Ana Cuervo

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. pmc Functional interaction between autophagy and ciliogenesis
    Olatz Pampliega
    Department of Development and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Nature 502:194-200. 2013
  2. pmc Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives
    Jaime Anguiano
    Department of Development and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, USA
    Nat Chem Biol 9:374-82. 2013
  3. pmc Interplay of LRRK2 with chaperone-mediated autophagy
    Samantha J Orenstein
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, USA
    Nat Neurosci 16:394-406. 2013
  4. pmc Lipophagy: connecting autophagy and lipid metabolism
    Rajat Singh
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Int J Cell Biol 2012:282041. 2012
  5. pmc Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease
    Marta Martinez-Vicente
    Department of Developmental and Molecular Biology, Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, New York, USA
    Nat Neurosci 13:567-76. 2010
  6. pmc Autophagy, nutrition and immunology
    Ana Maria Cuervo
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Mol Aspects Med 33:2-13. 2012
  7. doi request reprint Chaperone-mediated autophagy: Dice's 'wild' idea about lysosomal selectivity
    Ana Maria Cuervo
    Department of Developmental and Molecular Biology, Marion Bessin Liver Research Center and Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Nat Rev Mol Cell Biol 12:535-41. 2011
  8. pmc Chaperone-mediated autophagy dysfunction in the pathogenesis of neurodegeneration
    Hiroshi Koga
    Department of Developmental and Molecular Biology, Institute for Aging Research, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, USA
    Neurobiol Dis 43:29-37. 2011
  9. pmc Autophagy and disease: always two sides to a problem
    Sunandini Sridhar
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Pathol 226:255-73. 2012
  10. doi request reprint Protein degradation, aggregation, and misfolding
    Ana Maria Cuervo
    Department of Developmental and Molecular Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Mov Disord 25:S49-54. 2010

Research Grants

  1. DECREASED PROTEIN DEGRADATION IN AGING
    Ana Cuervo; Fiscal Year: 2003
  2. DECREASED PROTEIN DEGRADATION IN AGING
    Ana Cuervo; Fiscal Year: 2009
  3. DECREASED PROTEIN DEGRADATION IN AGING
    Ana Cuervo; Fiscal Year: 2007
  4. DECREASED PROTEIN DEGRADATION IN AGING
    Ana Cuervo; Fiscal Year: 2007
  5. DECREASED PROTEIN DEGRADATION IN AGING
    Ana Cuervo; Fiscal Year: 2006
  6. DECREASED PROTEIN DEGRADATION IN AGING
    Ana Cuervo; Fiscal Year: 2005
  7. DECREASED PROTEIN DEGRADATION IN AGING
    Ana Cuervo; Fiscal Year: 2005
  8. DECREASED PROTEIN DEGRADATION IN AGING
    Ana Cuervo; Fiscal Year: 2004
  9. DECREASED PROTEIN DEGRADATION IN AGING
    ANA M CUERVO; Fiscal Year: 2010

Collaborators

  • Bhaskar C Das
  • Rajat Singh
  • Peter Lansbury
  • L Stefanis
  • Alexei Terman
  • Erik J Bonten
  • E Bergamini
  • JAMES DICE
  • Wulf Dröge
  • David L Sulzer
  • Hiroshi Koga
  • Sunandini Sridhar
  • Jaime Anguiano
  • Samantha J Orenstein
  • Olatz Pampliega
  • Esperanza Arias
  • Marta Martinez-Vicente
  • Eloy Bejarano
  • Etty Cortes
  • Lawrence S Honig
  • Idil Orhon
  • Isabelle Beau
  • Patrice Codogno
  • Thomas P Garner
  • Murugesan Mahalingam
  • Antonella Consiglio
  • Peter Satir
  • Evripidis Gavathiotis
  • Antonio Díaz-Carretero
  • Sheng Han Kuo
  • William Dauer
  • Bindi Patel
  • Inmaculada Tasset
  • Birgit H Satir
  • Angel Raya
  • Irene Fernandez-Carasa
  • Fernando Macian
  • Yair Botbol
  • Rosa de Vries
  • Spike Harris
  • Zsolt Talloczy
  • Guomei Tang
  • Susmita Kaushik
  • Esther Wong

Detail Information

Publications20

  1. pmc Functional interaction between autophagy and ciliogenesis
    Olatz Pampliega
    Department of Development and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Nature 502:194-200. 2013
    ..We propose that basal autophagy regulates ciliary growth through the degradation of proteins required for intraflagellar transport. Compromised ability to activate the autophagic response may underlie some common ciliopathies. ..
  2. pmc Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives
    Jaime Anguiano
    Department of Development and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, USA
    Nat Chem Biol 9:374-82. 2013
    ..We demonstrate that chemical enhancement of CMA protects cells from oxidative stress and from proteotoxicity, supporting a potential therapeutic opportunity when reduced CMA contributes to cellular dysfunction and disease...
  3. pmc Interplay of LRRK2 with chaperone-mediated autophagy
    Samantha J Orenstein
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, USA
    Nat Neurosci 16:394-406. 2013
    ..This newly described LRRK2 self-perpetuating inhibitory effect on CMA could underlie toxicity in Parkinson's disease by compromising the degradation of α-synuclein, another Parkinson's disease-related protein degraded by this pathway...
  4. pmc Lipophagy: connecting autophagy and lipid metabolism
    Rajat Singh
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Int J Cell Biol 2012:282041. 2012
    ..Defective lipophagy has been already linked to important metabolic disorders such as fatty liver, obesity and atherosclerosis, and the age-dependent decrease in autophagy could underline the basis for the metabolic syndrome of aging...
  5. pmc Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease
    Marta Martinez-Vicente
    Department of Developmental and Molecular Biology, Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, New York, USA
    Nat Neurosci 13:567-76. 2010
    ..We propose that inefficient engulfment of cytosolic components by autophagosomes is responsible for their slower turnover, functional decay and accumulation inside HD cells...
  6. pmc Autophagy, nutrition and immunology
    Ana Maria Cuervo
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Mol Aspects Med 33:2-13. 2012
    ..We describe their direct effect on autophagy and discuss how the autophagic reaction to these stimuli allows cells to accommodate the requirements of the cellular response to stress, including those specific to the immune responses...
  7. doi request reprint Chaperone-mediated autophagy: Dice's 'wild' idea about lysosomal selectivity
    Ana Maria Cuervo
    Department of Developmental and Molecular Biology, Marion Bessin Liver Research Center and Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Nat Rev Mol Cell Biol 12:535-41. 2011
    ..That scientist was J. Fred Dice, and his lifetime's discovery was the degradative pathway that we now know as chaperone-mediated autophagy...
  8. pmc Chaperone-mediated autophagy dysfunction in the pathogenesis of neurodegeneration
    Hiroshi Koga
    Department of Developmental and Molecular Biology, Institute for Aging Research, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, USA
    Neurobiol Dis 43:29-37. 2011
    ..This article is part of a Special Issue entitled "Autophagy and protein degradation in neurological diseases."..
  9. pmc Autophagy and disease: always two sides to a problem
    Sunandini Sridhar
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Pathol 226:255-73. 2012
    ....
  10. doi request reprint Protein degradation, aggregation, and misfolding
    Ana Maria Cuervo
    Department of Developmental and Molecular Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Mov Disord 25:S49-54. 2010
    ....
  11. pmc Cathepsin A regulates chaperone-mediated autophagy through cleavage of the lysosomal receptor
    Ana Maria Cuervo
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    EMBO J 22:47-59. 2003
    ..In addition to the well-studied role of PPCA in targeting and protecting two lysosomal glycosidases, we have defined a role for the proteolytic activity of this multifunctional protein...
  12. ncbi request reprint Autophagy and aging--when "all you can eat" is yourself
    Ana Maria Cuervo
    Department of Anatomy, Marion Bessin Liver Research Center of the Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Sci Aging Knowledge Environ 2003:pe25. 2003
    ..Research such as that covered in this Perspective shows that there is much more than trash to worry about when autophagy is not functioning properly...
  13. ncbi request reprint Autophagy: in sickness and in health
    Ana Maria Cuervo
    Department of Anatomy and Structural Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Ullmann B 614, Bronx, NY 10461, USA
    Trends Cell Biol 14:70-7. 2004
    ..This article reviews our current knowledge of the role of autophagy in disease and the efforts to reconcile its proposed dual function as both a cell protector and a cell killer...
  14. ncbi request reprint Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy
    Ana Maria Cuervo
    Department of Anatomy and Structural Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Science 305:1292-5. 2004
    ..These findings may underlie the toxic gain-of-function by the mutants...
  15. ncbi request reprint Autophagy: many paths to the same end
    Ana Maria Cuervo
    Department of Anatomy and Structural Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Mol Cell Biochem 263:55-72. 2004
    ..Using the heart as an example of such cells, we analyze the relevance of autophagy in aging and cell death, as well as in different pathological conditions...
  16. ncbi request reprint Autophagy and aging: the importance of maintaining "clean" cells
    Ana Maria Cuervo
    Department of Anatomy and Structural Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Autophagy 1:131-40. 2005
    ..Dietary caloric restriction and antilipolytic agents have been proven to efficiently stimulate autophagy in old rodents. These and other possible experimental restorative efforts are discussed...
  17. ncbi request reprint Autophagy in neurons: it is not all about food
    Ana Maria Cuervo
    Department of Anatomy and Structural Biology, Marion Bassin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Trends Mol Med 12:461-4. 2006
    ..These studies provide new insights into the relationship between autophagy malfunctioning and neurodegenerative disorders...
  18. pmc Autophagy and aging: keeping that old broom working
    Ana Maria Cuervo
    Department of Developmental and Molecular Biology, Marion Bessin Liver Research Center and Institute for Aging Studies, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Ullmann B 611, Bronx, NY 10461, USA
    Trends Genet 24:604-12. 2008
    ..Here, I review the recent genetic evidence in support of tight connections between autophagy, health span and aging...
  19. pmc Chaperone-mediated autophagy: selectivity pays off
    Ana Maria Cuervo
    Department of Developmental and Molecular Biology, Marion Bessin Liver Research Center and Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Trends Endocrinol Metab 21:142-50. 2010
    ..Prevention of the age-dependent decline in CMA has major beneficial effects on cellular and organ homeostasis and function, revealing that CMA is an essential component of the anti-aging fight...
  20. pmc Chaperone-mediated autophagy
    Eloy Bejarano
    Department of Developmental and Molecular Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Am Thorac Soc 7:29-39. 2010
    ....

Research Grants11

  1. DECREASED PROTEIN DEGRADATION IN AGING
    Ana Cuervo; Fiscal Year: 2003
    ..If only a partial restoration is attained, we will combine in the future similar restorative attempts for any other defective component(s) identified through this project. ..
  2. DECREASED PROTEIN DEGRADATION IN AGING
    Ana Cuervo; Fiscal Year: 2009
    ....
  3. DECREASED PROTEIN DEGRADATION IN AGING
    Ana Cuervo; Fiscal Year: 2007
    ..If only a partial restoration is attained, we will combine in the future similar restorative attempts for any other defective component(s) identified through this project. ..
  4. DECREASED PROTEIN DEGRADATION IN AGING
    Ana Cuervo; Fiscal Year: 2007
    ..If only a partial restoration is attained, we will combine in the future similar restorative attempts for any other defective component(s) identified through this project. ..
  5. DECREASED PROTEIN DEGRADATION IN AGING
    Ana Cuervo; Fiscal Year: 2006
    ..If only a partial restoration is attained, we will combine in the future similar restorative attempts for any other defective component(s) identified through this project. ..
  6. DECREASED PROTEIN DEGRADATION IN AGING
    Ana Cuervo; Fiscal Year: 2005
    ..If only a partial restoration is attained, we will combine in the future similar restorative attempts for any other defective component(s) identified through this project. ..
  7. DECREASED PROTEIN DEGRADATION IN AGING
    Ana Cuervo; Fiscal Year: 2005
    ..If only a partial restoration is attained, we will combine in the future similar restorative attempts for any other defective component(s) identified through this project. ..
  8. DECREASED PROTEIN DEGRADATION IN AGING
    Ana Cuervo; Fiscal Year: 2004
    ..If only a partial restoration is attained, we will combine in the future similar restorative attempts for any other defective component(s) identified through this project. ..
  9. DECREASED PROTEIN DEGRADATION IN AGING
    ANA M CUERVO; Fiscal Year: 2010
    ....