Feliksas F Bukauskas

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. pmc Neurons and β-cells of the pancreas express connexin36, forming gap junction channels that exhibit strong cationic selectivity
    Feliksas F Bukauskas
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Membr Biol 245:243-53. 2012
  2. pmc pH-dependent modulation of voltage gating in connexin45 homotypic and connexin45/connexin43 heterotypic gap junctions
    Nicolas Palacios-Prado
    Dominick P Purpura Department of Neuroscience and Department of Anesthesiology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 107:9897-902. 2010
  3. pmc Modulation of metabolic communication through gap junction channels by transjunctional voltage; synergistic and antagonistic effects of gating and ionophoresis
    Nicolas Palacios-Prado
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, USA
    Biochim Biophys Acta 1818:1884-94. 2012
  4. pmc Gating properties of heterotypic gap junction channels formed of connexins 40, 43, and 45
    Mindaugas Rackauskas
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Biophys J 92:1952-65. 2007
  5. pmc Gating, permselectivity and pH-dependent modulation of channels formed by connexin57, a major connexin of horizontal cells in the mouse retina
    Nicolas Palacios-Prado
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Physiol 587:3251-69. 2009
  6. ncbi request reprint Functioning of cx43 hemichannels demonstrated by single channel properties
    Jorge E Contreras
    Department of Neuroscience, Albert Einstein College of Medicine, NY 10461, USA
    Cell Commun Adhes 10:245-9. 2003
  7. pmc Intracellular magnesium-dependent modulation of gap junction channels formed by neuronal connexin36
    Nicolas Palacios-Prado
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 33:4741-53. 2013
  8. pmc Stochastic 16-state model of voltage gating of gap-junction channels enclosing fast and slow gates
    Nerijus Paulauskas
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, New York, New York, USA
    Biophys J 102:2471-80. 2012
  9. pmc Permeability of homotypic and heterotypic gap junction channels formed of cardiac connexins mCx30.2, Cx40, Cx43, and Cx45
    Mindaugas Rackauskas
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Am J Physiol Heart Circ Physiol 293:H1729-36. 2007
  10. pmc Properties of mouse connexin 30.2 and human connexin 31.9 hemichannels: implications for atrioventricular conduction in the heart
    Feliksas F Bukauskas
    Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 103:9726-31. 2006

Collaborators

Detail Information

Publications20

  1. pmc Neurons and β-cells of the pancreas express connexin36, forming gap junction channels that exhibit strong cationic selectivity
    Feliksas F Bukauskas
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Membr Biol 245:243-53. 2012
    ..Thus, Cx36 GJs are highly cation-selective and should exhibit relatively low permeability to numerous vital negatively charged metabolites and high permeability to K⁺, a major charge carrier in cell-cell communication...
  2. pmc pH-dependent modulation of voltage gating in connexin45 homotypic and connexin45/connexin43 heterotypic gap junctions
    Nicolas Palacios-Prado
    Dominick P Purpura Department of Neuroscience and Department of Anesthesiology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 107:9897-902. 2010
    ..7, between the pK(a)s of Cx45 and Cx43-EGFP (approximately 6.5) homotypic GJs. In summary, pH(i) significantly modulates junctional conductance of Cx45 by affecting both V(j) gating and number of functional channels...
  3. pmc Modulation of metabolic communication through gap junction channels by transjunctional voltage; synergistic and antagonistic effects of gating and ionophoresis
    Nicolas Palacios-Prado
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, USA
    Biochim Biophys Acta 1818:1884-94. 2012
    ..This article is part of a Special Issue entitled: The Communicating junctions, composition, structure and characteristics...
  4. pmc Gating properties of heterotypic gap junction channels formed of connexins 40, 43, and 45
    Mindaugas Rackauskas
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Biophys J 92:1952-65. 2007
    ..Furthermore, both fast and slow gating mechanisms of Cx40 exhibit a negative gating polarity...
  5. pmc Gating, permselectivity and pH-dependent modulation of channels formed by connexin57, a major connexin of horizontal cells in the mouse retina
    Nicolas Palacios-Prado
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Physiol 587:3251-69. 2009
    ....
  6. ncbi request reprint Functioning of cx43 hemichannels demonstrated by single channel properties
    Jorge E Contreras
    Department of Neuroscience, Albert Einstein College of Medicine, NY 10461, USA
    Cell Commun Adhes 10:245-9. 2003
    ..The latter chimera was inserted into the surface and formed plaques, but did not express functional hemichannels or cell-cell channels. These data convincingly demonstrate the opening of Cx43 hemichannels...
  7. pmc Intracellular magnesium-dependent modulation of gap junction channels formed by neuronal connexin36
    Nicolas Palacios-Prado
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 33:4741-53. 2013
    ..Thus, this novel modulatory mechanism could underlie changes in neuronal synchronization under conditions in which ATP levels, and consequently [Mg(2+)]i, are modified...
  8. pmc Stochastic 16-state model of voltage gating of gap-junction channels enclosing fast and slow gates
    Nerijus Paulauskas
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, New York, New York, USA
    Biophys J 102:2471-80. 2012
    ....
  9. pmc Permeability of homotypic and heterotypic gap junction channels formed of cardiac connexins mCx30.2, Cx40, Cx43, and Cx45
    Mindaugas Rackauskas
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Am J Physiol Heart Circ Physiol 293:H1729-36. 2007
    ..2 than for Cx40, Cx43, and Cx45, suggesting that mCx30.2 GJs are notably more adapted to perform electrical rather than metabolic cell-cell communication...
  10. pmc Properties of mouse connexin 30.2 and human connexin 31.9 hemichannels: implications for atrioventricular conduction in the heart
    Feliksas F Bukauskas
    Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 103:9726-31. 2006
    ..Hemichannels formed of mCx30.2 and hCx31.9 may slow propagation of excitation in the sinoatrial and atrioventricular nodes by shortening the space constant and depolarizing the excitable membrane...
  11. pmc Coupling asymmetry of heterotypic connexin 45/ connexin 43-EGFP gap junctions: properties of fast and slow gating mechanisms
    Feliksas F Bukauskas
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 99:7113-8. 2002
    ..Cx45/Cx43 junctions are likely to be found in brain and heart and may mediate rectifying electrical transmission or modulatable chemical communication...
  12. pmc Gating and regulation of connexin 43 (Cx43) hemichannels
    Jorge E Contreras
    Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 100:11388-93. 2003
    ..Opening of Cx43 hemichannels may mediate normal signaling or be deleterious...
  13. pmc Regulation of connexin36 gap junction channels by n-alkanols and arachidonic acid
    Alina Marandykina
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Physiol 591:2087-101. 2013
    ..In addition, SCCAs increase gj by interfering with endogenous AA-dependent inhibition, increasing open probability and the fraction of functional channels...
  14. pmc Properties of human connexin 31, which is implicated in hereditary dermatological disease and deafness
    Charles K Abrams
    Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 103:5213-8. 2006
    ..These findings provide an important first step in evaluating the pathogenesis of inherited human diseases associated with mutations in the gene for Cx31...
  15. pmc Heterotypic gap junction channels as voltage-sensitive valves for intercellular signaling
    Nicolas Palacios-Prado
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 106:14855-60. 2009
    ..This modulation of intercellular signaling by Vj can play a crucial role in many aspects of intercellular communication in the adult, in embryonic development, and in tissue regeneration...
  16. pmc New roles for astrocytes: gap junction hemichannels have something to communicate
    Michael V L Bennett
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Trends Neurosci 26:610-7. 2003
    ..Most of these studies utilized cells in tissue culture that expressed a specific gap junction protein, connexin 43. Several such examples are reviewed here, with a particular focus on astrocytes...
  17. pmc A stochastic four-state model of contingent gating of gap junction channels containing two "fast" gates sensitive to transjunctional voltage
    Nerijus Paulauskas
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, The Bronx, New York, USA
    Biophys J 96:3936-48. 2009
    ..The proposed model can also be used to simulate gating properties of unapposed hemichannels...
  18. ncbi request reprint Connexin-GFPs shed light on regulation of cell-cell communication by gap junctions
    Vytas K Verselis
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Curr Drug Targets 3:483-99. 2002
    ....
  19. pmc Gap junction channel gating
    Feliksas F Bukauskas
    Department of Neuroscience, Albert Einstein College of Medicine, Yeshiva University, 1300 Morris Park Ave, Bronx, New York, NY 10461 1602, USA
    Biochim Biophys Acta 1662:42-60. 2004
    ....
  20. pmc Conductance and permeability of the residual state of connexin43 gap junction channels
    Feliksas F Bukauskas
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Gen Physiol 119:171-85. 2002
    ..Consequently, the fast V(j)-sensitive gating mechanism can serve as a selectivity filter, which allows electrical coupling but limits metabolic communication...