Eric E Bouhassira

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. pmc Complete genome phasing of family quartet by combination of genetic, physical and population-based phasing analysis
    Julien Lajugie
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 8:e64571. 2013
  2. pmc Production of embryonic and fetal-like red blood cells from human induced pluripotent stem cells
    Chan Jung Chang
    Department of Medicine, Hematology, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 6:e25761. 2011
  3. doi request reprint Therapeutic potential of hematopoietic cells derived from pluripotent stem cells
    Eric E Bouhassira
    Albert Einstein College of Medicine, Cell Biology, NY, USA
    Expert Opin Biol Ther 13:1099-102. 2013
  4. pmc Concise review: production of cultured red blood cells from stem cells
    Eric E Bouhassira
    Departments of Cell Biology and Medicine, Albert Einstein College of Medicine, New York, NY, USA
    Stem Cells Transl Med 1:927-33. 2012
  5. ncbi request reprint Large-scale production of embryonic red blood cells from human embryonic stem cells
    Emmanuel N Olivier
    Einstein Center for Human Embryonic Stem Cell Research, Department of Medicine, Hematology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Exp Hematol 34:1635-42. 2006
  6. doi request reprint Transferrin therapy ameliorates disease in beta-thalassemic mice
    Huihui Li
    Erythropoiesis Laboratory, Lindsley F Kimball Research Institute, New York Blood Center, New York, New York, USA
    Nat Med 16:177-82. 2010
  7. pmc Globin switches in yolk sac-like primitive and fetal-like definitive red blood cells produced from human embryonic stem cells
    Caihong Qiu
    Einstein Center for Human Embryonic Stem Cell Research, Department of Medicine, Hematology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Blood 111:2400-8. 2008
  8. pmc Novel, high-yield red blood cell production methods from CD34-positive cells derived from human embryonic stem, yolk sac, fetal liver, cord blood, and peripheral blood
    Emmanuel Olivier
    Departments of Medicine and Cell Biology, Albert Einstein College of Medicine, Bronx, NY, USA
    Stem Cells Transl Med 1:604-14. 2012
  9. pmc Predictable dynamic program of timing of DNA replication in human cells
    Romain Desprat
    Department of Medicine and Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Genome Res 19:2288-99. 2009
  10. pmc Zinc-finger nuclease-mediated correction of α-thalassemia in iPS cells
    Chan Jung Chang
    Department of Medicine, Division of Hematology, and Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Blood 120:3906-14. 2012

Collaborators

Detail Information

Publications27

  1. pmc Complete genome phasing of family quartet by combination of genetic, physical and population-based phasing analysis
    Julien Lajugie
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 8:e64571. 2013
    ..Improved genome phasing and family sequencing will increase the power of genome-wide sequencing as a clinical diagnosis tool and has myriad basic science applications...
  2. pmc Production of embryonic and fetal-like red blood cells from human induced pluripotent stem cells
    Chan Jung Chang
    Department of Medicine, Hematology, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 6:e25761. 2011
    ..The ability to produce large number of erythroid cells with embryonic and fetal-like characteristics is likely to have many translational applications...
  3. doi request reprint Therapeutic potential of hematopoietic cells derived from pluripotent stem cells
    Eric E Bouhassira
    Albert Einstein College of Medicine, Cell Biology, NY, USA
    Expert Opin Biol Ther 13:1099-102. 2013
    ..Interestingly, recent reports suggest that primitive hematopoietic cells might make important contributions to adult hematopoiesis. Production of primitive hematopoietic cells might therefore have clinical applications. ..
  4. pmc Concise review: production of cultured red blood cells from stem cells
    Eric E Bouhassira
    Departments of Cell Biology and Medicine, Albert Einstein College of Medicine, New York, NY, USA
    Stem Cells Transl Med 1:927-33. 2012
    ..The various cell sources, the niche applications most likely to reach the clinic first, and some of the remaining technical issues are reviewed here...
  5. ncbi request reprint Large-scale production of embryonic red blood cells from human embryonic stem cells
    Emmanuel N Olivier
    Einstein Center for Human Embryonic Stem Cell Research, Department of Medicine, Hematology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Exp Hematol 34:1635-42. 2006
    ..To develop a method to produce in culture large number of erythroid cells from human embryonic stem cells...
  6. doi request reprint Transferrin therapy ameliorates disease in beta-thalassemic mice
    Huihui Li
    Erythropoiesis Laboratory, Lindsley F Kimball Research Institute, New York Blood Center, New York, New York, USA
    Nat Med 16:177-82. 2010
    ..These results indicate that transferrin is a limiting factor contributing to anemia in these mice and suggest that transferrin therapy might be beneficial in human beta-thalassemia...
  7. pmc Globin switches in yolk sac-like primitive and fetal-like definitive red blood cells produced from human embryonic stem cells
    Caihong Qiu
    Einstein Center for Human Embryonic Stem Cell Research, Department of Medicine, Hematology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Blood 111:2400-8. 2008
    ..Development of a method that yields erythroid cells with an adult phenotype remains necessary, because the most mature cells that can be produced with current systems express less than 2% adult beta-globin mRNA...
  8. pmc Novel, high-yield red blood cell production methods from CD34-positive cells derived from human embryonic stem, yolk sac, fetal liver, cord blood, and peripheral blood
    Emmanuel Olivier
    Departments of Medicine and Cell Biology, Albert Einstein College of Medicine, Bronx, NY, USA
    Stem Cells Transl Med 1:604-14. 2012
    ....
  9. pmc Predictable dynamic program of timing of DNA replication in human cells
    Romain Desprat
    Department of Medicine and Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Genome Res 19:2288-99. 2009
    ....
  10. pmc Zinc-finger nuclease-mediated correction of α-thalassemia in iPS cells
    Chan Jung Chang
    Department of Medicine, Division of Hematology, and Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Blood 120:3906-14. 2012
    ..Homozygous insertion of the best of the 4 constructs tested led to complete correction of globin chain imbalance in erythroid cells differentiated from the corrected iPS cells...
  11. pmc DNA methylation supports intrinsic epigenetic memory in mammalian cells
    Yong Qing Feng
    Department of Medicine, Division of Hematology, Albert Einstein College of Medicine, Bronx, New York, New York, United States of America
    PLoS Genet 2:e65. 2006
    ..We propose that DNA methylation within transgenes serves as an intrinsic epigenetic memory to permanently silence transgenes and prevent their reactivation...
  12. pmc Gene specificity of suppression of transgene-mediated insertional transcriptional activation by the chicken HS4 insulator
    Romain Desprat
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 4:e5956. 2009
    ..Identification of insulators with minimal promoter specificity would also be of great value...
  13. pmc Reprogramming of embryonic human fibroblasts into fetal hematopoietic progenitors by fusion with human fetal liver CD34+ cells
    Vladislav M Sandler
    Division of Hematology, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 6:e18265. 2011
    ..Direct reprogramming of terminally differentiated cells into the tissue specific progenitors will likely prove useful for the development of novel cell therapies...
  14. doi request reprint Differentiation of human embryonic stem cells into mesenchymal stem cells by the "raclure" method
    Emmanuel N Olivier
    Hematology and Cell Biology Departments, Einstein Center for Human Embryonic Stem Cell Research Medicine, Albert Einstein College of Medicine, New York, NY, USA
    Methods Mol Biol 690:183-93. 2011
    ....
  15. pmc Allele-Specific Genome-wide Profiling in Human Primary Erythroblasts Reveal Replication Program Organization
    Rituparna Mukhopadhyay
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS Genet 10:e1004319. 2014
    ..The frequency of initiation in asynchronous regions was similar in the two homologs. Asynchronous regions were richer in origins of replication than synchronous regions. ..
  16. pmc High-resolution genome-wide cytosine methylation profiling with simultaneous copy number analysis and optimization for limited cell numbers
    Mayumi Oda
    Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, USA
    Nucleic Acids Res 37:3829-39. 2009
    ....
  17. ncbi request reprint Differentiation of human embryonic stem cells into hematopoietic cells by coculture with human fetal liver cells recapitulates the globin switch that occurs early in development
    Caihong Qiu
    Einstein Center for Human Embryonic Stem Cell Research, Department of Medicine, Division of Hematology and Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA
    Exp Hematol 33:1450-8. 2005
    ..To find a human cell line that could support differentiation of human embryonic stem cells (hESCs) into hematopoietic cells. To determine in detail the expression profiles of the beta-like globin genes in hESC-derived erythroid cells...
  18. pmc CG dinucleotide clustering is a species-specific property of the genome
    Jacob L Glass
    Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA, Division of Hematology Oncology, University of Kentucky, Markey Cancer Center, 800 Rose Street, Lexington KY 40536, USA
    Nucleic Acids Res 35:6798-807. 2007
    ..Finally, our approach is able to identify methylating genomes (such as Takifugu rubripes) that lack CG clustering entirely, in which it is inappropriate to annotate CpG islands or CG clusters...
  19. pmc Efficient generation of lens progenitor cells and lentoid bodies from human embryonic stem cells in chemically defined conditions
    Chunbo Yang
    Department of Ophthalmology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    FASEB J 24:3274-83. 2010
    ....
  20. pmc Systematic targeted integration to study Albumin gene control elements
    Sanchari Bhattacharyya
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 6:e23234. 2011
    ..Growth arrest by serum starvation strongly stimulated the function of some integrated enhancers, consistent with the expected disruption of enhancer-promoter looping during the cell cycle...
  21. pmc Human embryonic stem cells in culture possess primary cilia with hedgehog signaling machinery
    Enko N Kiprilov
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Cell Biol 180:897-904. 2008
    ..These findings show that hESCs contain primary cilia associated with working Hh machinery...
  22. pmc A transgenic mouse model expressing exclusively human hemoglobin E: indications of a mild oxidative stress
    Qiuying Chen
    Department of Medicine Hematology, Albert Einstein College of Medicine, Bronx, NY, USA
    Blood Cells Mol Dis 48:91-101. 2012
    ....
  23. ncbi request reprint Histone H1 depletion in mammals alters global chromatin structure but causes specific changes in gene regulation
    Yuhong Fan
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Cell 123:1199-212. 2005
    ..These results indicate that linker histones can participate in epigenetic regulation of gene expression by contributing to the maintenance or establishment of specific DNA methylation patterns...
  24. doi request reprint Exogenous iron increases hemoglobin in beta-thalassemic mice
    Yelena Z Ginzburg
    Erythropoiesis Laboratory, New York Blood Center, New York, NY 10065, USA
    Exp Hematol 37:172-83. 2009
    ..We hypothesized that exogenous iron would improve anemia in beta-thalassemia intermedia despite systemic iron overload and further suppress hepcidin secondary to progressive expansion of erythroid precursors...
  25. pmc Decreased replication origin activity in temporal transition regions
    Zeqiang Guan
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Cell Biol 187:623-35. 2009
    ..These findings indicate that the Igh TTR represents a repressive compartment that inhibits replication initiation, thus maintaining the boundaries between early and late replication domains...
  26. doi request reprint GenPlay, a multipurpose genome analyzer and browser
    Julien Lajugie
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Bioinformatics 27:1889-93. 2011
    ..Therefore, software tools to process, visualize, analyze and integrate data produced on multiple platforms and using multiple methods are needed...
  27. ncbi request reprint Differentiation of human embryonic stem cells into bipotent mesenchymal stem cells
    Emmanuel N Olivier
    Department of Medicine, Division of Hematology, Einstein Center for Human Embryonic Stem Cell Research, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Stem Cells 24:1914-22. 2006
    ..The ability to produce MSCs from hESCs should prove useful to produce large amounts of genetically identical and genetically modifiable MSCs that can be used to study the biology of MSCs and for therapeutic applications...