Gil Atzmon

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. ncbi request reprint Adiponectin levels and genotype: a potential regulator of life span in humans
    Gil Atzmon
    Institute for Aging Research, Diabetes Research and Training Center, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, NY 10461, USA
    J Gerontol A Biol Sci Med Sci 63:447-53. 2008
  2. pmc Evolution in health and medicine Sackler colloquium: Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians
    Gil Atzmon
    Department of Medicine and Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 107:1710-7. 2010
  3. pmc Enhanced activation of a "nutrient-sensing" pathway with age contributes to insulin resistance
    Francine H Einstein
    Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461, USA
    FASEB J 22:3450-7. 2008
  4. pmc Aging per se increases the susceptibility to free fatty acid-induced insulin resistance
    Francine H Einstein
    Department of Obstetrics and Gynecology and Women s Health at Montefiore Medical Center, Bronx, New York, USA
    J Gerontol A Biol Sci Med Sci 65:800-8. 2010
  5. pmc Distinguishing between longevity and buffered-deleterious genotypes for exceptional human longevity: the case of the MTP gene
    Derek M Huffman
    Department of Medicine, The Albert Einstein College of Medicine of Yeshiva University, New York, NY, USA
    J Gerontol A Biol Sci Med Sci 67:1153-60. 2012
  6. pmc Humanin: a novel central regulator of peripheral insulin action
    Radhika H Muzumdar
    Department of Pediatrics, Children s Hospital at Montefiore, Institute for Aging Research, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, NY, USA
    PLoS ONE 4:e6334. 2009
  7. ncbi request reprint Accretion of visceral fat and hepatic insulin resistance in pregnant rats
    Francine H Einstein
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology and Women s Health, The Albert Einstein College of Medicine Montefiore Medical Center, 1825 Eastchester Road, Bronx, NY 10461, USA
    Am J Physiol Endocrinol Metab 294:E451-5. 2008
  8. pmc Genetic predisposition to elevated serum thyrotropin is associated with exceptional longevity
    Gil Atzmon
    Division of Endocrinology, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Clin Endocrinol Metab 94:4768-75. 2009
  9. pmc North African Jewish and non-Jewish populations form distinctive, orthogonal clusters
    Christopher L Campbell
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 109:13865-70. 2012
  10. pmc Exceptional longevity is associated with decreased reproduction
    Vafa Tabatabaie
    Institute for Aging Research, Division of Endocrinology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Aging (Albany NY) 3:1202-5. 2011

Detail Information

Publications35

  1. ncbi request reprint Adiponectin levels and genotype: a potential regulator of life span in humans
    Gil Atzmon
    Institute for Aging Research, Diabetes Research and Training Center, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, NY 10461, USA
    J Gerontol A Biol Sci Med Sci 63:447-53. 2008
    ....
  2. pmc Evolution in health and medicine Sackler colloquium: Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians
    Gil Atzmon
    Department of Medicine and Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 107:1710-7. 2010
    ..Thus, variations in human telomerase gene that are associated with better maintenance of telomere length may confer healthy aging and exceptional longevity in humans...
  3. pmc Enhanced activation of a "nutrient-sensing" pathway with age contributes to insulin resistance
    Francine H Einstein
    Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461, USA
    FASEB J 22:3450-7. 2008
    ..These results suggest that altered nutrient sensing by HBP with age may be the link among nutrients, insulin resistance, and age-related diabetes...
  4. pmc Aging per se increases the susceptibility to free fatty acid-induced insulin resistance
    Francine H Einstein
    Department of Obstetrics and Gynecology and Women s Health at Montefiore Medical Center, Bronx, New York, USA
    J Gerontol A Biol Sci Med Sci 65:800-8. 2010
    ..Thus, aging per se increases the inflammatory response to excess nutrients and vulnerability to FFA-induced insulin resistance with aging...
  5. pmc Distinguishing between longevity and buffered-deleterious genotypes for exceptional human longevity: the case of the MTP gene
    Derek M Huffman
    Department of Medicine, The Albert Einstein College of Medicine of Yeshiva University, New York, NY, USA
    J Gerontol A Biol Sci Med Sci 67:1153-60. 2012
    ..05). Thus, we conclude that MTP CC is a buffered-deleterious genotype and that assessing genotype frequency across aging is essential for discerning longevity from buffered-deleterious genotypes...
  6. pmc Humanin: a novel central regulator of peripheral insulin action
    Radhika H Muzumdar
    Department of Pediatrics, Children s Hospital at Montefiore, Institute for Aging Research, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, NY, USA
    PLoS ONE 4:e6334. 2009
    ..A novel mitochondria-associated peptide, Humanin (HN), has a neuroprotective role against AD-related neurotoxicity. Considering the association between insulin resistance and AD, we investigated if HN influences insulin sensitivity...
  7. ncbi request reprint Accretion of visceral fat and hepatic insulin resistance in pregnant rats
    Francine H Einstein
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology and Women s Health, The Albert Einstein College of Medicine Montefiore Medical Center, 1825 Eastchester Road, Bronx, NY 10461, USA
    Am J Physiol Endocrinol Metab 294:E451-5. 2008
    ..05). Accretion of visceral fat is an important component in the development of hepatic IR in pregnancy, and accumulation of hepatic triglycerides is a mechanism by which visceral fat may modulate insulin action in pregnancy...
  8. pmc Genetic predisposition to elevated serum thyrotropin is associated with exceptional longevity
    Gil Atzmon
    Division of Endocrinology, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Clin Endocrinol Metab 94:4768-75. 2009
    ..Exceptional longevity is associated with raised serum TSH...
  9. pmc North African Jewish and non-Jewish populations form distinctive, orthogonal clusters
    Christopher L Campbell
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 109:13865-70. 2012
    ....
  10. pmc Exceptional longevity is associated with decreased reproduction
    Vafa Tabatabaie
    Institute for Aging Research, Division of Endocrinology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Aging (Albany NY) 3:1202-5. 2011
    ..The lower number of children in both genders together with the pattern of delayed reproductive maturity is suggestive of constitutional factors that might enhance human life span at the expense of reduced reproductive ability...
  11. ncbi request reprint Biological evidence for inheritance of exceptional longevity
    Gil Atzmon
    Department of Medicine, Institute for Aging Research, Diabetes Research and Training Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Mech Ageing Dev 126:341-5. 2005
    ..Hopefully, this line of research will lead us to establish which genotype is necessary (although not necessary sufficient) for a prolonged disease-free aging...
  12. pmc Discovery of novel non-synonymous SNP variants in 988 candidate genes from 6 centenarians by target capture and next-generation sequencing
    Jeehae Han
    Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Mech Ageing Dev 134:478-85. 2013
    ..Our study presents the potential of targeted next-generation sequencing for discovery of rare but functional genetic variation which may lead to exceptional longevity in humans...
  13. pmc Personality, self-rated health, and cognition in centenarians: do personality and self-rated health relate to cognitive function in advanced age?
    Kaori Kato
    Ferkauf Graduate School of Psychology, Bronx, NY 10461, USA
    Aging (Albany NY) 5:183-91. 2013
    ..Future studies will further elucidate the impact of personality and self-rated health on cognitive outcomes in the oldest old...
  14. ncbi request reprint Epigenetic genome-wide association methylation in aging and longevity
    Danny Ben-Avraham
    Department of Medicine, 1300 Morris Park Ave, Golding 502b, Bronx, NY 10461, USA
    Epigenomics 4:503-9. 2012
    ..This article systematically highlights the advances made in the field of epigenomics and their contribution to the understanding of the complex physiology of aging, lifespan and age-associated diseases...
  15. ncbi request reprint Lifestyle factors of people with exceptional longevity
    Swapnil N Rajpathak
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA
    J Am Geriatr Soc 59:1509-12. 2011
    ..To assess lifestyle factors including physical activity, smoking, alcohol consumption, and dietary habits in men and women with exceptional longevity...
  16. pmc Visceral adipose tissue modulates mammalian longevity
    Radhika Muzumdar
    Institute for Aging Research, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA
    Aging Cell 7:438-40. 2008
    ..13). Taken together, these observations provide the most direct evidence to date that a reduction in fat mass, specifically VF, may be one of the possible underlying mechanisms of the anti-aging effect of CR...
  17. pmc Lipoprotein genotype and conserved pathway for exceptional longevity in humans
    Gil Atzmon
    Institute for Aging Research, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS Biol 4:e113. 2006
    ..Because modulation of lipoproteins is also seen in genetically altered longevity models, it may be a common pathway influencing lifespan from nematodes to humans...
  18. pmc Comprehensive microRNA profiling in B-cells of human centenarians by massively parallel sequencing
    Saurabh Gombar
    Department of Systems and Computational Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    BMC Genomics 13:353. 2012
    ..Despite their demonstrated roles in age-associated pathologies, little is known about the role of miRNAs in human aging and longevity...
  19. pmc Cholesteryl ester transfer protein (CETP) genotype and reduced CETP levels associated with decreased prevalence of hypertension
    Clyde B Schechter
    Department of Family and Social Medicine, Albert Einstein College of Medicine, Bronx, NY, 10461, USA
    Mayo Clin Proc 85:522-6. 2010
    ....
  20. pmc Abraham's children in the genome era: major Jewish diaspora populations comprise distinct genetic clusters with shared Middle Eastern Ancestry
    Gil Atzmon
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Am J Hum Genet 86:850-9. 2010
    ..Thus, this study demonstrates that European/Syrian and Middle Eastern Jews represent a series of geographical isolates or clusters woven together by shared IBD genetic threads...
  21. pmc Extreme longevity is associated with increased serum thyrotropin
    Gil Atzmon
    Department of MedicineDivision of Endocrinology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Clin Endocrinol Metab 94:1251-4. 2009
    ..The distribution of serum TSH shifts progressively to higher concentrations with age...
  22. ncbi request reprint Unique lipoprotein phenotype and genotype associated with exceptional longevity
    Nir Barzilai
    Institute for Aging Research, Diabetes Research and Training Center, Albert Einstein College of Medicine, New York, NY 10461, USA
    JAMA 290:2030-40. 2003
    ..Individuals with exceptional longevity have a lower incidence and/or significant delay in the onset of age-related disease, and their family members may inherit biological factors that modulate aging processes and disease susceptibility...
  23. pmc Acute humanin therapy attenuates myocardial ischemia and reperfusion injury in mice
    Radhika H Muzumdar
    Department of Pediatrics, Children s Hospital at Montefiore, Diabetes Research and Training Center, Bronx, NY, USA 10461
    Arterioscler Thromb Vasc Biol 30:1940-8. 2010
    ..We evaluated the effects of a potent analog of HN (HNG) in an in vivo murine model of myocardial ischemia and reperfusion...
  24. pmc Positive attitude towards life and emotional expression as personality phenotypes for centenarians
    Kaori Kato
    Ferkauf Graduate School of Psychology, Yeshiva University, Bronx, NY 10461, USA
    Aging (Albany NY) 4:359-67. 2012
    ....
  25. pmc Functionally significant insulin-like growth factor I receptor mutations in centenarians
    Yousin Suh
    Departments of Medicine and Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 105:3438-42. 2008
    ..Thus, genetic alterations in the human IGF1R that result in altered IGF signaling pathway confer an increase in susceptibility to human longevity, suggesting a role of this pathway in modulation of human lifespan...
  26. pmc Tissue-specific dysregulation of DNA methylation in aging
    Reid F Thompson
    Departments of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA
    Aging Cell 9:506-18. 2010
    ..We conclude that different patterns of epigenetic dysregulation occur in each tissue over time and may cause some of the physiological changes associated with normal aging...
  27. ncbi request reprint Clinical phenotype of families with longevity
    Gil Atzmon
    Institute for Aging Research, Diabetes Research and Training Center, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Am Geriatr Soc 52:274-7. 2004
    ..To determine whether offspring of centenarians acquired protection from age-related diseases...
  28. pmc Individuals with exceptional longevity manifest a delayed association between vitamin d insufficiency and cognitive impairment
    Sofiya Milman
    Division of Endocrinology, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York Institute for Aging Research, Albert Einstein College of Medicine, Bronx, New York
    J Am Geriatr Soc 62:153-8. 2014
    ..To define vitamin D levels and their association with cognition in subjects with exceptional longevity...
  29. ncbi request reprint Resistance to leptin action is the major determinant of hepatic triglyceride accumulation in vivo
    Sigal Fishman
    Institute for Aging Research, Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    FASEB J 21:53-60. 2007
    ..By dissociating action of leptin from that of insulin, we suggest that the failure of leptin action is the major physiological mechanism for hepatic steatosis...
  30. pmc Gene size matters
    Alexandra Mirina
    Department of Systems and Computational Biology, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 7:e49093. 2012
    ..We investigate several methods of obtaining gene level statistical significance in GWAS, and compare their effectiveness in correcting such bias. We also propose a simple algorithm based on first order statistic that corrects such bias...
  31. pmc Abdominal obesity, independent from caloric intake, accounts for the development of intestinal tumors in Apc(1638N/+) female mice
    Derek M Huffman
    Department of Medicine, Division of Endocrinology, Institute for Aging Research, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Golding Building Room 502, Bronx, NY 10461, USA
    Cancer Prev Res (Phila) 6:177-87. 2013
    ..Furthermore, these data emphasize that strategies designed to deplete visceral fat stores in humans should be considered in the prevention of intestinal cancer. Cancer Prev Res; 6(3); 177-87. ©2012 AACR...
  32. pmc Genetic studies reveal the role of the endocrine and metabolic systems in aging
    Nir Barzilai
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Clin Endocrinol Metab 95:4493-500. 2010
    ..We will demonstrate that genetic factors that are associated with human longevity are heritable and may contribute not only to quantitative longevity but also to protection from age-dependent disease and exceptional good health...
  33. ncbi request reprint Differential responses of visceral and subcutaneous fat depots to nutrients
    Francine H Einstein
    Department of Obstetrics and Gynecology and Women s Health, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Diabetes 54:672-8. 2005
    ..Because a biologic sensing pathway can dynamically couple daily food intake to abnormal plasma levels of important FDPs, we challenge the practice of obtaining plasma levels after fasting to assess risk factors for metabolic syndrome...
  34. ncbi request reprint The paradox of the insulin/IGF-1 signaling pathway in longevity
    Marielisa Rincon
    Department of Medicine, Institute for Aging Research, Diabetes Research and Training Center, Albert Einstein College of Medicine, Belfer Bld 701, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Mech Ageing Dev 125:397-403. 2004
    ..In this review we focus on the downstream cascade of events in the insulin and IGF-1 signaling to identify specific pathways that are relevant to human longevity...
  35. ncbi request reprint Plasma HDL levels highly correlate with cognitive function in exceptional longevity
    Gil Atzmon
    Institute for Aging Research, Diabetes Research and Training Center, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Gerontol A Biol Sci Med Sci 57:M712-5. 2002
    ..Because plasma HDL level declines progressively with aging, we examined whether centenarians with higher plasma HDL levels have better cognitive function...