Research Topics
| MARTA L FELDMESSERSummaryAffiliation: Albert Einstein College of Medicine Country: USA Publications
Research Grants
| Collaborators |
Detail Information
Publications
Eosinophil-Cryptococcus neoformans interactions in vivo and in vitroM Feldmesser
Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461 1602, USA
Infect Immun 65:1899-907. 1997..Mast cells were observed to occasionally phagocytose C. neoformans in vitro in the presence of IgE MAb. Our observations suggest that eosinophils may be effector cells against C. neoformans...- Prospects of vaccines for invasive aspergillosisMarta Feldmesser
Division of Infectious Diseases, Department of Medicine, Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Med Mycol 43:571-87. 2005..Strategies using antigen-exposed dendritic cells as adjuvants appear to be particularly promising. Though we currently are far away from a candidate that is applicable for human trials, recent progress is encouraging... - New and emerging antifungal agents: impact on respiratory infectionsMarta Feldmesser
Departments of Medicine and Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Am J Respir Med 2:371-83. 2003..However, at the present time, our ability to assess their impact is limited by the problematic nature of conducting trials for antifungal therapy... - Antibody-mediated protection in murine Cryptococcus neoformans infection is associated with pleotrophic effects on cytokine and leukocyte responsesMarta Feldmesser
Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Infect Immun 70:1571-80. 2002..MAb may function partly by down-regulating the inflammatory response and reducing host damage. Our findings demonstrate unexpected complexity in the interaction between specific MAb and other components of the host immune response... - Dynamic changes in the morphology of Cryptococcus neoformans during murine pulmonary infectionM Feldmesser
Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Microbiology 147:2355-65. 2001..The results indicate that the population of C. neoformans cells in tissue is in a highly dynamic state, implying that the immune system must confront cells with varying characteristics during the course of infection... - Intracellular crystal formation as a mechanism of cytotoxicity in murine pulmonary Cryptococcus neoformans infectionM Feldmesser
Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Infect Immun 69:2723-7. 2001..The crystals apparently formed because of the interaction of a host protein with the cryptococcal polysaccharide. Crystal formation likely contributes to pathogenesis by causing cellular damage... - The effect of the echinocandin analogue caspofungin on cell wall glucan synthesis by Cryptococcus neoformansM Feldmesser
Dept of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, Golding Bldg, Bronx, NY 10461, USA
J Infect Dis 182:1791-5. 2000..neoformans may result from reduced activity against C. neoformans glucan synthase or from yet undiscovered mechanisms of action operative in other fungal pathogens but not in C. neoformans... - Cryptococcus neoformans is a facultative intracellular pathogen in murine pulmonary infectionM Feldmesser
Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Infect Immun 68:4225-37. 2000..Furthermore, our observations suggest that C. neoformans occupies a unique niche among the intracellular pathogens whereby survival in phagocytic cells is accompanied by intracellular polysaccharide production... - Effect of antibody to capsular polysaccharide on eosinophilic pneumonia in murine infection with Cryptococcus neoformansM Feldmesser
Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Infect Dis 177:1639-46. 1998..Our results provide additional evidence that antibody administration can produce quantitative and qualitative changes in the inflammatory response to a pathogen... - Role of neutrophils in invasive aspergillosisMarta Feldmesser
Albert Einstein College of Medicine, Forchheimer Building, Room 402, 1300 Morris Park Avenue, Bronx, NY 10461, USA
Infect Immun 74:6514-6. 2006
Research Grants
- Monoclonal antibodies to inhibit Aspergillus germinationMARTA L FELDMESSER; Fiscal Year: 2010..It is anticipated that this study will identify fungal molecules important for germination and begin to define their interaction with host immune responses. ..
- Monoclonal antibodies for invasive aspergillosisMarta Feldmesser; Fiscal Year: 2003..To determine the biological activity of MAbs generated in Aim 2 in murine models of invasive aspergillosis. It is anticipated that this study will identify important targets for further investigation. ..
- Aspergillosis: Engineering Antibody for DiagnosisMarta Feldmesser; Fiscal Year: 2006..The availability of reagents that have potential to improve both sensitivity and specificity of galactomannan detection would be a significant advance. ..
- Monoclonal antibodies to inhibit Aspergillus germinationMarta Feldmesser; Fiscal Year: 2007..It is anticipated that this study will identify fungal molecules important for germination and begin to define their interaction with host immune responses. ..
- Monoclonal antibodies to inhibit Aspergillus germinationMarta Feldmesser; Fiscal Year: 2009..It is anticipated that this study will identify fungal molecules important for germination and begin to define their interaction with host immune responses. ..