Genomes and Genes
A W Ashton
Affiliation: Albert Einstein College of Medicine
- Protein kinase Cdelta inhibition of S-phase transition in capillary endothelial cells involves the cyclin-dependent kinase inhibitor p27(Kip1)A W Ashton
Cardiovascular Division, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Biol Chem 274:20805-11. 1999..Transfection of full-length p27(Kip1) antisense into the PCKdeltaEC line reversed the S-phase arrest and resulted in normal cell cycle progression, suggesting a critical role for p27(Kip1) in the PKCdelta-mediated S-phase arrest...
- Thromboxane A2 receptor agonists antagonize the proangiogenic effects of fibroblast growth factor-2: role of receptor internalization, thrombospondin-1, and alpha(v)beta3Anthony W Ashton
Department of Medicine Cardiology and Molecular Pharmacology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10461, USA
Circ Res 94:735-42. 2004....
- Thromboxane A2 receptor signaling inhibits vascular endothelial growth factor-induced endothelial cell differentiation and migrationAnthony W Ashton
Department of Medicine Cardiology, Albert Einstein College of Medicine, Yeshiva University, 1300 Morris Park Ave, Bronx, NY 10461, USA
Circ Res 95:372-9. 2004..These data further support a role for antagonism of TP activation in enhancing the angiogenic response in tissues exposed to elevated TXA2 levels in which revascularization is important...
- Inhibition of endothelial cell migration, intercellular communication, and vascular tube formation by thromboxane A(2)A W Ashton
Department of Medicine Cardiology, The Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, USA
J Biol Chem 274:35562-70. 1999..Thus, this finding that TXA(2) mimetics can prevent HEC migration and tube formation, possibly by impairing intercellular communication, suggests that antagonizing TXA(2) signaling might enhance vascularization of ischemic tissue...
- Thymidine phosphorylase and 2-deoxyribose stimulate human endothelial cell migration by specific activation of the integrins alpha 5 beta 1 and alpha V beta 3Kylie A Hotchkiss
Department of Oncology, Albert Einstein College of Medicine, Bronx, New York 10467, USA
J Biol Chem 278:19272-9. 2003..These experiments are the first to demonstrate a direct effect of thymidine phosphorylase and 2-deoxyribose on signaling pathways associated with endothelial cell migration...
- Regulation of connexin43 protein complexes by intracellular acidificationHeather S Duffy
Department of Neuroscience, Albert Einstein College of Medicine, 1410 Pelham Pkwy S, Bronx, NY 10464, USA
Circ Res 94:215-22. 2004..These data suggest that protracted acidification may remodel protein-protein interactions involving Cx43 and thus provide an important protective mechanism to limit lesion spread after ischemic injury...
- Caveolin-1 knockout mice show an impaired angiogenic response to exogenous stimuliScott E Woodman
Department of Molecular Pharmacology, Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Am J Pathol 162:2059-68. 2003..These results provide novel evidence that Cav-1 and caveolae play an important positive role in the process of pathological angiogenesis in vivo...
- Endothelial cell activation in patients with decompensated heart failurePaolo C Colombo
Department of Medicine, Division of Cardiology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Circulation 111:58-62. 2005..The present study tested whether endothelial cell activation occurs in veins of patients with decompensated CHF and whether activation, if present, subsides with return to a clinically compensated state...
- Biopsy coupled to quantitative immunofluorescence: a new method to study the human vascular endotheliumPaolo C Colombo
Department of Medicine, Division of Cardiology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Appl Physiol (1985) 92:1331-8. 2002..In summary, vascular endothelial biopsy coupled with measurement of protein expression by quantitative immunofluorescence analysis provides a novel approach to the study of the vascular endothelium in humans...
- Inhibition of tumor necrosis factor alpha-mediated NFkappaB activation and leukocyte adhesion, with enhanced endothelial apoptosis, by G protein-linked receptor (TP) ligandsAnthony W Ashton
Department of Medicine, Albert Einstein College of Medicine, Yeshiva University, Bronx, New York 10461, USA
J Biol Chem 278:11858-66. 2003..By stimulating the vessel wall and inducing endothelial cell apoptosis, TXA(2), in combination with TNFalpha, may hamper the angiogenic response during inflammation or ischemia, thus reducing revascularization and tissue viability...
- Inhibition of endothelial cell function in vitro and angiogenesis in vivo by docetaxel (Taxotere): association with impaired repositioning of the microtubule organizing centerKylie A Hotchkiss
Department of Oncology, Albert Einstein College of Medicine, Bronx, New York 10467, USA
Mol Cancer Ther 1:1191-200. 2002..In conclusion, Taxotere is a potent and potentially specific inhibitor of endothelial cell migration in vitro and angiogenesis in vitro and in vivo...
- Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactionsYoung Jae Nam
Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
Mol Cell 15:901-12. 2004..Conversely, physiological levels of ARC suppress these events. These studies establish a critical role for nonhomotypic death-fold interactions in the regulation of apoptosis...
- Thromboxane A2 is a key regulator of pathogenesis during Trypanosoma cruzi infectionAnthony W Ashton
Department of Medicine, Divisions of Cardiology and Infectious Disease, Albert Einstein College of Medicine, Bronx, NY 10461, USA
J Exp Med 204:929-40. 2007..cruzi infection is possibly an important determinant of mortality and parasitism. A deeper understanding of the role of TXA(2) may result in novel therapeutic targets for a disease with limited treatment options...
- Regulation of p53 tetramerization and nuclear export by ARCRoger S Y Foo
Departments of Medicine and Cell Biology, Cardiovascular Research Center, and Cancer Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Proc Natl Acad Sci U S A 104:20826-31. 2007..In primary human breast cancers with nuclear ARC, p53 is almost always WT. Conversely, nearly all breast cancers with mutant p53 lack nuclear ARC. We conclude that nuclear ARC is induced in cancer cells and negatively regulates p53...
- Mechanisms of hepatocyte growth factor-mediated vascular smooth muscle cell migrationHarry Ma
Department of Pathology, Albert Einstein College of Medicine, Forchheimer 727, 1300 Morris Park Ave, Bronx, NY 10461, USA
Circ Res 93:1066-73. 2003..Neither SB203580 nor LY294002 inhibited HGF-induced ERK1/2 activation. Thus, ERK1/2 signaling may play an important role in HGF-mediated SMC migration by contributing to focal adhesion redistribution and FAK and Pyk2 activation...
- Mechanisms by which tumor cells and monocytes expressing the angiogenic factor thymidine phosphorylase mediate human endothelial cell migrationKylie A Hotchkiss
Departments of Oncology, Albert Einstein College of Medicine, Bronx, New York 10467, USA
Cancer Res 63:527-33. 2003..These studies demonstrate that TP-expressing cells mediate EC migration via the intracellular metabolism of thymidine and subsequent extracellular release of 2dR, which forms a chemotactic gradient...
- Anthrax lethal toxin kills macrophages in a strain-specific manner by apoptosis or caspase-1-mediated necrosisStefan M Muehlbauer
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Cell Cycle 6:758-66. 2007..We propose that caspase-1-mediated macrophage necrosis is the source of the cytokine storm and rapid disease progression reported in LT-treated BALB/c mice...
- Hydroxychloroquine protects the annexin A5 anticoagulant shield from disruption by antiphospholipid antibodies: evidence for a novel effect for an old antimalarial drugJacob H Rand
Department of Pathology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10467, USA
Blood 115:2292-9. 2010..These results support the concept of novel therapeutic approaches that address specific APS disease mechanisms...
- Fibroblast growth factor-2 induces Lef/Tcf-dependent transcription in human endothelial cellsWolfgang Holnthoner
Department of Dermatology, Division of General Dermatology, University of Vienna Medical School, Waehringer Guertel 18 20, A 1090 Vienna, Austria
J Biol Chem 277:45847-53. 2002..In conclusion, FGF-2 is a novel modulator of Lef/Tcf-beta-catenin signaling in endothelial cells, suggesting that angiogenic properties of FGF-2 are at least in part mediated by Lef/Tcf-beta-catenin activation...
- Taking the BAD out of adrenergic stimulationKartik Mani
J Mol Cell Cardiol 34:709-12. 2002
- Novel role of thromboxane receptors beta isoform in bladder cancer pathogenesisOmar Moussa
Department of Pathology and Laboratory Medicine, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Cancer Res 68:4097-104. 2008..These results support the model that the TP-beta receptor isoform plays a unique role in bladder cancer progression and its expression may have predictive value and provide a novel therapeutic target...