A W Ashton


Affiliation: Albert Einstein College of Medicine
Country: USA


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    Ashton A, Yokota R, John G, Zhao S, Suadicani S, Spray D, et al. Inhibition of endothelial cell migration, intercellular communication, and vascular tube formation by thromboxane A(2). J Biol Chem. 1999;274:35562-70 pubmed
    ..Thus, this finding that TXA(2) mimetics can prevent HEC migration and tube formation, possibly by impairing intercellular communication, suggests that antagonizing TXA(2) signaling might enhance vascularization of ischemic tissue. ..
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    Ashton A, Cheng Y, Helisch A, Ware J. Thromboxane A2 receptor agonists antagonize the proangiogenic effects of fibroblast growth factor-2: role of receptor internalization, thrombospondin-1, and alpha(v)beta3. Circ Res. 2004;94:735-42 pubmed
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    Ashton A, Ware J. Thromboxane A2 receptor signaling inhibits vascular endothelial growth factor-induced endothelial cell differentiation and migration. Circ Res. 2004;95:372-9 pubmed
    ..These data further support a role for antagonism of TP activation in enhancing the angiogenic response in tissues exposed to elevated TXA2 levels in which revascularization is important. ..