Research Topics
Genomes and GenesSpecies | Gil AtzmonSummaryAffiliation: Albert Einstein College of Medicine Country: USA Publications
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Detail Information
Publications
Evolution in health and medicine Sackler colloquium: Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenariansGil Atzmon
Department of Medicine and Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Proc Natl Acad Sci U S A 107:1710-7. 2010..Thus, variations in human telomerase gene that are associated with better maintenance of telomere length may confer healthy aging and exceptional longevity in humans...- Enhanced activation of a "nutrient-sensing" pathway with age contributes to insulin resistanceFrancine H Einstein
Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461, USA
FASEB J 22:3450-7. 2008..These results suggest that altered nutrient sensing by HBP with age may be the link among nutrients, insulin resistance, and age-related diabetes... - Aging per se increases the susceptibility to free fatty acid-induced insulin resistanceFrancine H Einstein
Department of Obstetrics and Gynecology and Women s Health at Montefiore Medical Center, Bronx, New York, USA
J Gerontol A Biol Sci Med Sci 65:800-8. 2010..Thus, aging per se increases the inflammatory response to excess nutrients and vulnerability to FFA-induced insulin resistance with aging... - Distinguishing between longevity and buffered-deleterious genotypes for exceptional human longevity: the case of the MTP geneDerek M Huffman
Department of Medicine, The Albert Einstein College of Medicine of Yeshiva University, New York, NY, USA
J Gerontol A Biol Sci Med Sci 67:1153-60. 2012..05). Thus, we conclude that MTP CC is a buffered-deleterious genotype and that assessing genotype frequency across aging is essential for discerning longevity from buffered-deleterious genotypes... 
Accretion of visceral fat and hepatic insulin resistance in pregnant ratsFrancine H Einstein
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology and Women s Health, The Albert Einstein College of Medicine Montefiore Medical Center, 1825 Eastchester Road, Bronx, NY 10461, USA
Am J Physiol Endocrinol Metab 294:E451-5. 2008..05). Accretion of visceral fat is an important component in the development of hepatic IR in pregnancy, and accumulation of hepatic triglycerides is a mechanism by which visceral fat may modulate insulin action in pregnancy...- Humanin: a novel central regulator of peripheral insulin actionRadhika H Muzumdar
Department of Pediatrics, Children s Hospital at Montefiore, Institute for Aging Research, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, NY, USA
PLoS ONE 4:e6334. 2009..A novel mitochondria-associated peptide, Humanin (HN), has a neuroprotective role against AD-related neurotoxicity. Considering the association between insulin resistance and AD, we investigated if HN influences insulin sensitivity... - Genetic predisposition to elevated serum thyrotropin is associated with exceptional longevityGil Atzmon
Division of Endocrinology, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Clin Endocrinol Metab 94:4768-75. 2009..Exceptional longevity is associated with raised serum TSH... - North African Jewish and non-Jewish populations form distinctive, orthogonal clustersChristopher L Campbell
Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Proc Natl Acad Sci U S A 109:13865-70. 2012.... - Exceptional longevity is associated with decreased reproductionVafa Tabatabaie
Institute for Aging Research, Division of Endocrinology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Aging (Albany NY) 3:1202-5. 2011..The lower number of children in both genders together with the pattern of delayed reproductive maturity is suggestive of constitutional factors that might enhance human life span at the expense of reduced reproductive ability... - Adiponectin levels and genotype: a potential regulator of life span in humansGil Atzmon
Institute for Aging Research, Diabetes Research and Training Center, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, NY 10461, USA
J Gerontol A Biol Sci Med Sci 63:447-53. 2008.... - Biological evidence for inheritance of exceptional longevityGil Atzmon
Department of Medicine, Institute for Aging Research, Diabetes Research and Training Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
Mech Ageing Dev 126:341-5. 2005..Hopefully, this line of research will lead us to establish which genotype is necessary (although not necessary sufficient) for a prolonged disease-free aging... 
Lifestyle factors of people with exceptional longevitySwapnil N Rajpathak
Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA
J Am Geriatr Soc 59:1509-12. 2011..To assess lifestyle factors including physical activity, smoking, alcohol consumption, and dietary habits in men and women with exceptional longevity...- Visceral adipose tissue modulates mammalian longevityRadhika Muzumdar
Institute for Aging Research, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA
Aging Cell 7:438-40. 2008..13). Taken together, these observations provide the most direct evidence to date that a reduction in fat mass, specifically VF, may be one of the possible underlying mechanisms of the anti-aging effect of CR... - Lipoprotein genotype and conserved pathway for exceptional longevity in humansGil Atzmon
Institute for Aging Research, Albert Einstein College of Medicine, Bronx, New York, United States of America
PLoS Biol 4:e113. 2006..Because modulation of lipoproteins is also seen in genetically altered longevity models, it may be a common pathway influencing lifespan from nematodes to humans... - Abraham's children in the genome era: major Jewish diaspora populations comprise distinct genetic clusters with shared Middle Eastern AncestryGil Atzmon
Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Am J Hum Genet 86:850-9. 2010..Thus, this study demonstrates that European/Syrian and Middle Eastern Jews represent a series of geographical isolates or clusters woven together by shared IBD genetic threads... - Cholesteryl ester transfer protein (CETP) genotype and reduced CETP levels associated with decreased prevalence of hypertensionClyde B Schechter
Department of Family and Social Medicine, Albert Einstein College of Medicine, Bronx, NY, 10461, USA
Mayo Clin Proc 85:522-6. 2010.... - Extreme longevity is associated with increased serum thyrotropinGil Atzmon
Department of MedicineDivision of Endocrinology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Clin Endocrinol Metab 94:1251-4. 2009..The distribution of serum TSH shifts progressively to higher concentrations with age... - Acute humanin therapy attenuates myocardial ischemia and reperfusion injury in miceRadhika H Muzumdar
Department of Pediatrics, Children s Hospital at Montefiore, Diabetes Research and Training Center, Bronx, NY, USA 10461
Arterioscler Thromb Vasc Biol 30:1940-8. 2010..We evaluated the effects of a potent analog of HN (HNG) in an in vivo murine model of myocardial ischemia and reperfusion... - Unique lipoprotein phenotype and genotype associated with exceptional longevityNir Barzilai
Institute for Aging Research, Diabetes Research and Training Center, Albert Einstein College of Medicine, New York, NY 10461, USA
JAMA 290:2030-40. 2003..Individuals with exceptional longevity have a lower incidence and/or significant delay in the onset of age-related disease, and their family members may inherit biological factors that modulate aging processes and disease susceptibility... - Positive attitude towards life and emotional expression as personality phenotypes for centenariansKaori Kato
Ferkauf Graduate School of Psychology, Yeshiva University, Bronx, NY 10461, USA
Aging (Albany NY) 4:359-67. 2012.... - Tissue-specific dysregulation of DNA methylation in agingReid F Thompson
Departments of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA
Aging Cell 9:506-18. 2010..We conclude that different patterns of epigenetic dysregulation occur in each tissue over time and may cause some of the physiological changes associated with normal aging... - Functionally significant insulin-like growth factor I receptor mutations in centenariansYousin Suh
Departments of Medicine and Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Proc Natl Acad Sci U S A 105:3438-42. 2008..Thus, genetic alterations in the human IGF1R that result in altered IGF signaling pathway confer an increase in susceptibility to human longevity, suggesting a role of this pathway in modulation of human lifespan... - Clinical phenotype of families with longevityGil Atzmon
Institute for Aging Research, Diabetes Research and Training Center, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Am Geriatr Soc 52:274-7. 2004..The authors suggest that a cohort of these subjects and their spouses is ideal to study the phenotype and genotype of longevity and its interaction with the environment... - Resistance to leptin action is the major determinant of hepatic triglyceride accumulation in vivoSigal Fishman
Institute for Aging Research, Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
FASEB J 21:53-60. 2007..By dissociating action of leptin from that of insulin, we suggest that the failure of leptin action is the major physiological mechanism for hepatic steatosis... - Comprehensive microRNA profiling in B-cells of human centenarians by massively parallel sequencingSaurabh Gombar
Department of Systems and Computational Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
BMC Genomics 13:353. 2012..Despite their demonstrated roles in age-associated pathologies, little is known about the role of miRNAs in human aging and longevity... - Gene size mattersAlexandra Mirina
Department of Systems and Computational Biology, Albert Einstein College of Medicine, Bronx, New York, United States of America
PLoS ONE 7:e49093. 2012..We investigate several methods of obtaining gene level statistical significance in GWAS, and compare their effectiveness in correcting such bias. We also propose a simple algorithm based on first order statistic that corrects such bias... - Abdominal obesity, independent from caloric intake, accounts for the development of intestinal tumors in Apc(1638N/+) female miceDerek M Huffman
Department of Medicine, Division of Endocrinology, Institute for Aging Research, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Golding Building Room 502, Bronx, NY 10461, USA
Cancer Prev Res (Phila) 6:177-87. 2013..Furthermore, these data emphasize that strategies designed to deplete visceral fat stores in humans should be considered in the prevention of intestinal cancer. Cancer Prev Res; 6(3); 177-87. ©2012 AACR... - Epigenetic genome-wide association methylation in aging and longevityDanny Ben-Avraham
Department of Medicine, 1300 Morris Park Ave, Golding 502b, Bronx, NY 10461, USA
Epigenomics 4:503-9. 2012..This article systematically highlights the advances made in the field of epigenomics and their contribution to the understanding of the complex physiology of aging, lifespan and age-associated diseases... - Genetic studies reveal the role of the endocrine and metabolic systems in agingNir Barzilai
Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Clin Endocrinol Metab 95:4493-500. 2010..We will demonstrate that genetic factors that are associated with human longevity are heritable and may contribute not only to quantitative longevity but also to protection from age-dependent disease and exceptional good health... - Differential responses of visceral and subcutaneous fat depots to nutrientsFrancine H Einstein
Department of Obstetrics and Gynecology and Women's Health, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
Diabetes 54:672-8. 2005..Because a biologic sensing pathway can dynamically couple daily food intake to abnormal plasma levels of important FDPs, we challenge the practice of obtaining plasma levels after fasting to assess risk factors for metabolic syndrome... - The paradox of the insulin/IGF-1 signaling pathway in longevityMarielisa Rincon
Department of Medicine, Institute for Aging Research, Diabetes Research and Training Center, Albert Einstein College of Medicine, Belfer Bld 701, 1300 Morris Park Avenue, Bronx, NY 10461, USA
Mech Ageing Dev 125:397-403. 2004..In this review we focus on the downstream cascade of events in the insulin and IGF-1 signaling to identify specific pathways that are relevant to human longevity... - Plasma HDL levels highly correlate with cognitive function in exceptional longevityGil Atzmon
Institute for Aging Research, Diabetes Research and Training Center, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Gerontol A Biol Sci Med Sci 57:M712-5. 2002..This underscores the protective effects of increased plasma HDL and its role in maintaining superior cognition in longevity...