MICHAEL A BROWNLEE

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. ncbi The pathobiology of diabetic complications: a unifying mechanism
    Michael Brownlee
    Departments of Medicine and Pathology, Albert Einstein College of Medicine, F-531 1300 Morris Park Ave, Bronx, NY 10461-1602, USA
    Diabetes 54:1615-25. 2005
  2. ncbi Biochemistry and molecular cell biology of diabetic complications
    M Brownlee
    Department of Medicine, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York, 10461, USA
    Nature 414:813-20. 2001
  3. ncbi A radical explanation for glucose-induced beta cell dysfunction
    Michael Brownlee
    Diabetes Research Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, New York, New York 10461, USA
    J Clin Invest 112:1788-90. 2003
  4. ncbi Hyperglycemia-induced reactive oxygen species increase expression of the receptor for advanced glycation end products (RAGE) and RAGE ligands
    Dachun Yao
    Department of Medicine, Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York, USA
    Diabetes 59:249-55. 2010

Research Grants

  1. INTRACELLULAR GLYCATION AND DIABETIC COMPLICATIONS
    Michael Brownlee; Fiscal Year: 2006
  2. Progenitor Cell Dysfunction and Impaired Vasculogenesis*
    Michael Brownlee; Fiscal Year: 2007
  3. INTRACELLULAR GLYCATION AND DIABETIC COMPLICATIONS
    Michael Brownlee; Fiscal Year: 2007
  4. INTRACELLULAR GLYCATION AND DIABETIC COMPLICATIONS
    Michael Brownlee; Fiscal Year: 2000
  5. GLUCOSE-DERIVED CROSS-LINKS AND DIABETIC PATHOLOGY
    Michael Brownlee; Fiscal Year: 1992
  6. INTRACELLULAR GLYCATION AND DIABETIC COMPLICATIONS
    Michael Brownlee; Fiscal Year: 1993

Collaborators

  • Dachun Yao

Detail Information

Publications4

  1. ncbi The pathobiology of diabetic complications: a unifying mechanism
    Michael Brownlee
    Departments of Medicine and Pathology, Albert Einstein College of Medicine, F-531 1300 Morris Park Ave, Bronx, NY 10461-1602, USA
    Diabetes 54:1615-25. 2005
  2. ncbi Biochemistry and molecular cell biology of diabetic complications
    M Brownlee
    Department of Medicine, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York, 10461, USA
    Nature 414:813-20. 2001
    ..This integrating paradigm provides a new conceptual framework for future research and drug discovery...
  3. ncbi A radical explanation for glucose-induced beta cell dysfunction
    Michael Brownlee
    Diabetes Research Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, New York, New York 10461, USA
    J Clin Invest 112:1788-90. 2003
    ....
  4. ncbi Hyperglycemia-induced reactive oxygen species increase expression of the receptor for advanced glycation end products (RAGE) and RAGE ligands
    Dachun Yao
    Department of Medicine, Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York, USA
    Diabetes 59:249-55. 2010
    ..Since hyperglycemia-induced reactive oxygen species (ROS) activate many pathways of diabetic tissue damage, the effect of these ROS on RAGE and RAGE ligand expression was evaluated...

Research Grants24

  1. INTRACELLULAR GLYCATION AND DIABETIC COMPLICATIONS
    Michael Brownlee; Fiscal Year: 2006
    ..Supershift experiments will use commercially available antibodies. IP-westerns of cell extracts will be immunoblotted with antibodies to glyoxalase I-substrate- derived advanced glycation endproducts. ..
  2. Progenitor Cell Dysfunction and Impaired Vasculogenesis*
    Michael Brownlee; Fiscal Year: 2007
    ..groups will allow for the rational development of novel strategies to restore normal compensatory vasculogenesis in diabetes, thus preventing the poor outcome of cardiovascular events (Ml, stroke, amputation) associated with the disease ..
  3. INTRACELLULAR GLYCATION AND DIABETIC COMPLICATIONS
    Michael Brownlee; Fiscal Year: 2007
    ..Supershift experiments will use commercially availableantibodies. IP-westernsof cell extracts will be immunoblotted with antibodies to glyoxalase I-substrate-derived advanced glycationendproducts. ..
  4. INTRACELLULAR GLYCATION AND DIABETIC COMPLICATIONS
    Michael Brownlee; Fiscal Year: 2000
    ....
  5. GLUCOSE-DERIVED CROSS-LINKS AND DIABETIC PATHOLOGY
    Michael Brownlee; Fiscal Year: 1992
    ....
  6. INTRACELLULAR GLYCATION AND DIABETIC COMPLICATIONS
    Michael Brownlee; Fiscal Year: 1993
    ..Peptide mapping, sequencing, and fast-atom bombardment mass spectroscopy will be used to analyze peptide and carbohydrate of intracellularly glycated bFGF...