S M Crain

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. doi request reprint Low doses of cyclic AMP-phosphodiesterase inhibitors rapidly evoke opioid receptor-mediated thermal hyperalgesia in naïve mice which is converted to prominent analgesia by cotreatment with ultra-low-dose naltrexone
    Stanley M Crain
    Department of Neuroscience, Albert Einstein College of Medicine, Yeshiva University, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Brain Res 1231:16-24. 2008
  2. ncbi request reprint Naloxone rapidly evokes endogenous kappa opioid receptor-mediated hyperalgesia in naïve mice pretreated briefly with GM1 ganglioside or in chronic morphine-dependent mice
    Stanley M Crain
    Department of Neuroscience, Albert Einstein College of Medicine, Yeshiva University, 1300 Morris Park Ave Bronx, NY 10461, USA
    Brain Res 1167:31-41. 2007
  3. ncbi request reprint Neuraminidase inhibitor, oseltamivir blocks GM1 ganglioside-regulated excitatory opioid receptor-mediated hyperalgesia, enhances opioid analgesia and attenuates tolerance in mice
    Stanley M Crain
    Department of Neuroscience, Albert Einstein College of Medicine, Yeshiva University, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Brain Res 995:260-6. 2004
  4. ncbi request reprint Acute thermal hyperalgesia elicited by low-dose morphine in normal mice is blocked by ultra-low-dose naltrexone, unmasking potent opioid analgesia
    S M Crain
    Department of Neuroscience, Albert Einstein College of Medicine, Yeshiva University, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Brain Res 888:75-82. 2001
  5. ncbi request reprint Enhanced analgesic potency and reduced tolerance of morphine in 129/SvEv mice: evidence for a deficiency in GM1 ganglioside-regulated excitatory opioid receptor functions
    S M Crain
    Department of Neuroscience, Albert Einstein College of Medicine, Yeshiva University, 1300 Morris Park Ave, Bronx, NY, USA
    Brain Res 856:227-35. 2000
  6. ncbi request reprint Antagonists of excitatory opioid receptor functions enhance morphine's analgesic potency and attenuate opioid tolerance/dependence liability
    S M Crain
    Department of Neuroscience, Albert Einstein College of Medicine, Yeshiva University, Bronx, New York, USA
    Pain 84:121-31. 2000
  7. ncbi request reprint GM1 ganglioside-induced modulation of opioid receptor-mediated functions
    S M Crain
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Ann N Y Acad Sci 845:106-25. 1998
  8. ncbi request reprint Cholera toxin-B subunit blocks excitatory opioid receptor-mediated hyperalgesic effects in mice, thereby unmasking potent opioid analgesia and attenuating opioid tolerance/dependence
    K F Shen
    Department of Neuroscience, Albert Einstein College of Medicine, Yeshiva University, 1300 Morris Park Ave. Bronx, NY 10461, USA
    Brain Res 919:20-30. 2001
  9. pmc Direct coupling of opioid receptors to both stimulatory and inhibitory guanine nucleotide-binding proteins in F-11 neuroblastoma-sensory neuron hybrid cells
    R A Cruciani
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461
    Proc Natl Acad Sci U S A 90:3019-23. 1993
  10. ncbi request reprint Nerve growth factor rapidly prolongs the action potential of mature sensory ganglion neurons in culture, and this effect requires activation of Gs-coupled excitatory kappa-opioid receptors on these cells
    K F Shen
    Department of Neuroscience, Albert Einstein College of Medicine, Yeshiva University, Bronx, New York 10461
    J Neurosci 14:5570-9. 1994

Collaborators

  • K F Shen
  • R A Cruciani
  • M H Makman
  • B Dvorkin
  • S A Morris

Detail Information

Publications10

  1. doi request reprint Low doses of cyclic AMP-phosphodiesterase inhibitors rapidly evoke opioid receptor-mediated thermal hyperalgesia in naïve mice which is converted to prominent analgesia by cotreatment with ultra-low-dose naltrexone
    Stanley M Crain
    Department of Neuroscience, Albert Einstein College of Medicine, Yeshiva University, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Brain Res 1231:16-24. 2008
    ..The present study provides a novel pharmacologic paradigm that may facilitate development of valuable non-narcotic clinical analgesics utilizing cotreatment with ultra-low-dose rolipram plus ultra-low-dose NTX or related agents...
  2. ncbi request reprint Naloxone rapidly evokes endogenous kappa opioid receptor-mediated hyperalgesia in naïve mice pretreated briefly with GM1 ganglioside or in chronic morphine-dependent mice
    Stanley M Crain
    Department of Neuroscience, Albert Einstein College of Medicine, Yeshiva University, 1300 Morris Park Ave Bronx, NY 10461, USA
    Brain Res 1167:31-41. 2007
    ..These studies may clarify complex mechanisms underlying opioid physical dependence and opioid addiction...
  3. ncbi request reprint Neuraminidase inhibitor, oseltamivir blocks GM1 ganglioside-regulated excitatory opioid receptor-mediated hyperalgesia, enhances opioid analgesia and attenuates tolerance in mice
    Stanley M Crain
    Department of Neuroscience, Albert Einstein College of Medicine, Yeshiva University, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Brain Res 995:260-6. 2004
    ....
  4. ncbi request reprint Acute thermal hyperalgesia elicited by low-dose morphine in normal mice is blocked by ultra-low-dose naltrexone, unmasking potent opioid analgesia
    S M Crain
    Department of Neuroscience, Albert Einstein College of Medicine, Yeshiva University, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Brain Res 888:75-82. 2001
    ..This low-dose-morphine cotreatment procedure should markedly attenuate morphine tolerance, dependence and other aversive side-effects...
  5. ncbi request reprint Enhanced analgesic potency and reduced tolerance of morphine in 129/SvEv mice: evidence for a deficiency in GM1 ganglioside-regulated excitatory opioid receptor functions
    S M Crain
    Department of Neuroscience, Albert Einstein College of Medicine, Yeshiva University, 1300 Morris Park Ave, Bronx, NY, USA
    Brain Res 856:227-35. 2000
    ..The present study may provide insights into factors that regulate the marked variability in nociceptive sensitivity and opioid tolerance/dependence liability among individual humans...
  6. ncbi request reprint Antagonists of excitatory opioid receptor functions enhance morphine's analgesic potency and attenuate opioid tolerance/dependence liability
    S M Crain
    Department of Neuroscience, Albert Einstein College of Medicine, Yeshiva University, Bronx, New York, USA
    Pain 84:121-31. 2000
    ....
  7. ncbi request reprint GM1 ganglioside-induced modulation of opioid receptor-mediated functions
    S M Crain
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Ann N Y Acad Sci 845:106-25. 1998
    ....
  8. ncbi request reprint Cholera toxin-B subunit blocks excitatory opioid receptor-mediated hyperalgesic effects in mice, thereby unmasking potent opioid analgesia and attenuating opioid tolerance/dependence
    K F Shen
    Department of Neuroscience, Albert Einstein College of Medicine, Yeshiva University, 1300 Morris Park Ave. Bronx, NY 10461, USA
    Brain Res 919:20-30. 2001
    ..Furthermore, chronic cotreatment of mice with morphine plus CTX-B attenuates development of opioid tolerance and physical dependence, as previously shown to occur during cotreatment with low-dose NTX...
  9. pmc Direct coupling of opioid receptors to both stimulatory and inhibitory guanine nucleotide-binding proteins in F-11 neuroblastoma-sensory neuron hybrid cells
    R A Cruciani
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461
    Proc Natl Acad Sci U S A 90:3019-23. 1993
    ..This Gs-adenylate cyclase interaction is postulated to be responsible for the novel excitatory electrophysiologic responses to opioids found in our previous studies of sensory neurons and F-11 cells...
  10. ncbi request reprint Nerve growth factor rapidly prolongs the action potential of mature sensory ganglion neurons in culture, and this effect requires activation of Gs-coupled excitatory kappa-opioid receptors on these cells
    K F Shen
    Department of Neuroscience, Albert Einstein College of Medicine, Yeshiva University, Bronx, New York 10461
    J Neurosci 14:5570-9. 1994
    ..These in vitro studies suggest that excitatory opioid receptor-mediated functions may play a role in mediating some types of rapid NGF-induced hyperalgesic and other physiologic effects on the nervous system...