Affiliation: Albert Einstein College of Medicine
- Single molecule profiling of tau gene expression in Alzheimer's diseaseChris Conrad
Department of Neurology, MassGeneral Institute for Neurodegenerative Disease MIND, Charlestown, Massachusetts, USA
J Neurochem 103:1228-36. 2007..Furthermore, splicing-based therapeutics is an emerging area of drug development, and a well-defined and quantitative assay for monitoring single-gene transcriptome will be relevant for such development...
- A polymorphic gene nested within an intron of the tau gene: implications for Alzheimer's diseaseChris Conrad
Department of Pathology, F526, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
Proc Natl Acad Sci U S A 99:7751-6. 2002..The Q7R polymorphism appears to be over-represented in the homozygous state in late onset Alzheimer's disease subjects...
- Molecular evolution and genetics of the Saitohin gene and tau haplotype in Alzheimer's disease and argyrophilic grain diseaseChris Conrad
Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA
J Neurochem 89:179-88. 2004..More detailed studies confirm the H2 haplotype to be the ancestral tau gene. This situation is reminiscent of the evolution of the apolipoprotein (ApoE) gene, another locus that is potentially important for the risk of development of AD...