Dongsheng Cai

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. pmc IKKβ/NF-κB disrupts adult hypothalamic neural stem cells to mediate a neurodegenerative mechanism of dietary obesity and pre-diabetes
    Juxue Li
    Department of Molecular Pharmacology, Bronx, New York 10461, USA
    Nat Cell Biol 14:999-1012. 2012
  2. pmc Treatment of obesity and diabetes using oxytocin or analogs in patients and mouse models
    Hai Zhang
    Department of Molecular Pharmacology, Diabetes Research Center, Institute of Aging, Albert Einstein College of Medicine, Bronx, New York, USA
    PLoS ONE 8:e61477. 2013
  3. pmc Uncoupling the mechanisms of obesity and hypertension by targeting hypothalamic IKK-β and NF-κB
    Sudarshana Purkayastha
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, New York, New York, USA
    Nat Med 17:883-7. 2011
  4. pmc Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH
    Guo Zhang
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Nature 497:211-6. 2013
  5. pmc Hypoxia-inducible factor directs POMC gene to mediate hypothalamic glucose sensing and energy balance regulation
    Hai Zhang
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS Biol 9:e1001112. 2011
  6. pmc Inflammatory cause of metabolic syndrome via brain stress and NF-κB
    Dongsheng Cai
    Department of Molecular Pharmacology and Diabetes Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Aging (Albany NY) 4:98-115. 2012
  7. doi request reprint Neuroinflammation in overnutrition-induced diseases
    Dongsheng Cai
    Department of Molecular Pharmacology, Institute of Aging, Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York, USA
    Vitam Horm 91:195-218. 2013
  8. pmc Neuroinflammation and neurodegeneration in overnutrition-induced diseases
    Dongsheng Cai
    Department of Molecular Pharmacology, Institute of Aging, Diabetes Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Trends Endocrinol Metab 24:40-7. 2013
  9. ncbi request reprint Hypothalamic inflammation: a double-edged sword to nutritional diseases
    Dongsheng Cai
    Department of Molecular Pharmacology, Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Ann N Y Acad Sci 1243:E1-39. 2011
  10. pmc Neural dysregulation of peripheral insulin action and blood pressure by brain endoplasmic reticulum stress
    Sudarshana Purkayastha
    Department of Molecular Pharmacology and Diabetes Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 108:2939-44. 2011

Collaborators

Detail Information

Publications18

  1. pmc IKKβ/NF-κB disrupts adult hypothalamic neural stem cells to mediate a neurodegenerative mechanism of dietary obesity and pre-diabetes
    Juxue Li
    Department of Molecular Pharmacology, Bronx, New York 10461, USA
    Nat Cell Biol 14:999-1012. 2012
    ..In conclusion, adult htNSCs are important for the central regulation of metabolic physiology, and IKKβ/NF-κB-mediated impairment of adult htNSCs is a critical neurodegenerative mechanism for obesity and related diabetes...
  2. pmc Treatment of obesity and diabetes using oxytocin or analogs in patients and mouse models
    Hai Zhang
    Department of Molecular Pharmacology, Diabetes Research Center, Institute of Aging, Albert Einstein College of Medicine, Bronx, New York, USA
    PLoS ONE 8:e61477. 2013
    ..In conclusion, oxytocin and its analogs have multi-level effects in improving weight control, insulin sensitivity and insulin secretion, and bear potentials for being developed as therapeutic peptides for obesity and diabetes...
  3. pmc Uncoupling the mechanisms of obesity and hypertension by targeting hypothalamic IKK-β and NF-κB
    Sudarshana Purkayastha
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, New York, New York, USA
    Nat Med 17:883-7. 2011
    ..Breaking this pathogenic link may represent an avenue for controlling obesity-related hypertension and CVD without requiring obesity control...
  4. pmc Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH
    Guo Zhang
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Nature 497:211-6. 2013
    ....
  5. pmc Hypoxia-inducible factor directs POMC gene to mediate hypothalamic glucose sensing and energy balance regulation
    Hai Zhang
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS Biol 9:e1001112. 2011
    ..In conclusion, HIF controls hypothalamic POMC gene to direct the central nutrient sensing in regulation of energy and body weight balance...
  6. pmc Inflammatory cause of metabolic syndrome via brain stress and NF-κB
    Dongsheng Cai
    Department of Molecular Pharmacology and Diabetes Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Aging (Albany NY) 4:98-115. 2012
    ..This article reviews recent research advances in the neural mechanisms of metabolic syndrome and related diseases from the perspective of pathogenic induction by intracellular stresses and NF-κB pathway of the brain...
  7. doi request reprint Neuroinflammation in overnutrition-induced diseases
    Dongsheng Cai
    Department of Molecular Pharmacology, Institute of Aging, Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York, USA
    Vitam Horm 91:195-218. 2013
    ....
  8. pmc Neuroinflammation and neurodegeneration in overnutrition-induced diseases
    Dongsheng Cai
    Department of Molecular Pharmacology, Institute of Aging, Diabetes Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Trends Endocrinol Metab 24:40-7. 2013
    ..Targeting neuroinflammation and neurodegeneration will provide promising approaches for treating obesity and other overnutrition-related diseases...
  9. ncbi request reprint Hypothalamic inflammation: a double-edged sword to nutritional diseases
    Dongsheng Cai
    Department of Molecular Pharmacology, Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Ann N Y Acad Sci 1243:E1-39. 2011
    ....
  10. pmc Neural dysregulation of peripheral insulin action and blood pressure by brain endoplasmic reticulum stress
    Sudarshana Purkayastha
    Department of Molecular Pharmacology and Diabetes Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 108:2939-44. 2011
    ..In conclusion, ER stress in the brain represents a mediator of the sympathetic disorders that underlie the development of insulin resistance syndrome and T2D...
  11. doi request reprint Neuropeptide exocytosis involving synaptotagmin-4 and oxytocin in hypothalamic programming of body weight and energy balance
    Guo Zhang
    Department of Molecular Pharmacology and Diabetes Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Neuron 69:523-35. 2011
    ..In conclusion, the negative regulation of synaptotagmin-4 on oxytocin release represents a hypothalamic basis of neuropeptide exocytosis in controlling obesity and related diseases...
  12. pmc Disruption of neurogenesis by hypothalamic inflammation in obesity or aging
    Sudarshana Purkayastha
    Department of Molecular Pharmacology, Diabetes Research Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, 10461, USA
    Rev Endocr Metab Disord 14:351-6. 2013
    ..This article reviews the crucial role of hypothalamic inflammation in affecting neural stem cells which mediates the neurodegenerative mechanisms of causing metabolic derangements as well as aging-associated disorders or diseases. ..
  13. pmc Defective hypothalamic autophagy directs the central pathogenesis of obesity via the IkappaB kinase beta (IKKbeta)/NF-kappaB pathway
    Qingyuan Meng
    Department of Molecular Pharmacology and Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 286:32324-32. 2011
    ....
  14. pmc Circadian intervention of obesity development via resting-stage feeding manipulation or oxytocin treatment
    Guo Zhang
    Department of Molecular Pharmacology and Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Physiol Endocrinol Metab 301:E1004-12. 2011
    ..In conclusion, resting-stage oxytocin release and feeding activity represent a critical circadian mechanism and therapeutic target for obesity...
  15. pmc Counterbalance between BAG and URX neurons via guanylate cyclases controls lifespan homeostasis in C. elegans
    Tiewen Liu
    Department of Molecular Pharmacology, Institute of Aging, Diabetes Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    EMBO J 32:1529-42. 2013
    ..In conclusion, BAG and URX neurons work as a neural-regulatory system to counterbalance each other via different GCYs to control lifespan homeostasis...
  16. ncbi request reprint NFkappaB-mediated metabolic inflammation in peripheral tissues versus central nervous system
    Dongsheng Cai
    Department of Molecular Pharmacology, Diabetes Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Cell Cycle 8:2542-8. 2009
    ..Here, we comparatively review the tissue-specific programs and actions of IKKbeta/NFkappaB in causing and promoting overnutrition-related diseases...

Research Grants1

  1. Role of Hypothalamic IKK-beta/NF-kappaB in Nutritional Control of Aging
    Dongsheng Cai; Fiscal Year: 2010
    ..Success of this study will advance our knowledge about how nutrition is involved in the development of aging and aging-related diseases, and provide broad new strategies to combat aging-related diseases. ..