Ekaterina Dadachova

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. pmc Treating cancer as an infectious disease--viral antigens as novel targets for treatment and potential prevention of tumors of viral etiology
    Xing Guo Wang
    Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 2:e1114. 2007
  2. pmc Positron emission tomography agent 2-deoxy-2-[18F]fluoro-D-glucose has a therapeutic potential in breast cancer
    Renee M Moadel
    Department of Nuclear Medicine, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York, USA
    Breast Cancer Res 5:R199-205. 2003
  3. pmc Cryptococcus neoformans as a Model for Radioimmunotherapy of Infections
    Ekaterina Dadachova
    Department of Nuclear Medicine, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY 10461, USA
    Interdiscip Perspect Infect Dis 2011:830286. 2011
  4. pmc Physico-chemical evaluation of rationally designed melanins as novel nature-inspired radioprotectors
    Andrew D Schweitzer
    Department of Nuclear Medicine, Albert Einstein College of Medicine, New York, New York, United States of America
    PLoS ONE 4:e7229. 2009
  5. pmc Safety and efficacy of 188-rhenium-labeled antibody to melanin in patients with metastatic melanoma
    M Klein
    Hadassah Medical Center, Hebrew University, Kiryat Hadassah, 91120 Jerusalem, Israel
    J Skin Cancer 2013:828329. 2013
  6. ncbi request reprint Melanin as a potential target for radionuclide therapy of metastatic melanoma
    Ekaterina Dadachova
    Albert Einstein College of Medicine of Yeshiva University, Department of Nuclear Medicine, Bronx, NY 10461, USA
    Future Oncol 1:541-9. 2005
  7. ncbi request reprint Treatment of infection with radiolabeled antibodies
    E Dadachova
    Department of Nuclear Medicine, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10461, USA
    Q J Nucl Med Mol Imaging 50:193-204. 2006
  8. pmc In vitro evaluation, biodistribution and scintigraphic imaging in mice of radiolabeled anthrax toxins
    Ekaterina Dadachova
    Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Nucl Med Biol 35:755-61. 2008
  9. pmc Ionizing radiation: how fungi cope, adapt, and exploit with the help of melanin
    Ekaterina Dadachova
    Department of Nuclear Medicine, Albert Einstein College of Medicine, 1695A Eastchester Road, Bronx, NY 10461, USA
    Curr Opin Microbiol 11:525-31. 2008
  10. ncbi request reprint Radiolabeled melanin-binding peptides are safe and effective in treatment of human pigmented melanoma in a mouse model of disease
    Ekaterina Dadachova
    Department of Nuclear Medicine, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY 10461, USA
    Cancer Biother Radiopharm 21:117-29. 2006

Research Grants

  1. Rhenium-188 therapy of NIS-expressing breast tumors
    Ekaterina Dadachova; Fiscal Year: 2003
  2. Radioimmunotherapy of opportunistic infections
    Ekaterina Dadachova; Fiscal Year: 2003
  3. Interaction of AIDS-associated microbes with radiation
    Ekaterina Dadachova; Fiscal Year: 2005
  4. Interaction of AIDS-associated microbes with radiation
    Ekaterina Dadachova; Fiscal Year: 2006
  5. Interaction of AIDS-associated microbes with radiation
    Ekaterina Dadachova; Fiscal Year: 2007
  6. Interaction of AIDS-associated microbes with radiation
    Ekaterina Dadachova; Fiscal Year: 2007
  7. Interaction of AIDS-associated microbes with radiation
    Ekaterina Dadachova; Fiscal Year: 2009

Collaborators

Detail Information

Publications73

  1. pmc Treating cancer as an infectious disease--viral antigens as novel targets for treatment and potential prevention of tumors of viral etiology
    Xing Guo Wang
    Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 2:e1114. 2007
    ..There is an urgent need to find new approaches to treatment and prevention of virus-associated cancers...
  2. pmc Positron emission tomography agent 2-deoxy-2-[18F]fluoro-D-glucose has a therapeutic potential in breast cancer
    Renee M Moadel
    Department of Nuclear Medicine, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York, USA
    Breast Cancer Res 5:R199-205. 2003
    ..2-Deoxy-2-[18F]fluoro-D-glucose (18F-FDG) was evaluated as a potential radiomolecular therapy agent in breast cancer animal models and, retrospectively, in patients with metastatic breast cancer...
  3. pmc Cryptococcus neoformans as a Model for Radioimmunotherapy of Infections
    Ekaterina Dadachova
    Department of Nuclear Medicine, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY 10461, USA
    Interdiscip Perspect Infect Dis 2011:830286. 2011
    ..In addition, the creation of "panantibodies" for RIT which would recognize antigens shared by the whole class of pathogens such as fungi, for example, would facilitate the introduction of RIT into the clinic...
  4. pmc Physico-chemical evaluation of rationally designed melanins as novel nature-inspired radioprotectors
    Andrew D Schweitzer
    Department of Nuclear Medicine, Albert Einstein College of Medicine, New York, New York, United States of America
    PLoS ONE 4:e7229. 2009
    ..Melanin, a high-molecular weight pigment that is ubiquitous in nature, protects melanized microorganisms against high doses of ionizing radiation. However, the physics of melanin interaction with ionizing radiation is unknown...
  5. pmc Safety and efficacy of 188-rhenium-labeled antibody to melanin in patients with metastatic melanoma
    M Klein
    Hadassah Medical Center, Hebrew University, Kiryat Hadassah, 91120 Jerusalem, Israel
    J Skin Cancer 2013:828329. 2013
    ..The data demonstrate that (188)Re-6D2 was well tolerated, localized in melanoma metastases, and had antitumor activity, thus warranting its further investigation in patients with metastatic melanoma...
  6. ncbi request reprint Melanin as a potential target for radionuclide therapy of metastatic melanoma
    Ekaterina Dadachova
    Albert Einstein College of Medicine of Yeshiva University, Department of Nuclear Medicine, Bronx, NY 10461, USA
    Future Oncol 1:541-9. 2005
    ..The authors are optimistic that therapeutic agents targeting melanin to deliver radionuclide therapy could appear in the clinic within a decade...
  7. ncbi request reprint Treatment of infection with radiolabeled antibodies
    E Dadachova
    Department of Nuclear Medicine, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10461, USA
    Q J Nucl Med Mol Imaging 50:193-204. 2006
    ..However, considerable basic work remains to be done to ascertain the optimal conditions for the efficacy of RIT for infection...
  8. pmc In vitro evaluation, biodistribution and scintigraphic imaging in mice of radiolabeled anthrax toxins
    Ekaterina Dadachova
    Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Nucl Med Biol 35:755-61. 2008
    ....
  9. pmc Ionizing radiation: how fungi cope, adapt, and exploit with the help of melanin
    Ekaterina Dadachova
    Department of Nuclear Medicine, Albert Einstein College of Medicine, 1695A Eastchester Road, Bronx, NY 10461, USA
    Curr Opin Microbiol 11:525-31. 2008
    ....
  10. ncbi request reprint Radiolabeled melanin-binding peptides are safe and effective in treatment of human pigmented melanoma in a mouse model of disease
    Ekaterina Dadachova
    Department of Nuclear Medicine, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY 10461, USA
    Cancer Biother Radiopharm 21:117-29. 2006
    ..These results indicate that radiolabeled melanin-binding peptides are efficient and safe in treatment of melanoma and could be potentially useful against this tumor...
  11. pmc Targeted killing of virally infected cells by radiolabeled antibodies to viral proteins
    Ekaterina Dadachova
    Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS Med 3:e427. 2006
    ..The aim of this proof-of-principle study was to demonstrate the efficacy of a therapeutic strategy of targeting and eliminating HIV-1-infected cells with radiolabeled antibodies specific to viral proteins in vitro and in vivo...
  12. ncbi request reprint Pre-clinical evaluation and efficacy studies of a melanin-binding IgM antibody labeled with 188Re against experimental human metastatic melanoma in nude mice
    Ekaterina Dadachova
    Department of Nuclear Medicine, Department of Microbiology and Immunology, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, USA
    Cancer Biol Ther 7:1116-27. 2008
    ..Here we carried out pre-clinical development of (188)Re-6D2 to accrue information necessary for a Phase I trial in patients with metastatic melanoma...
  13. doi request reprint The radioprotective properties of fungal melanin are a function of its chemical composition, stable radical presence and spatial arrangement
    Ekaterina Dadachova
    Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, NY, USA
    Pigment Cell Melanoma Res 21:192-9. 2008
    ..Melanin protected fungi against ionizing radiation and its radioprotective properties were a function of its chemical composition, free radical quenching, and spherical spatial arrangement...
  14. ncbi request reprint Renaissance of targeting molecules for melanoma
    Ekaterina Dadachova
    Department of Nuclear Medicine, Albert Einstein Medicine of Yeshiva University, Bronx, NY 10461, USA
    Cancer Biother Radiopharm 21:545-52. 2006
    ..Overall, we are hopeful that targeted radionuclide therapy of metastatic melanoma will become a reality within the next few years...
  15. pmc Ionizing radiation changes the electronic properties of melanin and enhances the growth of melanized fungi
    Ekaterina Dadachova
    Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 2:e457. 2007
    ..We hypothesized that ionizing radiation could change the electronic properties of melanin and might enhance the growth of melanized microorganisms...
  16. ncbi request reprint Targeting the virus with radioimmunotherapy in virus-associated cancers
    Ekaterina Dadachova
    Department of Nuclear Medicine, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY 10461, USA
    Cancer Biother Radiopharm 22:303-8. 2007
    ..RIT of VAC is fundamentally different from the previously described uses of RIT, which have targeted tumor-associated antigens that are "self" proteins...
  17. ncbi request reprint Comparative evaluation of capsular polysaccharide-specific IgM and IgG antibodies and F(ab')2 and Fab fragments as delivery vehicles for radioimmunotherapy of fungal infection
    Ekaterina Dadachova
    Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Clin Cancer Res 13:5629s-5635s. 2007
    ....
  18. ncbi request reprint Interaction of radiolabeled antibodies with fungal cells and components of the immune system in vitro and during radioimmunotherapy for experimental fungal infection
    Ekaterina Dadachova
    Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Infect Dis 193:1427-36. 2006
    ..The usefulness of radioimmunotherapy (RIT) for infectious diseases was recently demonstrated for several fungal and bacterial infections, but the mechanisms by which RIT is effective against microbes are uncertain...
  19. pmc Radioimmunotherapy is effective against high-inoculum Cryptococcus neoformans infection in mice and does not select for radiation-resistant cryptococcal cells
    Ruth A Bryan
    Departments of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Antimicrob Agents Chemother 53:1679-82. 2009
    ..RIT reduced mortality in high-burden infections, and we found no evidence for the development of radiation-resistant cells...
  20. pmc Radioimmunotherapy of infectious diseases
    Ekaterina Dadachova
    Department of Nuclear Medicine, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY 10461, USA
    Semin Nucl Med 39:146-53. 2009
    ..The availability of such antibodies would eliminate the necessity of having antibodies specific for each particular microorganism and would enormously enhance the development of RIT of infectious diseases...
  21. pmc Ionizing radiation delivered by specific antibody is therapeutic against a fungal infection
    Ekaterina Dadachova
    Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 100:10942-7. 2003
    ..This study establishes the principle that targeted radiation can be used for the therapy of an infectious disease, and suggests that it may have wide applicability as an antimicrobial strategy...
  22. ncbi request reprint Susceptibility of the human pathogenic fungi Cryptococcus neoformans and Histoplasma capsulatum to gamma-radiation versus radioimmunotherapy with alpha- and beta-emitting radioisotopes
    Ekaterina Dadachova
    Department of Nuclear Medicine, Albert Einstein College of Medicine, 1695A Eastchester Road, Bronx, NY 10461, USA
    J Nucl Med 45:313-20. 2004
    ....
  23. pmc Feasibility of radioimmunotherapy of experimental pneumococcal infection
    E Dadachova
    Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Antimicrob Agents Chemother 48:1624-9. 2004
    ..01). The treatment did not cause hematological toxicity, as demonstrated by platelet counts. This feasibility study establishes that RIT can be applied to the treatment of bacterial infections...
  24. pmc Dead cells in melanoma tumors provide abundant antigen for targeted delivery of ionizing radiation by a mAb to melanin
    Ekaterina Dadachova
    Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 101:14865-70. 2004
    ....
  25. ncbi request reprint Host and microbial cells as targets for armed antibodies in the treatment of infectious diseases
    Ekaterina Dadachova
    Albert Einstein College of Medicine of Yeshiva University, Department of Nuclear Medicine, Bronx, NY 10461 USA
    Curr Opin Investig Drugs 9:184-8. 2008
    ..This review highlights the use of armed antibodies to target infected host cells or to target the microbes themselves, describing challenges and future directions for both approaches...
  26. ncbi request reprint Antibodies as delivery vehicles for radioimmunotherapy of infectious diseases
    Ekaterina Dadachova
    Department of Nuclear Medicine, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY 10461, USA
    Expert Opin Drug Deliv 2:1075-84. 2005
    ..Dadachova and Casadevall anticipate that RIT can be developed for many types of infectious diseases, including microbes resistant to conventional antimicrobial therapy and agents of biological warfare...
  27. pmc Radioimmunotherapy is more effective than antifungal treatment in experimental cryptococcal infection
    Ruth A Bryan
    Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Infect Dis 202:633-7. 2010
    ..We conclude that RIT is more effective than amphotericin B against systemic infection with C. neoformans...
  28. pmc Treatment of early and established Cryptococcus neoformans infection with radiolabeled antibodies in immunocompetent mice
    Zewei Jiang
    Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, New York, USA
    Antimicrob Agents Chemother 56:552-4. 2012
    ..The results point to the independence of RIT of the immune status of the host, which is encouraging for translation of this strategy into the clinic...
  29. pmc Neutralizing monoclonal antibody to edema toxin and its effect on murine anthrax
    Lisa Winterroth
    Departments of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Infect Immun 78:2890-8. 2010
    ....
  30. doi request reprint Radioimmunotherapy of experimental human metastatic melanoma with melanin-binding antibodies and in combination with dacarbazine
    Ekaterina Revskaya
    Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Clin Cancer Res 15:2373-9. 2009
    ....
  31. ncbi request reprint Phage display library derived peptides that bind to human tumor melanin as potential vehicles for targeted radionuclide therapy of metastatic melanoma
    Robertha C Howell
    Department of Nuclear Medicine, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY 10461, USA
    Bioconjug Chem 18:1739-48. 2007
    ..Thus, these heptapeptides appear to have potentially significant advantages for targeted therapy of melanoma relative to existing melanin-binding peptides...
  32. pmc Melanin-covered nanoparticles for protection of bone marrow during radiation therapy of cancer
    Andrew D Schweitzer
    Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Int J Radiat Oncol Biol Phys 78:1494-502. 2010
    ....
  33. ncbi request reprint Computational model predicts effective delivery of 188-Re-labeled melanin-binding antibody to metastatic melanoma tumors with wide range of melanin concentrations
    Andrew D Schweitzer
    The Mount Sinai School of Medicine, Cornell University, Ithaca, New York, USA
    Melanoma Res 17:291-303. 2007
    ..In conclusion, RIT of metastatic melanoma can be effective over a wide range of tumor melanin concentrations. The results can be useful in the design of a clinical trial of melanin-targeting RIT in patients with metastatic melanoma...
  34. doi request reprint Complement-dependent cytotoxicity of an antibody to melanin in radioimmunotherapy of metastatic melanoma
    Thomas Jandl
    Department of Radiology, Albert Einstein College of Medicine, 1695A Eastchester Road, Bronx, NY 10461, USA
    Immunotherapy 5:357-64. 2013
    ..Novel treatments for metastatic melanoma are urgently needed...
  35. pmc Pre-clinical evaluation of a 213Bi-labeled 2556 antibody to HIV-1 gp41 glycoprotein in HIV-1 mouse models as a reagent for HIV eradication
    Ekaterina Dadachova
    Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 7:e31866. 2012
    ..Based on our earlier proof-of-principle results targeting HIV-1 infected cells with radiolabeled antibody (mAb) to gp41 viral antigen, we embarked on identifying a suitable candidate mAb for preclinical development...
  36. pmc Radiolabeled antibodies to Bacillus anthracis toxins are bactericidal and partially therapeutic in experimental murine anthrax
    Johanna Rivera
    Department of Microbiology and Immunology, Division of Infectious Diseases, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Antimicrob Agents Chemother 53:4860-8. 2009
    ..anthracis Sterne spores. These results indicate that RIT with MAbs that target B. anthracis toxin components can be used to treat experimental anthrax infection and suggest that toxigenic bacteria may be targeted with radiolabeled MAbs...
  37. pmc Radioimmunotherapy with an antibody to the HPV16 E6 oncoprotein is effective in an experimental cervical tumor expressing low levels of E6
    Rébécca Phaeton
    Department of Obstetrics and Gynecology and Women s Health, Albert Einstein College of Medicine, Albert Einstein Cancer Center, Bronx, NY, USA
    Cancer Biol Ther 10:1041-7. 2010
    ..However, that study opened the question whether radioimmunotherapy can suppress the growth of cervical tumors with low E6 and E7 expression, such as may be seen in patients...
  38. ncbi request reprint Treatment with rhenium-188-perrhenate and iodine-131 of NIS-expressing mammary cancer in a mouse model remarkably inhibited tumor growth
    Ekaterina Dadachova
    Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Nucl Med Biol 32:695-700. 2005
    ..We report the results of a therapy study with (131)I(-) and (188)ReO(4)(-) of breast cancer in polyoma middle T oncoprotein (PyMT) transgenic mice endogenously expressing the Na(+)/I(-) symporter (NIS)...
  39. ncbi request reprint Positherapy: targeted nuclear therapy of breast cancer with 18F-2-deoxy-2-fluoro-D-glucose
    Renee M Moadel
    Department of Nuclear Medicine, Albert Einstein College of Medicine, 1695A Eastchester Road, Bronx, NY 10461, USA
    Cancer Res 65:698-702. 2005
    ..These results are important for the development of positherapy with (18)F-FDG for refractory metastatic breast and other cancers...
  40. doi request reprint Radioimmunotherapy of Cryptococcus neoformans spares bystander mammalian cells
    Ruth A Bryan
    Department of Radiology, 1695A Eastchester Road, Albert Einstein College of Medicine, Bronx, NY, USA
    Future Microbiol 8:1081-9. 2013
    ....
  41. doi request reprint Melanoma stem cells in experimental melanoma are killed by radioimmunotherapy
    Thomas Jandl
    Department of Radiology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Nucl Med Biol 40:177-81. 2013
    ..Here we investigated the interaction of MSC with RIT as a possible mechanism for RIT efficacy...
  42. ncbi request reprint Comparative analysis of Cryptococcus neoformans acid-resistant particles generated from pigmented cells grown in different laccase substrates
    Javier Garcia-Rivera
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Fungal Genet Biol 42:989-98. 2005
    ..neoformans in different substrates affected cell and capsule size but not capsule induction. Hence, the type of pigment produced by C. neoformans is dependent on the substrate and not all pigments meet the criteria for melanins...
  43. pmc Compton scattering by internal shields based on melanin-containing mushrooms provides protection of gastrointestinal tract from ionizing radiation
    Ekaterina Revskaya
    Department of Radiology, Albert Einstein College of Medicine, Bronx, New York, USA
    Cancer Biother Radiopharm 27:570-6. 2012
    ..The ability of melanin-containing mushrooms to provide remarkable protection against radiation suggests that they could be developed into oral radioprotectors...
  44. pmc The influence of proteasome inhibitor MG132, external radiation, and unlabeled antibody on the tumor uptake and biodistribution of (188)re-labeled anti-E6 C1P5 antibody in cervical cancer in mice
    Rébécca Phaeton
    Department of Obstetrics and Gynecology and Women s Health, Division of Gynecologic Oncology, Albert Einstein College of Medicine, Albert Einstein Cancer Center, Bronx, NY 10461, USA
    Cancer 116:1067-74. 2010
    ..They hypothesized that the pretreatment of tumor cells with various agents that cause cell death and/or elevation of E6 levels would increase the accumulation of radiolabeled antibodies to E6 in cervical tumors...
  45. pmc Murine IgG1 and IgG3 isotype switch variants promote phagocytosis of Cryptococcus neoformans through different receptors
    Carolyn A Saylor
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 184:336-43. 2010
    ..We conclude that a specific receptor for IgG3 exists in mice that is structurally different from the known FcgammaRs...
  46. pmc Radioimmunotherapy of experimental head and neck squamous cell carcinoma (HNSCC) with E6-specific antibody using a novel HPV-16 positive HNSCC cell line
    Matthew Harris
    Department of Nuclear Medicine, Albert Einstein College of Medicine, Albert Einstein Cancer Center, Bronx, New York, USA
    Head Neck Oncol 3:9. 2011
    ..We aimed at extending this approach to HPV-related head and neck cancer by performing radioimmunotherapy (RIT) targeting E6 and E7 oncogenes with radiolabeled mAbs...
  47. pmc A monoclonal antibody to Bacillus anthracis protective antigen defines a neutralizing epitope in domain 1
    Johanna Rivera
    Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Infect Immun 74:4149-56. 2006
    ..However, MAb 7.5G slowed the proteolytic digestion of PA by furin in vitro, suggesting a potential mechanism for Ab-mediated protection. These observations indicate that some Abs to domain 1 can contribute to host protection...
  48. ncbi request reprint Targeting host cells harbouring viruses with radiolabeled antibodies
    Arturo Casadevall
    Albert Einstein College of Medicine, Department of Microbiology and Immunology, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Expert Opin Biol Ther 7:595-7. 2007
    ..This approach was recently shown to target and eliminate HIV-1-infected cells in vitro and in mouse models, and provides a new approach for eliminating virally infected cells...
  49. pmc In vitro and in vivo evaluation of melanin-binding decapeptide 4B4 radiolabeled with 177Lu, 166Ho, and 153Sm radiolanthanides for the purpose of targeted radionuclide therapy of melanoma
    Beau Ballard
    Department of Chemistry, Hunter College of the City University of New York, 695 Park Avenue, New York, NY 10065, USA
    Cancer Biother Radiopharm 26:547-56. 2011
    ....
  50. pmc Radial mass density, charge, and epitope distribution in the Cryptococcus neoformans capsule
    Michelle E Maxson
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Eukaryot Cell 6:95-109. 2007
    ..neoformans is heterogeneous in its spatial distribution and changes with age. Furthermore, our results suggest several mechanisms by which the capsule may protect the fungal cell against exogenous environmental factors...
  51. pmc Nontoxic radioactive Listeria(at) is a highly effective therapy against metastatic pancreatic cancer
    Wilber Quispe-Tintaya
    Department of Microbiology and Immunology and Department of Radiology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 110:8668-73. 2013
    ..The nontoxic RL treatment is attractive for clinical development as a therapy to prevent pancreatic cancer recurrence and metastases...
  52. pmc Protection of melanized Cryptococcus neoformans from lethal dose gamma irradiation involves changes in melanin's chemical structure and paramagnetism
    Abdelahad Khajo
    Department of Chemistry, Brooklyn College of the City University of New York, Brooklyn, New York, United States of America
    PLoS ONE 6:e25092. 2011
    ..Our results show that melanin in C. neoformans cells is susceptible to some damage by hydroxyl radical formed in lethal radioactive aqueous environments and serves a protective role in melanized fungi that involves sacrificial breakdown...
  53. pmc Cryptococcus neoformans can utilize the bacterial melanin precursor homogentisic acid for fungal melanogenesis
    Susana Frases
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Appl Environ Microbiol 73:615-21. 2007
    ..HGA melanization was laccase dependent and repressed by high concentrations of glucose. The ability of C. neoformans to utilize a bacterial melanin precursor compound suggests a new substrate source for melanization in the environment...
  54. pmc Induction by Klebsiella aerogenes of a melanin-like pigment in Cryptococcus neoformans
    Susana Frases
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Appl Environ Microbiol 72:1542-50. 2006
    ..This observation provides a precedent that could explain the source of a substrate for C. neoformans melanization in the environment...
  55. ncbi request reprint Passive antibody therapy for infectious diseases
    Arturo Casadevall
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Nat Rev Microbiol 2:695-703. 2004
    ....
  56. pmc Effects of disrupting the polyketide synthase gene WdPKS1 in Wangiella [Exophiala] dermatitidis on melanin production and resistance to killing by antifungal compounds, enzymatic degradation, and extremes in temperature
    William F Paolo
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA
    BMC Microbiol 6:55. 2006
    ..Cell wall pigmentation in W. dermatitidis depends on the WdPKS1 gene, which encodes a polyketide synthase required for generating the key precursor for dihydroxynaphthalene melanin biosynthesis...
  57. doi request reprint The effects of gamma radiation, UV and visible light on ATP levels in yeast cells depend on cellular melanization
    Ruth Bryan
    Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Fungal Biol 115:945-9. 2011
    ..In contrast, in non-melanized cells visible light led to increase in ATP levels; gamma radiation did not cause any changes while UV exposure resulted in some ATP decrease, however, much less pronounced than in melanized cells...
  58. pmc Monoclonal antibody-based therapies for microbial diseases
    Carolyn Saylor
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Vaccine 27:G38-46. 2009
    ..Hence, there is cautious optimism that the years ahead will see more mAbs in clinical use against microbial diseases...
  59. doi request reprint Microbicidal power of alpha radiation in sterilizing germinating Bacillus anthracis spores
    Johanna Rivera
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA
    Antimicrob Agents Chemother 58:1813-5. 2014
    ..In contrast, when spores were germinating, 213Bi-EA2-1 mediated MAb-specific killing in a dose-dependent manner. Dormant spores are very resistant to RIT, and RIT should focus on targeting vegetative cells and germinating spores...
  60. ncbi request reprint The polysaccharide capsule of the pathogenic fungus Cryptococcus neoformans enlarges by distal growth and is rearranged during budding
    Oscar Zaragoza
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Mol Microbiol 59:67-83. 2006
    ..Our results indicate that C. neoformans capsular enlargement also occurs by apical growth and that budding results in capsular rearrangements...
  61. doi request reprint Cancer therapy with alpha-emitters labeled peptides
    Ekaterina Dadachova
    Department of Nuclear Medicine, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY, USA
    Semin Nucl Med 40:204-8. 2010
    ....
  62. ncbi request reprint The Na/I symporter (NIS): imaging and therapeutic applications
    Ekaterina Dadachova
    Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Semin Nucl Med 34:23-31. 2004
    ....
  63. doi request reprint Mathematical modeling predicts enhanced growth of X-ray irradiated pigmented fungi
    Igor Shuryak
    Center for Radiological Research, Columbia University, New York, New York, United States of America
    PLoS ONE 9:e85561. 2014
    ....
  64. doi request reprint FDG for therapy of metabolically active tumors
    Sridivya Jaini
    Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Semin Nucl Med 42:185-9. 2012
    ..Also, recent developments in targeted PET imaging could increase the range of PET pharmaceuticals potentially useful for positron therapy of metastatic cancers because of increased specificity of these tracers in comparison with FDG...
  65. pmc Mechanism of anion selectivity and stoichiometry of the Na+/I- symporter (NIS)
    Monika Paroder-Belenitsky
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 108:17933-8. 2011
    ....
  66. pmc Radioimmunotherapy of fungal diseases: the therapeutic potential of cytocidal radiation delivered by antibody targeting fungal cell surface antigens
    Joshua D Nosanchuk
    Department of Medicine, Albert Einstein College of Medicine Bronx, NY, USA
    Front Microbiol 2:283. 2011
    ....
  67. pmc Finite-element model of interaction between fungal polysaccharide and monoclonal antibody in the capsule of Cryptococcus neoformans
    Vineet Rakesh
    Department of Biological and Environmental Engineering, Cornell University, Ithaca, New York 14853, USA
    J Phys Chem B 112:8514-22. 2008
    ..These results have implications for the development of new antibody-based therapies...
  68. ncbi request reprint A single treatment of yttrium-90-labeled CHX-A"-C6.5 diabody inhibits the growth of established human tumor xenografts in immunodeficient mice
    Gregory P Adams
    Divison of Medical Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Res 64:6200-6. 2004
    ..The maximum tolerated dose was also dependent on the tumor xenograft model used. These studies indicate that genetically engineered antitumor diabody molecules can be used as effective vehicles for radioimmunotherapy...
  69. ncbi request reprint Radioimmunotherapy of human colon carcinoma xenografts using a 213Bi-labeled domain-deleted humanized monoclonal antibody
    Diane Milenic
    Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cancer Biother Radiopharm 19:135-47. 2004
    ..As further validation of the use of 213Bi-HuCC49DeltaCH2 for RIT, a study using 131I was conducted. The overall survival of mice receiving 213Bi-HuCC49DeltaCH2 was greater than those that received 131I-HuCC49DeltaCH2...
  70. ncbi request reprint In vivo comparison of macrocyclic and acyclic ligands for radiolabeling of monoclonal antibodies with 177Lu for radioimmunotherapeutic applications
    Diane E Milenic
    Chemistry Section, Radiation Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA
    Nucl Med Biol 29:431-42. 2002
    ..Based on these in vitro and in vivo studies, the CHX-A" DTPA ligand should be considered a suitable bifunctional chelate for the radiolabeling of monoclonal antibodies with 177Lu for radioimmunotherapy applications...
  71. pmc Radiofungicidal effects of external gamma radiation and antibody-targeted beta and alpha radiation on Cryptococcus neoformans
    Ruth A Bryan
    Department of Nuclear Medicine, Joint Research Centre, Institute for Transuranium Elements, Karlsruhe, Germany
    Antimicrob Agents Chemother 52:2232-5. 2008
    ..We found that gamma, beta, and alpha radiation affected cells through different pathways...
  72. ncbi request reprint Kinetics of perrhenate uptake and comparative biodistribution of perrhenate, pertechnetate, and iodide by NaI symporter-expressing tissues in vivo
    Lionel S Zuckier
    Department of Radiology, New Jersey Medical School, Newark, New Jersey 07101 1709, USA
    J Nucl Med 45:500-7. 2004
    ..In this study, we endeavored to characterize the biologic behavior of perrhenate, especially in relation to iodide and pertechnetate, to better explore its possible therapeutic role...
  73. ncbi request reprint Overlooked contributions on sodium iodide symporter
    Ekaterina Dadachova
    J Nucl Med 44:1707. 2003

Research Grants8

  1. Rhenium-188 therapy of NIS-expressing breast tumors
    Ekaterina Dadachova; Fiscal Year: 2003
    ..The long-term goal of this research is to contribute to the development of a novel cost-effective radionuclide therapy for treatment of breast cancer and, possibly, for other NIS-expressing cancers such as thyroid cancer. ..
  2. Radioimmunotherapy of opportunistic infections
    Ekaterina Dadachova; Fiscal Year: 2003
    ..It will also provide some understanding of the fundamentals of interactions between microorganisms and antibodies radiolabeled with particulate-emitting radioisotopes in vitro and in vivo. ..
  3. Interaction of AIDS-associated microbes with radiation
    Ekaterina Dadachova; Fiscal Year: 2005
    ..Such knowledge will contribute to development of a novel therapeutic modality based on radioimmunotherapy for treatment of currently incurable or multidrug-resistant AIDS-associated opportunistic infections. ..
  4. Interaction of AIDS-associated microbes with radiation
    Ekaterina Dadachova; Fiscal Year: 2006
    ..Such knowledge will contribute to development of a novel therapeutic modality based on radioimmunotherapy for treatment of currently incurable or multidrug-resistant AIDS-associated opportunistic infections. ..
  5. Interaction of AIDS-associated microbes with radiation
    Ekaterina Dadachova; Fiscal Year: 2007
    ..Such knowledge will contribute to development of a novel therapeutic modality based on radioimmunotherapy for treatment of currently incurable or multidrug-resistant AIDS-associated opportunistic infections. ..
  6. Interaction of AIDS-associated microbes with radiation
    Ekaterina Dadachova; Fiscal Year: 2007
    ..Such knowledge will contribute to development of a novel therapeutic modality based on radioimmunotherapy for treatment of currently incurable or multidrug-resistant AIDS-associated opportunistic infections. ..
  7. Interaction of AIDS-associated microbes with radiation
    Ekaterina Dadachova; Fiscal Year: 2009
    ..Such knowledge will contribute to development of a novel therapeutic modality based on radioimmunotherapy for treatment of currently incurable or multidrug-resistant AIDS-associated opportunistic infections. ..