A Casadevall

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. ncbi request reprint Unexpected diversity in the fine specificity of monoclonal antibodies that use the same V region gene to glucuronoxylomannan of Cryptococcus neoformans
    Diane C McFadden
    Department of Medicine, Division of Infectious Disease, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 172:3670-7. 2004
  2. pmc Rethinking T cell immunity in oropharyngeal candidiasis
    Liise Anne Pirofski
    Department of Medicine, Albert Einstein College of Medicine College of Medicine, Bronx, NY, USA
    J Exp Med 206:269-73. 2009
  3. pmc Pulmonary cryptococcosis induces chitinase in the rat
    Alfin G Vicencio
    Department of Pediatrics, Division of Respiratory and Sleep Medicine, Albert Einstein College of Medicine and Children s Hospital at Montefiore, Bronx, USA
    Respir Res 9:40. 2008
  4. pmc Effects of disrupting the polyketide synthase gene WdPKS1 in Wangiella [Exophiala] dermatitidis on melanin production and resistance to killing by antifungal compounds, enzymatic degradation, and extremes in temperature
    William F Paolo
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA
    BMC Microbiol 6:55. 2006
  5. pmc Passive administration of monoclonal antibodies to anthrolysin O prolong survival in mice lethally infected with Bacillus anthracis
    Antonio Nakouzi
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    BMC Microbiol 8:159. 2008
  6. pmc The outcome of Cryptococcus neoformans intracellular pathogenesis in human monocytes
    Mauricio Alvarez
    Department of Microbiology and Immunology and Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    BMC Microbiol 9:51. 2009
  7. pmc Cell-to-cell spread and massive vacuole formation after Cryptococcus neoformans infection of murine macrophages
    Mauricio Alvarez
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    BMC Immunol 8:16. 2007
  8. pmc Passive antibody administration (immediate immunity) as a specific defense against biological weapons
    Arturo Casadevall
    Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Emerg Infect Dis 8:833-41. 2002
  9. pmc Antibody-mediated immunity against intracellular pathogens: two-dimensional thinking comes full circle
    Arturo Casadevall
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Infect Immun 71:4225-8. 2003
  10. pmc Antibody-mediated protection through cross-reactivity introduces a fungal heresy into immunological dogma
    Arturo Casadevall
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Infect Immun 75:5074-8. 2007

Research Grants

  1. MOLECULAR CHARACTERIZATION OF C NEOFORMANS ANTIBODIES
    Arturo Casadevall; Fiscal Year: 2001
  2. Synergy of Host Defense Mechanisms in the Lung
    Arturo Casadevall; Fiscal Year: 2009
  3. PROTECTIVE ANTIBODIES FOR CRYPTOCOCCAL INFECTIONS
    Arturo Casadevall; Fiscal Year: 2007
  4. Molecular Characterization of C. neoformans Antibodies
    Arturo Casadevall; Fiscal Year: 2007
  5. Biology of Fungal Melanin
    Arturo Casadevall; Fiscal Year: 2007
  6. MOLECULAR CHARACTERIZATION OF C NEOFORMANS ANTIBODIES
    Arturo Casadevall; Fiscal Year: 2002
  7. Mining slime mold for susceptibility genes to fungi
    Arturo Casadevall; Fiscal Year: 2005
  8. MOLECULAR CHARACTERIZATION OF C NEOFORMANS ANTIBODIES
    Arturo Casadevall; Fiscal Year: 1999
  9. MOLECULAR PATHOGENESIS OF INFECTIOUS DISEASES
    Arturo Casadevall; Fiscal Year: 2006
  10. MOLECULAR CHARACTERIZATION OF C NEOFORMANS ANTIBODIES
    Arturo Casadevall; Fiscal Year: 2000

Collaborators

Detail Information

Publications187 found, 100 shown here

  1. ncbi request reprint Unexpected diversity in the fine specificity of monoclonal antibodies that use the same V region gene to glucuronoxylomannan of Cryptococcus neoformans
    Diane C McFadden
    Department of Medicine, Division of Infectious Disease, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 172:3670-7. 2004
    ....
  2. pmc Rethinking T cell immunity in oropharyngeal candidiasis
    Liise Anne Pirofski
    Department of Medicine, Albert Einstein College of Medicine College of Medicine, Bronx, NY, USA
    J Exp Med 206:269-73. 2009
    ..These findings clarify and extend our current thinking about how CD4 T cell deficiency influences susceptibility to OPC...
  3. pmc Pulmonary cryptococcosis induces chitinase in the rat
    Alfin G Vicencio
    Department of Pediatrics, Division of Respiratory and Sleep Medicine, Albert Einstein College of Medicine and Children s Hospital at Montefiore, Bronx, USA
    Respir Res 9:40. 2008
    ....
  4. pmc Effects of disrupting the polyketide synthase gene WdPKS1 in Wangiella [Exophiala] dermatitidis on melanin production and resistance to killing by antifungal compounds, enzymatic degradation, and extremes in temperature
    William F Paolo
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA
    BMC Microbiol 6:55. 2006
    ..Cell wall pigmentation in W. dermatitidis depends on the WdPKS1 gene, which encodes a polyketide synthase required for generating the key precursor for dihydroxynaphthalene melanin biosynthesis...
  5. pmc Passive administration of monoclonal antibodies to anthrolysin O prolong survival in mice lethally infected with Bacillus anthracis
    Antonio Nakouzi
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    BMC Microbiol 8:159. 2008
    ..anthracis but subsequent studies have questioned its relevance in pathogenesis. In this study, we examined the immunogenicity of recombinant anthrolysin O (rALO) in mice...
  6. pmc The outcome of Cryptococcus neoformans intracellular pathogenesis in human monocytes
    Mauricio Alvarez
    Department of Microbiology and Immunology and Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    BMC Microbiol 9:51. 2009
    ..In this study we extended studies of C. neoformans-macrophage cellular interaction/s to human peripheral blood monocytes...
  7. pmc Cell-to-cell spread and massive vacuole formation after Cryptococcus neoformans infection of murine macrophages
    Mauricio Alvarez
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    BMC Immunol 8:16. 2007
    ..In this report we have used time-lapse imaging to determine if this occurs with Cn...
  8. pmc Passive antibody administration (immediate immunity) as a specific defense against biological weapons
    Arturo Casadevall
    Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Emerg Infect Dis 8:833-41. 2002
    ..This article proposes a biological defense initiative based on developing, producing, and stockpiling specific antibody reagents that can be used to protect the population against biological warfare threats...
  9. pmc Antibody-mediated immunity against intracellular pathogens: two-dimensional thinking comes full circle
    Arturo Casadevall
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Infect Immun 71:4225-8. 2003
  10. pmc Antibody-mediated protection through cross-reactivity introduces a fungal heresy into immunological dogma
    Arturo Casadevall
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Infect Immun 75:5074-8. 2007
  11. pmc Exploiting the redundancy in the immune system: vaccines can mediate protection by eliciting 'unnatural' immunity
    Arturo Casadevall
    Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    J Exp Med 197:1401-4. 2003
  12. pmc Accidental virulence, cryptic pathogenesis, martians, lost hosts, and the pathogenicity of environmental microbes
    Arturo Casadevall
    Department of Microbiology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Eukaryot Cell 6:2169-74. 2007
  13. ncbi request reprint Microbial threat lists: obstacles in the quest for biosecurity?
    Arturo Casadevall
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, New York 10461, USA
    Nat Rev Microbiol 8:149-54. 2010
    ....
  14. ncbi request reprint Virulence factors and their mechanisms of action: the view from a damage-response framework
    Arturo Casadevall
    Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Water Health 7:S2-S18. 2009
    ..In fact, this concept appears to work best for certain types of bacterial pathogens, being less well suited for viruses and commensal organisms with pathogenic potential...
  15. ncbi request reprint Adjunctive immune therapy for fungal infections
    A Casadevall
    Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA
    Clin Infect Dis 33:1048-56. 2001
    ....
  16. ncbi request reprint Host-pathogen interactions: the attributes of virulence
    A Casadevall
    Division of Infectious Diseases of the Department of Medicine and Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Infect Dis 184:337-44. 2001
    ....
  17. ncbi request reprint Antibodies for defense against biological attack
    Arturo Casadevall
    Division of Infectious Diseases, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, New York 10461, USA
    Nat Biotechnol 20:114. 2002
  18. ncbi request reprint Induced humoral immunity and vaccination against major human fungal pathogens
    Arturo Casadevall
    Department of Medicine, The Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York, NY 10461, USA
    Curr Opin Microbiol 5:386-91. 2002
    ..Protective monoclonal antibodies can be used to identify antigens that induce useful humoral responses...
  19. doi request reprint Vesicular transport across the fungal cell wall
    Arturo Casadevall
    Departments of Microbiology and Immunology, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Trends Microbiol 17:158-62. 2009
    ..The discovery of vesicular transport in fungi opens many new avenues for investigation in basic cell biology and pathogenesis...
  20. doi request reprint Evolution of intracellular pathogens
    Arturo Casadevall
    Department of Microbiology and Immunology, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, USA
    Annu Rev Microbiol 62:19-33. 2008
    ..Although often viewed as a specialized adaptation, the capacity for intracellular survival may be widespread among microbes, thus questioning whether the intracellular lifestyle warrants a category of special distinctiveness...
  21. ncbi request reprint 'Ready made' virulence and 'dual use' virulence factors in pathogenic environmental fungi--the Cryptococcus neoformans paradigm
    Arturo Casadevall
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, New York 10461, USA
    Curr Opin Microbiol 6:332-7. 2003
    ..The findings with C. neoformans may provide a paradigm for understanding the origin and maintenance of virulence in other pathogenic environmental fungi...
  22. ncbi request reprint Targeting host cells harbouring viruses with radiolabeled antibodies
    Arturo Casadevall
    Albert Einstein College of Medicine, Department of Microbiology and Immunology, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Expert Opin Biol Ther 7:595-7. 2007
    ..This approach was recently shown to target and eliminate HIV-1-infected cells in vitro and in mouse models, and provides a new approach for eliminating virally infected cells...
  23. pmc Antibody-based therapies for emerging infectious diseases
    A Casadevall
    Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Emerg Infect Dis 2:200-8. 1996
    ..The potential of antibodies as antiinfective agents has not been fully tapped. Antibody-based therapies constitute a potentially useful option against newly emergent pathogens...
  24. ncbi request reprint The potential of antibody-mediated immunity in the defence against biological weapons
    Arturo Casadevall
    Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Expert Opin Biol Ther 5:1359-72. 2005
    ..Nevertheless, the advantages inherent in the therapeutic and prophylactic use of AMI provide a powerful rationale for continued development that will undoubtedly yield many new vaccines and therapeutic Abs...
  25. ncbi request reprint Antibody-mediated protection against intracellular pathogens
    A Casadevall
    Dept of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Trends Microbiol 6:102-7. 1998
    ..The challenge now is to identify antigens that elicit protective antibodies, use them in vaccine design and understand how humoral and cellular immune mechanisms cooperate...
  26. ncbi request reprint Polysaccharide-containing conjugate vaccines for fungal diseases
    Arturo Casadevall
    Division of Infectious Diseases of the Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Trends Mol Med 12:6-9. 2006
    ..The description of a vaccine that could protect against various fungal pathogens opens exciting new dimensions in the search for approaches to control fungal diseases...
  27. ncbi request reprint Feasibility and prospects for a vaccine to prevent cryptococcosis
    Arturo Casadevall
    Division of Infectious Diseases of the Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Med Mycol 43:667-80. 2005
    ..Hence, a vaccine against cryptococcosis in humans is probably feasible but there are significant obstacles to vaccine development that range from uncertainties about the pathogenesis of infection to economic considerations...
  28. pmc Characterization of a murine monoclonal antibody to Cryptococcus neoformans polysaccharide that is a candidate for human therapeutic studies
    A Casadevall
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Antimicrob Agents Chemother 42:1437-46. 1998
    ..The results show that both the variable and constant regions of MAb 18B7 are biologically functional and support the use of this MAb in human therapeutic trials...
  29. pmc Chronological aging is associated with biophysical and chemical changes in the capsule of Cryptococcus neoformans
    Radames J B Cordero
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA
    Infect Immun 79:4990-5000. 2011
    ..Changes associated with cellular aging in chronic infections could contribute to the remarkable capacity of this fungus to persist in tissues by generating phenotypically and antigenically different capsules...
  30. ncbi request reprint Fungal virulence, vertebrate endothermy, and dinosaur extinction: is there a connection?
    Arturo Casadevall
    Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Fungal Genet Biol 42:98-106. 2005
    ..Deforestation and proliferation of fungal spores at cretaceous-tertiary boundary suggests that fungal diseases could have contributed to the demise of dinosaurs and the flourishing of mammalian species...
  31. pmc Descriptive science
    Arturo Casadevall
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461 1975, USA
    Infect Immun 76:3835-6. 2008
  32. pmc New concepts in antibody-mediated immunity
    Arturo Casadevall
    Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Infect Immun 72:6191-6. 2004
  33. ncbi request reprint The weapon potential of a microbe
    Arturo Casadevall
    Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Trends Microbiol 12:259-63. 2004
    ....
  34. ncbi request reprint Antibody-mediated regulation of cellular immunity and the inflammatory response
    Arturo Casadevall
    Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, New York, NY 10461, USA
    Trends Immunol 24:474-8. 2003
  35. ncbi request reprint The weapon potential of human pathogenic fungi
    Arturo Casadevall
    Department of Microbiology and Immunology and the Division of Infectious Diseases of the Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, New York, USA
    Med Mycol 44:689-96. 2006
    ..Awareness of the weapon potential of human pathogenic fungi is an important consideration for greater preparedness against the threat posed by biowarfare and bioterrorism...
  36. ncbi request reprint Insights into mechanisms of antibody-mediated immunity from studies with Cryptococcus neoformans
    A Casadevall
    Division of Infectious Diseases or the Department of Medicine and the Department of Microbiology and Immunology of the Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Curr Mol Med 5:421-33. 2005
    ..Observations with C. neoformans have stimulated a reappraisal of the role of humoral immunity for other pathogens and highlighted the limitations in current methods of assessing the role of Ab in host defense...
  37. ncbi request reprint The damage-response framework of microbial pathogenesis
    Arturo Casadevall
    Departments of Medicine Division of Infectious Diseases and Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Nat Rev Microbiol 1:17-24. 2003
    ..To address this impediment to studies of host-microorganism interactions, we propose a new theoretical approach to understanding microbial pathogenesis, known as the 'damage-response' framework...
  38. ncbi request reprint The methodology for determining the efficacy of antibody-mediated immunity
    Arturo Casadevall
    Division of Infectious Diseases, Department of Microbiology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Immunol Methods 291:1-10. 2004
    ..Furthermore, studies with monoclonal antibodies suggest various explanations for the inability of standard methods to demonstrate the potential efficacy of AMI for certain pathogens...
  39. ncbi request reprint Passive antibody therapy for infectious diseases
    Arturo Casadevall
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Nat Rev Microbiol 2:695-703. 2004
    ....
  40. pmc Host as the variable: model hosts approach the immunological asymptote
    Arturo Casadevall
    Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Infect Immun 73:3829-32. 2005
  41. ncbi request reprint Immunoglobulin M efficacy against Cryptococcus neoformans: mechanism, dose dependence, and prozone-like effects in passive protection experiments
    C P Taborda
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 166:2100-7. 2001
    ....
  42. pmc Eosinophil-Cryptococcus neoformans interactions in vivo and in vitro
    M Feldmesser
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461 1602, USA
    Infect Immun 65:1899-907. 1997
    ..Mast cells were observed to occasionally phagocytose C. neoformans in vitro in the presence of IgE MAb. Our observations suggest that eosinophils may be effector cells against C. neoformans...
  43. ncbi request reprint Effect of antibody to capsular polysaccharide on eosinophilic pneumonia in murine infection with Cryptococcus neoformans
    M Feldmesser
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Infect Dis 177:1639-46. 1998
    ..Our results provide additional evidence that antibody administration can produce quantitative and qualitative changes in the inflammatory response to a pathogen...
  44. pmc Phenotypic switching of Cryptococcus neoformans occurs in vivo and influences the outcome of infection
    B C Fries
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Clin Invest 108:1639-48. 2001
    ..The importance of this finding is underscored by the increased likelihood of phenotypic switching in chronic cryptococcosis; thus this mechanism may account for the inability to eradicate the organism in immunocompromised hosts...
  45. pmc Feasibility of radioimmunotherapy of experimental pneumococcal infection
    E Dadachova
    Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Antimicrob Agents Chemother 48:1624-9. 2004
    ..01). The treatment did not cause hematological toxicity, as demonstrated by platelet counts. This feasibility study establishes that RIT can be applied to the treatment of bacterial infections...
  46. pmc Both Th1 and Th2 cytokines affect the ability of monoclonal antibodies to protect mice against Cryptococcus neoformans
    D O Beenhouwer
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Infect Immun 69:6445-55. 2001
    ..neoformans requires both Th1- and Th2-associated cytokines and reveal the complexity of the mechanisms through which antibodies modulate infection with this organism...
  47. pmc Neutralizing monoclonal antibody to edema toxin and its effect on murine anthrax
    Lisa Winterroth
    Departments of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Infect Immun 78:2890-8. 2010
    ....
  48. pmc Cryptococcus neoformans is a facultative intracellular pathogen in murine pulmonary infection
    M Feldmesser
    Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Infect Immun 68:4225-37. 2000
    ..Furthermore, our observations suggest that C. neoformans occupies a unique niche among the intracellular pathogens whereby survival in phagocytic cells is accompanied by intracellular polysaccharide production...
  49. pmc Clearance and organ distribution of Mycobacterium tuberculosis lipoarabinomannan (LAM) in the presence and absence of LAM-binding immunoglobulin M
    A Glatman-Freedman
    Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Infect Immun 68:335-41. 2000
    ..The results indicate that serum clearance and organ deposition of LAM in mice are affected by the presence of LAM-binding antibody and suggest a mechanism by which antibody could modify the course of mycobacterial infection...
  50. pmc Antibody interactions with the capsule of Cryptococcus neoformans
    M Feldmesser
    Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA
    Infect Immun 68:3642-50. 2000
    ....
  51. pmc The mouse antibody response to infection with Cryptococcus neoformans: VH and VL usage in polysaccharide binding antibodies
    A Casadevall
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461
    J Exp Med 174:151-60. 1991
    ..Sequence and Southern blot analysis indicate that the serotype-D CNPS-specific mAbs arose from only a few precursor B cells...
  52. pmc Antigen-induced protective and nonprotective cell-mediated immune components against Cryptococcus neoformans
    J W Murphy
    Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73190, USA
    Infect Immun 66:2632-9. 1998
    ..Our results imply that there are protective and nonprotective cell-mediated immune responses and highlight the complexity of the immune response to C. neoformans antigens...
  53. pmc Persistent Cryptococcus neoformans pulmonary infection in the rat is associated with intracellular parasitism, decreased inducible nitric oxide synthase expression, and altered antibody responsiveness to cryptococcal polysaccharide
    D L Goldman
    Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Infect Immun 68:832-8. 2000
    ..neoformans; and (iv) reduced antibody responses to cryptococcal polysaccharide. The results show that maintenance of persistent infection is associated with downregulation of both cellular and humoral immune responses...
  54. pmc Bacillus anthracis produces membrane-derived vesicles containing biologically active toxins
    Johanna Rivera
    Department of Microbiology and Immunology, Division of Infectious Diseases, The Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 107:19002-7. 2010
    ..Our observations may have important implications for the design of vaccines, for passive antibody strategies, and provide a previously unexplored system for studying secretory pathways in Gram-positive bacteria...
  55. pmc Antibody-guided alpha radiation effectively damages fungal biofilms
    L R Martinez
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA
    Antimicrob Agents Chemother 50:2132-6. 2006
    ..Our results indicate that C. neoformans biofilms are susceptible to treatment with antibody-targeted alpha radiation, suggesting a novel option for the prevention or treatment of microbial biofilms on indwelling medical devices...
  56. pmc Effects of voriconazole on Cryptococcus neoformans
    David van Duin
    Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Antimicrob Agents Chemother 48:2014-20. 2004
    ..The high activity of voriconazole against both melanized and nonmelanized cells results suggest that voriconazole may be a particularly valuable drug for cryptococcosis...
  57. ncbi request reprint Phagosome extrusion and host-cell survival after Cryptococcus neoformans phagocytosis by macrophages
    Mauricio Alvarez
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, 10461, USA
    Curr Biol 16:2161-5. 2006
    ....
  58. pmc Radioimmunotherapy is more effective than antifungal treatment in experimental cryptococcal infection
    Ruth A Bryan
    Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Infect Dis 202:633-7. 2010
    ..We conclude that RIT is more effective than amphotericin B against systemic infection with C. neoformans...
  59. ncbi request reprint Mouse genetic background is a major determinant of isotype-related differences for antibody-mediated protective efficacy against Cryptococcus neoformans
    Johanna Rivera
    Department of Microbiology and Immunology, Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 174:8017-26. 2005
    ..The dependence of isotype efficacy on host genetics underscores a previously unsuspected complex relationship between the cellular and humoral arms of the adaptive immune response...
  60. ncbi request reprint Neutropenia alters lung cytokine production in mice and reduces their susceptibility to pulmonary cryptococcosis
    Aron J Mednick
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA
    Eur J Immunol 33:1744-53. 2003
    ..Our results support the emerging concept that neutrophils play an important function in modulating the development of the immune response...
  61. ncbi request reprint More is not necessarily better: prozone-like effects in passive immunization with IgG
    Carlos P Taborda
    Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 170:3621-30. 2003
    ..Our findings have implications for the potential contribution of Ab responses to defense against microbial diseases because Ab-mediated immunity may be protective, nonprotective, or even deleterious to the host...
  62. pmc Antibody-mediated protection in mice with lethal intracerebral Cryptococcus neoformans infection
    J Mukherjee
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461
    Proc Natl Acad Sci U S A 90:3636-40. 1993
    ..Thus, systemic administration of a monoclonal antibody can modify the course of lethal intracerebral C. neoformans infection in mice by prolonging survival and decreasing fungal burden in brain tissues...
  63. pmc Phenotypic switching in the human pathogenic fungus Cryptococcus neoformans is associated with changes in virulence and pulmonary inflammatory response in rodents
    D L Goldman
    Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, USA
    Proc Natl Acad Sci U S A 95:14967-72. 1998
    ..Phenotypic switching may play a role in the ability of this fungus to escape host defenses and establish chronic infections...
  64. ncbi request reprint The effect of the echinocandin analogue caspofungin on cell wall glucan synthesis by Cryptococcus neoformans
    M Feldmesser
    Dept of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, Golding Bldg, Bronx, NY 10461, USA
    J Infect Dis 182:1791-5. 2000
    ..neoformans may result from reduced activity against C. neoformans glucan synthase or from yet undiscovered mechanisms of action operative in other fungal pathogens but not in C. neoformans...
  65. ncbi request reprint Glyphosate inhibits melanization of Cryptococcus neoformans and prolongs survival of mice after systemic infection
    J D Nosanchuk
    Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Infect Dis 183:1093-9. 2001
    ..neoformans delayed melanization of yeast cells in vivo and prolonged average mouse survival. The results suggest that inhibition of melanization in vivo may facilitate control of C. neoformans infection...
  66. pmc Passive immunization with melanin-binding monoclonal antibodies prolongs survival of mice with lethal Cryptococcus neoformans infection
    A L Rosas
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Infect Immun 69:3410-2. 2001
    ..MAbs to melanin reduced the growth rate of in vitro-melanized C. neoformans cells, suggesting a new mechanism of antibody-mediated protection...
  67. pmc Antibody-mediated protection against Cryptococcus neoformans pulmonary infection is dependent on B cells
    Johanna Rivera
    Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Infect Immun 73:1141-50. 2005
    ..The results indicate an important role for B cells in host defense against C. neoformans infection and demonstrate a surprising dependence of Ab-mediated protection on B cells in this system...
  68. ncbi request reprint The immunoglobulin heavy chain constant region affects kinetic and thermodynamic parameters of antibody variable region interactions with antigen
    Marcela Torres
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 282:13917-27. 2007
    ..Furthermore, isotype affected the polyreactivity of V region identical antibodies, implying a role for C region in determining self-reactivity...
  69. pmc Interaction of Blastomyces dermatitidis, Sporothrix schenckii, and Histoplasma capsulatum with Acanthamoeba castellanii
    Judith N Steenbergen
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Infect Immun 72:3478-88. 2004
    ..These results are consistent with the view that soil amoebae may contribute to the selection and maintenance of certain traits in pathogenic dimorphic fungi that confer on these microbes the capacity for virulence in mammals...
  70. pmc Susceptibility of Cryptococcus neoformans biofilms to antifungal agents in vitro
    Luis R Martinez
    Department of Medicine and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, New York 10461, USA
    Antimicrob Agents Chemother 50:1021-33. 2006
    ..neoformans biofilm formation involved capsular polysaccharide release and adherence. Our results suggest that biofilm formation may diminish the efficacies of some antifungal drugs during cryptococcal infection...
  71. ncbi request reprint Isotype can affect the fine specificity of an antibody for a polysaccharide antigen
    Gary R McLean
    Departments of Medicine and Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461
    J Immunol 169:1379-86. 2002
    ....
  72. pmc Melanization of Cryptococcus neoformans and Histoplasma capsulatum reduces their susceptibilities to amphotericin B and caspofungin
    David van Duin
    Department of Medicine, Division of Infectious Diseases Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Antimicrob Agents Chemother 46:3394-400. 2002
    ..Furthermore, the results indicate that fungal melanins protect C. neoformans and H. capsulatum from the activities of amphotericin B and caspofungin and that this protection is not demonstrable by standard broth macrodilution assays...
  73. pmc The common Cryptococcus neoformans glucuronoxylomannan M2 motif elicits non-protective antibodies
    Antonio Nakouzi
    Department of Microbiology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Vaccine 27:3513-8. 2009
    ..Furthermore, the results illustrate the first molecular assignment of a C. neoformans polysaccharide epitope and suggest a general strategy for the identification of GXM epitopes...
  74. pmc Capsular localization of the Cryptococcus neoformans polysaccharide component galactoxylomannan
    Magdia De Jesus
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Eukaryot Cell 8:96-103. 2009
    ..Hence, the function of GalXM appears to be more consistent with that of an exopolysaccharide than a structural component of the cryptococcal capsule...
  75. pmc Laccase expression in murine pulmonary Cryptococcus neoformans infection
    Javier Garcia-Rivera
    Division of Infectious Disease, Albert Einstein College of Medicine, 1300 Morris Park Ave, Golding 701, Bronx, NY 10461, USA
    Infect Immun 73:3124-7. 2005
    ..Laccase was detected in the fungal cell cytoplasm, cell wall, and capsule in vivo. The amount of laccase found in different sites varied as a function of the time of infection...
  76. pmc Immunogenicity of Bacillus anthracis protective antigen domains and efficacy of elicited antibody responses depend on host genetic background
    Nareen Abboud
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Clin Vaccine Immunol 15:1115-23. 2008
    ..The results suggest that the variability observed in vaccination studies with PA-derived vaccines is a result of host heterogeneity and implies a need to develop other antigens as vaccine candidates...
  77. pmc Identification of linear epitopes in Bacillus anthracis protective antigen bound by neutralizing antibodies
    Nareen Abboud
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 284:25077-86. 2009
    ..These results identify the first linear neutralizing epitopes of PA and show that peptides containing epitope sequences can elicit neutralizing antibody responses, a finding that could be exploited for vaccine design...
  78. pmc Cryptococcus neoformans var. neoformans (serotype D) strains are more susceptible to heat than C. neoformans var. grubii (serotype A) strains
    L R Martinez
    Department of Biology, Long Island University, Brooklyn, New York, USA
    J Clin Microbiol 39:3365-7. 2001
    ..neoformans strains being more susceptible, on average, to heat killing. The results suggest a consistent explanation for the geographic differences between serotype A and D strains and for the dermatotropism of serotype D strains...
  79. pmc Intracellular crystal formation as a mechanism of cytotoxicity in murine pulmonary Cryptococcus neoformans infection
    M Feldmesser
    Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Infect Immun 69:2723-7. 2001
    ..The crystals apparently formed because of the interaction of a host protein with the cryptococcal polysaccharide. Crystal formation likely contributes to pathogenesis by causing cellular damage...
  80. pmc Molecular basis for immunoglobulin M specificity to epitopes in Cryptococcus neoformans polysaccharide that elicit protective and nonprotective antibodies
    A Nakouzi
    Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Infect Immun 69:3398-409. 2001
    ..neoformans. This has important implications for immunotherapy and vaccine design that are reinforced by the finding that GXM and peptide reactivities are determined by different amino acid residues...
  81. ncbi request reprint Extracellular phospholipase activity is a virulence factor for Cryptococcus neoformans
    G M Cox
    Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Mol Microbiol 39:166-75. 2001
    ..We also found that the plb1 strain exhibited a growth defect in a macrophage-like cell line. These data demonstrate that secretory phospholipase is a virulence factor for C. neoformans...
  82. ncbi request reprint Dynamic changes in the morphology of Cryptococcus neoformans during murine pulmonary infection
    M Feldmesser
    Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Microbiology 147:2355-65. 2001
    ..The results indicate that the population of C. neoformans cells in tissue is in a highly dynamic state, implying that the immune system must confront cells with varying characteristics during the course of infection...
  83. pmc Phenotypic switching in Cryptococcus neoformans results in changes in cellular morphology and glucuronoxylomannan structure
    B C Fries
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Infect Immun 67:6076-83. 1999
    ..Hence, phenotypic switching is an adaptive mechanism linked to virulence that can generate cell types with very different biological characteristics...
  84. ncbi request reprint An innate immune system cell is a major determinant of species-related susceptibility differences to fungal pneumonia
    Xiuping Shao
    Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 175:3244-51. 2005
    ..In summary, differences in AM function in rats and mice suggest an explanation for the species differences in susceptibility to C. neoformans based on the inherent efficacy of a central effector cell of the innate immune system...
  85. ncbi request reprint Structural and functional characterization of glycosylation in an immunoglobulin G1 to Cryptococcus neoformans glucuronoxylomannan
    Fang Wang
    Laboratory for Macromolecular Analysis and Proteomics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Mol Immunol 43:987-98. 2006
    ..The results imply that the contribution of N-glycan structure to immunoglobulin function varies depending on the Ag-Ab system...
  86. pmc A requirement for FcγR in antibody-mediated bacterial toxin neutralization
    Nareen Abboud
    Department of Microbiology and Immunology, Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Exp Med 207:2395-405. 2010
    ..These findings highlight a new parameter for evaluating vaccine responses and the possibility of harnessing optimal FcγR interactions in the design of passive immunization strategies...
  87. pmc Radiolabeled antibodies to Bacillus anthracis toxins are bactericidal and partially therapeutic in experimental murine anthrax
    Johanna Rivera
    Department of Microbiology and Immunology, Division of Infectious Diseases, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Antimicrob Agents Chemother 53:4860-8. 2009
    ..anthracis Sterne spores. These results indicate that RIT with MAbs that target B. anthracis toxin components can be used to treat experimental anthrax infection and suggest that toxigenic bacteria may be targeted with radiolabeled MAbs...
  88. ncbi request reprint Antibody action after phagocytosis promotes Cryptococcus neoformans and Cryptococcus gattii macrophage exocytosis with biofilm-like microcolony formation
    Mauricio Alvarez
    Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Cell Microbiol 10:1622-33. 2008
    ..This finding suggests that antibody agglutination effects persist in the phagosome to entangle nascent daughter cells and this phenomenon may contribute to antibody-mediated protection...
  89. pmc Physico-chemical evaluation of rationally designed melanins as novel nature-inspired radioprotectors
    Andrew D Schweitzer
    Department of Nuclear Medicine, Albert Einstein College of Medicine, New York, New York, United States of America
    PLoS ONE 4:e7229. 2009
    ..Melanin, a high-molecular weight pigment that is ubiquitous in nature, protects melanized microorganisms against high doses of ionizing radiation. However, the physics of melanin interaction with ionizing radiation is unknown...
  90. pmc Voriconazole inhibits melanization in Cryptococcus neoformans
    Luis R Martinez
    Department of Medicine Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Antimicrob Agents Chemother 51:4396-400. 2007
    ..Hence, voriconazole affects melanization in C. neoformans by interacting directly with laccase, which may increase the efficacy of this potent antifungal against certain pigmented fungi...
  91. ncbi request reprint Phage display library derived peptides that bind to human tumor melanin as potential vehicles for targeted radionuclide therapy of metastatic melanoma
    Robertha C Howell
    Department of Nuclear Medicine, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY 10461, USA
    Bioconjug Chem 18:1739-48. 2007
    ..Thus, these heptapeptides appear to have potentially significant advantages for targeted therapy of melanoma relative to existing melanin-binding peptides...
  92. ncbi request reprint Computational model predicts effective delivery of 188-Re-labeled melanin-binding antibody to metastatic melanoma tumors with wide range of melanin concentrations
    Andrew D Schweitzer
    The Mount Sinai School of Medicine, Cornell University, Ithaca, New York, USA
    Melanoma Res 17:291-303. 2007
    ..In conclusion, RIT of metastatic melanoma can be effective over a wide range of tumor melanin concentrations. The results can be useful in the design of a clinical trial of melanin-targeting RIT in patients with metastatic melanoma...
  93. pmc A monoclonal antibody to Bacillus anthracis protective antigen defines a neutralizing epitope in domain 1
    Johanna Rivera
    Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Infect Immun 74:4149-56. 2006
    ..However, MAb 7.5G slowed the proteolytic digestion of PA by furin in vitro, suggesting a potential mechanism for Ab-mediated protection. These observations indicate that some Abs to domain 1 can contribute to host protection...
  94. ncbi request reprint The physical properties of the capsular polysaccharides from Cryptococcus neoformans suggest features for capsule construction
    Diane C McFadden
    Department of Medicine, Division of Infectious Disease, and Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Biol Chem 281:1868-75. 2006
    ..A mechanism for capsule growth is proposed based on the extracellular release and entanglement of GXM molecules...
  95. ncbi request reprint Fc- and complement-receptor activation stimulates cell cycle progression of macrophage cells from G1 to S
    Yong Luo
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 174:7226-33. 2005
    ..This observation suggests a potential mechanism for increasing the number of effector cells after microbial ingestion, but can also promote the spread of infection...
  96. doi request reprint Radioimmunotherapy of experimental human metastatic melanoma with melanin-binding antibodies and in combination with dacarbazine
    Ekaterina Revskaya
    Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Clin Cancer Res 15:2373-9. 2009
    ....

Research Grants55

  1. MOLECULAR CHARACTERIZATION OF C NEOFORMANS ANTIBODIES
    Arturo Casadevall; Fiscal Year: 2001
    ..On a practical level, Dr. Casadevall s laboratory hopes to use this information in design of therapeutic antibodies and vaccines against C. neoformans. ..
  2. Synergy of Host Defense Mechanisms in the Lung
    Arturo Casadevall; Fiscal Year: 2009
    ..Furthermore, these studies will provide information that could be used to design vaccines and new therapies based on immunological reagents such as antibodies. ..
  3. PROTECTIVE ANTIBODIES FOR CRYPTOCOCCAL INFECTIONS
    Arturo Casadevall; Fiscal Year: 2007
    ..neoformans and also to other efforts to develop Ab therapy, vaccines and fundamental immunology. ..
  4. Molecular Characterization of C. neoformans Antibodies
    Arturo Casadevall; Fiscal Year: 2007
    ..neoformans; 3) To determine how GalXM contributes to C. neoformans capsular structure organization and evaluate the efficacy of antibodies to this polysaccharide. ..
  5. Biology of Fungal Melanin
    Arturo Casadevall; Fiscal Year: 2007
    ..It is anticipated that the work proposed here will provide important insights into the biology of melanin and in doing so highlight novel strategies for antimicrobial drug development. ..
  6. MOLECULAR CHARACTERIZATION OF C NEOFORMANS ANTIBODIES
    Arturo Casadevall; Fiscal Year: 2002
    ..These studies are expected to yield new insights on fundamental aspects of antibody function as well as practical information for the development of second generation antibody reagents for human therapy. ..
  7. Mining slime mold for susceptibility genes to fungi
    Arturo Casadevall; Fiscal Year: 2005
    ..discoideum system will lead to the identification of genetic pathways that are not immediately obvious from standard fungal-macrophage experiments. ..
  8. MOLECULAR CHARACTERIZATION OF C NEOFORMANS ANTIBODIES
    Arturo Casadevall; Fiscal Year: 1999
    ..On a practical level, Dr. Casadevall s laboratory hopes to use this information in design of therapeutic antibodies and vaccines against C. neoformans. ..
  9. MOLECULAR PATHOGENESIS OF INFECTIOUS DISEASES
    Arturo Casadevall; Fiscal Year: 2006
    ....
  10. MOLECULAR CHARACTERIZATION OF C NEOFORMANS ANTIBODIES
    Arturo Casadevall; Fiscal Year: 2000
    ..On a practical level, Dr. Casadevall s laboratory hopes to use this information in design of therapeutic antibodies and vaccines against C. neoformans. ..
  11. MOLECULAR CHARACTERIZATION OF C NEOFORMANS ANTIBODIES
    Arturo Casadevall; Fiscal Year: 2006
    ..These studies are expected to yield new insights on fundamental aspects of antibody function as well as practical information for the development of second generation antibody reagents for human therapy. ..
  12. MOLECULAR CHARACTERIZATION OF C NEOFORMANS ANTIBODIES
    Arturo Casadevall; Fiscal Year: 2003
    ..These studies are expected to yield new insights on fundamental aspects of antibody function as well as practical information for the development of second generation antibody reagents for human therapy. ..
  13. MOLECULAR CHARACTERIZATION OF C NEOFORMANS ANTIBODIES
    Arturo Casadevall; Fiscal Year: 2004
    ..These studies are expected to yield new insights on fundamental aspects of antibody function as well as practical information for the development of second generation antibody reagents for human therapy. ..
  14. MOLECULAR CHARACTERIZATION OF C NEOFORMANS ANTIBODIES
    Arturo Casadevall; Fiscal Year: 2005
    ..These studies are expected to yield new insights on fundamental aspects of antibody function as well as practical information for the development of second generation antibody reagents for human therapy. ..
  15. SYNERGY OF HOST DEFENSE MECHANISMS IN LUNG
    Arturo Casadevall; Fiscal Year: 2005
    ..By comparing the immune response in Ab-permissive and Ab-non-permissive murine strains we will learn the conditions and mechanisms by which Ab-mediates protection against C. neoformans. ..
  16. Biology of Fungal Melanin
    Arturo Casadevall; Fiscal Year: 2006
    ..It is anticipated that the work proposed here will provide important insights into the biology of melanin and in doing so highlight novel strategies for antimicrobial drug development. ..
  17. PROTECTIVE ANTIBODIES FOR CRYPTOCOCCAL INFECTIONS
    Arturo Casadevall; Fiscal Year: 2005
    ..neoformans and also to other efforts to develop Ab therapy, vaccines and fundamental immunology. ..
  18. PROTECTIVE ANTIBODIES FOR CRYPTOCOCCAL INFECTIONS
    Arturo Casadevall; Fiscal Year: 2006
    ..neoformans and also to other efforts to develop Ab therapy, vaccines and fundamental immunology. ..
  19. Biology of Fungal Melanin
    Arturo Casadevall; Fiscal Year: 2009
    ..In this regard, a monoclonal antibody to fungal melanin made as part of this research program is already in clinical evaluation for the therapy of melanoma. ..
  20. PROTECTIVE ANTIBODIES FOR CRYPTOCOCCAL INFECTIONS
    Arturo Casadevall; Fiscal Year: 2005
    ..neoformans and also to other efforts to develop Ab therapy, vaccines and fundamental immunology. ..
  21. SYNERGY OF HOST DEFENSE MECHANISMS IN LUNG
    Arturo Casadevall; Fiscal Year: 2006
    ..By comparing the immune response in Ab-permissive and Ab-non-permissive murine strains we will learn the conditions and mechanisms by which Ab-mediates protection against C. neoformans. ..
  22. SYNERGY OF HOST DEFENSE MECHANISMS IN LUNG
    Arturo Casadevall; Fiscal Year: 2003
    ..By comparing the immune response in Ab-permissive and Ab-non-permissive murine strains we will learn the conditions and mechanisms by which Ab-mediates protection against C. neoformans. ..
  23. PROTECTIVE ANTIBODIES FOR CRYPTOCOCCAL INFECTIONS
    Arturo Casadevall; Fiscal Year: 2004
    ..neoformans and also to other efforts to develop Ab therapy, vaccines and fundamental immunology. ..
  24. SYNERGY OF HOST DEFENSE MECHANISMS IN LUNG
    Arturo Casadevall; Fiscal Year: 1999
    ..To determine the effect of polysaccharide-protein conjugate vaccination on pulmonary defenses against C. neoformans in the context of cytokine- and nitric oxide-related mechanisms. ..
  25. PROTECTIVE ANTIBODIES FOR CRYPTOCOCCAL INFECTIONS
    Arturo Casadevall; Fiscal Year: 1999
    ..To establish the most effective and least toxic human constant region against C. neoformans in mice; and Aim 3. To determine the consequences of antibody-mediated deposition of cryptococcal polysaccharide in reticuloendothelial cells. ..
  26. PROTECTIVE ANTIBODIES FOR CRYPTOCOCCAL INFECTIONS
    Arturo Casadevall; Fiscal Year: 2000
    ..To establish the most effective and least toxic human constant region against C. neoformans in mice; and Aim 3. To determine the consequences of antibody-mediated deposition of cryptococcal polysaccharide in reticuloendothelial cells. ..
  27. SYNERGY OF HOST DEFENSE MECHANISMS IN LUNG
    Arturo Casadevall; Fiscal Year: 2000
    ..To determine the effect of polysaccharide-protein conjugate vaccination on pulmonary defenses against C. neoformans in the context of cytokine- and nitric oxide-related mechanisms. ..
  28. SYNERGY OF HOST DEFENSE MECHANISMS IN LUNG
    Arturo Casadevall; Fiscal Year: 2004
    ..By comparing the immune response in Ab-permissive and Ab-non-permissive murine strains we will learn the conditions and mechanisms by which Ab-mediates protection against C. neoformans. ..
  29. Biology of Fungal Melanin
    Arturo Casadevall; Fiscal Year: 2003
    ..It is anticipated that the work proposed here will provide important insights into the biology of melanin and in doing so highlight novel strategies for antimicrobial drug development. ..
  30. SYNERGY OF HOST DEFENSE MECHANISMS IN LUNG
    Arturo Casadevall; Fiscal Year: 2003
    ..By comparing the immune response in Ab-permissive and Ab-non-permissive murine strains we will learn the conditions and mechanisms by which Ab-mediates protection against C. neoformans. ..
  31. PROTECTIVE ANTIBODIES FOR CRYPTOCOCCAL INFECTIONS
    Arturo Casadevall; Fiscal Year: 2003
    ..To establish the most effective and least toxic human constant region against C. neoformans in mice; and Aim 3. To determine the consequences of antibody-mediated deposition of cryptococcal polysaccharide in reticuloendothelial cells. ..
  32. SYNERGY OF HOST DEFENSE MECHANISMS IN LUNG
    Arturo Casadevall; Fiscal Year: 2002
    ..By comparing the immune response in Ab-permissive and Ab-non-permissive murine strains we will learn the conditions and mechanisms by which Ab-mediates protection against C. neoformans. ..
  33. PROTECTIVE ANTIBODIES FOR CRYPTOCOCCAL INFECTIONS
    Arturo Casadevall; Fiscal Year: 2002
    ..To establish the most effective and least toxic human constant region against C. neoformans in mice; and Aim 3. To determine the consequences of antibody-mediated deposition of cryptococcal polysaccharide in reticuloendothelial cells. ..
  34. SYNERGY OF HOST DEFENSE MECHANISMS IN LUNG
    Arturo Casadevall; Fiscal Year: 2001
    ..To determine the effect of polysaccharide-protein conjugate vaccination on pulmonary defenses against C. neoformans in the context of cytokine- and nitric oxide-related mechanisms. ..
  35. PROTECTIVE ANTIBODIES FOR CRYPTOCOCCAL INFECTIONS
    Arturo Casadevall; Fiscal Year: 2001
    ..To establish the most effective and least toxic human constant region against C. neoformans in mice; and Aim 3. To determine the consequences of antibody-mediated deposition of cryptococcal polysaccharide in reticuloendothelial cells. ..