Nicholas Baker

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. pmc Genes affecting cell competition in Drosophila
    David M Tyler
    Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Genetics 175:643-57. 2007
  2. pmc Expanded and fat regulate growth and differentiation in the Drosophila eye through multiple signaling pathways
    David M Tyler
    Department of Molecular Genetics, Albert Einstein College of Medicine 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Dev Biol 305:187-201. 2007
  3. pmc Developmental regulation of nucleolus size during Drosophila eye differentiation
    Nicholas E Baker
    Departments of Genetics, Ophthalmology and Visual Sciences, and Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, USA
    PLoS ONE 8:e58266. 2013
  4. pmc Notch activity opposes Ras-induced differentiation during the Second Mitotic Wave of the developing Drosophila eye
    Lihui Yang
    Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    BMC Dev Biol 6:8. 2006
  5. pmc Competition between Delta and the Abruptex domain of Notch
    Zifei Pei
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    BMC Dev Biol 8:4. 2008
  6. pmc The roles of cis-inactivation by Notch ligands and of neuralized during eye and bristle patterning in Drosophila
    Yanxia Li
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10261, USA
    BMC Dev Biol 4:5. 2004
  7. doi request reprint Cell competition and its possible relation to cancer
    Nicholas E Baker
    Department of Molecular Genetics, Albet Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 68:5505-7. 2008
  8. pmc Regulation of Hh signal transduction as Drosophila eye differentiation progresses
    Nicholas E Baker
    Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Dev Biol 335:356-66. 2009
  9. ncbi request reprint Patterning signals and proliferation in Drosophila imaginal discs
    Nicholas E Baker
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Curr Opin Genet Dev 17:287-93. 2007
  10. pmc Spitz from the retina regulates genes transcribed in the second mitotic wave, peripodial epithelium, glia and plasmatocytes of the Drosophila eye imaginal disc
    Lucy C Firth
    Department of Molecular Genetics, Albert Einstein College of Medicine, NY 10461, USA
    Dev Biol 307:521-38. 2007

Research Grants

  1. CELL CELL INTERACTIONS IN DEVELOPING RETINA
    Nicholas Baker; Fiscal Year: 2004
  2. CELL-CELL INTERACTIONS IN DEVELOPING RETINA
    Nicholas Baker; Fiscal Year: 2007
  3. DEVELOPMENTAL REGULATION OF GROWTH, SIZE AND SHAPE
    Nicholas Baker; Fiscal Year: 2007
  4. CELL-CELL INTERACTIONS IN DEVELOPING RETINA
    Nicholas Baker; Fiscal Year: 2007
  5. DEVELOPMENTAL REGULATION OF GROWTH, SIZE AND SHAPE
    Nicholas Baker; Fiscal Year: 2009
  6. CELL-CELL INTERACTIONS IN DEVELOPING RETINA
    Nicholas E Baker; Fiscal Year: 2010
  7. DEVELOPMENTAL REGULATION OF GROWTH, SIZE AND SHAPE
    Nicholas E Baker; Fiscal Year: 2010
  8. DEVELOPMENTAL REGULATION OF GROWTH, SIZE AND SHAPE
    Nicholas Baker; Fiscal Year: 2004
  9. CELL-CELL INTERACTIONS IN DEVELOPING RETINA
    Nicholas Baker; Fiscal Year: 1993
  10. CELL CELL INTERACTIONS IN DEVELOPING RETINA
    Nicholas Baker; Fiscal Year: 2000

Collaborators

Detail Information

Publications29

  1. pmc Genes affecting cell competition in Drosophila
    David M Tyler
    Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Genetics 175:643-57. 2007
    ..We suggest that cell competition might occur during tumor development in mammals...
  2. pmc Expanded and fat regulate growth and differentiation in the Drosophila eye through multiple signaling pathways
    David M Tyler
    Department of Molecular Genetics, Albert Einstein College of Medicine 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Dev Biol 305:187-201. 2007
    ..During disc growth, ex was largely epistatic to ft, and the Warts pathway mutation hippo largely epistatic to ex. Our data suggest that ft and ex act partially through the Warts pathway...
  3. pmc Developmental regulation of nucleolus size during Drosophila eye differentiation
    Nicholas E Baker
    Departments of Genetics, Ophthalmology and Visual Sciences, and Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, USA
    PLoS ONE 8:e58266. 2013
    ....
  4. pmc Notch activity opposes Ras-induced differentiation during the Second Mitotic Wave of the developing Drosophila eye
    Lihui Yang
    Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    BMC Dev Biol 6:8. 2006
    ..It is not known how fate specification is limited to G1-arrested cells...
  5. pmc Competition between Delta and the Abruptex domain of Notch
    Zifei Pei
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    BMC Dev Biol 8:4. 2008
    ..Extracellular domains of the Notch family of signalling receptors contain many EGF repeat domains, as do their major ligands. Some EGF repeats are modified by O-fucosylation, and most have no identified role in ligand binding...
  6. pmc The roles of cis-inactivation by Notch ligands and of neuralized during eye and bristle patterning in Drosophila
    Yanxia Li
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10261, USA
    BMC Dev Biol 4:5. 2004
    ..Cis-inactivation and role of Neuralized have not yet been studied in tissues where neural precursor cells are resistant to nearby Delta, however, such as the R8 cells of the eye or the bristle precursor cells of the epidermis...
  7. doi request reprint Cell competition and its possible relation to cancer
    Nicholas E Baker
    Department of Molecular Genetics, Albet Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 68:5505-7. 2008
    ..Here, we discuss the possible relevance of cell competition to cancer...
  8. pmc Regulation of Hh signal transduction as Drosophila eye differentiation progresses
    Nicholas E Baker
    Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Dev Biol 335:356-66. 2009
    ..A model is presented for regulation of the Cullin-3 and Cullin-1 pathways that modifies Hedgehog signaling as the morphogenetic furrow moves and the responses of retinal cells change...
  9. ncbi request reprint Patterning signals and proliferation in Drosophila imaginal discs
    Nicholas E Baker
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Curr Opin Genet Dev 17:287-93. 2007
    ..Reminiscent of pattern formation, cell cycle effects of each signaling pathway differ in distinct developmental fields, making use of a variety of target genes...
  10. pmc Spitz from the retina regulates genes transcribed in the second mitotic wave, peripodial epithelium, glia and plasmatocytes of the Drosophila eye imaginal disc
    Lucy C Firth
    Department of Molecular Genetics, Albert Einstein College of Medicine, NY 10461, USA
    Dev Biol 307:521-38. 2007
    ..These novel targets suggest that during eye development, EGFR activity coordinates transcriptional programs in other tissues with retinal differentiation...
  11. ncbi request reprint Notch activity in neural cells triggered by a mutant allele with altered glycosylation
    Yanxia Li
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Development 130:2829-40. 2003
    ..These results suggest that the pattern of neurogenesis is determined by blocking Notch signaling, as well as by activating Notch signaling...
  12. ncbi request reprint A pathway of signals regulating effector and initiator caspases in the developing Drosophila eye
    Sun Yun Yu
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Development 129:3269-78. 2002
    ..Taken together, these findings indicate that in eye development spatial regulation of cell death and survival is integrated through a single intracellular pathway...
  13. ncbi request reprint Extracellular signals responsible for spatially regulated proliferation in the differentiating Drosophila eye
    Lucy C Firth
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Dev Cell 8:541-51. 2005
    ..These studies identify the specific extracellular signals that pattern the retinal cell cycles and show how differentiation can be uncoupled from cell cycle exit...
  14. ncbi request reprint Cell cycle withdrawal, progression, and cell survival regulation by EGFR and its effectors in the differentiating Drosophila eye
    Lihui Yang
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Dev Cell 4:359-69. 2003
    ..Our results suggest that, rather than triggering all or none responses, EGFR coordinates partially independent processes as the eye differentiates...
  15. ncbi request reprint Atonal points the way- protein-protein interactions and developmental biology
    Nicholas E Baker
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 1046, USA
    Dev Cell 7:632-4. 2004
    ..In this issue of Developmental Cell, zur Lage and colleagues describe how certain cells sustain proneural gene expression through direct interactions between transcription factors...
  16. ncbi request reprint Deciphering synergistic and redundant roles of Hedgehog, Decapentaplegic and Delta that drive the wave of differentiation in Drosophila eye development
    Weimin Fu
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Development 130:5229-39. 2003
    ..Notch acted in part through downregulation of Hairy; Hh signaling downregulated Hairy independently of Notch. One feature of this signaling network is to limit Dpp signaling spatially to a range coincident with Hh...
  17. pmc The pineapple eye gene is required for survival of Drosophila imaginal disc cells
    Wei Shi
    Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Genetics 165:1869-79. 2003
    ..The pineapple eye gene was identified and predicted to encode a novel 582-amino-acid protein. The protein contains a novel, cysteine-rich domain of 270 amino acids also found in predicted proteins of unknown function from other animals...
  18. pmc Retinal determination genes as targets and possible effectors of extracellular signals
    Lucy C Firth
    Department of Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Dev Biol 327:366-75. 2009
    ....
  19. pmc The HLH protein Extramacrochaetae is required for R7 cell and cone cell fates in the Drosophila eye
    Abhishek Bhattacharya
    Department of Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Dev Biol 327:288-300. 2009
    ..A model is proposed in which Extramacrochaetae acts in parallel to or as a feed-forward regulator of the E(spl)-Complex to promote Notch signaling in particular cellular contexts...
  20. ncbi request reprint Scabrous and Gp150 are endosomal proteins that regulate Notch activity
    Yanxia Li
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Development 130:2819-27. 2003
    ..Gp150 concentrated Sca protein in late endosomes. A model is proposed in which endosomal Sca and Gp150 promote Notch activation in response to Delta, by regulating acquisition of insensitivity to Delta in a subset of cells...
  21. pmc Individual carboxypeptidase D domains have both redundant and unique functions in Drosophila development and behavior
    Galyna Sidyelyeva
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Cell Mol Life Sci 67:2991-3004. 2010
    ..These findings suggest that CPD domains-1 and -2 have largely redundant functions in the processing of growth factors, hormones, and neuropeptides...
  22. pmc Cell cycle arrest by a gradient of Dpp signaling during Drosophila eye development
    Lucy C Firth
    Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    BMC Dev Biol 10:28. 2010
    ..The dpp gene is expressed at multiple locations in the eye imaginal disc, including the morphogenetic furrow that sweeps across the eye disc as differentiation initiates...
  23. ncbi request reprint Analyses of RAS regulation of eye development in Drosophila melanogaster
    Lucy C Firth
    Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York, USA
    Methods Enzymol 407:711-21. 2006
    ....
  24. ncbi request reprint Engulfment is required for cell competition
    Wei Li
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Cell 129:1215-25. 2007
    ..Wild-type cells can themselves be killed by cells with elevated engulfing activity. Thus engulfment genes act downstream of growth differences between cells to eliminate cells with reduced ribosomal gene dose...
  25. ncbi request reprint Size isn't everything
    David Tyler
    Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Bioessays 25:5-8. 2003
    ..A recent paper suggests that a hitherto overlooked cellular behaviour governs the size and shape of a growing tissue, and issues a challenge to developmental biologists to identify the molecular mechanisms involved...
  26. ncbi request reprint EGF receptor signaling: a prickly proposition
    Lucy C Firth
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Curr Biol 13:R773-4. 2003
  27. ncbi request reprint Characterization of the molecular basis of the Drosophila mutations in carboxypeptidase D. Effect on enzyme activity and expression
    Galyna Sidyelyeva
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 281:13844-52. 2006
    ..Flies that retain the short form are viable, whereas flies that are missing all forms of CPD do not survive past the early larval stages...
  28. pmc Oriented cell division as a response to cell death and cell competition
    Wei Li
    Department of Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Curr Biol 19:1821-6. 2009
    ..These findings show that planar cell polarity genes are required for responses to cell death. Oriented mitosis may help maintain morphology as dividing cells replace those that have been lost...
  29. ncbi request reprint The active role of corpse engulfment pathways during cell competition
    Wei Li
    Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Fly (Austin) 1:274-8. 2007
    ..We also speculate about how cell interactions at clone boundaries may initiate cell competition...

Research Grants28

  1. CELL CELL INTERACTIONS IN DEVELOPING RETINA
    Nicholas Baker; Fiscal Year: 2004
    ..Together these studies will precisely dissect pathways of RTK function in vivo and identify those components that are specific for particular cellular responses important in human disease. ..
  2. CELL-CELL INTERACTIONS IN DEVELOPING RETINA
    Nicholas Baker; Fiscal Year: 2007
    ..These studies will take a systematic approach to the regulation of the retina by extracellular signals. ..
  3. DEVELOPMENTAL REGULATION OF GROWTH, SIZE AND SHAPE
    Nicholas Baker; Fiscal Year: 2007
    ....
  4. CELL-CELL INTERACTIONS IN DEVELOPING RETINA
    Nicholas Baker; Fiscal Year: 2007
    ..These studies will take a systematic approach to the regulation of the retina by extracellular signals. ..
  5. DEVELOPMENTAL REGULATION OF GROWTH, SIZE AND SHAPE
    Nicholas Baker; Fiscal Year: 2009
    ....
  6. CELL-CELL INTERACTIONS IN DEVELOPING RETINA
    Nicholas E Baker; Fiscal Year: 2010
    ..Our studies will suggest new approaches to neuroprotection and regenerative approaches involving proliferation and specification of replacement neurons. ..
  7. DEVELOPMENTAL REGULATION OF GROWTH, SIZE AND SHAPE
    Nicholas E Baker; Fiscal Year: 2010
    ....
  8. DEVELOPMENTAL REGULATION OF GROWTH, SIZE AND SHAPE
    Nicholas Baker; Fiscal Year: 2004
    ..abstract_text> ..
  9. CELL-CELL INTERACTIONS IN DEVELOPING RETINA
    Nicholas Baker; Fiscal Year: 1993
    ..To test if Notch or other proteins is a receptor for scabrous, the nature of the scabrous protein products and Notch scabrous binding will be investigated biochemically...
  10. CELL CELL INTERACTIONS IN DEVELOPING RETINA
    Nicholas Baker; Fiscal Year: 2000
    ..They will yield information about normal regulatory mechanisms that are likely to be widely conserved; the posttranslational regulatory aspects are a particularly useful starting point for rational drug design. ..
  11. DEVELOPMENTAL REGULATION OF GROWTH, SIZE AND SHAPE
    Nicholas Baker; Fiscal Year: 2009
    ....