Arturo Casadevall

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. pmc A requirement for FcγR in antibody-mediated bacterial toxin neutralization
    Nareen Abboud
    Department of Microbiology and Immunology, Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Exp Med 207:2395-405. 2010
  2. pmc Phospholipids trigger Cryptococcus neoformans capsular enlargement during interactions with amoebae and macrophages
    Cara J Chrisman
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS Pathog 7:e1002047. 2011
  3. doi request reprint The intracellular life of Cryptococcus neoformans
    Carolina Coelho
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Yeshiva University, Bronx, New York 10461 email
    Annu Rev Pathol 9:219-38. 2014
  4. doi request reprint Is the Nobel Prize good for science?
    Arturo Casadevall
    1Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461 USA
    FASEB J 27:4682-90. 2013
  5. pmc Immunoglobulins in defense, pathogenesis, and therapy of fungal diseases
    Arturo Casadevall
    Department of Microbiology and Immunology and Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Cell Host Microbe 11:447-56. 2012
  6. pmc Fungal melanins differ in planar stacking distances
    Arturo Casadevall
    Department of Microbiology and Immunology, Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 7:e30299. 2012
  7. pmc Radioimmunotherapy of experimental head and neck squamous cell carcinoma (HNSCC) with E6-specific antibody using a novel HPV-16 positive HNSCC cell line
    Matthew Harris
    Department of Nuclear Medicine, Albert Einstein College of Medicine, Albert Einstein Cancer Center, Bronx, New York, USA
    Head Neck Oncol 3:9. 2011
  8. doi request reprint Amoeba provide insight into the origin of virulence in pathogenic fungi
    Arturo Casadevall
    Departments of Microbiology and Immunology and Medicine Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Adv Exp Med Biol 710:1-10. 2012
  9. pmc Destruction of microbial collections in response to select agent and toxin list regulations
    Arturo Casadevall
    Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Biosecur Bioterror 8:151-4. 2010
  10. pmc A new synthesis for antibody-mediated immunity
    Arturo Casadevall
    Arturo Casadevall and Liise anne Pirofski are in the Department of Microbiology and Immunology and Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA
    Nat Immunol 13:21-8. 2012

Research Grants

  1. PROTECTIVE ANTIBODIES FOR CRYPTOCOCCAL INFECTIONS
    Arturo Casadevall; Fiscal Year: 2005
  2. PROTECTIVE ANTIBODIES FOR CRYPTOCOCCAL INFECTIONS
    Arturo Casadevall; Fiscal Year: 2006
  3. Biology of Fungal Melanin
    Arturo Casadevall; Fiscal Year: 2006
  4. SYNERGY OF HOST DEFENSE MECHANISMS IN LUNG
    Arturo Casadevall; Fiscal Year: 2005
  5. PROTECTIVE ANTIBODIES FOR CRYPTOCOCCAL INFECTIONS
    Arturo Casadevall; Fiscal Year: 2005
  6. SYNERGY OF HOST DEFENSE MECHANISMS IN LUNG
    Arturo Casadevall; Fiscal Year: 2003
  7. PROTECTIVE ANTIBODIES FOR CRYPTOCOCCAL INFECTIONS
    Arturo Casadevall; Fiscal Year: 2004
  8. SYNERGY OF HOST DEFENSE MECHANISMS IN LUNG
    Arturo Casadevall; Fiscal Year: 2006
  9. Biology of Fungal Melanin
    Arturo Casadevall; Fiscal Year: 2007
  10. Biology of Fungal Melanin
    Arturo Casadevall; Fiscal Year: 2010

Collaborators

Detail Information

Publications113 found, 100 shown here

  1. pmc A requirement for FcγR in antibody-mediated bacterial toxin neutralization
    Nareen Abboud
    Department of Microbiology and Immunology, Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Exp Med 207:2395-405. 2010
    ..These findings highlight a new parameter for evaluating vaccine responses and the possibility of harnessing optimal FcγR interactions in the design of passive immunization strategies...
  2. pmc Phospholipids trigger Cryptococcus neoformans capsular enlargement during interactions with amoebae and macrophages
    Cara J Chrisman
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS Pathog 7:e1002047. 2011
    ..neoformans to both amoebae and macrophages provide additional support for the notion that certain aspects of cryptococcal virulence emerged as a consequence of environmental interactions with other microorganisms such as protists...
  3. doi request reprint The intracellular life of Cryptococcus neoformans
    Carolina Coelho
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Yeshiva University, Bronx, New York 10461 email
    Annu Rev Pathol 9:219-38. 2014
    ..neoformans and discuss the unique and remarkable features of its intracellular life, including the proposed mechanisms for fungal persistence and killing in phagocytic cells. ..
  4. doi request reprint Is the Nobel Prize good for science?
    Arturo Casadevall
    1Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461 USA
    FASEB J 27:4682-90. 2013
    ....
  5. pmc Immunoglobulins in defense, pathogenesis, and therapy of fungal diseases
    Arturo Casadevall
    Department of Microbiology and Immunology and Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Cell Host Microbe 11:447-56. 2012
    ..Furthermore, the study of antibody function against medically important fungi has provided fresh immunological insights into the complexity of humoral immunity that are likely to apply to other pathogens...
  6. pmc Fungal melanins differ in planar stacking distances
    Arturo Casadevall
    Department of Microbiology and Immunology, Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 7:e30299. 2012
    ..The stacking peak appears to be a distinguishing universal feature of melanins that may be of use in characterizing these enigmatic pigments...
  7. pmc Radioimmunotherapy of experimental head and neck squamous cell carcinoma (HNSCC) with E6-specific antibody using a novel HPV-16 positive HNSCC cell line
    Matthew Harris
    Department of Nuclear Medicine, Albert Einstein College of Medicine, Albert Einstein Cancer Center, Bronx, New York, USA
    Head Neck Oncol 3:9. 2011
    ..We aimed at extending this approach to HPV-related head and neck cancer by performing radioimmunotherapy (RIT) targeting E6 and E7 oncogenes with radiolabeled mAbs...
  8. doi request reprint Amoeba provide insight into the origin of virulence in pathogenic fungi
    Arturo Casadevall
    Departments of Microbiology and Immunology and Medicine Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Adv Exp Med Biol 710:1-10. 2012
    ..Hence the virulence of environmental pathogenic fungi is proposed to originate from a combination of selection by amoeboid predators and perhaps other soil organism with thermal tolerance sufficient to allow survival in mammalian hosts...
  9. pmc Destruction of microbial collections in response to select agent and toxin list regulations
    Arturo Casadevall
    Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Biosecur Bioterror 8:151-4. 2010
    ..We recommend that government agencies develop plans to ensure that microbial collections are preserved when considering future additions to microbial threat lists under which the possession of certain microbes is criminalized...
  10. pmc A new synthesis for antibody-mediated immunity
    Arturo Casadevall
    Arturo Casadevall and Liise anne Pirofski are in the Department of Microbiology and Immunology and Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA
    Nat Immunol 13:21-8. 2012
    ..Given that emergent properties are neither reducible to first principles nor predictable, there is a need for new conceptual approaches for understanding antibody function and mechanisms of antibody immunity...
  11. pmc Cryptococci at the brain gate: break and enter or use a Trojan horse?
    Arturo Casadevall
    Department of Microbiology and Immunology and Medicine, Albert Einstein College of Medicine, New York, New York, USA
    J Clin Invest 120:1389-92. 2010
    ..neoformans, but a consideration of all the currently available evidence suggests a role for both direct and phagocyte-associated invasion. Hence, the remarkable neurotropism of C. neoformans may have more than one mechanism...
  12. ncbi request reprint Radiolabeled melanin-binding peptides are safe and effective in treatment of human pigmented melanoma in a mouse model of disease
    Ekaterina Dadachova
    Department of Nuclear Medicine, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY 10461, USA
    Cancer Biother Radiopharm 21:117-29. 2006
    ..These results indicate that radiolabeled melanin-binding peptides are efficient and safe in treatment of melanoma and could be potentially useful against this tumor...
  13. pmc Identification of linear epitopes in Bacillus anthracis protective antigen bound by neutralizing antibodies
    Nareen Abboud
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 284:25077-86. 2009
    ..These results identify the first linear neutralizing epitopes of PA and show that peptides containing epitope sequences can elicit neutralizing antibody responses, a finding that could be exploited for vaccine design...
  14. pmc Neutralizing monoclonal antibody to edema toxin and its effect on murine anthrax
    Lisa Winterroth
    Departments of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Infect Immun 78:2890-8. 2010
    ....
  15. pmc Physico-chemical evaluation of rationally designed melanins as novel nature-inspired radioprotectors
    Andrew D Schweitzer
    Department of Nuclear Medicine, Albert Einstein College of Medicine, New York, New York, United States of America
    PLoS ONE 4:e7229. 2009
    ..Melanin, a high-molecular weight pigment that is ubiquitous in nature, protects melanized microorganisms against high doses of ionizing radiation. However, the physics of melanin interaction with ionizing radiation is unknown...
  16. pmc Radioimmunotherapy is more effective than antifungal treatment in experimental cryptococcal infection
    Ruth A Bryan
    Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Infect Dis 202:633-7. 2010
    ..We conclude that RIT is more effective than amphotericin B against systemic infection with C. neoformans...
  17. ncbi request reprint Interaction of radiolabeled antibodies with fungal cells and components of the immune system in vitro and during radioimmunotherapy for experimental fungal infection
    Ekaterina Dadachova
    Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Infect Dis 193:1427-36. 2006
    ..The usefulness of radioimmunotherapy (RIT) for infectious diseases was recently demonstrated for several fungal and bacterial infections, but the mechanisms by which RIT is effective against microbes are uncertain...
  18. pmc Antibodies to a cell surface histone-like protein protect against Histoplasma capsulatum
    Joshua D Nosanchuk
    Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, New York, New York 10461, USA
    J Clin Invest 112:1164-75. 2003
    ....
  19. ncbi request reprint Comparative evaluation of capsular polysaccharide-specific IgM and IgG antibodies and F(ab')2 and Fab fragments as delivery vehicles for radioimmunotherapy of fungal infection
    Ekaterina Dadachova
    Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Clin Cancer Res 13:5629s-5635s. 2007
    ....
  20. pmc Bacillus anthracis produces membrane-derived vesicles containing biologically active toxins
    Johanna Rivera
    Department of Microbiology and Immunology, Division of Infectious Diseases, The Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 107:19002-7. 2010
    ..Our observations may have important implications for the design of vaccines, for passive antibody strategies, and provide a previously unexplored system for studying secretory pathways in Gram-positive bacteria...
  21. pmc Galactoxylomannans from Cryptococcus neoformans varieties neoformans and grubii are structurally and antigenically variable
    Magdia De Jesus
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Eukaryot Cell 9:1018-28. 2010
    ..gattii. As a result of the deleterious effects of GalXM on immune function, structural and antigenic variability between serotypes may translate into differences in immunomodulatory effects...
  22. ncbi request reprint An innate immune system cell is a major determinant of species-related susceptibility differences to fungal pneumonia
    Xiuping Shao
    Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 175:3244-51. 2005
    ..In summary, differences in AM function in rats and mice suggest an explanation for the species differences in susceptibility to C. neoformans based on the inherent efficacy of a central effector cell of the innate immune system...
  23. pmc Voriconazole inhibits melanization in Cryptococcus neoformans
    Luis R Martinez
    Department of Medicine Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Antimicrob Agents Chemother 51:4396-400. 2007
    ..Hence, voriconazole affects melanization in C. neoformans by interacting directly with laccase, which may increase the efficacy of this potent antifungal against certain pigmented fungi...
  24. pmc Effects of voriconazole on Cryptococcus neoformans
    David van Duin
    Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Antimicrob Agents Chemother 48:2014-20. 2004
    ..The high activity of voriconazole against both melanized and nonmelanized cells results suggest that voriconazole may be a particularly valuable drug for cryptococcosis...
  25. pmc A monoclonal antibody to Bacillus anthracis protective antigen defines a neutralizing epitope in domain 1
    Johanna Rivera
    Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Infect Immun 74:4149-56. 2006
    ..However, MAb 7.5G slowed the proteolytic digestion of PA by furin in vitro, suggesting a potential mechanism for Ab-mediated protection. These observations indicate that some Abs to domain 1 can contribute to host protection...
  26. doi request reprint Radioimmunotherapy of experimental human metastatic melanoma with melanin-binding antibodies and in combination with dacarbazine
    Ekaterina Revskaya
    Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Clin Cancer Res 15:2373-9. 2009
    ....
  27. pmc Treatment of early and established Cryptococcus neoformans infection with radiolabeled antibodies in immunocompetent mice
    Zewei Jiang
    Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, New York, USA
    Antimicrob Agents Chemother 56:552-4. 2012
    ..The results point to the independence of RIT of the immune status of the host, which is encouraging for translation of this strategy into the clinic...
  28. pmc Macrophage autophagy in immunity to Cryptococcus neoformans and Candida albicans
    André Moraes Nicola
    Departments of Microbiology and Immunology and Medicine, Albert Einstein College of Medicine, Bronx, New York, USA
    Infect Immun 80:3065-76. 2012
    ..These results demonstrate the complex roles of macrophage autophagy in restricting intracellular parasitism by fungi and reveal connections with nonlytic exocytosis, humoral immunity, and cytokine signaling...
  29. pmc Radiolabeled antibodies to Bacillus anthracis toxins are bactericidal and partially therapeutic in experimental murine anthrax
    Johanna Rivera
    Department of Microbiology and Immunology, Division of Infectious Diseases, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Antimicrob Agents Chemother 53:4860-8. 2009
    ..anthracis Sterne spores. These results indicate that RIT with MAbs that target B. anthracis toxin components can be used to treat experimental anthrax infection and suggest that toxigenic bacteria may be targeted with radiolabeled MAbs...
  30. pmc Chronological aging is associated with biophysical and chemical changes in the capsule of Cryptococcus neoformans
    Radames J B Cordero
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA
    Infect Immun 79:4990-5000. 2011
    ..Changes associated with cellular aging in chronic infections could contribute to the remarkable capacity of this fungus to persist in tissues by generating phenotypically and antigenically different capsules...
  31. pmc Murine IgG1 and IgG3 isotype switch variants promote phagocytosis of Cryptococcus neoformans through different receptors
    Carolyn A Saylor
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 184:336-43. 2010
    ..We conclude that a specific receptor for IgG3 exists in mice that is structurally different from the known FcgammaRs...
  32. doi request reprint The radioprotective properties of fungal melanin are a function of its chemical composition, stable radical presence and spatial arrangement
    Ekaterina Dadachova
    Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, NY, USA
    Pigment Cell Melanoma Res 21:192-9. 2008
    ..Melanin protected fungi against ionizing radiation and its radioprotective properties were a function of its chemical composition, free radical quenching, and spherical spatial arrangement...
  33. ncbi request reprint Mouse genetic background is a major determinant of isotype-related differences for antibody-mediated protective efficacy against Cryptococcus neoformans
    Johanna Rivera
    Department of Microbiology and Immunology, Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 174:8017-26. 2005
    ..The dependence of isotype efficacy on host genetics underscores a previously unsuspected complex relationship between the cellular and humoral arms of the adaptive immune response...
  34. ncbi request reprint A dual role for TGF-beta1 in the control and persistence of fungal pneumonia
    Xiuping Shao
    Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 175:6757-63. 2005
    ....
  35. pmc Laccase expression in murine pulmonary Cryptococcus neoformans infection
    Javier Garcia-Rivera
    Division of Infectious Disease, Albert Einstein College of Medicine, 1300 Morris Park Ave, Golding 701, Bronx, NY 10461, USA
    Infect Immun 73:3124-7. 2005
    ..Laccase was detected in the fungal cell cytoplasm, cell wall, and capsule in vivo. The amount of laccase found in different sites varied as a function of the time of infection...
  36. ncbi request reprint Antibody action after phagocytosis promotes Cryptococcus neoformans and Cryptococcus gattii macrophage exocytosis with biofilm-like microcolony formation
    Mauricio Alvarez
    Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Cell Microbiol 10:1622-33. 2008
    ..This finding suggests that antibody agglutination effects persist in the phagosome to entangle nascent daughter cells and this phenomenon may contribute to antibody-mediated protection...
  37. pmc Comparative evaluation of profiles of antibodies to mycobacterial capsular polysaccharides in tuberculosis patients and controls stratified by HIV status
    Xian Yu
    Departments of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA
    Clin Vaccine Immunol 19:198-208. 2012
    ..This study also provides new and important insights into the differences in the profiles of Abs to mycobacterial antigens between HIV(-) and HIV(+) TB patients...
  38. pmc Monoclonal antibodies to Mycobacterium tuberculosis CDC 1551 reveal subcellular localization of MPT51
    Ban Al-Sayyed
    Division of Pediatric Infectious Diseases, Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Tuberculosis (Edinb) 87:489-97. 2007
    ..This immunogenic protein of unknown function was previously reported only in culture filtrates of M. tuberculosis. Our findings suggest for the first time that this protein is found within the M. tuberculosis cell...
  39. pmc Ionizing radiation changes the electronic properties of melanin and enhances the growth of melanized fungi
    Ekaterina Dadachova
    Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 2:e457. 2007
    ..We hypothesized that ionizing radiation could change the electronic properties of melanin and might enhance the growth of melanized microorganisms...
  40. pmc Effects of antifungal interventions on the outcome of experimental infections with phenotypic switch variants of Cryptococcus neoformans
    Bettina C Fries
    Department of Medicine, Albert Einstein College of Medicine, Golding 702, 1300 Morris Park Ave, Bronx, New York 10461, USA
    Antimicrob Agents Chemother 49:350-7. 2005
    ..This finding suggests that both chemotherapeutic and immunological antifungal interventions may promote the selection of the more virulent mucoid variant, which could affect the outcome of infection in chronically infected hosts...
  41. pmc Melanin-covered nanoparticles for protection of bone marrow during radiation therapy of cancer
    Andrew D Schweitzer
    Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Int J Radiat Oncol Biol Phys 78:1494-502. 2010
    ....
  42. pmc Fcgamma receptor cross-linking stimulates cell proliferation of macrophages via the ERK pathway
    Yong Luo
    Departments of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 285:4232-42. 2010
    ..In addition, our results suggest the possibility of new treatment options for certain infectious diseases, chronic inflammatory diseases, and leukemias based on interference with FcgammaR-stimulated macrophage cell proliferation...
  43. pmc Interaction of Blastomyces dermatitidis, Sporothrix schenckii, and Histoplasma capsulatum with Acanthamoeba castellanii
    Judith N Steenbergen
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Infect Immun 72:3478-88. 2004
    ..These results are consistent with the view that soil amoebae may contribute to the selection and maintenance of certain traits in pathogenic dimorphic fungi that confer on these microbes the capacity for virulence in mammals...
  44. ncbi request reprint Structural and functional characterization of glycosylation in an immunoglobulin G1 to Cryptococcus neoformans glucuronoxylomannan
    Fang Wang
    Laboratory for Macromolecular Analysis and Proteomics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Mol Immunol 43:987-98. 2006
    ..The results imply that the contribution of N-glycan structure to immunoglobulin function varies depending on the Ag-Ab system...
  45. ncbi request reprint Enhanced allergic inflammation and airway responsiveness in rats with chronic Cryptococcus neoformans infection: potential role for fungal pulmonary infection in the pathogenesis of asthma
    David L Goldman
    Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Infect Dis 193:1178-86. 2006
    ..neoformans infection to potentiate allergic responses and airway reactivity and suggest a potential role for subclinical pulmonary cryptococcosis in the pathogenesis of asthma...
  46. pmc Capsular localization of the Cryptococcus neoformans polysaccharide component galactoxylomannan
    Magdia De Jesus
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Eukaryot Cell 8:96-103. 2009
    ..Hence, the function of GalXM appears to be more consistent with that of an exopolysaccharide than a structural component of the cryptococcal capsule...
  47. pmc Cryptococcus neoformans responds to mannitol by increasing capsule size in vitro and in vivo
    Allan Jefferson Guimarães
    Department of Medicine, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY, USA
    Cell Microbiol 12:740-53. 2010
    ..Our results demonstrate the capacity of carbohydrate source and concentration to modify the expression of a major virulence factor of C. neoformans. These findings may impact the clinical management of cryptococcosis...
  48. ncbi request reprint Phagosome extrusion and host-cell survival after Cryptococcus neoformans phagocytosis by macrophages
    Mauricio Alvarez
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, 10461, USA
    Curr Biol 16:2161-5. 2006
    ....
  49. pmc Specificity and diversity of antibodies to Mycobacterium tuberculosis arabinomannan
    Josephine Anne D Navoa
    Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York, New York 10461, USA
    Clin Diagn Lab Immunol 10:88-94. 2003
    ..One MAb and a subset of human antibodies bind AM specifically, suggesting that this polysaccharide is antigenically distinct and is expressed in human infection...
  50. pmc Immunogenicity of Bacillus anthracis protective antigen domains and efficacy of elicited antibody responses depend on host genetic background
    Nareen Abboud
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Clin Vaccine Immunol 15:1115-23. 2008
    ..The results suggest that the variability observed in vaccination studies with PA-derived vaccines is a result of host heterogeneity and implies a need to develop other antigens as vaccine candidates...
  51. pmc Radioimmunotherapy of Cryptococcus neoformans spares bystander mammalian cells
    Ruth A Bryan
    Department of Radiology, 1695A Eastchester Road, Albert Einstein College of Medicine, Bronx, NY, USA
    Future Microbiol 8:1081-9. 2013
    ..Here, we investigate the effects of RIT on bystander mammalian cells...
  52. pmc Combinations of monoclonal antibodies to anthrax toxin manifest new properties in neutralization assays
    Mary Ann Pohl
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA
    Infect Immun 81:1880-8. 2013
    ....
  53. pmc Antibody binding to Cryptococcus neoformans impairs budding by altering capsular mechanical properties
    Radames J B Cordero
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 190:317-23. 2013
    ..Our findings add to the growing body of evidence that Abs have direct antimicrobial functions independent of other components of the immune system...
  54. pmc Antibodies against immunodominant antigens of Mycobacterium tuberculosis in subjects with suspected tuberculosis in the United States compared by HIV status
    Jacqueline M Achkar
    Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Clin Vaccine Immunol 17:384-92. 2010
    ..0; 95% confidence interval, 2.3 to 51.2; P = 0.002). These findings have implications for the adjunctive use of TB serodiagnosis with these antigens in HIV(+) subjects...
  55. pmc The common Cryptococcus neoformans glucuronoxylomannan M2 motif elicits non-protective antibodies
    Antonio Nakouzi
    Department of Microbiology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Vaccine 27:3513-8. 2009
    ..Furthermore, the results illustrate the first molecular assignment of a C. neoformans polysaccharide epitope and suggest a general strategy for the identification of GXM epitopes...
  56. ncbi request reprint The damage-response framework of microbial pathogenesis
    Arturo Casadevall
    Departments of Medicine Division of Infectious Diseases and Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Nat Rev Microbiol 1:17-24. 2003
    ..To address this impediment to studies of host-microorganism interactions, we propose a new theoretical approach to understanding microbial pathogenesis, known as the 'damage-response' framework...
  57. pmc Antigenic evidence of prevalence and diversity of Mycobacterium tuberculosis arabinomannan
    Aharona Glatman-Freedman
    Department of Pediatrics, Children s Hospital at Montefiore, Albert Einstein College of Medicine, Golding Bldg, Room 702, 1300 Morris Park Ave, Bronx, NY 10461, USA
    J Clin Microbiol 42:3225-31. 2004
    ..tuberculosis strains tested, with differences in epitope distributions of certain strains. In addition, our results suggest that an experimental AM-rEPA vaccine has a moderate effect on the numbers of CFU in organs early after infection...
  58. pmc The relative susceptibility of mouse strains to pulmonary Cryptococcus neoformans infection is associated with pleiotropic differences in the immune response
    Oscar Zaragoza
    Departments of Microbiology and Immunology and Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Infect Immun 75:2729-39. 2007
    ....
  59. pmc Melanization of Cryptococcus neoformans affects lung inflammatory responses during cryptococcal infection
    Aron J Mednick
    Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Infect Immun 73:2012-9. 2005
    ..The results provide strong evidence that cryptococcal melanization can influence the immune response to infection and suggest that immunomodulation is an additional mechanism by which the pigment contributes to virulence...
  60. ncbi request reprint Variable-region-identical antibodies differing in isotype demonstrate differences in fine specificity and idiotype
    Marcela Torres
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 174:2132-42. 2005
    ..Given that isotype class switching and Ig gene somatic hypermutation share molecular mechanisms, these observations unify these processes in the sense that both can alter specificity and affinity...
  61. pmc Cryptococcus neoformans capsular polysaccharide and exopolysaccharide fractions manifest physical, chemical, and antigenic differences
    Susana Frases
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Eukaryot Cell 7:319-27. 2008
    ....
  62. ncbi request reprint Phage display library derived peptides that bind to human tumor melanin as potential vehicles for targeted radionuclide therapy of metastatic melanoma
    Robertha C Howell
    Department of Nuclear Medicine, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY 10461, USA
    Bioconjug Chem 18:1739-48. 2007
    ..Thus, these heptapeptides appear to have potentially significant advantages for targeted therapy of melanoma relative to existing melanin-binding peptides...
  63. ncbi request reprint Comparative analysis of Cryptococcus neoformans acid-resistant particles generated from pigmented cells grown in different laccase substrates
    Javier Garcia-Rivera
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Fungal Genet Biol 42:989-98. 2005
    ..neoformans in different substrates affected cell and capsule size but not capsule induction. Hence, the type of pigment produced by C. neoformans is dependent on the substrate and not all pigments meet the criteria for melanins...
  64. pmc Targeted killing of virally infected cells by radiolabeled antibodies to viral proteins
    Ekaterina Dadachova
    Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS Med 3:e427. 2006
    ..The aim of this proof-of-principle study was to demonstrate the efficacy of a therapeutic strategy of targeting and eliminating HIV-1-infected cells with radiolabeled antibodies specific to viral proteins in vitro and in vivo...
  65. ncbi request reprint Computational model predicts effective delivery of 188-Re-labeled melanin-binding antibody to metastatic melanoma tumors with wide range of melanin concentrations
    Andrew D Schweitzer
    The Mount Sinai School of Medicine, Cornell University, Ithaca, New York, USA
    Melanoma Res 17:291-303. 2007
    ..In conclusion, RIT of metastatic melanoma can be effective over a wide range of tumor melanin concentrations. The results can be useful in the design of a clinical trial of melanin-targeting RIT in patients with metastatic melanoma...
  66. pmc Cryptococcus neoformans biofilm formation depends on surface support and carbon source and reduces fungal cell susceptibility to heat, cold, and UV light
    Luis R Martinez
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Appl Environ Microbiol 73:4592-601. 2007
    ..Our findings demonstrate that fungal biofilm formation is dependent on support surface characteristics and that growth in the biofilm state makes fungal cells less susceptible to potential environmental stresses...
  67. pmc Passive administration of monoclonal antibodies to anthrolysin O prolong survival in mice lethally infected with Bacillus anthracis
    Antonio Nakouzi
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    BMC Microbiol 8:159. 2008
    ..anthracis but subsequent studies have questioned its relevance in pathogenesis. In this study, we examined the immunogenicity of recombinant anthrolysin O (rALO) in mice...
  68. pmc Susceptibility of Cryptococcus neoformans biofilms to antifungal agents in vitro
    Luis R Martinez
    Department of Medicine and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, New York 10461, USA
    Antimicrob Agents Chemother 50:1021-33. 2006
    ..neoformans biofilm formation involved capsular polysaccharide release and adherence. Our results suggest that biofilm formation may diminish the efficacies of some antifungal drugs during cryptococcal infection...
  69. pmc In vitro evaluation, biodistribution and scintigraphic imaging in mice of radiolabeled anthrax toxins
    Ekaterina Dadachova
    Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Nucl Med Biol 35:755-61. 2008
    ....
  70. ncbi request reprint Cryptococcus neoformans laccase catalyses melanin synthesis from both D- and L-DOPA
    Helene C Eisenman
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Microbiology 153:3954-62. 2007
    ....
  71. pmc Radioimmunotherapy with an antibody to the HPV16 E6 oncoprotein is effective in an experimental cervical tumor expressing low levels of E6
    Rébécca Phaeton
    Department of Obstetrics and Gynecology and Women s Health, Albert Einstein College of Medicine, Albert Einstein Cancer Center, Bronx, NY, USA
    Cancer Biol Ther 10:1041-7. 2010
    ..However, that study opened the question whether radioimmunotherapy can suppress the growth of cervical tumors with low E6 and E7 expression, such as may be seen in patients...
  72. pmc Mycobacteria release active membrane vesicles that modulate immune responses in a TLR2-dependent manner in mice
    Rafael Prados-Rosales
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, New York 10461, USA
    J Clin Invest 121:1471-83. 2011
    ..These findings may open up new horizons for understanding the pathogenesis of tuberculosis and developing vaccines...
  73. ncbi request reprint The weapon potential of a microbe
    Arturo Casadevall
    Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Trends Microbiol 12:259-63. 2004
    ....
  74. pmc Evaluation of Cryptococcus neoformans galactoxylomannan-protein conjugate as vaccine candidate against murine cryptococcosis
    Siu Kei Chow
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Vaccine 29:1891-8. 2011
    ..neoformans. These results demonstrated the effectiveness of the GalXM-protein conjugate to induce robust immune responses although no evidence was obtained that such responses contributed to host defense...
  75. ncbi request reprint Efficacy of voriconazole in experimental Cryptococcus neoformans infection
    Nikolaos Mavrogiorgos
    Department of Microbiology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Mycopathologia 162:111-4. 2006
    ..The antifungal reduced serum polysaccharide and significantly prolonged the survival of lethally infected animals...
  76. pmc Impact of melanin on microbial virulence and clinical resistance to antimicrobial compounds
    Joshua D Nosanchuk
    Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Antimicrob Agents Chemother 50:3519-28. 2006
  77. pmc Antibody-mediated protection against Cryptococcus neoformans pulmonary infection is dependent on B cells
    Johanna Rivera
    Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Infect Immun 73:1141-50. 2005
    ..The results indicate an important role for B cells in host defense against C. neoformans infection and demonstrate a surprising dependence of Ab-mediated protection on B cells in this system...
  78. pmc The outcome of phagocytic cell division with infectious cargo depends on single phagosome formation
    Yong Luo
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 3:e3219. 2008
    ..Post-mitotic infectious cargo distribution is a new parameter to consider in the study of intracellular pathogens since it could potentially define the outcome of phagocytic-microbial interactions...
  79. pmc Cryptococcus neoformans virulence is enhanced after growth in the genetically malleable host Dictyostelium discoideum
    Judith N Steenbergen
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Infect Immun 71:4862-72. 2003
    ..neoformans virulence in the environment and suggest that D. discoideum promises to be an extremely useful system for studying the interaction of C. neoformans with phagocytic cells...
  80. ncbi request reprint Blastomyces dermatitidis produces melanin in vitro and during infection
    Joshua D Nosanchuk
    Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    FEMS Microbiol Lett 239:187-93. 2004
    ..Melanization reduced susceptibility to amphotericin B, but not to itraconazole or voriconazole. Since melanin is an important virulence factor in other pathogenic fungi, this pigment may affect the pathogenesis of blastomycosis...
  81. ncbi request reprint Passive antibody therapy for infectious diseases
    Arturo Casadevall
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Nat Rev Microbiol 2:695-703. 2004
    ....
  82. pmc Vesicle-associated melanization in Cryptococcus neoformans
    Helene C Eisenman
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Microbiology 155:3860-7. 2009
    ..A model for C. neoformans melanization is proposed that accounts for these observations and provides a mechanism for the assembly of melanin into relatively uniform spherical particles stacked in an orderly arrangement in the cell wall...
  83. ncbi request reprint More is not necessarily better: prozone-like effects in passive immunization with IgG
    Carlos P Taborda
    Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 170:3621-30. 2003
    ..Our findings have implications for the potential contribution of Ab responses to defense against microbial diseases because Ab-mediated immunity may be protective, nonprotective, or even deleterious to the host...
  84. ncbi request reprint Neutropenia alters lung cytokine production in mice and reduces their susceptibility to pulmonary cryptococcosis
    Aron J Mednick
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA
    Eur J Immunol 33:1744-53. 2003
    ..Our results support the emerging concept that neutrophils play an important function in modulating the development of the immune response...
  85. ncbi request reprint Isotype can affect the fine specificity of an antibody for a polysaccharide antigen
    Gary R McLean
    Departments of Medicine and Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461
    J Immunol 169:1379-86. 2002
    ....
  86. ncbi request reprint Unexpected diversity in the fine specificity of monoclonal antibodies that use the same V region gene to glucuronoxylomannan of Cryptococcus neoformans
    Diane C McFadden
    Department of Medicine, Division of Infectious Disease, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 172:3670-7. 2004
    ....
  87. ncbi request reprint The immunoglobulin heavy chain constant region affects kinetic and thermodynamic parameters of antibody variable region interactions with antigen
    Marcela Torres
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 282:13917-27. 2007
    ..Furthermore, isotype affected the polyreactivity of V region identical antibodies, implying a role for C region in determining self-reactivity...
  88. pmc Melanization of Cryptococcus neoformans and Histoplasma capsulatum reduces their susceptibilities to amphotericin B and caspofungin
    David van Duin
    Department of Medicine, Division of Infectious Diseases Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Antimicrob Agents Chemother 46:3394-400. 2002
    ..Furthermore, the results indicate that fungal melanins protect C. neoformans and H. capsulatum from the activities of amphotericin B and caspofungin and that this protection is not demonstrable by standard broth macrodilution assays...
  89. ncbi request reprint Fc- and complement-receptor activation stimulates cell cycle progression of macrophage cells from G1 to S
    Yong Luo
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 174:7226-33. 2005
    ..This observation suggests a potential mechanism for increasing the number of effector cells after microbial ingestion, but can also promote the spread of infection...
  90. ncbi request reprint The physical properties of the capsular polysaccharides from Cryptococcus neoformans suggest features for capsule construction
    Diane C McFadden
    Department of Medicine, Division of Infectious Disease, and Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Biol Chem 281:1868-75. 2006
    ..A mechanism for capsule growth is proposed based on the extracellular release and entanglement of GXM molecules...
  91. pmc Phagocytic activity and monocyte chemotactic protein expression by pulmonary macrophages in persistent pulmonary cryptococcosis
    Wu He
    Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Infect Immun 71:930-6. 2003
    ..Furthermore, we find that phagocytosis of C. neoformans can serve as an important stimulus for MCP-1 production by PuM, though the efficiency of this process is dependent on the opsonin type and may be affected by aging...
  92. ncbi request reprint Immunomodulators as an antimicrobial tool
    Liise Anne Pirofski
    Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine and Montefiore Medical Center, NY 10461, USA
    Curr Opin Microbiol 9:489-95. 2006
    ..However, to date only a few immunomodulators have been evaluated for their efficacy as antimicrobial tools...
  93. ncbi request reprint CR3 (CD11b/CD18) and CR4 (CD11c/CD18) are involved in complement-independent antibody-mediated phagocytosis of Cryptococcus neoformans
    Carlos P Taborda
    Division of Infectious Diseases, The Department of Medicine and The Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Immunity 16:791-802. 2002
    ..Phagocytosis by IgM and IgA but not IgG1 was inhibited by soluble GXM, which binds CD18. Involvement of CR in antibody-mediated complement-independent phagocytosis indicates a new link between innate and adaptive immune systems...

Research Grants40

  1. PROTECTIVE ANTIBODIES FOR CRYPTOCOCCAL INFECTIONS
    Arturo Casadevall; Fiscal Year: 2005
    ..neoformans and also to other efforts to develop Ab therapy, vaccines and fundamental immunology. ..
  2. PROTECTIVE ANTIBODIES FOR CRYPTOCOCCAL INFECTIONS
    Arturo Casadevall; Fiscal Year: 2006
    ..neoformans and also to other efforts to develop Ab therapy, vaccines and fundamental immunology. ..
  3. Biology of Fungal Melanin
    Arturo Casadevall; Fiscal Year: 2006
    ..It is anticipated that the work proposed here will provide important insights into the biology of melanin and in doing so highlight novel strategies for antimicrobial drug development. ..
  4. SYNERGY OF HOST DEFENSE MECHANISMS IN LUNG
    Arturo Casadevall; Fiscal Year: 2005
    ..By comparing the immune response in Ab-permissive and Ab-non-permissive murine strains we will learn the conditions and mechanisms by which Ab-mediates protection against C. neoformans. ..
  5. PROTECTIVE ANTIBODIES FOR CRYPTOCOCCAL INFECTIONS
    Arturo Casadevall; Fiscal Year: 2005
    ..neoformans and also to other efforts to develop Ab therapy, vaccines and fundamental immunology. ..
  6. SYNERGY OF HOST DEFENSE MECHANISMS IN LUNG
    Arturo Casadevall; Fiscal Year: 2003
    ..By comparing the immune response in Ab-permissive and Ab-non-permissive murine strains we will learn the conditions and mechanisms by which Ab-mediates protection against C. neoformans. ..
  7. PROTECTIVE ANTIBODIES FOR CRYPTOCOCCAL INFECTIONS
    Arturo Casadevall; Fiscal Year: 2004
    ..neoformans and also to other efforts to develop Ab therapy, vaccines and fundamental immunology. ..
  8. SYNERGY OF HOST DEFENSE MECHANISMS IN LUNG
    Arturo Casadevall; Fiscal Year: 2006
    ..By comparing the immune response in Ab-permissive and Ab-non-permissive murine strains we will learn the conditions and mechanisms by which Ab-mediates protection against C. neoformans. ..
  9. Biology of Fungal Melanin
    Arturo Casadevall; Fiscal Year: 2007
    ..It is anticipated that the work proposed here will provide important insights into the biology of melanin and in doing so highlight novel strategies for antimicrobial drug development. ..
  10. Biology of Fungal Melanin
    Arturo Casadevall; Fiscal Year: 2010
    ..In this regard, a monoclonal antibody to fungal melanin made as part of this research program is already in clinical evaluation for the therapy of melanoma. ..
  11. PROTECTIVE ANTIBODIES FOR CRYPTOCOCCAL INFECTIONS
    Arturo Casadevall; Fiscal Year: 2010
    ....
  12. Synergy of Host Defense Mechanisms in the Lung
    Arturo Casadevall; Fiscal Year: 2010
    ..Furthermore, these studies will provide information that could be used to design vaccines and new therapies based on immunological reagents such as antibodies. ..
  13. Biology of Fungal Melanin
    Arturo Casadevall; Fiscal Year: 2009
    ..In this regard, a monoclonal antibody to fungal melanin made as part of this research program is already in clinical evaluation for the therapy of melanoma. ..
  14. Synergy of Host Defense Mechanisms in the Lung
    Arturo Casadevall; Fiscal Year: 2009
    ..Furthermore, these studies will provide information that could be used to design vaccines and new therapies based on immunological reagents such as antibodies. ..
  15. PROTECTIVE ANTIBODIES FOR CRYPTOCOCCAL INFECTIONS
    Arturo Casadevall; Fiscal Year: 2007
    ..neoformans and also to other efforts to develop Ab therapy, vaccines and fundamental immunology. ..
  16. SYNERGY OF HOST DEFENSE MECHANISMS IN LUNG
    Arturo Casadevall; Fiscal Year: 2004
    ..By comparing the immune response in Ab-permissive and Ab-non-permissive murine strains we will learn the conditions and mechanisms by which Ab-mediates protection against C. neoformans. ..
  17. PROTECTIVE ANTIBODIES FOR CRYPTOCOCCAL INFECTIONS
    Arturo Casadevall; Fiscal Year: 1999
    ..To establish the most effective and least toxic human constant region against C. neoformans in mice; and Aim 3. To determine the consequences of antibody-mediated deposition of cryptococcal polysaccharide in reticuloendothelial cells. ..
  18. SYNERGY OF HOST DEFENSE MECHANISMS IN LUNG
    Arturo Casadevall; Fiscal Year: 1999
    ..To determine the effect of polysaccharide-protein conjugate vaccination on pulmonary defenses against C. neoformans in the context of cytokine- and nitric oxide-related mechanisms. ..
  19. PROTECTIVE ANTIBODIES FOR CRYPTOCOCCAL INFECTIONS
    Arturo Casadevall; Fiscal Year: 2000
    ..To establish the most effective and least toxic human constant region against C. neoformans in mice; and Aim 3. To determine the consequences of antibody-mediated deposition of cryptococcal polysaccharide in reticuloendothelial cells. ..
  20. Biology of Fungal Melanin
    Arturo Casadevall; Fiscal Year: 2003
    ..It is anticipated that the work proposed here will provide important insights into the biology of melanin and in doing so highlight novel strategies for antimicrobial drug development. ..
  21. SYNERGY OF HOST DEFENSE MECHANISMS IN LUNG
    Arturo Casadevall; Fiscal Year: 2003
    ..By comparing the immune response in Ab-permissive and Ab-non-permissive murine strains we will learn the conditions and mechanisms by which Ab-mediates protection against C. neoformans. ..
  22. PROTECTIVE ANTIBODIES FOR CRYPTOCOCCAL INFECTIONS
    Arturo Casadevall; Fiscal Year: 2003
    ..To establish the most effective and least toxic human constant region against C. neoformans in mice; and Aim 3. To determine the consequences of antibody-mediated deposition of cryptococcal polysaccharide in reticuloendothelial cells. ..
  23. SYNERGY OF HOST DEFENSE MECHANISMS IN LUNG
    Arturo Casadevall; Fiscal Year: 2002
    ..By comparing the immune response in Ab-permissive and Ab-non-permissive murine strains we will learn the conditions and mechanisms by which Ab-mediates protection against C. neoformans. ..
  24. PROTECTIVE ANTIBODIES FOR CRYPTOCOCCAL INFECTIONS
    Arturo Casadevall; Fiscal Year: 2002
    ..To establish the most effective and least toxic human constant region against C. neoformans in mice; and Aim 3. To determine the consequences of antibody-mediated deposition of cryptococcal polysaccharide in reticuloendothelial cells. ..
  25. SYNERGY OF HOST DEFENSE MECHANISMS IN LUNG
    Arturo Casadevall; Fiscal Year: 2001
    ..To determine the effect of polysaccharide-protein conjugate vaccination on pulmonary defenses against C. neoformans in the context of cytokine- and nitric oxide-related mechanisms. ..
  26. PROTECTIVE ANTIBODIES FOR CRYPTOCOCCAL INFECTIONS
    Arturo Casadevall; Fiscal Year: 2001
    ..To establish the most effective and least toxic human constant region against C. neoformans in mice; and Aim 3. To determine the consequences of antibody-mediated deposition of cryptococcal polysaccharide in reticuloendothelial cells. ..
  27. SYNERGY OF HOST DEFENSE MECHANISMS IN LUNG
    Arturo Casadevall; Fiscal Year: 2000
    ..To determine the effect of polysaccharide-protein conjugate vaccination on pulmonary defenses against C. neoformans in the context of cytokine- and nitric oxide-related mechanisms. ..
  28. PROTECTIVE ANTIBODIES FOR CRYPTOCOCCAL INFECTIONS
    Arturo Casadevall; Fiscal Year: 2011
    ....