Melissa J Fazzari

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. ncbi request reprint Epigenomics: beyond CpG islands
    Melissa J Fazzari
    Department of Epidemiology and Social Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Nat Rev Genet 5:446-55. 2004
  2. pmc Late-replicating heterochromatin is characterized by decreased cytosine methylation in the human genome
    Masako Suzuki
    Department of Genetics Computational Genetics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Genome Res 21:1833-40. 2011
  3. pmc CG dinucleotide clustering is a species-specific property of the genome
    Jacob L Glass
    Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA, Division of Hematology Oncology, University of Kentucky, Markey Cancer Center, 800 Rose Street, Lexington KY 40536, USA
    Nucleic Acids Res 35:6798-807. 2007
  4. pmc Septin 9 isoform expression, localization and epigenetic changes during human and mouse breast cancer progression
    Diana Connolly
    Department of Genetics, Albert Einstein College of Medicine, Yeshiva University, 1301 Morris Park Avenue, Bronx, NY 10461, USA
    Breast Cancer Res 13:R76. 2011
  5. doi request reprint DNA methylation changes in murine breast adenocarcinomas allow the identification of candidate genes for human breast carcinogenesis
    Deanna Acosta
    Department of Genetics, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY 10461, USA
    Mamm Genome 22:249-59. 2011
  6. doi request reprint Introduction to epigenomics and epigenome-wide analysis
    Melissa J Fazzari
    Division of Biostatistics, Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA
    Methods Mol Biol 620:243-65. 2010
  7. pmc Experimental intrauterine growth restriction induces alterations in DNA methylation and gene expression in pancreatic islets of rats
    Reid F Thompson
    Departments of Genetics Computational Genetics, Albert Einstein College of Medicine, Bronx, New York, New York 10461, USA
    J Biol Chem 285:15111-8. 2010
  8. pmc Cytosine methylation dysregulation in neonates following intrauterine growth restriction
    Francine Einstein
    Department of Obstetrics, Gynecology and Women s Health, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 5:e8887. 2010
  9. pmc Experimental approaches to the study of epigenomic dysregulation in ageing
    Reid F Thompson
    Department of Genetics and Center for Epigenomics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Exp Gerontol 45:255-68. 2010
  10. doi request reprint The Einstein Center for Epigenomics: studying the role of epigenomic dysregulation in human disease
    Andrew S McLellan
    Price Center for Genetics and Translational Medicine, Albert Einstein College of Medicine, 1301 Morris Park Avenue, Bronx, NY 10461, USA
    Epigenomics 1:33-8. 2009

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Epigenomics: beyond CpG islands
    Melissa J Fazzari
    Department of Epidemiology and Social Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Nat Rev Genet 5:446-55. 2004
  2. pmc Late-replicating heterochromatin is characterized by decreased cytosine methylation in the human genome
    Masako Suzuki
    Department of Genetics Computational Genetics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Genome Res 21:1833-40. 2011
    ....
  3. pmc CG dinucleotide clustering is a species-specific property of the genome
    Jacob L Glass
    Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA, Division of Hematology Oncology, University of Kentucky, Markey Cancer Center, 800 Rose Street, Lexington KY 40536, USA
    Nucleic Acids Res 35:6798-807. 2007
    ..Finally, our approach is able to identify methylating genomes (such as Takifugu rubripes) that lack CG clustering entirely, in which it is inappropriate to annotate CpG islands or CG clusters...
  4. pmc Septin 9 isoform expression, localization and epigenetic changes during human and mouse breast cancer progression
    Diana Connolly
    Department of Genetics, Albert Einstein College of Medicine, Yeshiva University, 1301 Morris Park Avenue, Bronx, NY 10461, USA
    Breast Cancer Res 13:R76. 2011
    ..The mechanisms regulating its expression during tumor initiation and progression in vivo and the oncogenic function of its different isoforms remain elusive...
  5. doi request reprint DNA methylation changes in murine breast adenocarcinomas allow the identification of candidate genes for human breast carcinogenesis
    Deanna Acosta
    Department of Genetics, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY 10461, USA
    Mamm Genome 22:249-59. 2011
    ..Based on these studies, we present a model in which comparative epigenetic techniques can be used to identify novel candidate genes important for human breast tumorigenesis, in both primary and metastatic tumors...
  6. doi request reprint Introduction to epigenomics and epigenome-wide analysis
    Melissa J Fazzari
    Division of Biostatistics, Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA
    Methods Mol Biol 620:243-65. 2010
    ..We will conclude this chapter by identifying issues in building methylation-based models for prediction and potential directions of further statistical research in epigenetics...
  7. pmc Experimental intrauterine growth restriction induces alterations in DNA methylation and gene expression in pancreatic islets of rats
    Reid F Thompson
    Departments of Genetics Computational Genetics, Albert Einstein College of Medicine, Bronx, New York, New York 10461, USA
    J Biol Chem 285:15111-8. 2010
    ..These results demonstrate that epigenetic dysregulation is a strong candidate for propagating the cellular memory of intrauterine events, causing changes in expression of nearby genes and long term susceptibility to type 2 diabetes...
  8. pmc Cytosine methylation dysregulation in neonates following intrauterine growth restriction
    Francine Einstein
    Department of Obstetrics, Gynecology and Women s Health, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 5:e8887. 2010
    ....
  9. pmc Experimental approaches to the study of epigenomic dysregulation in ageing
    Reid F Thompson
    Department of Genetics and Center for Epigenomics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Exp Gerontol 45:255-68. 2010
    ..We describe how such experiments are currently performed, their limitations technically and analytically and their application to ageing research...
  10. doi request reprint The Einstein Center for Epigenomics: studying the role of epigenomic dysregulation in human disease
    Andrew S McLellan
    Price Center for Genetics and Translational Medicine, Albert Einstein College of Medicine, 1301 Morris Park Avenue, Bronx, NY 10461, USA
    Epigenomics 1:33-8. 2009
    ..As a result, several avenues of research are now expanding, with cancer epigenomics being complemented by studies of the epigenomics of infectious disease and a neuroepigenomics program...
  11. doi request reprint CG dinucleotide periodicities recognized by the Dnmt3a-Dnmt3L complex are distinctive at retroelements and imprinted domains
    Jacob L Glass
    Department of Genetics Computational Genetics, Albert Einstein College of Medicine, 1301 Morris Park Avenue, Bronx, NY 10461, USA
    Mamm Genome 20:633-43. 2009
    ..We conclude that CG dinucleotide periodicity helps to explain some but not all of the relative sequence specificity of mutations of Dnmt3a or Dnmt3L in the establishment of germline cytosine methylation patterns...
  12. doi request reprint DNA methylation alterations in multiple myeloma as a model for epigenetic changes in cancer
    Amy Sharma
    Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Wiley Interdiscip Rev Syst Biol Med 2:654-69. 2010
    ..We have thus focused on DNA methylation changes in the pathogenesis of multiple myeloma, which promises to become an excellent model for systems biological studies of epigenomic dysregulation in human disease...
  13. doi request reprint Akt inhibitors MK-2206 and nelfinavir overcome mTOR inhibitor resistance in diffuse large B-cell lymphoma
    Adam M Petrich
    Montefiore Medical Center, Bronx, New York, USA
    Clin Cancer Res 18:2534-44. 2012
    ....
  14. pmc Comparative isoschizomer profiling of cytosine methylation: the HELP assay
    Batbayar Khulan
    Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Genome Res 16:1046-55. 2006
    ..The HELP assay is robust, quantitative, and accurate and is providing new insights into the distribution and dynamic nature of cytosine methylation in the genome...
  15. doi request reprint Prognostic and predictive value of 16p12.1 and 16q22.1 copy number changes in human breast cancer
    Tricia E Downing
    Jacobi Medical Center, Department of Internal Medicine, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY 10461, USA
    Cancer Genet Cytogenet 198:52-61. 2010
    ..0001). The finding that higher q/p ratios occur in younger patients offers a tool to identify high-risk individuals most likely to proceed to high grade...
  16. ncbi request reprint Clinical application of molecular profiling in breast cancer
    Joseph A Sparano
    Montefiore Einstein Cancer Center, Albert Einstein College of Medicine, Room 47, 1825 Eastchester Road, 2 South, Bronx, NY 10461, USA
    Future Oncol 1:485-96. 2005
    ..The completion of these important studies will represent the first step toward integrating molecular profiling into treatment selection for adjuvant therapy in breast cancer...
  17. ncbi request reprint Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences
    Tarjei S Mikkelsen
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 447:167-77. 2007
    ..A substantial proportion of these eutherian-specific CNEs arose from sequence inserted by transposable elements, pointing to transposons as a major creative force in the evolution of mammalian gene regulation...