Yong Xiao Wang

Summary

Affiliation: Albany Medical College
Country: USA

Publications

  1. ncbi request reprint Role of FKBP12.6 in hypoxia- and norepinephrine-induced Ca2+ release and contraction in pulmonary artery myocytes
    Yun Min Zheng
    Center for Cardiovascular Sciences MC 8, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    Cell Calcium 35:345-55. 2004
  2. pmc Type-3 ryanodine receptors mediate hypoxia-, but not neurotransmitter-induced calcium release and contraction in pulmonary artery smooth muscle cells
    Yun Min Zheng
    Center for Cardiovascular Sciences, Neuroscience, and Neuropharmacology, Albany Medical College, NY 12208, USA
    J Gen Physiol 125:427-40. 2005
  3. pmc The international effort: building the bridge for Translational Medicine: Report of the 1st International Conference of Translational Medicine (ICTM)
    Xiaoming Chen
    Infectious Disease and Immunogenetics Section IDIS, Department of Transfusion Medicine, Clinical Center and Center for Human Immunology CHI, NIH, Bethesda MD, USA
    Clin Transl Med 1:15. 2012
  4. pmc Important role of PLC-γ1 in hypoxic increase in intracellular calcium in pulmonary arterial smooth muscle cells
    Vishal R Yadav
    Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 12208, USA
    Am J Physiol Lung Cell Mol Physiol 304:L143-51. 2013
  5. pmc Molecular expression and functional role of canonical transient receptor potential channels in airway smooth muscle cells
    Yong Xiao Wang
    Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 12208, USA
    Adv Exp Med Biol 704:731-47. 2011
  6. pmc Role of ROS signaling in differential hypoxic Ca2+ and contractile responses in pulmonary and systemic vascular smooth muscle cells
    Yong Xiao Wang
    Center for Cardiovascular Sciences, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    Respir Physiol Neurobiol 174:192-200. 2010
  7. pmc ROS-dependent signaling mechanisms for hypoxic Ca(2+) responses in pulmonary artery myocytes
    Yong Xiao Wang
    Center for Cardiovascular Sciences, Albany Medical College, New York 12208, USA
    Antioxid Redox Signal 12:611-23. 2010
  8. ncbi request reprint Two distinct signaling pathways for regulation of spontaneous local Ca2+ release by phospholipase C in airway smooth muscle cells
    Qing Hua Liu
    Center for Cardiovascular Sciences, Albany Medical College MC 8, 47 New Scotland Avenue, Albany, NY 12208, USA
    Pflugers Arch 453:531-41. 2007
  9. ncbi request reprint Metabolic inhibition with cyanide induces calcium release in pulmonary artery myocytes and Xenopus oocytes
    Yong Xiao Wang
    Center for Cardiovascular Sciences, Albany Medical College, Albany 12208, USA
    Am J Physiol Cell Physiol 284:C378-88. 2003
  10. ncbi request reprint FKBP12.6 and cADPR regulation of Ca2+ release in smooth muscle cells
    Yong Xiao Wang
    Center for Cardiovascular Sciences, Albany Medical College, Albany, New York 12208, USA
    Am J Physiol Cell Physiol 286:C538-46. 2004

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Role of FKBP12.6 in hypoxia- and norepinephrine-induced Ca2+ release and contraction in pulmonary artery myocytes
    Yun Min Zheng
    Center for Cardiovascular Sciences MC 8, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    Cell Calcium 35:345-55. 2004
    ..6 null mice. These findings suggest that FKBP12.6 plays an important role in hypoxia- and neurotransmitter-induced Ca(2+) and contractile responses by regulating the activity of RyRs in PASMCs...
  2. pmc Type-3 ryanodine receptors mediate hypoxia-, but not neurotransmitter-induced calcium release and contraction in pulmonary artery smooth muscle cells
    Yun Min Zheng
    Center for Cardiovascular Sciences, Neuroscience, and Neuropharmacology, Albany Medical College, NY 12208, USA
    J Gen Physiol 125:427-40. 2005
    ....
  3. pmc The international effort: building the bridge for Translational Medicine: Report of the 1st International Conference of Translational Medicine (ICTM)
    Xiaoming Chen
    Infectious Disease and Immunogenetics Section IDIS, Department of Transfusion Medicine, Clinical Center and Center for Human Immunology CHI, NIH, Bethesda MD, USA
    Clin Transl Med 1:15. 2012
    ..abstract:..
  4. pmc Important role of PLC-γ1 in hypoxic increase in intracellular calcium in pulmonary arterial smooth muscle cells
    Vishal R Yadav
    Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 12208, USA
    Am J Physiol Lung Cell Mol Physiol 304:L143-51. 2013
    ....
  5. pmc Molecular expression and functional role of canonical transient receptor potential channels in airway smooth muscle cells
    Yong Xiao Wang
    Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 12208, USA
    Adv Exp Med Biol 704:731-47. 2011
    ..However, continual studies are necessary to further determine whether, which, and how TRPC-encoded channels are involved in cellular responses in normal and diseased (e.g., asthmatic) airway SMCs...
  6. pmc Role of ROS signaling in differential hypoxic Ca2+ and contractile responses in pulmonary and systemic vascular smooth muscle cells
    Yong Xiao Wang
    Center for Cardiovascular Sciences, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    Respir Physiol Neurobiol 174:192-200. 2010
    ..All these findings have greatly improved our understanding of the molecular processes for the differential hypoxic Ca2+ and contractile responses in vascular SMCs from distinct pulmonary and systemic circulation systems...
  7. pmc ROS-dependent signaling mechanisms for hypoxic Ca(2+) responses in pulmonary artery myocytes
    Yong Xiao Wang
    Center for Cardiovascular Sciences, Albany Medical College, New York 12208, USA
    Antioxid Redox Signal 12:611-23. 2010
    ..In concert with ROS, PKCepsilon may also affect K(V) channels, SOC channels, and RyRs, contributing to hypoxic Ca(2+) and contractile responses in PASMCs...
  8. ncbi request reprint Two distinct signaling pathways for regulation of spontaneous local Ca2+ release by phospholipase C in airway smooth muscle cells
    Qing Hua Liu
    Center for Cardiovascular Sciences, Albany Medical College MC 8, 47 New Scotland Avenue, Albany, NY 12208, USA
    Pflugers Arch 453:531-41. 2007
    ....
  9. ncbi request reprint Metabolic inhibition with cyanide induces calcium release in pulmonary artery myocytes and Xenopus oocytes
    Yong Xiao Wang
    Center for Cardiovascular Sciences, Albany Medical College, Albany 12208, USA
    Am J Physiol Cell Physiol 284:C378-88. 2003
    ..We conclude that metabolic inhibition with CN increases [Ca(2+)](i) in both pulmonary and systemic artery myocytes by stimulating Ca(2+) release from the SR and mitochondria...
  10. ncbi request reprint FKBP12.6 and cADPR regulation of Ca2+ release in smooth muscle cells
    Yong Xiao Wang
    Center for Cardiovascular Sciences, Albany Medical College, Albany, New York 12208, USA
    Am J Physiol Cell Physiol 286:C538-46. 2004
    ..Taken together, these findings point to an important role of the FKBP12.6/RyR2 complex in stochastic (spontaneous) and receptor-mediated Ca2+ release in smooth muscle...
  11. pmc Genetic evidence for functional role of ryanodine receptor 1 in pulmonary artery smooth muscle cells
    Xiao Qiang Li
    Center for Cardiovascular Sciences MC 8, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    Pflugers Arch 457:771-83. 2009
    ....
  12. pmc Heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells
    Yun Min Zheng
    Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 12158, USA
    J Vasc Res 45:469-79. 2008
    ..In this study, we aimed to investigate whether the gene expression and functional activity of ryanodine receptors (RyRs) would be different in these 3 cell types...
  13. pmc Mitochondrial ROS-PKCepsilon signaling axis is uniquely involved in hypoxic increase in [Ca2+]i in pulmonary artery smooth muscle cells
    Rakesh Rathore
    Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 12208, USA
    Biochem Biophys Res Commun 351:784-90. 2006
    ..These data suggest that acute hypoxia may specifically increase mitochondrial ROS generation, which subsequently activates PKC, particularly PKCepsilon, contributing to hypoxia-induced increase in [Ca(2+)](i) and contraction in PASMCs...
  14. pmc Protein kinase C-epsilon regulates local calcium signaling in airway smooth muscle cells
    Qing Hua Liu
    Center for Cardiovascular Sciences, Albany Medical College, Albany, New York 12208, USA
    Am J Respir Cell Mol Biol 40:663-71. 2009
    ..Taken together, these results indicate that PKCepsilon regulates Ca(2+) sparks by specifically interacting with RyR1, which plays an important role in the control of contractile responses in airway SMCs...
  15. pmc Membrane depolarization causes a direct activation of G protein-coupled receptors leading to local Ca2+ release in smooth muscle
    Qing Hua Liu
    Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 12208, USA
    Proc Natl Acad Sci U S A 106:11418-23. 2009
    ..These findings demonstrate an important mechanism for Ca(2+) signaling and attendant physiological function in SMCs...
  16. pmc Hypoxia induces intracellular Ca2+ release by causing reactive oxygen species-mediated dissociation of FK506-binding protein 12.6 from ryanodine receptor 2 in pulmonary artery myocytes
    Bo Liao
    Center for Cardiovascular Sciences, Albany Medical College, Albany, New York, USA
    Antioxid Redox Signal 14:37-47. 2011
    ..6 removal enhanced, whereas RyR2 gene deletion blocked the hypoxic increase in [Ca(2+)](i) in PASMCs. Collectively, we conclude that hypoxia may induce Ca(2+) release by causing ROS-mediated dissociation of FKBP12.6 from RyR2 in PASMCs...
  17. pmc Hypoxia activates NADPH oxidase to increase [ROS]i and [Ca2+]i through the mitochondrial ROS-PKCepsilon signaling axis in pulmonary artery smooth muscle cells
    Rakesh Rathore
    Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 12208, USA
    Free Radic Biol Med 45:1223-31. 2008
    ....
  18. pmc Role of mitochondrial reactive oxygen species in hypoxia-dependent increase in intracellular calcium in pulmonary artery myocytes
    Qing Song Wang
    Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 12208, USA
    Free Radic Biol Med 42:642-53. 2007
    ....
  19. ncbi request reprint Functional and molecular evidence for impairment of calcium-activated potassium channels in type-1 diabetic cerebral artery smooth muscle cells
    Ling Dong
    Center for Cardiovascular Sciences, Albany Medical College, Albany, New York 12208, USA
    J Cereb Blood Flow Metab 28:377-86. 2008
    ..In conclusion, the BK channel beta1-subunit is impaired in type-1 diabetic vascular SMCs, resulting in increased vasoconstriction and elevated blood pressure, thereby contributing to vascular diseases in type-1 diabetes...
  20. pmc Primary role of mitochondrial Rieske iron-sulfur protein in hypoxic ROS production in pulmonary artery myocytes
    Amit S Korde
    Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 12208, USA
    Free Radic Biol Med 50:945-52. 2011
    ....
  21. pmc Functional role of canonical transient receptor potential 1 and canonical transient receptor potential 3 in normal and asthmatic airway smooth muscle cells
    Jun Hua Xiao
    Albany Medical College, Center for Cardiovascular Science, 47 New Scotland Avenue, Albany, NY 12208, USA
    Am J Respir Cell Mol Biol 43:17-25. 2010
    ....
  22. pmc Distinct activity of BK channel β1-subunit in cerebral and pulmonary artery smooth muscle cells
    Yun Min Zheng
    Center for Cardiovascular Sciences, Albany Medical College, 47 New Scotland Ave, Albany, NY 12208, USA
    Am J Physiol Cell Physiol 304:C780-9. 2013
    ..This heterogeneity is primarily determined by the differential β(1)-subunit function and contributes to diverse cellular responses in these two distinct types of cells...
  23. ncbi request reprint Sodium-calcium exchanger in pulmonary artery smooth muscle cells
    Yun Min Zheng
    Center for Cardiovascular Sciences, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    Ann N Y Acad Sci 1099:427-35. 2007
    ..Taken together, we provide clear evidence that NCX1 is functionally and molecularly expressed and plays a physiological role in pulmonary artery SMCs...
  24. ncbi request reprint Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy
    Hong Bo Xin
    Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37235, USA
    Nature 416:334-8. 2002
    ..We conclude that FKBP12.6 modulates cardiac excitation-contraction coupling and that oestrogen plays a protective role in the hypertrophic response of the heart to Ca2+ dysregulation...
  25. ncbi request reprint Calcium release by ryanodine receptors in smooth muscle
    M L Kotlikoff
    Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853 6401, USA
    Novartis Found Symp 246:108-19; discussion 119-24, 221-7. 2002
    ..Here we summarize some of our recent findings on Ca2+-induced Ca2+ release (CICR) and stretch-induced Ca2+ release (SICR) in smooth muscle...

Research Grants18

  1. HYPOXIC CA+2 RELEASE IN PULMONARY ARTERY MYOCYTE
    Yong Xiao Wang; Fiscal Year: 2001
    ..The findings of this proposed research will extend our understanding of cellular and molecular mechanisms responsible for the development of HPV, and may lead to identify a potential novel target to treat HPV. ..
  2. Mechanisms for hypoxic Ca2+ release in pulmonary artery myocytes
    Yong Xiao Wang; Fiscal Year: 2009
    ..The findings from this proposal will enhance our understanding of cellular molecular mechanisms for hypoxic [Ca2+]i rise in PASMCs and associated HPV, and may lead to identify potential novel targets to treat pulmonary hypertension. ..
  3. Mechanisms for hypoxic Ca2+ release in pulmonary artery myocytes
    Yong Xiao Wang; Fiscal Year: 2009
    ..The findings from this proposal will enhance our understanding of cellular molecular mechanisms for hypoxic [Ca2+]i rise in PASMCs and associated HPV, and may lead to identify potential novel targets to treat pulmonary hypertension. ..
  4. Mechanisms for hypoxic Ca2+ release in pulmonary artery myocytes
    Yong Xiao Wang; Fiscal Year: 2007
    ..The findings from this proposal will enhance our understanding of cellular molecular mechanisms for hypoxic [Ca2+]i rise in PASMCs and associated HPV, and may lead to identify potential novel targets to treat pulmonary hypertension. ..
  5. Novel Signaling for Ca2+ and Release in Airway Myocytes
    Yong Xiao Wang; Fiscal Year: 2007
    ..6, and/or RyRs are ubiquitously expressed in a variety of cell types, the mechanistic findings from the proposed study will have general biological and pathological significance for various Ca2+-mediated cellular effects. ..
  6. Mechanisms for hypoxic Ca2+ release in pulmonary artery myocytes
    Yong Xiao Wang; Fiscal Year: 2006
    ..The findings from this proposal will enhance our understanding of cellular molecular mechanisms for hypoxic [Ca2+]i rise in PASMCs and associated HPV, and may lead to identify potential novel targets to treat pulmonary hypertension. ..
  7. Heterogeneity of hypoxic Ca2+ release in pulmonary and *
    Yong Xiao Wang; Fiscal Year: 2006
    ..The proposed studies are also of fundamental physiological significance with respect to the regulation of Ca2+ release in other cell types. ..
  8. Novel Signaling for Ca2+ and Release in Airway Myocytes
    Yong Xiao Wang; Fiscal Year: 2006
    ..6, and/or RyRs are ubiquitously expressed in a variety of cell types, the mechanistic findings from the proposed study will have general biological and pathological significance for various Ca2+-mediated cellular effects. ..
  9. Heterogeneity of hypoxic Ca2+ release in pulmonary and *
    Yong Xiao Wang; Fiscal Year: 2005
    ..The proposed studies are also of fundamental physiological significance with respect to the regulation of Ca2+ release in other cell types. ..
  10. Novel Signaling for Ca2+ and Release in Airway Myocytes
    Yong Xiao Wang; Fiscal Year: 2005
    ..6, and/or RyRs are ubiquitously expressed in a variety of cell types, the mechanistic findings from the proposed study will have general biological and pathological significance for various Ca2+-mediated cellular effects. ..
  11. Heterogeneity of hypoxic Ca2+ release in pulmonary and *
    Yong Xiao Wang; Fiscal Year: 2004
    ..The proposed studies are also of fundamental physiological significance with respect to the regulation of Ca2+ release in other cell types. ..
  12. Novel Signaling for Ca2+ and Release in Airway Myocytes
    Yong Xiao Wang; Fiscal Year: 2004
    ..6, and/or RyRs are ubiquitously expressed in a variety of cell types, the mechanistic findings from the proposed study will have general biological and pathological significance for various Ca2+-mediated cellular effects. ..
  13. Hypoxic Ca2+ release /pulmonary /systemic artery myocyte
    Yong Xiao Wang; Fiscal Year: 2003
    ..The proposed studies are also of fundamental physiological significance with respect to the regulation of Ca2+ release in other cell types. ..
  14. HYPOXIC CA+2 RELEASE IN PULMONARY ARTERY MYOCYTE
    Yong Xiao Wang; Fiscal Year: 2003
    ..The findings of this proposed research will extend our understanding of cellular and molecular mechanisms responsible for the development of HPV, and may lead to identify a potential novel target to treat HPV. ..
  15. Novel Signaling for Ca2+ and Release in Airway Myocytes
    Yong Xiao Wang; Fiscal Year: 2003
    ..6, and/or RyRs are ubiquitously expressed in a variety of cell types, the mechanistic findings from the proposed study will have general biological and pathological significance for various Ca2+-mediated cellular effects. ..
  16. HYPOXIC CA+2 RELEASE IN PULMONARY ARTERY MYOCYTE
    Yong Xiao Wang; Fiscal Year: 2002
    ..The findings of this proposed research will extend our understanding of cellular and molecular mechanisms responsible for the development of HPV, and may lead to identify a potential novel target to treat HPV. ..
  17. Mechanisms for hypoxic Ca2+ release in pulmonary artery myocytes
    Yong Xiao Wang; Fiscal Year: 2010
    ..The findings from this proposal will enhance our understanding of cellular molecular mechanisms for hypoxic [Ca2+]i rise in PASMCs and associated HPV, and may lead to identify potential novel targets to treat pulmonary hypertension. ..