ANA M CUERVO

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. ncbi Medical bioremediation: prospects for the application of microbial catabolic diversity to aging and several major age-related diseases
    Aubrey D N J de Grey
    Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
    Ageing Res Rev 4:315-38. 2005
  2. ncbi Lysosome membrane lipid microdomains: novel regulators of chaperone-mediated autophagy
    Susmita Kaushik
    Department of Anatomy and Structural Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    EMBO J 25:3921-33. 2006
  3. ncbi Eat your heart out
    Richard N Kitsis
    Nat Med 13:539-41. 2007
  4. ncbi Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy
    Ana Maria Cuervo
    Department of Anatomy and Structural Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Science 305:1292-5. 2004
  5. ncbi Chaperone-mediated autophagy: selectivity pays off
    Ana Maria Cuervo
    Department of Developmental and Molecular Biology, Marion Bessin Liver Research Center and Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Trends Endocrinol Metab 21:142-50. 2010
  6. ncbi Protein degradation, aggregation, and misfolding
    Ana Maria Cuervo
    Department of Developmental and Molecular Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Mov Disord 25:S49-54. 2010
  7. ncbi Autophagy: many paths to the same end
    Ana Maria Cuervo
    Department of Anatomy and Structural Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Mol Cell Biochem 263:55-72. 2004
  8. ncbi Autophagy and aging: the importance of maintaining "clean" cells
    Ana Maria Cuervo
    Department of Anatomy and Structural Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Autophagy 1:131-40. 2005
  9. ncbi Autophagy and aging: keeping that old broom working
    Ana Maria Cuervo
    Department of Developmental and Molecular Biology, Marion Bessin Liver Research Center and Institute for Aging Studies, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Ullmann B 611, Bronx, NY 10461, USA
    Trends Genet 24:604-12. 2008
  10. ncbi Cathepsin A regulates chaperone-mediated autophagy through cleavage of the lysosomal receptor
    Ana Maria Cuervo
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    EMBO J 22:47-59. 2003

Research Grants

  1. PROTEOMIC ANALYSIS OF DECREASED AUTOPHAGY IN AGING
    Ana Cuervo; Fiscal Year: 2005
  2. Gordon Conference-Autophagy/Stress/Development/Disease
    Ana Cuervo; Fiscal Year: 2007

Detail Information

Publications59

  1. ncbi Medical bioremediation: prospects for the application of microbial catabolic diversity to aging and several major age-related diseases
    Aubrey D N J de Grey
    Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
    Ageing Res Rev 4:315-38. 2005
    ..We discuss how microbes capable of degrading them can be isolated, characterised and their relevant enzymes engineered for this purpose and ways to avoid potential side-effects...
  2. ncbi Lysosome membrane lipid microdomains: novel regulators of chaperone-mediated autophagy
    Susmita Kaushik
    Department of Anatomy and Structural Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    EMBO J 25:3921-33. 2006
    ..Our results support that changes in the dynamic distribution of LAMP-2A into and out of discrete microdomains of the lysosomal membrane contribute to regulate CMA...
  3. ncbi Eat your heart out
    Richard N Kitsis
    Nat Med 13:539-41. 2007
  4. ncbi Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy
    Ana Maria Cuervo
    Department of Anatomy and Structural Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Science 305:1292-5. 2004
    ..These findings may underlie the toxic gain-of-function by the mutants...
  5. ncbi Chaperone-mediated autophagy: selectivity pays off
    Ana Maria Cuervo
    Department of Developmental and Molecular Biology, Marion Bessin Liver Research Center and Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Trends Endocrinol Metab 21:142-50. 2010
    ..Prevention of the age-dependent decline in CMA has major beneficial effects on cellular and organ homeostasis and function, revealing that CMA is an essential component of the anti-aging fight...
  6. ncbi Protein degradation, aggregation, and misfolding
    Ana Maria Cuervo
    Department of Developmental and Molecular Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Mov Disord 25:S49-54. 2010
    ....
  7. ncbi Autophagy: many paths to the same end
    Ana Maria Cuervo
    Department of Anatomy and Structural Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Mol Cell Biochem 263:55-72. 2004
    ..Using the heart as an example of such cells, we analyze the relevance of autophagy in aging and cell death, as well as in different pathological conditions...
  8. ncbi Autophagy and aging: the importance of maintaining "clean" cells
    Ana Maria Cuervo
    Department of Anatomy and Structural Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Autophagy 1:131-40. 2005
    ..Dietary caloric restriction and antilipolytic agents have been proven to efficiently stimulate autophagy in old rodents. These and other possible experimental restorative efforts are discussed...
  9. ncbi Autophagy and aging: keeping that old broom working
    Ana Maria Cuervo
    Department of Developmental and Molecular Biology, Marion Bessin Liver Research Center and Institute for Aging Studies, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Ullmann B 611, Bronx, NY 10461, USA
    Trends Genet 24:604-12. 2008
    ..Here, I review the recent genetic evidence in support of tight connections between autophagy, health span and aging...
  10. ncbi Cathepsin A regulates chaperone-mediated autophagy through cleavage of the lysosomal receptor
    Ana Maria Cuervo
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    EMBO J 22:47-59. 2003
    ..In addition to the well-studied role of PPCA in targeting and protecting two lysosomal glycosidases, we have defined a role for the proteolytic activity of this multifunctional protein...
  11. ncbi Autophagy in neurons: it is not all about food
    Ana Maria Cuervo
    Department of Anatomy and Structural Biology, Marion Bassin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Trends Mol Med 12:461-4. 2006
    ..These studies provide new insights into the relationship between autophagy malfunctioning and neurodegenerative disorders...
  12. ncbi Autophagy and aging--when "all you can eat" is yourself
    Ana Maria Cuervo
    Department of Anatomy, Marion Bessin Liver Research Center of the Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Sci Aging Knowledge Environ 2003:pe25. 2003
    ..Research such as that covered in this Perspective shows that there is much more than trash to worry about when autophagy is not functioning properly...
  13. ncbi Autophagy: in sickness and in health
    Ana Maria Cuervo
    Department of Anatomy and Structural Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Ullmann B 614, Bronx, NY 10461, USA
    Trends Cell Biol 14:70-7. 2004
    ..This article reviews our current knowledge of the role of autophagy in disease and the efforts to reconcile its proposed dual function as both a cell protector and a cell killer...
  14. ncbi Protein homeostasis and aging: taking care of proteins from the cradle to the grave
    Richard I Morimoto
    Department of Developmental and Molecular Biology, Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Gerontol A Biol Sci Med Sci 64:167-70. 2009
    ..We summarize here some of the key topics and main outcomes of the discussions...
  15. ncbi Chaperone-mediated autophagy in aging and neurodegeneration: lessons from alpha-synuclein
    Urmi Bandyopadhyay
    Department of Anatomy and Structural Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Exp Gerontol 42:120-8. 2007
    ..Finally, we also comment on the effect that aggravating conditions, such as oxidative stress and aging, have on the functioning of the autophagic system and its ability to cope with altered proteins...
  16. ncbi Protein degradation and aging
    Marta Martinez-Vicente
    Department of Anatomy and Structural Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Exp Gerontol 40:622-33. 2005
    ..We discuss here, in light of the current findings, how malfunctioning of these two proteolytic systems can contribute to different aspects of the phenotype of aging and to the pathogenesis of some age-related diseases...
  17. ncbi Chasing the elusive mammalian microautophagy
    Laura Santambrogio
    Departments of Pathology, Albert Einstein College of Medicine Bronx, NY, USA
    Autophagy 7:652-4. 2011
    ....
  18. ncbi Chaperone-mediated autophagy in aging and disease
    Ashish C Massey
    Department of Anatomy and Structural Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Curr Top Dev Biol 73:205-35. 2006
    ..In this chapter, we cover current findings on the molecular mechanisms for CMA and the possible pathophysiological relevance of this selective lysosomal degradation...
  19. ncbi Chaperone-mediated autophagy
    Eloy Bejarano
    Department of Developmental and Molecular Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Am Thorac Soc 7:29-39. 2010
    ....
  20. ncbi Chaperone-mediated autophagy: molecular mechanisms and physiological relevance
    Samantha J Orenstein
    Department of Developmental and Molecular Biology, Marion Bessin Liver Research Center, Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Semin Cell Dev Biol 21:719-26. 2010
    ..Changes with age in CMA activity and the contribution of failure of CMA to the phenotype of aging and to the pathogenesis of several age-related pathologies are also described...
  21. ncbi Autophagy and neurodegeneration: when the cleaning crew goes on strike
    Marta Martinez-Vicente
    Department of Anatomy and Structural Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Lancet Neurol 6:352-61. 2007
    ....
  22. ncbi Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function
    Cong Zhang
    Department of Developmental and Molecular Biology, Marion Bessin Liver Research Center and Institute for Aging Research, 1300 Morris Park Avenue, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Nat Med 14:959-65. 2008
    ....
  23. ncbi Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy
    Marta Martinez-Vicente
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Yeshiva University, New York, New York 10461, USA
    J Clin Invest 118:777-88. 2008
    ..As blockage of CMA increases cellular vulnerability to stressors, we propose that dopamine-induced autophagic inhibition could explain the selective degeneration of PD dopaminergic neurons...
  24. ncbi Altered lipid content inhibits autophagic vesicular fusion
    Hiroshi Koga
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    FASEB J 24:3052-65. 2010
    ..Changes in the intracellular lipid content (i.e., metabolic disorders) may thus have pronounced effects on the fusion step of macroautophagy and affect the overall activity of this intracellular proteolytic pathway...
  25. ncbi Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease
    Marta Martinez-Vicente
    Department of Developmental and Molecular Biology, Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, New York, USA
    Nat Neurosci 13:567-76. 2010
    ..We propose that inefficient engulfment of cytosolic components by autophagosomes is responsible for their slower turnover, functional decay and accumulation inside HD cells...
  26. ncbi Early cellular changes after blockage of chaperone-mediated autophagy
    Ashish C Massey
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Autophagy 4:442-56. 2008
    ..Based on the time-course of the cellular changes, we propose that a minimal threshold of these toxic products needs to accumulate in order to constitutively activate macroautophagy and thus return cellular homeostasis to normal...
  27. ncbi Identification of regulators of chaperone-mediated autophagy
    Urmi Bandyopadhyay
    Department of Development and Molecular Biology, Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Mol Cell 39:535-47. 2010
    ..The dynamic interactions of these two proteins at the lysosomal membrane unveil now a role for GTP as a negative regulator of CMA...
  28. ncbi Activation of chaperone-mediated autophagy during oxidative stress
    Roberta Kiffin
    Department of Anatomy and Structural Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY 1046, USA
    Mol Biol Cell 15:4829-40. 2004
    ....
  29. ncbi Chaperone-mediated autophagy and aging: a novel regulatory role of lipids revealed
    Susmita Kaushik
    Department of Anatomy and Structural Biology, Marion Bessin Liver ResearchCenter, Institute for Aging Research, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Autophagy 3:387-9. 2007
    ....
  30. ncbi The chaperone-mediated autophagy receptor organizes in dynamic protein complexes at the lysosomal membrane
    Urmi Bandyopadhyay
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Mol Cell Biol 28:5747-63. 2008
    ..Thus, we have identified a novel function for hsc70 in the disassembly of LAMP-2A from these complexes, whereas the presence of lysosome-associated hsp90 is essential to preserve the stability of LAMP-2A at the lysosomal membrane...
  31. ncbi Entering the lysosome through a transient gate by chaperone-mediated autophagy
    Urmi Bandyopadhyay
    Department of Developmental and Molecular Biology, Marion Bessin Liver Research Center, Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY, New York 10461, USA
    Autophagy 4:1101-3. 2008
    ..The possible advantages of this transitory lysosomal translocon are discussed in light of the unique properties of the lysosomal compartment...
  32. ncbi Autophagic defects in aging: looking for an "emergency exit"?
    Ashish C Massey
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York, USA
    Cell Cycle 5:1292-6. 2006
    ....
  33. ncbi Autophagy and neurodegeneration
    Annamaria Ventruti
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Curr Neurol Neurosci Rep 7:443-51. 2007
    ....
  34. ncbi Altered dynamics of the lysosomal receptor for chaperone-mediated autophagy with age
    Roberta Kiffin
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Cell Sci 120:782-91. 2007
    ..We conclude that age-related changes at the lysosomal membrane are responsible for the altered turnover of the CMA receptor in old organisms and the consequent decline in this pathway...
  35. ncbi Pathophysiology of chaperone-mediated autophagy
    Ashish Massey
    Department of Anatomy and Structural Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Ullmann Building Room 614, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Int J Biochem Cell Biol 36:2420-34. 2004
    ..In view of these functions, we discuss the relevance of the changes in CMA activity in aging and in different pathological conditions...
  36. ncbi Constitutive activation of chaperone-mediated autophagy in cells with impaired macroautophagy
    Susmita Kaushik
    Departments of Anatomy and Structural Biology and Developmental and Molecular Biology, Marion Bessin Liver Research Center and Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Mol Biol Cell 19:2179-92. 2008
    ..This work supports a direct cross-talk between these two forms of autophagy, and it identifies changes in the lysosomal compartment that underlie the basis for the communication between both autophagic pathways...
  37. ncbi Autophagy gone awry in neurodegenerative diseases
    Esther Wong
    Department of Developmental and Molecular Biology, Marion Bessin Liver Research Center and Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, New York, USA
    Nat Neurosci 13:805-11. 2010
    ....
  38. ncbi Lysosomal chat maintains the balance
    Ashish C Massey
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Autophagy 2:325-7. 2006
    ....
  39. ncbi Consequences of the selective blockage of chaperone-mediated autophagy
    Ashish C Massey
    Department of Anatomy and Structural Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Ullmann Building, Room 611, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 103:5805-10. 2006
    ..Our results also denote the existence of cross-talk among different forms of autophagy...
  40. ncbi Chaperone-mediated autophagy in health and disease
    Maria Kon
    Department of Developmental and Molecular Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    FEBS Lett 584:1399-404. 2010
    ..Here we review the unique properties of CMA compared to other autophagic pathways and its relevance in health and disease...
  41. ncbi Methods to monitor chaperone-mediated autophagy
    Susmita Kaushik
    Department of Developmental and Molecular Biology, Marion Bessin Liver Research Center, Institute for Aging Research, Albert Einstein College of Medicine, Bronx, New York, USA
    Methods Enzymol 452:297-324. 2009
    ..In this chapter we review the different experimental approaches used to assess CMA activity both in cells in culture and in different organs from animals...
  42. ncbi Oxidative stress and autophagy
    Roberta Kiffin
    Department of Anatomy and Structural Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Antioxid Redox Signal 8:152-62. 2006
    ..The opposing roles for the lysosomal system under oxidizing conditions are discussed in this review...
  43. ncbi Autophagy regulates lipid metabolism
    Rajat Singh
    Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Nature 458:1131-5. 2009
    ..This study identifies a critical function for autophagy in lipid metabolism that could have important implications for human diseases with lipid over-accumulation such as those that comprise the metabolic syndrome...
  44. ncbi Loss of macroautophagy promotes or prevents fibroblast apoptosis depending on the death stimulus
    Yongjun Wang
    Department of Medicine, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Biol Chem 283:4766-77. 2008
    ....
  45. ncbi Inhibitory effect of intracellular lipid load on macroautophagy
    Hiroshi Koga
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA
    Autophagy 6:825-7. 2010
    ..Labeling of either membrane proteins on the surface of the organelles or dye-loading of the vesicles permits the monitoring of hemi-membrane fusion and complete vesicular fusion (cargo mixing)...
  46. ncbi Characterization of chronic low-level proteasome inhibition on neural homeostasis
    Qunxing Ding
    Department of Anatomy and Neurobiology, University of Kentucky, Lexington, Kentucky 40536 0230, USA
    J Neurochem 86:489-97. 2003
    ....
  47. ncbi Unifying nomenclature for the isoforms of the lysosomal membrane protein LAMP-2
    Eeva Liisa Eskelinen
    University of Kiel, Institute of Biochemistry, Kiel, Germany
    Traffic 6:1058-61. 2005
    ..To avoid confusion in the literature, we further propose to adopt the use of capital letters for the updated nomenclature of all the isoforms in all three species: LAMP-2A, LAMP-2B, and LAMP-2C...
  48. ncbi Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study
    Ralph A Nixon
    Center for Dementia Research, Nathan Kline Institute for Psychiatric Research, New York University School of Medicine, Orangeburg, New York 10962, USA
    J Neuropathol Exp Neurol 64:113-22. 2005
    ..The striking accumulations of immature AV forms in dystrophic neurites suggest that the transport of AVs and their maturation to lysosomes may be impaired, thereby impeding the suspected neuroprotective functions of autophagy...
  49. ncbi Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease
    W Haung Yu
    Center for Dementia Research, Nathan Kline Institute, Orangeburg, NY 10962, USA
    J Cell Biol 171:87-98. 2005
    ..Our results, therefore, link beta-amyloidogenic and cell survival pathways through macroautophagy, which is activated and is abnormal in AD...
  50. ncbi Stimulatory effect of vitamin C on autophagy in glial cells
    Antonio Martin
    Neuroscience Laboratory, HNRC on Aging, Tufts University, Boston, Massachusetts, USA
    J Neurochem 82:538-49. 2002
    ..At the doses analyzed, vitamin C lowered and stabilized the acidic intralysosomal pH at values that result in maximum activation of the lysosomal hydrolases...
  51. ncbi Methods for monitoring autophagy from yeast to human
    Daniel J Klionsky
    Life Sciences Institute and Department of Molecular, Cellular and Developmental Bioloy, University of Michigan, Ann Arbor, Michigan 48109, USA
    Autophagy 3:181-206. 2007
    ..This information is meant to provide a resource for newcomers as well as a stimulus for experienced researchers who may be prompted to develop additional assays to examine autophagy-related pathways...
  52. ncbi Disease-modifying pathways in neurodegeneration
    Steven Finkbeiner
    Gladstone Institute of Neurological Disease and Department of Physiology, University of California, San Francisco, San Francisco, California 94158, USA
    J Neurosci 26:10349-57. 2006
  53. ncbi How shall I eat thee?
    Daniel J Klionsky
    Life Sciences Institute and Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    Autophagy 3:413-6. 2007
  54. ncbi Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
    Daniel J Klionsky
    Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    Autophagy 4:151-75. 2008
    ..In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to verify an autophagic response...
  55. ncbi Autophagy fights disease through cellular self-digestion
    Noboru Mizushima
    Department of Physiology and Cell Biology, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    Nature 451:1069-75. 2008
    ..Understanding autophagy may ultimately allow scientists and clinicians to harness this process for the purpose of improving human health...
  56. ncbi Autophagy-mediated clearance of aggresomes is not a universal phenomenon
    Esther S P Wong
    Neurodegeneration Research Laboratory, National Neuroscience Institute, Singapore
    Hum Mol Genet 17:2570-82. 2008
    ..Taken together, our results demonstrate that not all aggresomes are efficiently primed for autophagic clearance and highlight a certain degree of selectivity for the supposedly non-discriminative pathway...
  57. ncbi Calorie restriction and aging: the ultimate "cleansing diet"
    Ana Maria Cuervo
    J Gerontol A Biol Sci Med Sci 63:547-9. 2008
  58. ncbi Autophagy is disrupted in a knock-in mouse model of juvenile neuronal ceroid lipofuscinosis
    Yi Cao
    Molecular Neurogenetics Unit and Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Biol Chem 281:20483-93. 2006
    ....
  59. ncbi 4th International Symposium on Autophagy: exploiting the frontiers of autophagy research
    Eeva Liisa Eskelinen
    Department of Biological and Environmental Sciences, Division of Biochemistry, University of Helsinki, Helsinki, Finland
    Autophagy 3:166-73. 2007
    ..Two themes were discussed in many sessions during the symposium: the role of autophagy in the degradation of aggregate-prone proteins and protein aggregates, and the possible role of p62 in autophagy...

Research Grants2

  1. PROTEOMIC ANALYSIS OF DECREASED AUTOPHAGY IN AGING
    Ana Cuervo; Fiscal Year: 2005
    ..abstract_text> ..
  2. Gordon Conference-Autophagy/Stress/Development/Disease
    Ana Cuervo; Fiscal Year: 2007
    ....