MICHAEL V BENNETT

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. ncbi request reprint Seeing is relieving: electrical synapses between visualized neurons
    M V Bennett
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Nat Neurosci 3:7-9. 2000
  2. ncbi request reprint Neoreticularism and neuronal polarization
    Michael V L Bennett
    Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10804, USA
    Prog Brain Res 136:189-201. 2002
  3. ncbi request reprint Electrical coupling and neuronal synchronization in the Mammalian brain
    Michael V L Bennett
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Neuron 41:495-511. 2004
  4. pmc New roles for astrocytes: gap junction hemichannels have something to communicate
    Michael V L Bennett
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Trends Neurosci 26:610-7. 2003
  5. ncbi request reprint Pyramid power: principal cells of the hippocampus unite!
    Michael V L Bennett
    Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Brain Cell Biol 35:5-11. 2006
  6. ncbi request reprint Electrical synapses, a personal perspective (or history)
    M V Bennett
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Brain Res Brain Res Rev 32:16-28. 2000
  7. pmc Blockade of calcium-permeable AMPA receptors protects hippocampal neurons against global ischemia-induced death
    Kyung Min Noh
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 102:12230-5. 2005
  8. pmc Connexin-based gap junction hemichannels: gating mechanisms
    Juan C Saez
    Departamento de Ciencias Fisiologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Biochim Biophys Acta 1711:215-24. 2005
  9. ncbi request reprint Protein kinase A regulates calcium permeability of NMDA receptors
    V Arvydas Skeberdis
    Rose F Kennedy Center for Research in Mental Retardation and Developmental Disabilities, Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Nat Neurosci 9:501-10. 2006
  10. pmc S-nitrosylation and permeation through connexin 43 hemichannels in astrocytes: induction by oxidant stress and reversal by reducing agents
    Mauricio A Retamal
    Departamento de Ciencias Fisiologicas, Pontificia Universidad Catolica de Chile, Santiago 6513492, Chile
    Proc Natl Acad Sci U S A 103:4475-80. 2006

Research Grants

  1. Connexins in Ischemia-Induced Neuronal Death
    Michael Bennett; Fiscal Year: 2003
  2. Cx43 Hemichannels: Gating, Modification and Function
    Michael Bennett; Fiscal Year: 2009
  3. Cx43 Hemichannels: Gating, Modification and Function
    Michael Bennett; Fiscal Year: 2007
  4. MECHANISMS OF INTERCELLULAR COMMUNICATION
    Michael Bennett; Fiscal Year: 2007
  5. Connexins in Ischemia-Induced Neuronal Death
    Michael Bennett; Fiscal Year: 2007
  6. Connexins in Ischemia-Induced Neuronal Death
    Michael Bennett; Fiscal Year: 2006
  7. Cx43 Hemichannels: Gating, Modification and Function
    Michael V L Bennett; Fiscal Year: 2010

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Seeing is relieving: electrical synapses between visualized neurons
    M V Bennett
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Nat Neurosci 3:7-9. 2000
    ..Two reports of electrical synapses between identified inhibitory neurons in the neocortex suggest that many neuron types known to communicate chemically may also be electrically coupled...
  2. ncbi request reprint Neoreticularism and neuronal polarization
    Michael V L Bennett
    Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10804, USA
    Prog Brain Res 136:189-201. 2002
    ..Cajal leaves ample evidence in his writings that he would have no difficulty in accepting these very minor modifications to the vast body of his contributions...
  3. ncbi request reprint Electrical coupling and neuronal synchronization in the Mammalian brain
    Michael V L Bennett
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Neuron 41:495-511. 2004
    ..This article reviews the many subtleties of transmission mediated by gap junctions and the mechanisms whereby these junctions contribute to synchronous firing...
  4. pmc New roles for astrocytes: gap junction hemichannels have something to communicate
    Michael V L Bennett
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Trends Neurosci 26:610-7. 2003
    ..Most of these studies utilized cells in tissue culture that expressed a specific gap junction protein, connexin 43. Several such examples are reviewed here, with a particular focus on astrocytes...
  5. ncbi request reprint Pyramid power: principal cells of the hippocampus unite!
    Michael V L Bennett
    Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Brain Cell Biol 35:5-11. 2006
    ..Increased coupling could well contribute to the known tendency of the hippocampus to exhibit seizure activity...
  6. ncbi request reprint Electrical synapses, a personal perspective (or history)
    M V Bennett
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Brain Res Brain Res Rev 32:16-28. 2000
    ..The new molecular, cellular and physiological techniques will clarify where gap junctions and electrical coupling do and do not occur and permit experimental manipulation with high specificity...
  7. pmc Blockade of calcium-permeable AMPA receptors protects hippocampal neurons against global ischemia-induced death
    Kyung Min Noh
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 102:12230-5. 2005
    ..This receptor subtype appears to be an important therapeutic target for intervention in ischemia-induced neuronal death in humans...
  8. pmc Connexin-based gap junction hemichannels: gating mechanisms
    Juan C Saez
    Departamento de Ciencias Fisiologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Biochim Biophys Acta 1711:215-24. 2005
    ..Taken together, the data indicate that hemichannels are gated by multiple mechanisms that independently or cooperatively affect their open probability under physiological as well as pathological conditions...
  9. ncbi request reprint Protein kinase A regulates calcium permeability of NMDA receptors
    V Arvydas Skeberdis
    Rose F Kennedy Center for Research in Mental Retardation and Developmental Disabilities, Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Nat Neurosci 9:501-10. 2006
    ..Our data link PKA-dependent synaptic plasticity to Ca2+ signaling in spines and thus provide a new mechanism whereby PKA regulates the induction of LTP...
  10. pmc S-nitrosylation and permeation through connexin 43 hemichannels in astrocytes: induction by oxidant stress and reversal by reducing agents
    Mauricio A Retamal
    Departamento de Ciencias Fisiologicas, Pontificia Universidad Catolica de Chile, Santiago 6513492, Chile
    Proc Natl Acad Sci U S A 103:4475-80. 2006
    ....
  11. ncbi request reprint Neuroscience. The neuron doctrine, redux
    Theodore H Bullock
    Scripps Institution of Oceanography and Department of Neuroscience, University of California, San Diego, La Jolla, CA 92093, USA
    Science 310:791-3. 2005
  12. pmc Properties of human connexin 31, which is implicated in hereditary dermatological disease and deafness
    Charles K Abrams
    Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 103:5213-8. 2006
    ..These findings provide an important first step in evaluating the pathogenesis of inherited human diseases associated with mutations in the gene for Cx31...
  13. pmc Properties of mouse connexin 30.2 and human connexin 31.9 hemichannels: implications for atrioventricular conduction in the heart
    Feliksas F Bukauskas
    Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 103:9726-31. 2006
    ..Hemichannels formed of mCx30.2 and hCx31.9 may slow propagation of excitation in the sinoatrial and atrioventricular nodes by shortening the space constant and depolarizing the excitable membrane...
  14. pmc PSD-95 and PKC converge in regulating NMDA receptor trafficking and gating
    Ying Lin
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 103:19902-7. 2006
    ..These findings predict that synaptic scaffolding proteins and protein kinases convergently modulate NMDAR gating and trafficking at synaptic sites...
  15. pmc HIV-tat induces formation of an LRP-PSD-95- NMDAR-nNOS complex that promotes apoptosis in neurons and astrocytes
    Eliseo A Eugenin
    Department of Pathology and Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 104:3438-43. 2007
    ..These findings implicate the complex in HIV-induced neuronal apoptosis and suggest therapeutic targets for intervention in the pathogenesis of NeuroAIDS...
  16. pmc Opening of connexin 43 hemichannels is increased by lowering intracellular redox potential
    Mauricio A Retamal
    Núcleo Milenio Inmunología e Inmunoterapia, Departamento de Ciencias Fisiologicas, Pontificia Universidad Catolica de Chile, Santiago 4860, Chile
    Proc Natl Acad Sci U S A 104:8322-7. 2007
    ..These findings suggest that lowering intracellular redox potential increases the opening of Cx43 and Cx43-EGFP hemichannels, possibly by action on cytoplasmic cysteine residues in the connexin C terminus...
  17. pmc Bcl-xL induces Drp1-dependent synapse formation in cultured hippocampal neurons
    Hongmei Li
    Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 105:2169-74. 2008
    ..These findings suggest that Bcl-xL positively regulates Drp1 to alter mitochondrial function in a manner that stimulates synapse formation...
  18. pmc Ischemic preconditioning blocks BAD translocation, Bcl-xL cleavage, and large channel activity in mitochondria of postischemic hippocampal neurons
    Takahiro Miyawaki
    Dominick P Purpura Department of Neuroscience, Rose F Kennedy Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 105:4892-7. 2008
    ..These findings implicate PI3K/Akt signaling in maintenance of the integrity of the mitochondrial outer membrane...
  19. pmc Role of connexin-based gap junction channels and hemichannels in ischemia-induced cell death in nervous tissue
    Jorge E Contreras
    Departamento de Ciencias Fisiologicas, Pontificia Universidad Catolica de Chile, Chile
    Brain Res Brain Res Rev 47:290-303. 2004
    ..In addition to the cell specific features of an ischemic insult, propagation of cell damage and death within affected tissues may be affected by expression and regulation of gap junction channels and hemichannels formed by connexins...
  20. ncbi request reprint Dynamics of electrical transmission at club endings on the Mauthner cells
    Alberto E Pereda
    Department of Neuroscience, Albert Einstein College of Medicine, New York, USA
    Brain Res Brain Res Rev 47:227-44. 2004
    ..The widespread distribution of connexin35 and connexin36 and the ubiquity of some of the proposed regulatory elements suggest that other electrical synapses may be similarly regulated...
  21. pmc Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture
    Jorge E Contreras
    Departamento de Ciencias Fisiologicas, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago 340, Chile
    Proc Natl Acad Sci U S A 99:495-500. 2002
    ..Alternatively, dying astrocytes might compromise the health of neighboring cells via Cx43 gap junctions, thereby promoting the propagation of cell death...
  22. pmc Ischemic preconditioning acts upstream of GluR2 down-regulation to afford neuroprotection in the hippocampal CA1
    Hidenobu Tanaka
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 99:2362-7. 2002
    ....
  23. pmc Coupling asymmetry of heterotypic connexin 45/ connexin 43-EGFP gap junctions: properties of fast and slow gating mechanisms
    Feliksas F Bukauskas
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 99:7113-8. 2002
    ..Cx45/Cx43 junctions are likely to be found in brain and heart and may mediate rectifying electrical transmission or modulatable chemical communication...
  24. ncbi request reprint Identification of second messengers that induce expression of functional gap junctions in microglia cultured from newborn rats
    Agustin D Martinez
    Departamento de Ciencias Fisiologicas, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Alameda 340, Santiago, Chile
    Brain Res 943:191-201. 2002
    ....
  25. pmc Interaction between connexin35 and zonula occludens-1 and its potential role in the regulation of electrical synapses
    Carmen E Flores
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 105:12545-50. 2008
    ..The interaction of ZO-1 with conserved regions of the C termini of Cx35/Cx36 orthologs may have a common function at electrical synapses of mammals and other vertebrates...
  26. ncbi request reprint Ischemic insults derepress the gene silencer REST in neurons destined to die
    Agata Calderone
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 23:2112-21. 2003
    ..Derepression of REST is likely to be an important mechanism of insult-induced neuronal death...
  27. pmc Gating and regulation of connexin 43 (Cx43) hemichannels
    Jorge E Contreras
    Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 100:11388-93. 2003
    ..Opening of Cx43 hemichannels may mediate normal signaling or be deleterious...
  28. ncbi request reprint Pathogenesis of X-linked Charcot-Marie-Tooth disease: differential effects of two mutations in connexin 32
    Charles K Abrams
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10463, USA
    J Neurosci 23:10548-58. 2003
    ..This restricted functional abnormality may explain the relatively mild phenotype seen in the xenograft model and in E102G patients...
  29. ncbi request reprint Postsynaptic density protein-95 regulates NMDA channel gating and surface expression
    Ying Lin
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461 1975, USA
    J Neurosci 24:10138-48. 2004
    ..Given that activity bi-directionally modifies synaptic levels of PSD-95, our findings suggest a novel mechanism for activity-dependent regulation of NMDARs at central synapses...
  30. ncbi request reprint Functioning of cx43 hemichannels demonstrated by single channel properties
    Jorge E Contreras
    Department of Neuroscience, Albert Einstein College of Medicine, NY 10461, USA
    Cell Commun Adhes 10:245-9. 2003
    ..The latter chimera was inserted into the surface and formed plaques, but did not express functional hemichannels or cell-cell channels. These data convincingly demonstrate the opening of Cx43 hemichannels...
  31. ncbi request reprint Late calcium EDTA rescues hippocampal CA1 neurons from global ischemia-induced death
    Agata Calderone
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 24:9903-13. 2004
    ..The finding of neuroprotection by late CaEDTA administration has striking implications for intervention in the delayed neuronal death associated with global ischemia...
  32. ncbi request reprint Estrogen protects against global ischemia-induced neuronal death and prevents activation of apoptotic signaling cascades in the hippocampal CA1
    Teresa Jover
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 22:2115-24. 2002
    ..quot;..
  33. ncbi request reprint Possible involvement of different connexin43 domains in plasma membrane permeabilization induced by ischemia-reperfusion
    Mauricio A Retamal
    Departamento de Ciencias Fisiologicas, Pontificia Universidad Catolica de Chile, Alameda 340, Santiago, Chile
    J Membr Biol 218:49-63. 2007
    ....
  34. ncbi request reprint Ischemic preconditioning: neuronal survival in the face of caspase-3 activation
    Hidenobu Tanaka
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461 1975, USA
    J Neurosci 24:2750-9. 2004
    ..These findings suggest that preconditioning preserves the integrity of the mitochondrial membrane, enabling neurons to survive in the face of caspase activation...
  35. pmc Ischemic insults promote epigenetic reprogramming of mu opioid receptor expression in hippocampal neurons
    Luigi Formisano
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 104:4170-5. 2007
    ..These findings implicate MORs in ischemia-induced death of CA1 pyramidal neurons and document epigenetic remodeling of expression of OPRM1 in CA1 inhibitory interneurons...
  36. pmc Hypothermia rescues hippocampal CA1 neurons and attenuates down-regulation of the AMPA receptor GluR2 subunit after forebrain ischemia
    Frederick Colbourne
    Department of Psychology, Faculty of Science, University of Alberta, Edmonton, AB, Canada T6G 2E9
    Proc Natl Acad Sci U S A 100:2906-10. 2003
    ..These findings suggest that intervention at the level of transcriptional regulation of the GluR2 gene may be a mechanism by which prolonged postischemic cooling rescues CA1 neurons otherwise "destined to die."..

Research Grants10

  1. Connexins in Ischemia-Induced Neuronal Death
    Michael Bennett; Fiscal Year: 2003
    ..Moreover, this study has important implications for research on other neurodegenerative disorders including focal ischemia, epilepsy, AIDS encephalopathy, and Alzheimer's disease. ..
  2. Cx43 Hemichannels: Gating, Modification and Function
    Michael Bennett; Fiscal Year: 2009
    ..Cx43 is the primary connexin expressed by astrocytes; responses to metabolic challenge will relate to the clinical conditions of focal and global ischemia in the CNS, where the role of astrocytes remains largely unexplored. ..
  3. Cx43 Hemichannels: Gating, Modification and Function
    Michael Bennett; Fiscal Year: 2007
    ..Cx43 is the primary connexin expressed by astrocytes; responses to metabolic challenge will relate to the clinical conditions of focal and global ischemia in the CNS, where the role of astrocytes remains largely unexplored. ..
  4. MECHANISMS OF INTERCELLULAR COMMUNICATION
    Michael Bennett; Fiscal Year: 2007
    ..Trainees are encouraged to explore laboratories other than the one in which they are working and to take maximum advantage of the many scientific opportunities in the College as a whole. ..
  5. Connexins in Ischemia-Induced Neuronal Death
    Michael Bennett; Fiscal Year: 2007
    ..Moreover, this study has important implications for research on other neurodegenerative disorders including focal ischemia, epilepsy, AIDS encephalopathy, and Alzheimer's disease. ..
  6. Connexins in Ischemia-Induced Neuronal Death
    Michael Bennett; Fiscal Year: 2006
    ..Moreover, this study has important implications for research on other neurodegenerative disorders including focal ischemia, epilepsy, AIDS encephalopathy, and Alzheimer's disease. ..
  7. Cx43 Hemichannels: Gating, Modification and Function
    Michael V L Bennett; Fiscal Year: 2010
    ..Cx43 is the primary connexin expressed by astrocytes;responses to metabolic challenge will relate to the clinical conditions of focal and global ischemia in the CNS, where the role of astrocytes remains largely unexplored. ..