Ales Cvekl


Affiliation: Albert Einstein College of Medicine
Country: USA


  1. Cvekl A, Ashery Padan R. The cellular and molecular mechanisms of vertebrate lens development. Development. 2014;141:4432-47 pubmed publisher
  2. Zhao Y, Wilmarth P, Cheng C, Limi S, Fowler V, Zheng D, et al. Proteome-transcriptome analysis and proteome remodeling in mouse lens epithelium and fibers. Exp Eye Res. 2018;179:32-46 pubmed publisher
  3. McGreal Estrada R, Wolf L, Cvekl A. Promoter-enhancer looping and shadow enhancers of the mouse αA-crystallin locus. Biol Open. 2018;: pubmed publisher
    ..5. It remains to be elucidated however, which region of the αA-crystallin locus is responsible for expression in the lens pit at E10.5. ..
  4. Limi S, Senecal A, Coleman R, Lopez Jones M, Guo P, Polumbo C, et al. Transcriptional burst fraction and size dynamics during lens fiber cell differentiation and detailed insights into the denucleation process. J Biol Chem. 2018;293:13176-13190 pubmed publisher
  5. Cvekl A, Mitton K. Epigenetic regulatory mechanisms in vertebrate eye development and disease. Heredity (Edinb). 2010;105:135-51 pubmed publisher
    ..Epigenetic regulatory mechanisms in ocular tissues represent exciting areas of research that have opened new avenues for understanding normal eye development, inherited eye diseases and eye diseases related to aging and the environment. ..
  6. Cvekl A, McGreal R, Liu W. Lens Development and Crystallin Gene Expression. Prog Mol Biol Transl Sci. 2015;134:129-67 pubmed publisher
  7. Zhao Y, Zheng D, Cvekl A. A comprehensive spatial-temporal transcriptomic analysis of differentiating nascent mouse lens epithelial and fiber cells. Exp Eye Res. 2018;175:56-72 pubmed publisher
  8. Sun J, Rockowitz S, Xie Q, Ashery Padan R, Zheng D, Cvekl A. Identification of in vivo DNA-binding mechanisms of Pax6 and reconstruction of Pax6-dependent gene regulatory networks during forebrain and lens development. Nucleic Acids Res. 2015;43:6827-46 pubmed publisher
    ..Collectively, these studies provide genome-wide analysis of Pax6-dependent GRNs in lens and forebrain and establish novel roles of Pax6 in organogenesis. ..
  9. Xie Q, McGreal R, Harris R, Gao C, Liu W, Reneker L, et al. Regulation of c-Maf and αA-Crystallin in Ocular Lens by Fibroblast Growth Factor Signaling. J Biol Chem. 2016;291:3947-58 pubmed publisher
    ..These molecular mechanisms are applicable for other crystallins and genes highly expressed in terminally differentiated lens fibers. ..

More Information


  1. He S, Pirity M, Wang W, Wolf L, Chauhan B, Cveklova K, et al. Chromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and its denucleation. Epigenetics Chromatin. 2010;3:21 pubmed publisher
    ..Brg1 is directly or indirectly involved in processes that degrade lens fiber cell chromatin. The presence of nuclei and other organelles generates scattered light incompatible with the optical requirements for the lens. ..
  2. Cvekl A, Callaerts P. PAX6: 25th anniversary and more to learn. Exp Eye Res. 2017;156:10-21 pubmed publisher
  3. He S, Limi S, McGreal R, Xie Q, Brennan L, Kantorow W, et al. Chromatin remodeling enzyme Snf2h regulates embryonic lens differentiation and denucleation. Development. 2016;143:1937-47 pubmed publisher
  4. Cvekl A, Zhang X. Signaling and Gene Regulatory Networks in Mammalian Lens Development. Trends Genet. 2017;33:677-702 pubmed publisher
    ..Extensive crosstalk between a diverse array of signaling pathways controls the complexity and order of lens morphogenetic processes and lens transparency. ..