Harvey Babich

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. doi request reprint Cranberry juice extract, a mild prooxidant with cytotoxic properties independent of reactive oxygen species
    H Babich
    Department of Biology, Stern College for Women, 245 Lexington Avenue, New York, NY 10016, USA
    Phytother Res 26:1358-65. 2012
  2. ncbi request reprint Differential in vitro cytotoxicity of (-)-epicatechin gallate (ECG) to cancer and normal cells from the human oral cavity
    H Babich
    Department of Biology, Stern College for Women, Yeshiva University, 245 Lexington Avenue, New York, NY 10016, USA
    Toxicol In Vitro 19:231-42. 2005
  3. ncbi request reprint Mediation of the in vitro cytotoxicity of green and black tea polyphenols by cobalt chloride
    H Babich
    Department of Biology, Stern College for Women, Yeshiva University, 245 Lexington Avenue, New York, NY 10016, USA
    Toxicol Lett 155:195-205. 2005
  4. ncbi request reprint In vitro cytotoxicity of (-)-catechin gallate, a minor polyphenol in green tea
    H Babich
    Stern College for Women, Yeshiva University, Department of Biology, 245 Lexington Avenue, NY 10016, USA
    Toxicol Lett 171:171-80. 2007
  5. doi request reprint Theaflavin-3-gallate and theaflavin-3'-gallate, polyphenols in black tea with prooxidant properties
    Harvey Babich
    Department of Biology, Stern College for Women, Yeshiva University, New York, NY, USA
    Basic Clin Pharmacol Toxicol 103:66-74. 2008
  6. doi request reprint Choice of DMEM, formulated with or without pyruvate, plays an important role in assessing the in vitro cytotoxicity of oxidants and prooxidant nutraceuticals
    H Babich
    Department of Biology, Stern College for Women, Yeshiva University, 245 Lexington Avenue, New York, NY 10016, USA
    In Vitro Cell Dev Biol Anim 45:226-33. 2009
  7. doi request reprint Gingko biloba leaf extract induces oxidative stress in carcinoma HSC-2 cells
    Harvey Babich
    Department of Biology, Stern College for Women, Yeshiva University, New York, NY 10016, USA
    Toxicol In Vitro 23:992-9. 2009
  8. ncbi request reprint In vitro cytotoxicity of a theaflavin mixture from black tea to malignant, immortalized, and normal cells from the human oral cavity
    H Babich
    Department of Biology, Stern College for Women, Yeshiva University, 245 Lexington Avenue, New York, NY 10016, USA
    Toxicol In Vitro 20:677-88. 2006
  9. doi request reprint Theaflavin-3,3'-digallate, a component of black tea: an inducer of oxidative stress and apoptosis
    Alyssa G Schuck
    Department of Biology, Stern College for Women, Yeshiva University, 245 Lexington Avenue, New York, NY 10016, USA
    Toxicol In Vitro 22:598-609. 2008
  10. ncbi request reprint Pomegranate extract, a prooxidant with antiproliferative and proapoptotic activities preferentially towards carcinoma cells
    Jeffrey H Weisburg
    Department of Biology, Stern College for Women, Yeshiva University, 245 Lexington Avenue, New York, NY 10016, USA
    Anticancer Agents Med Chem 10:634-44. 2010

Collaborators

Detail Information

Publications21

  1. doi request reprint Cranberry juice extract, a mild prooxidant with cytotoxic properties independent of reactive oxygen species
    H Babich
    Department of Biology, Stern College for Women, 245 Lexington Avenue, New York, NY 10016, USA
    Phytother Res 26:1358-65. 2012
    ..These differences in toxicity between SOD-stabilized CJE, freshly prepared CJE, and 'spent' CJE were confirmed in HSC-2 cells stained with aceto-orcein, which also indicated that the mode of cell death was by the induction of apoptosis...
  2. ncbi request reprint Differential in vitro cytotoxicity of (-)-epicatechin gallate (ECG) to cancer and normal cells from the human oral cavity
    H Babich
    Department of Biology, Stern College for Women, Yeshiva University, 245 Lexington Avenue, New York, NY 10016, USA
    Toxicol In Vitro 19:231-42. 2005
    ..ECG induced apoptosis in the carcinoma HSC-2 cells, but not in the normal HGF-2 fibroblasts. This research supports those studies suggesting that tea green is an effective chemopreventive agent of oral carcinoma...
  3. ncbi request reprint Mediation of the in vitro cytotoxicity of green and black tea polyphenols by cobalt chloride
    H Babich
    Department of Biology, Stern College for Women, Yeshiva University, 245 Lexington Avenue, New York, NY 10016, USA
    Toxicol Lett 155:195-205. 2005
    ....
  4. ncbi request reprint In vitro cytotoxicity of (-)-catechin gallate, a minor polyphenol in green tea
    H Babich
    Stern College for Women, Yeshiva University, Department of Biology, 245 Lexington Avenue, NY 10016, USA
    Toxicol Lett 171:171-80. 2007
    ..The overall cytotoxicity of CG was similar to its epimer, ECG and both exhibited antiproliferative effects equivalent to, or stronger than, EGCG, the most abundant catechin in green tea...
  5. doi request reprint Theaflavin-3-gallate and theaflavin-3'-gallate, polyphenols in black tea with prooxidant properties
    Harvey Babich
    Department of Biology, Stern College for Women, Yeshiva University, New York, NY, USA
    Basic Clin Pharmacol Toxicol 103:66-74. 2008
    ..These studies demonstrated that the black tea theaflavin monomers, TF-2A and TF-2B, act as prooxidants and induce oxidative stress, with carcinoma cells more sensitive than normal fibroblasts...
  6. doi request reprint Choice of DMEM, formulated with or without pyruvate, plays an important role in assessing the in vitro cytotoxicity of oxidants and prooxidant nutraceuticals
    H Babich
    Department of Biology, Stern College for Women, Yeshiva University, 245 Lexington Avenue, New York, NY 10016, USA
    In Vitro Cell Dev Biol Anim 45:226-33. 2009
    ..This study suggested that the pyruvate status of Dulbecco's modified Eagle's medium be specified in the experimental design, especially in studies involving oxidative stress...
  7. doi request reprint Gingko biloba leaf extract induces oxidative stress in carcinoma HSC-2 cells
    Harvey Babich
    Department of Biology, Stern College for Women, Yeshiva University, New York, NY 10016, USA
    Toxicol In Vitro 23:992-9. 2009
    ..biloba extract was noted by apoptotic cell morphologies, by TUNEL staining, and by PARP cleavage. The data strongly suggest that the prooxidative nature of the G. biloba extract was the cause of apoptotic cell death...
  8. ncbi request reprint In vitro cytotoxicity of a theaflavin mixture from black tea to malignant, immortalized, and normal cells from the human oral cavity
    H Babich
    Department of Biology, Stern College for Women, Yeshiva University, 245 Lexington Avenue, New York, NY 10016, USA
    Toxicol In Vitro 20:677-88. 2006
    ..For both cell types, coexposures of the theaflavin mixture with catalase or CoCl(2) afforded protection...
  9. doi request reprint Theaflavin-3,3'-digallate, a component of black tea: an inducer of oxidative stress and apoptosis
    Alyssa G Schuck
    Department of Biology, Stern College for Women, Yeshiva University, 245 Lexington Avenue, New York, NY 10016, USA
    Toxicol In Vitro 22:598-609. 2008
    ..Apoptosis was not noted in GN46 fibroblasts treated with TF-3...
  10. ncbi request reprint Pomegranate extract, a prooxidant with antiproliferative and proapoptotic activities preferentially towards carcinoma cells
    Jeffrey H Weisburg
    Department of Biology, Stern College for Women, Yeshiva University, 245 Lexington Avenue, New York, NY 10016, USA
    Anticancer Agents Med Chem 10:634-44. 2010
    ..Lessening of caspase-3 activation and of PARP cleavage in cells co-treated with PE and either cobalt or pyruvate, respectively, as compared to PE alone, indicated that apoptosis was through the prooxidant nature of PE...
  11. ncbi request reprint In vitro cytotoxicity of epigallocatechin gallate and tea extracts to cancerous and normal cells from the human oral cavity
    Jeffrey H Weisburg
    Stern College for Women, Yeshiva University, Department of Biology, 245 Lexington Avenue, New York, NY 10016, U S A
    Basic Clin Pharmacol Toxicol 95:191-200. 2004
    ..The results presented herein are consistent with EGCG acting as a prooxidant, with the cancerous cells more sensitive to oxidative stress than the normal cells...
  12. ncbi request reprint Ellagic Acid, a Dietary Polyphenol, Selectively Cytotoxic to HSC-2 Oral Carcinoma Cells
    Jeffrey H Weisburg
    Department of Biology, Stern College for Women, 245 Lexington Avenue, New York, NY 10016 USA
    Anticancer Res 33:1829-36. 2013
    ..The antiproliferative and apoptotic effects of ellagic acid, a dietary polyphenol, were studied...
  13. ncbi request reprint In vitro cytotoxicity of protocatechuic acid to cultured human cells from oral tissue: involvement in oxidative stress
    Harvey Babich
    Stern College for Women, Yeshiva University, Department of Biology, 245 Lexington Avenue, New York, NY 10016, USA
    Pharmacol Toxicol 91:245-53. 2002
    ..5 mM) enhanced their sensitivity to a subsequent exposure to tert-butyl hydroperoxide. These findings were consistent with protocatechuic acid, at high levels (> or = 10 mM), acting as an inducer of oxidative stress...
  14. ncbi request reprint In vitro cytotoxicity of the nitric oxide donor, S-nitroso-N-acetyl-penicillamine, towards cells from human oral tissue
    H Babich
    Department of Biology, Stern College for Women, Yeshiva University, New York, New York 10016, USA
    Pharmacol Toxicol 84:218-25. 1999
    ..Cells exposed to SNAP exhibited nuclear aberrations, including multilobed nuclei and multinucleation. SNAP-induced cell death was apparently by apoptosis, as noted by fluorescence microscopy and DNA agarose gel electrophoresis...
  15. ncbi request reprint In vitro response of human gingival epithelial S-G cells to resveratrol
    H Babich
    Stern College for Women, Yeshiva University, Department of Biology, 245 Lexington Avenue, New York, NY 10016, USA
    Toxicol Lett 114:143-53. 2000
    ..For nitric oxide, only N-acetyl-L-cysteine reduced toxicity. The ability of resveratrol to function as an antioxidant was, therefore, not noted under these test conditions...
  16. ncbi request reprint Indirect cytotoxicity of dental materials: a study with Transwell inserts and the neutral red uptake assay
    H Babich
    Department of Biology, Stern College for Women, Yeshiva University, 245 Lexington Avenue, New York, NY 10016, USA
    Altern Lab Anim 29:9-13. 2001
    ..The sequence of cytotoxicity of the dental restoratives to the S-G cells was Vitremer > Ketac-Molar Aplicap > Flow-It...
  17. ncbi request reprint In vitro cytotoxicity of glyco-S-nitrosothiols. a novel class of nitric oxide donors
    H Babich
    Department of Biology, Stern College for Women, Yeshiva University, 245 Lexington Avenue, New York 10016, New York, USA
    Toxicol In Vitro 15:181-90. 2001
    ..In comparison with other classes of NO donors the sequence of toxicity towards S-G cells was S-nitrosoglutathione>glucose-SNAPs>SNAP, sodium nitroprusside>spermine NONOate>DPTA NONOate>DETA NONOate>fructose-1-SNAP>>SIN-1...
  18. ncbi request reprint In vitro response of human gingival epithelioid S-G cells to minocycline
    H Babich
    Department of Biology, Stern College for Women, Yeshiva University, 245 Lexington Avenue, New York, NY 10016, USA
    Toxicol In Vitro 16:11-21. 2002
    ....
  19. ncbi request reprint In vitro cytotoxicity to human cells in culture of some phenolics from olive oil
    H Babich
    Department of Biology, Stern College for Women, Yeshiva University, 245 Lexington Avenue, New York, NY 10016, USA
    Farmaco 58:403-7. 2003
    ..Cytotoxicity was noted only at phenolic concentrations far exceeding those attainable after habitual consumption, thus indicating that consumption of phenol-rich olive oil is safe...
  20. ncbi request reprint Sodium lauryl sulfate and triclosan: in vitro cytotoxicity studies with gingival cells
    H Babich
    Stern College for Women, Yeshiva University, Department of Biology, New York, NY 10016, USA
    Toxicol Lett 91:189-96. 1997
    ..Pretreatment with triclosan potentiated the toxicity of a subsequent exposure of SLS to the S-G cells; a similar pretreatment of the GF fibroblasts with triclosan had no effect on a subsequent challenge with SLS...
  21. pmc Research strategies in the study of the pro-oxidant nature of polyphenol nutraceuticals
    Harvey Babich
    Department of Biology, Stern College for Women, Yeshiva University, 245 Lexington Avenue, New York, NY 10016, USA
    J Toxicol 2011:467305. 2011
    ..Attention also must be directed to the influence of iron and copper ions and to the level of polyphenols, which mediate oxidative stress...