G J Christ

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. ncbi Gap junctions and ion channels: relevance to erectile dysfunction
    G J Christ
    Department of Urology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx NY 10461, USA
    Int J Impot Res 12:S15-25. 2000
  2. ncbi Gene therapy for erectile dysfunction: where is it going?
    George J Christ
    Department of Urology, Institute for Smooth Muscle Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Curr Opin Urol 12:497-501. 2002
  3. ncbi Increased connexin43-mediated intercellular communication in a rat model of bladder overactivity in vivo
    George J Christ
    Departments of Urology and Physiology and Biophysics, Institute for Smooth Muscle Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Physiol Regul Integr Comp Physiol 284:R1241-8. 2003
  4. ncbi K channels as molecular targets for the treatment of erectile dysfunction
    George J Christ
    Department of Urology, Institute for Smooth Muscle Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Androl 23:S10-9. 2002
  5. ncbi Gene therapy treatments for erectile and bladder dysfunction
    George J Christ
    Departments of Urology and Physiology and Biophysics, Institute for Smooth Muscle Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Curr Urol Rep 5:52-60. 2004
  6. ncbi Gene therapy: future therapy for erectile dysfunction
    G Schenk
    Institute for Smooth Muscle Biology, Department of Urology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Curr Urol Rep 2:480-7. 2001
  7. ncbi Physiology and biochemistry of erections
    George J Christ
    Departments of Urology and Physiology and Biophysics, Institute for Smooth Muscle Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Endocrine 23:93-100. 2004
  8. ncbi Intracorporal injection of hSlo cDNA restores erectile capacity in STZ-diabetic F-344 rats in vivo
    George J Christ
    Department of Urology, Institute for Smooth Muscle Biology, Rm 744, Forchheimer Bldg, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461
    Am J Physiol Heart Circ Physiol 287:H1544-53. 2004
  9. ncbi Bladder injection of "naked" hSlo/pcDNA3 ameliorates detrusor hyperactivity in obstructed rats in vivo
    G J Christ
    Department of Urology, Institute for Smooth Muscle Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Physiol Regul Integr Comp Physiol 281:R1699-709. 2001
  10. ncbi Analysis of the presence and physiological relevance of subconducting states of Connexin43-derived gap junction channels in cultured human corporal vascular smooth muscle cells
    G J Christ
    Departments of Urology and Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, NY, USA
    Circ Res 84:797-803. 1999

Collaborators

Detail Information

Publications46

  1. ncbi Gap junctions and ion channels: relevance to erectile dysfunction
    G J Christ
    Department of Urology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx NY 10461, USA
    Int J Impot Res 12:S15-25. 2000
    ..International Journal of Impotence Research (2000) 12, Suppl 4, S15-S25...
  2. ncbi Gene therapy for erectile dysfunction: where is it going?
    George J Christ
    Department of Urology, Institute for Smooth Muscle Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Curr Opin Urol 12:497-501. 2002
    ..The implications of these findings in the field of gene therapy in general, and more specifically to the treatment of non-life threatening disorders such as erectile dysfunction, will be outlined...
  3. ncbi Increased connexin43-mediated intercellular communication in a rat model of bladder overactivity in vivo
    George J Christ
    Departments of Urology and Physiology and Biophysics, Institute for Smooth Muscle Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Physiol Regul Integr Comp Physiol 284:R1241-8. 2003
    ....
  4. ncbi K channels as molecular targets for the treatment of erectile dysfunction
    George J Christ
    Department of Urology, Institute for Smooth Muscle Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Androl 23:S10-9. 2002
  5. ncbi Gene therapy treatments for erectile and bladder dysfunction
    George J Christ
    Departments of Urology and Physiology and Biophysics, Institute for Smooth Muscle Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Curr Urol Rep 5:52-60. 2004
    ....
  6. ncbi Gene therapy: future therapy for erectile dysfunction
    G Schenk
    Institute for Smooth Muscle Biology, Department of Urology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Curr Urol Rep 2:480-7. 2001
    ..If similar success is obtained in clinical trials, gene therapy for erectile dysfunction may provide the first concrete "proof of concept" for using gene therapy in the treatment of human smooth muscle disorders...
  7. ncbi Physiology and biochemistry of erections
    George J Christ
    Departments of Urology and Physiology and Biophysics, Institute for Smooth Muscle Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Endocrine 23:93-100. 2004
    ..This article reviews fundamental aspects of the physiology of erection and summarizes the most recent information available concerning the putative biochemical correlates of these physiologic events...
  8. ncbi Intracorporal injection of hSlo cDNA restores erectile capacity in STZ-diabetic F-344 rats in vivo
    George J Christ
    Department of Urology, Institute for Smooth Muscle Biology, Rm 744, Forchheimer Bldg, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461
    Am J Physiol Heart Circ Physiol 287:H1544-53. 2004
    ..Taken together, these observations suggest a fundamental diabetes-related change in corporal myocyte maxi-K channel regulation, expression, or function that may be corrected by expression of recombinant hSlo...
  9. ncbi Bladder injection of "naked" hSlo/pcDNA3 ameliorates detrusor hyperactivity in obstructed rats in vivo
    G J Christ
    Department of Urology, Institute for Smooth Muscle Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Physiol Regul Integr Comp Physiol 281:R1699-709. 2001
    ..These initial observations indicate a potential utility of gene therapy for urinary incontinence...
  10. ncbi Analysis of the presence and physiological relevance of subconducting states of Connexin43-derived gap junction channels in cultured human corporal vascular smooth muscle cells
    G J Christ
    Departments of Urology and Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, NY, USA
    Circ Res 84:797-803. 1999
    ..Under these conditions, our data clearly indicate that despite their greater frequency, the duration of subconductance events is so short relative to the main state duration as to render them physiologically insignificant...
  11. ncbi Further evidence for the selective disruption of intercellular communication by heptanol
    G J Christ
    Laboratory of Molecular and Integrative Urology, Department of Urology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Am J Physiol 276:H1911-7. 1999
    ..These data extend our previous observations to further document the potential utility of heptanol as a "relatively selective" uncoupling agent...
  12. ncbi Gap junctions in isolated rat aorta: evidence for contractile responses that exhibit a differential dependence on intercellular communication
    G J Christ
    Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Braz J Med Biol Res 33:423-9. 2000
    ..01); further increasing the heptanol concentration to 2 mM had no additional effect. In rat aorta then, junctional modulation of tissue contractility appears to be agonist-dependent...
  13. ncbi Gap junctions in vascular tissues. Evaluating the role of intercellular communication in the modulation of vasomotor tone
    G J Christ
    Department of Urology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Circ Res 79:631-46. 1996
    ....
  14. ncbi Integrative erectile biology. The effects of age and disease on gap junctions and ion channels and their potential value to the treatment of erectile dysfunction
    A Melman
    Department of Urology, Institute for Smooth Muscle Biology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York, USA
    Urol Clin North Am 28:217-31, vii. 2001
    ....
  15. ncbi Central modulation of the NO/cGMP pathway affects the MPOA-induced intracavernous pressure response
    Y Sato
    Department of Urology, Institute for Smooth Muscle Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Physiol Regul Integr Comp Physiol 281:R269-78. 2001
    ..These data clearly indicate that intrathecal drug administration affects central and not peripheral neural mechanisms and, moreover, documents that CNS NO/cGMP levels can affect erectile capacity per se (i.e., ICP) in the rat model...
  16. ncbi Potassium channels and human corporeal smooth muscle cell tone: diabetes and relaxation of human corpus cavernosum smooth muscle by adenosine triphosphate sensitive potassium channel openers
    K Venkateswarlu
    Department of Urology, Institute of Smooth Muscle Biology, Albert Einstein College of Medicine, The Bronx, New York, USA
    J Urol 168:355-61. 2002
    ..We also evaluated the possibility that there may be alterations in adenosine triphosphate sensitive K channel pharmacology/function related to the presence of diabetes mellitus...
  17. ncbi The successful long-term treatment of age related erectile dysfunction with hSlo cDNA in rats in vivo
    A Melman
    Department of Urology, Institute for Smooth Muscle Biology, Montefiore Medical Center, Albert Einstein College of Medicine, 3400 Bainbridge Avenue, Bronx, NY, USA
    J Urol 170:285-90. 2003
    ..We report our further investigations of the amplitude, duration and physiological relevance of this novel gene transfer approach...
  18. ncbi Intercellular communication in cultured human vascular smooth muscle cells
    H Z Wang
    Department of Urology, Institute for Smooth Muscle Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Physiol Cell Physiol 281:C75-88. 2001
    ..As such, it is conceivable that the presence and coexpression of Cx40 and Cx43 in IMA and SV myocytes may result in heteromeric channel formation. Nonetheless, in terms of gating, Cx43-like behavior clearly dominates...
  19. ncbi Significant physiological roles of ancillary penile nerves on increase in intracavernous pressure in rats: experiments using electrical stimulation of the medial preoptic area
    Y Sato
    Department of Urology, Institute for Smooth Muscle Biology, Albert Einstein College of Medicine, Bronx, New York, USA
    Int J Impot Res 13:82-8. 2001
    ..These data suggested that the ancillary penile nerves, which originate from the major pelvic ganglia, have a complementary role to the cavernous nerves in the autonomic motor innervation of the penis...
  20. doi Gene transfer with a vector expressing Maxi-K from a smooth muscle-specific promoter restores erectile function in the aging rat
    A Melman
    Department of Urology, Institute for Smooth Muscle Biology, Albert Einstein College of Medicine, Bronx, NY 10467, USA
    Gene Ther 15:364-70. 2008
    ..These data confirm and extend previous observations to document that smooth muscle cell-specific expression of hSlo in corporal tissue is both necessary and sufficient to restore erectile function in aging rats...
  21. ncbi Mutual-effect amplification of contractile responses elicited by simultaneous activation of alpha-1 adrenergic and 5-hydroxytryptamine2 receptors in isolated rat aorta
    G J Christ
    Department of Urology, Albert Einstein College of Medicine, Bronx, New York
    J Pharmacol Exp Ther 256:553-61. 1991
    ..This represents the first time a mathematical model has been used to accurately predict the outcome of coactivation of the alpha-1 and 5-HT2 receptors.(ABSTRACT TRUNCATED AT 250 WORDS)..
  22. ncbi Frontiers in gene therapy for erectile dysfunction
    G J Christ
    Department of Urology, Albert Einstein College of Medicine, Bronx, New York 10461
    Int J Impot Res 15:S33-40. 2003
    ..In fact, the potential benefits of the application of gene transfer techniques to this important medical problem is just now beginning to be appreciated/recognized...
  23. ncbi The physiology, pathophysiology and therapeutic potential of gap junctions in smooth muscle
    G Lagaud
    Department of Urology, Institute for Smooth Muscle Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Curr Drug Targets 3:427-40. 2002
    ..Such strategies have proved efficacious for the treatment of a wide range of human smooth muscle disorders including hypertension, urinary incontinence and sexual function...
  24. ncbi Physiological roles for K+ channels and gap junctions in urogenital smooth muscle: implications for improved understanding of urogenital function, disease and therapy
    V Karicheti
    Dept of Urology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Curr Drug Targets 2:1-20. 2001
    ....
  25. ncbi Inhibitors of gap junctions attenuate myogenic tone in cerebral arteries
    Guy Lagaud
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, Canada
    Am J Physiol Heart Circ Physiol 283:H2177-86. 2002
    ..These data indicate that gap junctions play an important role in the maintenance and modulation of membrane potential and tone in cerebral resistance arteries...
  26. pmc Trypanosoma cruzi infection induces proliferation of vascular smooth muscle cells
    Ghada S Hassan
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Infect Immun 74:152-9. 2006
    ..Taken together, these data suggest that T. cruzi infection stimulates smooth muscle cell proliferation and is likely a result of the upregulation of the ERK-cyclin D1-endothelin-1 pathway...
  27. ncbi Experimental diabetes alters connexin43 derived gap junction permeability in short-term cultures of rat corporeal vascular smooth muscle cells
    Peter R Brink
    Department of Physiology and Biophysics and Institute for Molecular Cardiology, State University of New York at Stony Brook, Stony Brook, USA
    J Urol 175:381-6. 2006
    ..Intercellular communication through gap junctions was assessed in 8 to 10-week STZ diabetic rats to evaluate diabetes related effects on gap junctional conductance and permeability in short-term cultures of corporeal myocytes...
  28. pmc Molecular mechanisms of detrusor and corporal myocyte contraction: identifying targets for pharmacotherapy of bladder and erectile dysfunction
    George J Christ
    Wake Forest Institute for Regenerative Medicine, Wake Forest University Baptist Medical Center, Winston Salem, NC 27157, USA
    Br J Pharmacol 147:S41-55. 2006
    ....
  29. ncbi Effects of streptozotocin-induced diabetes on bladder and erectile (dys)function in the same rat in vivo
    George J Christ
    Department of Regenerative Medicine, Wake Forest University Baptist Medical Center, Winston Salem, NC 27157, USA
    BJU Int 97:1076-82. 2006
    ....
  30. ncbi Gap junction channel activity in short-term cultured human detrusor myocyte cell pairs: gating and unitary conductances
    H Z Wang
    Department of Urology, Albert Einstein College of Medicine, Bronx
    Am J Physiol Cell Physiol 291:C1366-76. 2006
    ..These data confirm and extend previous observations and are consistent with reports in other smooth muscle cells types in which Cx43-mediated intercellular communication has been identified...
  31. pmc Diabetes-induced changes in the alternative splicing of the slo gene in corporal tissue
    Kelvin P Davies
    Department of Urology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Eur Urol 52:1229-37. 2007
    ..Therefore, we determined whether diabetes induces changes in the splicing of the Slo gene relevant to erectile function...
  32. pmc Using gene chips to identify organ-specific, smooth muscle responses to experimental diabetes: potential applications to urological diseases
    Jason D Hipp
    Wake Forest Institute for Regenerative Medicine, Winston Salem, NC 27157, USA
    BJU Int 99:418-30. 2007
    ....
  33. ncbi siRNA for erectile dysfunction
    George J Christ
    J Urol 174:819. 2005
  34. pmc Role of endothelin 1 in the pathogenesis of chronic chagasic heart disease
    Herbert B Tanowitz
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Infect Immun 73:2496-503. 2005
    ..These data provide further evidence of a role for ET-1, particularly cardiac myocyte-derived ET-1, in the pathogenesis of chronic Chagasic cardiomyopathy...
  35. doi Effects of long-term dietary soy treatment on female urethral morphology and function in ovariectomized nonhuman primates
    Christian Gratzke
    Wake Forest Institute for Regenerative Medicine, Wake Forest University, Winston Salem, North Carolina 27157, USA
    J Urol 180:2247-53. 2008
    ..Whether such effects can be achieved by soy based phytoestrogen diets is unclear. We studied the effects of chronic phytoestrogen treatment on the structural and functional properties of the urethra in ovariectomized monkeys...
  36. ncbi Potassium channels and human corporeal smooth muscle cell tone: further evidence of the physiological relevance of the Maxi-K channel subtype to the regulation of human corporeal smooth muscle tone in vitro
    Mariya Spektor
    Department of Urology, Institute for Smooth Muscle Biology, Albert Einstein College of Medicine, Bronx, NY, USA
    J Urol 167:2628-35. 2002
    ..We further clarified the contribution of the Maxi-K channel subtype to the generation of contractile responses in isolated human corporeal tissue strips...
  37. ncbi Cardioprotective effects of phosphoramidon on myocardial structure and function in murine Chagas' disease
    Linda A Jelicks
    Department of Physiology and Biophysics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Int J Parasitol 32:1497-506. 2002
    ....
  38. ncbi Phosphoramidon treatment improves the consequences of chagasic heart disease in mice
    Linda A Jelicks
    Department of Physiology and Biophysics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, U S A
    Clin Sci (Lond) 103:267S-271S. 2002
    ..These data are consistent with the hypothesis that ET-1 contributes to the pathogenesis of murine chagasic cardiomyopathy and suggests that interventions targeting ET-1 would improve the outcome in chagasic heart disease...
  39. ncbi The hemodynamics of erection and the pharmacotherapies of erectile dysfunction
    Arnold Melman
    Department of Urology, Albert Einstein College of Medicine Montefiore Medical Center, Bronx, New York, USA
    Heart Dis 4:252-64. 2002
    ..Improved mechanism-based, perhaps patient-specific therapies are foreseen that will dramatically increase the number of patients seeking treatment, as well as the quality of their lives...
  40. pmc Proteomics analysis identifies molecular targets related to diabetes mellitus-associated bladder dysfunction
    Elizabeth Yohannes
    Case Center for Proteomics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Mol Cell Proteomics 7:1270-85. 2008
    ....
  41. ncbi Effects of fidarestat, an aldose reductase inhibitor, on nerve conduction velocity and bladder function in streptozotocin-treated female rats
    Elena G Zotova
    Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10461, USA
    J Diabetes Complications 21:187-95. 2007
    ..Possible explanations for this dissociation are discussed...
  42. ncbi Caveolin-3 knock-out mice develop a progressive cardiomyopathy and show hyperactivation of the p42/44 MAPK cascade
    Scott E Woodman
    Department of Molecular Pharmacology, Division of Hormone Dependent Tumor Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 277:38988-97. 2002
    ..Taken together, our data argue that loss of Cav-3 expression is sufficient to induce a molecular program leading to cardiac myocyte hypertrophy and cardiomyopathy...
  43. ncbi Urogenital alterations in aged male caveolin-1 knockout mice
    Scott E Woodman
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Urol 171:950-7. 2004
    ..Because only smooth muscle contains all caveolin (Cav) family members (Cav-1, 2 and 3), we examined the contribution of each caveolin to urogenital smooth muscle structure/function...
  44. ncbi Intercellular communication and bladder function
    George J Christ
    Department of Urology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Adv Exp Med Biol 539:239-54. 2003
    ....
  45. pmc Caveolin-2-deficient mice show evidence of severe pulmonary dysfunction without disruption of caveolae
    Babak Razani
    Department of Molecular Pharmacology, Institute for Smooth Muscle Biology, The Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Mol Cell Biol 22:2329-44. 2002
    ..Taken together, our data show for the first time a specific role for caveolin-2 in mammalian physiology independent of caveolin-1...
  46. ncbi Proceedings of the Baltimore smooth muscle meeting: identifying research frontiers and priorities for the lower urinary tract
    George J Christ
    Department of Urology, Wake Forest Institute for Regenerative Medicine, Wake Forest University, Winston Salem, North Carolina 27157, USA
    J Urol 173:1406-9. 2005
    ..LUT diseases/disorders will continue to increase in an ever aging American population. The purpose of the Baltimore Smooth Muscle Meeting was to begin to identify some research frontiers and priorities...