Michael V L Bennett

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. pmc Connexin and pannexin hemichannels in inflammatory responses of glia and neurons
    Michael V L Bennett
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Brain Res 1487:3-15. 2012
  2. ncbi request reprint Late calcium EDTA rescues hippocampal CA1 neurons from global ischemia-induced death
    Agata Calderone
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 24:9903-13. 2004
  3. pmc Blockade of calcium-permeable AMPA receptors protects hippocampal neurons against global ischemia-induced death
    Kyung Min Noh
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 102:12230-5. 2005
  4. pmc Intracellular magnesium-dependent modulation of gap junction channels formed by neuronal connexin36
    Nicolas Palacios-Prado
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 33:4741-53. 2013
  5. pmc Repressor element-1 silencing transcription factor (REST)-dependent epigenetic remodeling is critical to ischemia-induced neuronal death
    Kyung Min Noh
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, New York, NY 10461, USA
    Proc Natl Acad Sci U S A 109:E962-71. 2012
  6. pmc Ischemic preconditioning blocks BAD translocation, Bcl-xL cleavage, and large channel activity in mitochondria of postischemic hippocampal neurons
    Takahiro Miyawaki
    Dominick P Purpura Department of Neuroscience, Rose F Kennedy Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 105:4892-7. 2008
  7. pmc Regulation of NMDA receptor Ca2+ signalling and synaptic plasticity
    C Geoffrey Lau
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Biochem Soc Trans 37:1369-74. 2009
  8. pmc SNAP-25 is a target of protein kinase C phosphorylation critical to NMDA receptor trafficking
    C Geoffrey Lau
    Rose F Kennedy Center, Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 30:242-54. 2010
  9. pmc PSD-95 and PKC converge in regulating NMDA receptor trafficking and gating
    Ying Lin
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 103:19902-7. 2006
  10. pmc Properties of human connexin 31, which is implicated in hereditary dermatological disease and deafness
    Charles K Abrams
    Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 103:5213-8. 2006

Collaborators

Detail Information

Publications34

  1. pmc Connexin and pannexin hemichannels in inflammatory responses of glia and neurons
    Michael V L Bennett
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Brain Res 1487:3-15. 2012
    ..These studies implicate two kinds of gap junction hemichannel in inflammatory responses and cell death. This article is part of a Special Issue entitled Electrical Synapses...
  2. ncbi request reprint Late calcium EDTA rescues hippocampal CA1 neurons from global ischemia-induced death
    Agata Calderone
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 24:9903-13. 2004
    ..The finding of neuroprotection by late CaEDTA administration has striking implications for intervention in the delayed neuronal death associated with global ischemia...
  3. pmc Blockade of calcium-permeable AMPA receptors protects hippocampal neurons against global ischemia-induced death
    Kyung Min Noh
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 102:12230-5. 2005
    ..This receptor subtype appears to be an important therapeutic target for intervention in ischemia-induced neuronal death in humans...
  4. pmc Intracellular magnesium-dependent modulation of gap junction channels formed by neuronal connexin36
    Nicolas Palacios-Prado
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 33:4741-53. 2013
    ..Thus, this novel modulatory mechanism could underlie changes in neuronal synchronization under conditions in which ATP levels, and consequently [Mg(2+)]i, are modified...
  5. pmc Repressor element-1 silencing transcription factor (REST)-dependent epigenetic remodeling is critical to ischemia-induced neuronal death
    Kyung Min Noh
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, New York, NY 10461, USA
    Proc Natl Acad Sci U S A 109:E962-71. 2012
    ....
  6. pmc Ischemic preconditioning blocks BAD translocation, Bcl-xL cleavage, and large channel activity in mitochondria of postischemic hippocampal neurons
    Takahiro Miyawaki
    Dominick P Purpura Department of Neuroscience, Rose F Kennedy Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 105:4892-7. 2008
    ..These findings implicate PI3K/Akt signaling in maintenance of the integrity of the mitochondrial outer membrane...
  7. pmc Regulation of NMDA receptor Ca2+ signalling and synaptic plasticity
    C Geoffrey Lau
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Biochem Soc Trans 37:1369-74. 2009
    ....
  8. pmc SNAP-25 is a target of protein kinase C phosphorylation critical to NMDA receptor trafficking
    C Geoffrey Lau
    Rose F Kennedy Center, Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 30:242-54. 2010
    ..These findings identify SNAP-25 as the target of PKC phosphorylation critical to PKC-dependent incorporation of synaptic NMDARs and document a postsynaptic action of this major SNARE protein relevant to synaptic plasticity...
  9. pmc PSD-95 and PKC converge in regulating NMDA receptor trafficking and gating
    Ying Lin
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 103:19902-7. 2006
    ..These findings predict that synaptic scaffolding proteins and protein kinases convergently modulate NMDAR gating and trafficking at synaptic sites...
  10. pmc Properties of human connexin 31, which is implicated in hereditary dermatological disease and deafness
    Charles K Abrams
    Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 103:5213-8. 2006
    ..These findings provide an important first step in evaluating the pathogenesis of inherited human diseases associated with mutations in the gene for Cx31...
  11. pmc Interaction between connexin35 and zonula occludens-1 and its potential role in the regulation of electrical synapses
    Carmen E Flores
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 105:12545-50. 2008
    ..The interaction of ZO-1 with conserved regions of the C termini of Cx35/Cx36 orthologs may have a common function at electrical synapses of mammals and other vertebrates...
  12. pmc Trafficking of gap junction channels at a vertebrate electrical synapse in vivo
    Carmen E Flores
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 109:E573-82. 2012
    ....
  13. ncbi request reprint Protein kinase A regulates calcium permeability of NMDA receptors
    V Arvydas Skeberdis
    Rose F Kennedy Center for Research in Mental Retardation and Developmental Disabilities, Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Nat Neurosci 9:501-10. 2006
    ..Our data link PKA-dependent synaptic plasticity to Ca2+ signaling in spines and thus provide a new mechanism whereby PKA regulates the induction of LTP...
  14. ncbi request reprint Postsynaptic density protein-95 regulates NMDA channel gating and surface expression
    Ying Lin
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461 1975, USA
    J Neurosci 24:10138-48. 2004
    ..Given that activity bi-directionally modifies synaptic levels of PSD-95, our findings suggest a novel mechanism for activity-dependent regulation of NMDARs at central synapses...
  15. ncbi request reprint Ischemic preconditioning: neuronal survival in the face of caspase-3 activation
    Hidenobu Tanaka
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461 1975, USA
    J Neurosci 24:2750-9. 2004
    ..These findings suggest that preconditioning preserves the integrity of the mitochondrial membrane, enabling neurons to survive in the face of caspase activation...
  16. ncbi request reprint Functioning of cx43 hemichannels demonstrated by single channel properties
    Jorge E Contreras
    Department of Neuroscience, Albert Einstein College of Medicine, NY 10461, USA
    Cell Commun Adhes 10:245-9. 2003
    ..The latter chimera was inserted into the surface and formed plaques, but did not express functional hemichannels or cell-cell channels. These data convincingly demonstrate the opening of Cx43 hemichannels...
  17. pmc Gating and regulation of connexin 43 (Cx43) hemichannels
    Jorge E Contreras
    Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 100:11388-93. 2003
    ..Opening of Cx43 hemichannels may mediate normal signaling or be deleterious...
  18. pmc pH-dependent modulation of voltage gating in connexin45 homotypic and connexin45/connexin43 heterotypic gap junctions
    Nicolas Palacios-Prado
    Dominick P Purpura Department of Neuroscience and Department of Anesthesiology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 107:9897-902. 2010
    ..7, between the pK(a)s of Cx45 and Cx43-EGFP (approximately 6.5) homotypic GJs. In summary, pH(i) significantly modulates junctional conductance of Cx45 by affecting both V(j) gating and number of functional channels...
  19. pmc The role of gap junction channels during physiologic and pathologic conditions of the human central nervous system
    Eliseo A Eugenin
    Department of Pathology, F727, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    J Neuroimmune Pharmacol 7:499-518. 2012
    ..The focus of this review is to summarize recent findings related to the role of GJs and uHC in physiologic and pathologic conditions of the central nervous system...
  20. pmc HIV-tat induces formation of an LRP-PSD-95- NMDAR-nNOS complex that promotes apoptosis in neurons and astrocytes
    Eliseo A Eugenin
    Department of Pathology and Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 104:3438-43. 2007
    ..These findings implicate the complex in HIV-induced neuronal apoptosis and suggest therapeutic targets for intervention in the pathogenesis of NeuroAIDS...
  21. pmc Properties of mouse connexin 30.2 and human connexin 31.9 hemichannels: implications for atrioventricular conduction in the heart
    Feliksas F Bukauskas
    Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 103:9726-31. 2006
    ..Hemichannels formed of mCx30.2 and hCx31.9 may slow propagation of excitation in the sinoatrial and atrioventricular nodes by shortening the space constant and depolarizing the excitable membrane...
  22. pmc Developmental switch in requirement for PKA RIIbeta in NMDA-receptor-dependent synaptic plasticity at Schaffer collateral to CA1 pyramidal cell synapses
    Yupeng Yang
    Dominick P Purpura Department of Neuroscience, Kennedy Center Room 602B, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Neuropharmacology 56:56-65. 2009
    ..These findings indicate that distinct PKA isoforms may subserve distinct forms of synaptic plasticity and are consistent with a developmental switch in the signaling cascades required for LTP induction...
  23. pmc Caveolin-1 knockout mice exhibit impaired induction of mGluR-dependent long-term depression at CA3-CA1 synapses
    Yukihiro Takayasu
    The Dominick P Purpura Department of Neuroscience, The Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 107:21778-83. 2010
    ..Taken together, our findings suggest that caveolin-1 is required for normal coupling of mGluR1/5 to downstream signaling cascades and induction of mGluR-LTD...
  24. pmc New roles for astrocytes: gap junction hemichannels have something to communicate
    Michael V L Bennett
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Trends Neurosci 26:610-7. 2003
    ..Most of these studies utilized cells in tissue culture that expressed a specific gap junction protein, connexin 43. Several such examples are reviewed here, with a particular focus on astrocytes...
  25. ncbi request reprint Electrical coupling and neuronal synchronization in the Mammalian brain
    Michael V L Bennett
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Neuron 41:495-511. 2004
    ..This article reviews the many subtleties of transmission mediated by gap junctions and the mechanisms whereby these junctions contribute to synchronous firing...
  26. pmc Ischemic insults promote epigenetic reprogramming of mu opioid receptor expression in hippocampal neurons
    Luigi Formisano
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 104:4170-5. 2007
    ..These findings implicate MORs in ischemia-induced death of CA1 pyramidal neurons and document epigenetic remodeling of expression of OPRM1 in CA1 inhibitory interneurons...
  27. pmc Dysregulation of synaptic plasticity precedes appearance of morphological defects in a Pten conditional knockout mouse model of autism
    Koichi Takeuchi
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, New York, NY 10461, USA
    Proc Natl Acad Sci U S A 110:4738-43. 2013
    ....
  28. ncbi request reprint Pyramid power: principal cells of the hippocampus unite!
    Michael V L Bennett
    Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Brain Cell Biol 35:5-11. 2006
    ..Increased coupling could well contribute to the known tendency of the hippocampus to exhibit seizure activity...
  29. ncbi request reprint Dynamics of electrical transmission at club endings on the Mauthner cells
    Alberto E Pereda
    Department of Neuroscience, Albert Einstein College of Medicine, New York, USA
    Brain Res Brain Res Rev 47:227-44. 2004
    ..The widespread distribution of connexin35 and connexin36 and the ubiquity of some of the proposed regulatory elements suggest that other electrical synapses may be similarly regulated...
  30. ncbi request reprint Pathogenesis of X-linked Charcot-Marie-Tooth disease: differential effects of two mutations in connexin 32
    Charles K Abrams
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10463, USA
    J Neurosci 23:10548-58. 2003
    ..This restricted functional abnormality may explain the relatively mild phenotype seen in the xenograft model and in E102G patients...
  31. ncbi request reprint Neoreticularism and neuronal polarization
    Michael V L Bennett
    Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10804, USA
    Prog Brain Res 136:189-201. 2002
    ..Cajal leaves ample evidence in his writings that he would have no difficulty in accepting these very minor modifications to the vast body of his contributions...
  32. pmc Coupling asymmetry of heterotypic connexin 45/ connexin 43-EGFP gap junctions: properties of fast and slow gating mechanisms
    Feliksas F Bukauskas
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 99:7113-8. 2002
    ..Cx45/Cx43 junctions are likely to be found in brain and heart and may mediate rectifying electrical transmission or modulatable chemical communication...
  33. ncbi request reprint Ischemic insults derepress the gene silencer REST in neurons destined to die
    Agata Calderone
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 23:2112-21. 2003
    ..Derepression of REST is likely to be an important mechanism of insult-induced neuronal death...