NIR J BARZILAI

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. pmc Lipoprotein genotype and conserved pathway for exceptional longevity in humans
    Gil Atzmon
    Institute for Aging Research, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS Biol 4:e113. 2006
  2. ncbi request reprint The effect of age-dependent increase in fat mass on peripheral insulin action is saturable
    N Barzilai
    Department of Medicine, the Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, NY, USA
    J Gerontol A Biol Sci Med Sci 53:B141-6. 1998
  3. ncbi request reprint A genotype of exceptional longevity is associated with preservation of cognitive function
    N Barzilai
    Institute for Aging Research, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Neurology 67:2170-5. 2006
  4. ncbi request reprint Unique lipoprotein phenotype and genotype associated with exceptional longevity
    Nir Barzilai
    Institute for Aging Research, Diabetes Research and Training Center, Albert Einstein College of Medicine, New York, NY 10461, USA
    JAMA 290:2030-40. 2003
  5. ncbi request reprint The role of fat depletion in the biological benefits of caloric restriction
    N Barzilai
    Department of Medicine, Division of Geriatrics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Nutr 131:903S-906S. 2001
  6. ncbi request reprint Searching for human longevity genes: the future history of gerontology in the post-genomic era
    N Barzilai
    Department of Medicine and Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Gerontol A Biol Sci Med Sci 56:M83-7. 2001
  7. ncbi request reprint Interaction between aging and syndrome X: new insights on the pathophysiology of fat distribution
    N Barzilai
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Ann N Y Acad Sci 892:58-72. 1999
  8. ncbi request reprint Decreased visceral adiposity accounts for leptin effect on hepatic but not peripheral insulin action
    N Barzilai
    Division of Geriatrics, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Physiol 277:E291-8. 1999
  9. ncbi request reprint Revisiting the role of fat mass in the life extension induced by caloric restriction
    N Barzilai
    Department of Medicine, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York, USA
    J Gerontol A Biol Sci Med Sci 54:B89-96; discussion B97-8. 1999
  10. ncbi request reprint Surgical removal of visceral fat reverses hepatic insulin resistance
    N Barzilai
    Department of Medicine, and Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Diabetes 48:94-8. 1999

Detail Information

Publications12

  1. pmc Lipoprotein genotype and conserved pathway for exceptional longevity in humans
    Gil Atzmon
    Institute for Aging Research, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS Biol 4:e113. 2006
    ..Because modulation of lipoproteins is also seen in genetically altered longevity models, it may be a common pathway influencing lifespan from nematodes to humans...
  2. ncbi request reprint The effect of age-dependent increase in fat mass on peripheral insulin action is saturable
    N Barzilai
    Department of Medicine, the Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, NY, USA
    J Gerontol A Biol Sci Med Sci 53:B141-6. 1998
    ..We suggest that decreasing insulin responsiveness, in a heterogeneous group such as humans, will only occur within a specific accretion of visceral or total FM...
  3. ncbi request reprint A genotype of exceptional longevity is associated with preservation of cognitive function
    N Barzilai
    Institute for Aging Research, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Neurology 67:2170-5. 2006
    ..To test whether cholesterol ester transfer protein (CETP) genotype (VV homozygosity for I405V) is associated with preservation of cognitive function in addition to its association with exceptional longevity...
  4. ncbi request reprint Unique lipoprotein phenotype and genotype associated with exceptional longevity
    Nir Barzilai
    Institute for Aging Research, Diabetes Research and Training Center, Albert Einstein College of Medicine, New York, NY 10461, USA
    JAMA 290:2030-40. 2003
    ..Individuals with exceptional longevity have a lower incidence and/or significant delay in the onset of age-related disease, and their family members may inherit biological factors that modulate aging processes and disease susceptibility...
  5. ncbi request reprint The role of fat depletion in the biological benefits of caloric restriction
    N Barzilai
    Department of Medicine, Division of Geriatrics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Nutr 131:903S-906S. 2001
    ....
  6. ncbi request reprint Searching for human longevity genes: the future history of gerontology in the post-genomic era
    N Barzilai
    Department of Medicine and Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Gerontol A Biol Sci Med Sci 56:M83-7. 2001
    ..This article reviews such evidence, its implications for the identification of human longevity-assurance genes, and the significance of finding longevity genes to human health and disease...
  7. ncbi request reprint Interaction between aging and syndrome X: new insights on the pathophysiology of fat distribution
    N Barzilai
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Ann N Y Acad Sci 892:58-72. 1999
    ..Thus, the cause-effect relationship between the age-related increase in VF and the decrease in hepatic insulin action may involve the failure of leptin to "cross talk" with other fat depots to regulate fat distribution...
  8. ncbi request reprint Decreased visceral adiposity accounts for leptin effect on hepatic but not peripheral insulin action
    N Barzilai
    Division of Geriatrics, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Physiol 277:E291-8. 1999
    ..We conclude that 1) a moderate decrease in VF uniformly leads to a marked increase in hepatic insulin action, but 2) the effects of leptin on peripheral insulin action are not due to the associated changes in VF or beta3 activation...
  9. ncbi request reprint Revisiting the role of fat mass in the life extension induced by caloric restriction
    N Barzilai
    Department of Medicine, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York, USA
    J Gerontol A Biol Sci Med Sci 54:B89-96; discussion B97-8. 1999
    ....
  10. ncbi request reprint Surgical removal of visceral fat reverses hepatic insulin resistance
    N Barzilai
    Department of Medicine, and Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Diabetes 48:94-8. 1999
    ..We conclude that visceral fat is a potent modulator of insulin action on hepatic glucose production and gene expression...
  11. pmc Caloric restriction reverses hepatic insulin resistance in aging rats by decreasing visceral fat
    N Barzilai
    Department of Medicine, Albert Einstein College of Medicine, New York 10461, USA
    J Clin Invest 101:1353-61. 1998
    ..Thus, interventions designed to prevent the accumulation of VF are likely to represent an effective mean to improve carbohydrate metabolism in aging...
  12. pmc Biological approaches to mechanistically understand the healthy life span extension achieved by calorie restriction and modulation of hormones
    Nir Barzilai
    Institute for Aging Research, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Gerontol A Biol Sci Med Sci 64:187-91. 2009
    ..quot;..

Research Grants19

  1. DYSREGULATION OF GLUCOSE HOMEOSTASIS IN AGING
    Nir Barzilai; Fiscal Year: 2007
    ..abstract_text> ..
  2. Role of Genes in Exceptional Longevity in Humans
    Nir Barzilai; Fiscal Year: 2007
    ..In addition, the Administrative Core is charged with maintaining relationships and contact with enrolled subjects, which is critical to the success of the longitudinal study design. ..
  3. Training in Aging Research
    Nir Barzilai; Fiscal Year: 2007
    ..Through formal course work, participation in research seminars, and individual research projects, trainees can develop the skills necessary for independent careers in aging research. ..
  4. DYSREGULATION OF GLUCOSE HOMEOSTASIS IN AGING
    Nir Barzilai; Fiscal Year: 2004
    ..Once mechanisms for dysregulation of glucose metabolism are identified in animal models, interventions specifically designed to alter body composition in human aging may be proposed. ..
  5. SEARCHING FOR LONGEVITY GENES IN HISTORICALLY UNIQUE JEWISH ASHKENAZI POPULATION
    Nir Barzilai; Fiscal Year: 2001
    ..abstract_text> ..
  6. SEARCHING FOR LONGEVITY GENES IN HISTORICALLY UNIQUE JEWISH ASHKENAZI POPULATION
    Nir Barzilai; Fiscal Year: 2000
    ..abstract_text> ..
  7. DETECTION OF HYPOXIA IN SICKLE CELL ANEMIA BY SUSCEPTIBILITY EFFECTS IN MRI
    Nir Barzilai; Fiscal Year: 1999
    ..BOLD-MRI will be useful in further understanding the pathophysiology of VOEs and the evaluation of treatment protocols. ..
  8. DYSREGULATION OF GLUCOSE HOMEOSTASIS IN AGING
    Nir Barzilai; Fiscal Year: 2009
    ..abstract_text> ..