ncbi request reprint Estradiol reduces seizure-induced hippocampal injury in ovariectomized female but not in male rats
    Aristea S Galanopoulou
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA
    Neurosci Lett 342:201-5. 2003
    ..In males, estradiol increased the total damage score. These findings suggest that the effects of estradiol on seizure threshold and damage may be altered by sex-related differences in the hormonal environment...
  18. pmc In search of epilepsy biomarkers in the immature brain: goals, challenges and strategies
    Aristea S Galanopoulou
    Saul R Korey Department of Neurology, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Kennedy Center, Room 306, Bronx, NY 10461, USA
    Biomark Med 5:615-28. 2011
    ....
  19. pmc A pulse rapamycin therapy for infantile spasms and associated cognitive decline
    Emmanuel Raffo
    Saul R Korey Department of Neurology, Albert Einstein College of Medicine, Bronx NY 10461, USA
    Neurobiol Dis 43:322-9. 2011
    ..Furthermore, a high-dose, pulse rapamycin treatment is a promising, well tolerated and disease-modifying new therapy for infantile spasms, including those refractory to ACTH...
  20. pmc Identification of new epilepsy treatments: issues in preclinical methodology
    Aristea S Galanopoulou
    Laboratory of Developmental Epilepsy, Saul R Korey Department of Neurology, Dominick P Purpura Department of Neuroscience, Montefiore Einstein Epilepsy Management Center, Albert Einstein College of Medicine, Bronx, NY, USA
    Epilepsia 53:571-82. 2012
    ....
  21. doi request reprint Epilepsy and epileptic syndrome
    Tomonori Ono
    Saul R Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA
    Adv Exp Med Biol 724:99-113. 2012
    ....
  22. pmc Altered GABA signaling in early life epilepsies
    Stephen W Briggs
    Saul R Korey Department of Neurology, Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Kennedy Center Rm 306, Bronx, NY 10461, USA
    Neural Plast 2011:527605. 2011
    ..However, more needs to be known so as to develop therapies capable of stopping seizures while preserving the age- and sex-appropriate development of the brain...
  23. ncbi request reprint Developmental aspects of the basal ganglia and therapeutic perspectives
    JANA VELISKOVA
    Deptartment of Neurology, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA
    Epileptic Disord 4:S73-82. 2002
    ..Better understanding of the influence of the endocrine system on brain development and neuronal activity may provide new insight into the treatment of age- and sex-dependent seizure disorders...
  24. pmc Carisbamate acutely suppresses spasms in a rat model of symptomatic infantile spasms
    Tomonori Ono
    Saul R Korey Department of Neurology, Laboratory of Developmental Epilepsy, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Epilepsia 52:1678-84. 2011
    ..We tested the efficacy of carisbamate, a novel neurotherapeutic drug, to suppress spasms in the multiple-hit rat model of SIS, and compared it with phenytoin to determine if its effect is via sodium-channel blockade...
  25. pmc Sexually dimorphic expression of KCC2 and GABA function
    Aristea S Galanopoulou
    Albert Einstein College of Medicine, Saul R Korey Department of Neurology, Bronx, NY, USA
    Epilepsy Res 80:99-113. 2008
    ..It is important therefore to study separately the effects of these factors not only on the course of epilepsy but also design new treatments that may not necessarily disturb the gender-appropriate brain development...
  26. pmc Basic mechanisms of catastrophic epilepsy -- overview from animal models
    Aristea S Galanopoulou
    Saul R Korey Department of Neurology, Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Kennedy Center Rm 306, Bronx NY 10461, USA
    Brain Dev 35:748-56. 2013
    ....
  27. ncbi request reprint CPP-115, a vigabatrin analogue, decreases spasms in the multiple-hit rat model of infantile spasms
    Stephen W Briggs
    Saul R Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, U S A Laboratory of Developmental Epilepsy and Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York, U S A
    Epilepsia 55:94-102. 2014
    ..Here, we test the efficacy of CPP-115 in reducing spasms and its tolerability in the multiple-hit rat model of IS, in which daily vigabatrin reduced spasms for only one day, but was not well tolerated...
  28. pmc Finding a better drug for epilepsy: the mTOR pathway as an antiepileptogenic target
    Aristea S Galanopoulou
    Saul R Korey Department of Neurology, Dominick P Purpura Department of Neuroscience, Laboratory of Developmental Epilepsy, Montefiore Einstein Epilepsy Management Center, Albert Einstein College of Medicine, Bronx, New York, USA
    Epilepsia 53:1119-30. 2012
    ..The use of mTOR inhibitors can reverse some of these epileptogenic processes, although their effects depend upon the timing and dose of administration as well as the model used...
  29. ncbi request reprint Does epilepsy cause a reversion to immature function?
    Aristea S Galanopoulou
    Saul R Korey Department of Neurology, Dominick P Purpura Department of Neuroscience, The Laboratory of Developmental Epilepsy, Comprehensive Einstein Montefiore Epilepsy Center, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Kennedy Center Rm 306, Bronx, NY, 10461, USA
    Adv Exp Med Biol 813:195-209. 2014
    ....

Research Grants2

  1. Sexual dimorphism in seizure control is KCC2 mediated
    ARISTEA GALANOPOULOU; Fiscal Year: 2007
    ..Albert Einstein College of Medicine will offer the necessary mentoring, laboratory space, equipment and training opportunities to achieve these goals. ..