Eliseo A Eugenin

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. pmc Human immunodeficiency virus infection of human astrocytes disrupts blood-brain barrier integrity by a gap junction-dependent mechanism
    Eliseo A Eugenin
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 31:9456-65. 2011
  2. pmc PrPC, the cellular isoform of the human prion protein, is a novel biomarker of HIV-associated neurocognitive impairment and mediates neuroinflammation
    Toni K Roberts
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Pathol 177:1848-60. 2010
  3. pmc Mechanisms of HIV entry into the CNS: increased sensitivity of HIV infected CD14+CD16+ monocytes to CCL2 and key roles of CCR2, JAM-A, and ALCAM in diapedesis
    Dionna W Williams
    Department of Pathology, The Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 8:e69270. 2013
  4. pmc Mechanisms of HIV-tat-induced phosphorylation of N-methyl-D-aspartate receptor subunit 2A in human primary neurons: implications for neuroAIDS pathogenesis
    Jessie E King
    Department of Pathology, The Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Am J Pathol 176:2819-30. 2010
  5. pmc Human immunodeficiency virus (HIV) infects human arterial smooth muscle cells in vivo and in vitro: implications for the pathogenesis of HIV-mediated vascular disease
    Eliseo A Eugenin
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA
    Am J Pathol 172:1100-11. 2008
  6. pmc Human immunodeficiency virus (HIV) infection of human macrophages is increased by dopamine: a bridge between HIV-associated neurologic disorders and drug abuse
    Peter J Gaskill
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Am J Pathol 175:1148-59. 2009
  7. pmc CCL2 disrupts the adherens junction: implications for neuroinflammation
    Toni K Roberts
    Department of Pathology, The Albert Einstein College of Medicine, Bronx, NY, USA
    Lab Invest 92:1213-33. 2012
  8. pmc CD40-CD40 ligand interactions in human microglia induce CXCL8 (interleukin-8) secretion by a mechanism dependent on activation of ERK1/2 and nuclear translocation of nuclear factor-kappaB (NFkappaB) and activator protein-1 (AP-1)
    Teresa G D'Aversa
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci Res 86:630-9. 2008
  9. pmc The role of gap junction channels during physiologic and pathologic conditions of the human central nervous system
    Eliseo A Eugenin
    Department of Pathology, F727, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    J Neuroimmune Pharmacol 7:499-518. 2012
  10. doi Methods to study monocyte migration induced by HIV-infected cells
    Vasudev R Rao
    Department of Microbiology, Albert Einstein College of Medicine, Bronx, NY, USA
    Methods Mol Biol 485:295-309. 2009

Collaborators

Detail Information

Publications23

  1. pmc Human immunodeficiency virus infection of human astrocytes disrupts blood-brain barrier integrity by a gap junction-dependent mechanism
    Eliseo A Eugenin
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 31:9456-65. 2011
    ..This mechanism of toxicity contributes to understanding how CNS damage is spread even in the current ART era and how minimal or controlled HIV infection still results in cognitive impairment in a large population of infected individuals...
  2. pmc PrPC, the cellular isoform of the human prion protein, is a novel biomarker of HIV-associated neurocognitive impairment and mediates neuroinflammation
    Toni K Roberts
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Pathol 177:1848-60. 2010
    ..This report presents the first evidence that PrP(C) dysregulation occurs in cognitively impaired HIV-1-infected individuals and that PrP(C) participates in the pathogenesis of HIV-1-associated CNS disease...
  3. pmc Mechanisms of HIV entry into the CNS: increased sensitivity of HIV infected CD14+CD16+ monocytes to CCL2 and key roles of CCR2, JAM-A, and ALCAM in diapedesis
    Dionna W Williams
    Department of Pathology, The Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 8:e69270. 2013
    ....
  4. pmc Mechanisms of HIV-tat-induced phosphorylation of N-methyl-D-aspartate receptor subunit 2A in human primary neurons: implications for neuroAIDS pathogenesis
    Jessie E King
    Department of Pathology, The Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Am J Pathol 176:2819-30. 2010
    ..These findings suggest new avenues of treatment for HIV-associated cognitive impairment...
  5. pmc Human immunodeficiency virus (HIV) infects human arterial smooth muscle cells in vivo and in vitro: implications for the pathogenesis of HIV-mediated vascular disease
    Eliseo A Eugenin
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA
    Am J Pathol 172:1100-11. 2008
    ..Our data suggest that direct infection of human arterial SMCs by HIV represents a potential mechanism in a multifactorial paradigm to explain the exacerbated atherosclerosis and vasculopathy reported in individuals infected with HIV...
  6. pmc Human immunodeficiency virus (HIV) infection of human macrophages is increased by dopamine: a bridge between HIV-associated neurologic disorders and drug abuse
    Peter J Gaskill
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Am J Pathol 175:1148-59. 2009
    ....
  7. pmc CCL2 disrupts the adherens junction: implications for neuroinflammation
    Toni K Roberts
    Department of Pathology, The Albert Einstein College of Medicine, Bronx, NY, USA
    Lab Invest 92:1213-33. 2012
    ..Our novel findings provide a mechanism for CCL2-mediated disruption of endothelial junctions that may contribute to BBB dysfunction and increased leukocyte recruitment in neuroinflammatory diseases...
  8. pmc CD40-CD40 ligand interactions in human microglia induce CXCL8 (interleukin-8) secretion by a mechanism dependent on activation of ERK1/2 and nuclear translocation of nuclear factor-kappaB (NFkappaB) and activator protein-1 (AP-1)
    Teresa G D'Aversa
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci Res 86:630-9. 2008
    ..Thus, CD40-CD40L interactions facilitate chemokine expression, leading to the influx of inflammatory cells into the CNS. These events can lead to the pathology that is associated with neuroinflammatory diseases...
  9. pmc The role of gap junction channels during physiologic and pathologic conditions of the human central nervous system
    Eliseo A Eugenin
    Department of Pathology, F727, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    J Neuroimmune Pharmacol 7:499-518. 2012
    ..The focus of this review is to summarize recent findings related to the role of GJs and uHC in physiologic and pathologic conditions of the central nervous system...
  10. doi Methods to study monocyte migration induced by HIV-infected cells
    Vasudev R Rao
    Department of Microbiology, Albert Einstein College of Medicine, Bronx, NY, USA
    Methods Mol Biol 485:295-309. 2009
    ..Here we describe methods, to measure the role of soluble factors, such as chemokines and Tat, released by HIV-infected cells or uninfected cells in their vicinity, in monocyte migration in vitro...
  11. pmc Purinergic receptors are required for HIV-1 infection of primary human macrophages
    Joy E Hazleton
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 188:4488-95. 2012
    ..Our data implicate a novel role for a family of host proteins in HIV replication in macrophages and suggest new therapeutic targets to reduce the devastating consequences of HIV infection and AIDS...
  12. ncbi Neuroimmunity and the blood-brain barrier: molecular regulation of leukocyte transmigration and viral entry into the nervous system with a focus on neuroAIDS
    Clarisa M Buckner
    Department of Pathology, F727, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    J Neuroimmune Pharmacol 1:160-81. 2006
    ..Finally, we review the pharmacologic interventions that address neuroinflammation, and the effect of substance abuse on HIV-1 related neuroimmunity...
  13. ncbi A role for CXCL12 (SDF-1alpha) in the pathogenesis of multiple sclerosis: regulation of CXCL12 expression in astrocytes by soluble myelin basic protein
    Tina M Calderon
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, United States
    J Neuroimmunol 177:27-39. 2006
    ..In agreement, EC treatment with CXCL12 was found to upregulate CCL2 (MCP-1) and CXCL8 (IL-8) by PI3-K and p38-dependent mechanisms. Our findings suggest that increased CXCL12 may initiate and augment the inflammatory response during MS...
  14. pmc Characterization and function of the human macrophage dopaminergic system: implications for CNS disease and drug abuse
    Peter J Gaskill
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA
    J Neuroinflammation 9:203. 2012
    ..The expression of these proteins and the effects of dopamine on human macrophage functions had not been studied...
  15. pmc Monocyte maturation, HIV susceptibility, and transmigration across the blood brain barrier are critical in HIV neuropathogenesis
    Dionna W Williams
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY, 10461, USA
    J Leukoc Biol 91:401-15. 2012
    ..It will focus on markers of monocyte subpopulations, how differentiation/maturation alters HIV infectivity, and the mechanisms that promote their increased transmigration across the BBB into the CNS...
  16. pmc HIV-1 clade-specific differences in the induction of neuropathogenesis
    Vasudev R Rao
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 28:10010-6. 2008
    ....
  17. pmc Gap junctions mediate human immunodeficiency virus-bystander killing in astrocytes
    Eliseo A Eugenin
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, New York 10461, USA
    J Neurosci 27:12844-50. 2007
    ..Our findings describe a novel mechanism of toxicity within the brain, triggered by low numbers of HIV-infected astrocytes and amplified by gap junctions, contributing to the pathogenesis of NeuroAIDS...
  18. pmc HIV-tat induces formation of an LRP-PSD-95- NMDAR-nNOS complex that promotes apoptosis in neurons and astrocytes
    Eliseo A Eugenin
    Department of Pathology and Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 104:3438-43. 2007
    ..These findings implicate the complex in HIV-induced neuronal apoptosis and suggest therapeutic targets for intervention in the pathogenesis of NeuroAIDS...
  19. ncbi TNF-alpha plus IFN-gamma induce connexin43 expression and formation of gap junctions between human monocytes/macrophages that enhance physiological responses
    Eliseo A Eugenin
    Departamento de Ciencias Fisiologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Immunol 170:1320-8. 2003
    ..We propose that some monocyte/macrophage responses are coordinated by connexin-formed membrane channels expressed transiently at inflammatory sites in which these cells form aggregates...
  20. ncbi CCL2/monocyte chemoattractant protein-1 mediates enhanced transmigration of human immunodeficiency virus (HIV)-infected leukocytes across the blood-brain barrier: a potential mechanism of HIV-CNS invasion and NeuroAIDS
    Eliseo A Eugenin
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 26:1098-106. 2006
    ..These data suggest that CCL2, but not other chemokines, plays a key role in infiltration of HIV-infected leukocytes into the CNS and the subsequent pathology characteristic of NeuroAIDS...
  21. pmc Novel mechanisms of central nervous system damage in HIV infection
    Joy E Hazleton
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA
    HIV AIDS (Auckl) 2:39-49. 2010
    ..These data suggest potential targets for novel therapeutics...
  22. pmc Inflammatory conditions induce gap junctional communication between rat Kupffer cells both in vivo and in vitro
    Eliseo A Eugenin
    Department of Pathology, F727, 1300 Morris Park Ave, Albert Einstein College of Medicine, Bronx, NY, USA
    Cell Immunol 247:103-10. 2007
    ..In conclusion, activation of KCs in vivo or in vitro resulted in enhanced Cx43 expression levels and formation of GJ that might play relevant roles during liver inflammation...
  23. ncbi HIV-1 tat protein induces a migratory phenotype in human fetal microglia by a CCL2 (MCP-1)-dependent mechanism: possible role in NeuroAIDS
    Eliseo A Eugenin
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Glia 49:501-10. 2005
    ..Our data indicate that tat facilitates microglia migration by inducing autocrine CCL2 release. Our results suggest that tat induced CCL2 secretion may be one of the early signals during NeuroAIDS...