Dale Tang

Summary

Affiliation: Albany Medical College
Country: USA

Publications

  1. ncbi Raf-1, actin dynamics, and abelson tyrosine kinase in human airway smooth muscle cells
    Ruping Wang
    Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 12208, USA
    Am J Respir Cell Mol Biol 48:172-8. 2013
  2. ncbi Abl regulates smooth muscle cell proliferation by modulating actin dynamics and ERK1/2 activation
    Li Jia
    Center for Cardiovascular Sciences, Albany Medical College, NY 12208, USA
    Am J Physiol Cell Physiol 302:C1026-34. 2012
  3. ncbi Silencing of p21-activated kinase attenuates vimentin phosphorylation on Ser-56 and reorientation of the vimentin network during stimulation of smooth muscle cells by 5-hydroxytryptamine
    Dale D Tang
    Center for Cardiovascular Sciences, Albany Medical College, 47 New Scotland Avenue, MC 8, ME 424, Albany, NY 12208, USA
    Biochem J 388:773-83. 2005
  4. ncbi Physiologic properties and regulation of the actin cytoskeleton in vascular smooth muscle
    Dale D Tang
    Center for Cardiovascular Sciences, Albany Medical College, Albany, New York 12208, USA
    J Cardiovasc Pharmacol Ther 13:130-40. 2008
  5. ncbi Intermediate filaments in smooth muscle
    Dale D Tang
    Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 12208, USA
    Am J Physiol Cell Physiol 294:C869-78. 2008
  6. ncbi p130 Crk-associated substrate (CAS) in vascular smooth muscle
    Dale D Tang
    Center for Cardiovascular Sciences, Albany Medical College, Albany, New York 12208, USA
    J Cardiovasc Pharmacol Ther 14:89-98. 2009
  7. ncbi Critical role of vimentin phosphorylation at Ser-56 by p21-activated kinase in vimentin cytoskeleton signaling
    Qing-Fen Li
    Center for Cardiovascular Sciences, Albany Medical College, Albany, New York 12208, USA
    J Biol Chem 281:34716-24. 2006
  8. ncbi Role of p47(phox) in regulating Cdc42GAP, vimentin, and contraction in smooth muscle cells
    Qing Fen Li
    The Center for Cardiovascular Sciences, Albany Medical College, NY 12208, USA
    Am J Physiol Cell Physiol 297:C1424-33. 2009
  9. ncbi Role of vimentin in smooth muscle force development
    Ruping Wang
    Center for Cardiovascular Sciences, Albany Medical College, 47 New Scotland Avenue MC 8, Albany, NY 12208, USA
    Am J Physiol Cell Physiol 291:C483-9. 2006
  10. ncbi Cdc42GAP, reactive oxygen species, and the vimentin network
    Qing Fen Li
    The Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 12208, USA
    Am J Physiol Cell Physiol 297:C299-309. 2009

Research Grants

  1. Molecular mechanisms of airway smooth muscle function
    Dale Tang; Fiscal Year: 2007

Collaborators

Detail Information

Publications25

  1. ncbi Raf-1, actin dynamics, and abelson tyrosine kinase in human airway smooth muscle cells
    Ruping Wang
    Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 12208, USA
    Am J Respir Cell Mol Biol 48:172-8. 2013
    ..The results suggest a novel mechanism that the interaction of Raf-1 with cytoskeletal actin is critical for Raf-1 redistribution and airway smooth muscle cell proliferation during activation with the growth factor...
  2. ncbi Abl regulates smooth muscle cell proliferation by modulating actin dynamics and ERK1/2 activation
    Li Jia
    Center for Cardiovascular Sciences, Albany Medical College, NY 12208, USA
    Am J Physiol Cell Physiol 302:C1026-34. 2012
    ..The results suggest that Abl may regulate smooth muscle cell proliferation by modulating actin dynamics and ERK1/2 phosphorylation during mitogenic activation...
  3. ncbi Silencing of p21-activated kinase attenuates vimentin phosphorylation on Ser-56 and reorientation of the vimentin network during stimulation of smooth muscle cells by 5-hydroxytryptamine
    Dale D Tang
    Center for Cardiovascular Sciences, Albany Medical College, 47 New Scotland Avenue, MC 8, ME 424, Albany, NY 12208, USA
    Biochem J 388:773-83. 2005
    ..These results suggest that the PAK-mediated site-specific phosphorylation of vimentin may play a role in regulating the reorganization of vimentin intermediate filaments during stimulation of smooth muscle cells with 5-HT...
  4. ncbi Physiologic properties and regulation of the actin cytoskeleton in vascular smooth muscle
    Dale D Tang
    Center for Cardiovascular Sciences, Albany Medical College, Albany, New York 12208, USA
    J Cardiovasc Pharmacol Ther 13:130-40. 2008
    ..These new findings promote our understanding on how smooth muscle contraction is regulated at cellular and molecular levels...
  5. ncbi Intermediate filaments in smooth muscle
    Dale D Tang
    Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 12208, USA
    Am J Physiol Cell Physiol 294:C869-78. 2008
    ..This review also summarizes our latest understanding on how the IF network may be regulated in smooth muscle...
  6. ncbi p130 Crk-associated substrate (CAS) in vascular smooth muscle
    Dale D Tang
    Center for Cardiovascular Sciences, Albany Medical College, Albany, New York 12208, USA
    J Cardiovasc Pharmacol Ther 14:89-98. 2009
    ..The CAS-associated processes may be new biological targets for the development of new treatment of cardiovascular diseases such as hypertension...
  7. ncbi Critical role of vimentin phosphorylation at Ser-56 by p21-activated kinase in vimentin cytoskeleton signaling
    Qing-Fen Li
    Center for Cardiovascular Sciences, Albany Medical College, Albany, New York 12208, USA
    J Biol Chem 281:34716-24. 2006
    ..Additionally, vimentin phosphorylation at this position is critical for vimentin filament spatial rearrangement elicited by agonists...
  8. ncbi Role of p47(phox) in regulating Cdc42GAP, vimentin, and contraction in smooth muscle cells
    Qing Fen Li
    The Center for Cardiovascular Sciences, Albany Medical College, NY 12208, USA
    Am J Physiol Cell Physiol 297:C1424-33. 2009
    ..p47(phox)-regulated GAP affects smooth muscle contraction likely through the Cdc42/PAK1/vimentin pathway...
  9. ncbi Role of vimentin in smooth muscle force development
    Ruping Wang
    Center for Cardiovascular Sciences, Albany Medical College, 47 New Scotland Avenue MC 8, Albany, NY 12208, USA
    Am J Physiol Cell Physiol 291:C483-9. 2006
    ..Vimentin downregulation impairs the structural organization of desmosomes, which may be associated with the decrease in force development...
  10. ncbi Cdc42GAP, reactive oxygen species, and the vimentin network
    Qing Fen Li
    The Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 12208, USA
    Am J Physiol Cell Physiol 297:C299-309. 2009
    ..Cdc42GAP regulates the vimentin network through the Cdc42-PAK pathway in smooth muscle cells during 5-HT stimulation...
  11. ncbi Dissociation of Crk-associated substrate from the vimentin network is regulated by p21-activated kinase on ACh activation of airway smooth muscle
    Ruping Wang
    Center for Cardiovascular Sciences, Albany Medical College, 47 New Scotland Ave, MC 8, Albany, NY 12208, USA
    Am J Physiol Lung Cell Mol Physiol 292:L240-8. 2007
    ..The PAK-mediated dissociation of CAS from the vimentin network may participate in the cellular processes that affect active force development during ACh activation of tracheal smooth muscle tissues...
  12. ncbi Abl activation regulates the dissociation of CAS from cytoskeletal vimentin by modulating CAS phosphorylation in smooth muscle
    Li Jia
    Center for Cardiovascular Sciences, Albany Medical College, Albany, New York, USA
    Am J Physiol Cell Physiol 299:C630-7. 2010
    ..These results suggest that Abl regulates the dissociation of CAS from the vimentin network, actin polymerization, and contraction by modulating CAS phosphorylation in smooth muscle...
  13. ncbi Abl knockout differentially affects p130 Crk-associated substrate, vinculin, and paxillin in blood vessels of mice
    Shu Chen
    The Center for Cardiovascular Sciences, Albany Medical College, Albany, New York 12208, USA
    Am J Physiol Heart Circ Physiol 297:H533-9. 2009
    ..The Abl-regulated cellular process and blood pressure are independent of myosin activation in vascular smooth muscle...
  14. ncbi Abl silencing inhibits CAS-mediated process and constriction in resistance arteries
    Yana Anfinogenova
    Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 12208, USA
    Circ Res 101:420-8. 2007
    ..Abl does not participate in the regulation of myosin activation in arterial vessels during contractile stimulation...
  15. ncbi The focal adhesion protein paxillin regulates contraction in canine tracheal smooth muscle
    Dale D Tang
    Department of Cellular and Integrative Physiology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    J Physiol 542:501-13. 2002
    ..Paxillin may be important in regulating actin filament dynamics and organization during smooth muscle contraction...
  16. ncbi Downregulation of profilin with antisense oligodeoxynucleotides inhibits force development during stimulation of smooth muscle
    Dale D Tang
    Department of Cellular and Integrative Physiology, Indiana University School of Medicine, 635 Barnhill Dr, Indianapolis, IN 46202, USA
    Am J Physiol Heart Circ Physiol 285:H1528-36. 2003
    ..Profilin may play a role in the regulation of actin polymerization or organization in response to contractile stimulation of smooth muscle...
  17. ncbi Role of Crk-associated substrate in the regulation of vascular smooth muscle contraction
    Dale D Tang
    Department of Cellular and Integrative Physiology, Indiana University School of Medicine, 635 Barnhill Dr, Indianapolis, Ind 46202, USA
    Hypertension 42:858-63. 2003
    ..This molecule may regulate actin dynamics in smooth muscle in response to contractile stimulation...
  18. ncbi Expression of non-phosphorylatable paxillin mutants in canine tracheal smooth muscle inhibits tension development
    Dale D Tang
    Department of Cellular and Integrative Physiology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    J Physiol 553:21-35. 2003
    ..Paxillin phosphorylation at these two sites may be important in regulating actin filament dynamics and organization during smooth muscle contraction...
  19. ncbi Cytoskeletal remodeling of the airway smooth muscle cell: a mechanism for adaptation to mechanical forces in the lung
    Susan J Gunst
    Department of Cellular and Integrative Physiology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202 5120, USA
    Respir Physiol Neurobiol 137:151-68. 2003
    ..The fluidity of the cytoskeletal structure of the airway smooth muscle cell may be fundamental to its ability to adapt and respond to the mechanical forces imposed on it in the lung during breathing...
  20. ncbi Tension development during contractile stimulation of smooth muscle requires recruitment of paxillin and vinculin to the membrane
    Anabelle Opazo Saez
    Department of Cellular and Integrative Physiology, Indiana University School of Medicine, 635 Barnhill Dr, Indianapolis, IN 46202, USA
    Am J Physiol Cell Physiol 286:C433-47. 2004
    ....
  21. ncbi The small GTPase Cdc42 regulates actin polymerization and tension development during contractile stimulation of smooth muscle
    Dale D Tang
    Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 279:51722-8. 2004
    ..Cdc42 may regulate the activation of neuronal Wiskott-Aldrich syndrome protein and the actin related protein complex, which in turn regulate actin filament polymerization initiated by the contractile stimulation of smooth muscle...
  22. ncbi On the terminology for describing the length-force relationship and its changes in airway smooth muscle
    Tony R Bai
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, Vancouver, Canada
    J Appl Physiol 97:2029-34. 2004
    ..We also discuss frequently used terms that do not have commonly accepted definitions that should be used cautiously...
  23. ncbi Activation of the Arp2/3 complex by N-WASp is required for actin polymerization and contraction in smooth muscle
    Wenwu Zhang
    Dept. of Cellular and Integrative Physiology, Indiana Univ. School of Medicine, 635 Barnhill Drive, MS374, Indianapolis, IN 46202, USA
    Am J Physiol Cell Physiol 288:C1145-60. 2005
    ....
  24. ncbi The adapter protein CrkII regulates neuronal Wiskott-Aldrich syndrome protein, actin polymerization, and tension development during contractile stimulation of smooth muscle
    Dale D Tang
    Department of Cellular and Integrative Physiology, School of Medicine, Indiana University, Indianapolis, 46202, USA
    J Biol Chem 280:23380-9. 2005
    ..These studies suggest a novel signaling pathway for the regulation of N-WASp activation and active contraction in smooth muscle tissues...
  25. ncbi A new signaling paradigm for serotonin: use of Crk-associated substrate in arterial contraction
    Kevin Ogden
    Dept of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, USA
    Am J Physiol Heart Circ Physiol 291:H2857-63. 2006
    ..These data are the first to implicate CAS in the signal transduction of 5-HT...

Research Grants5

  1. Molecular mechanisms of airway smooth muscle function
    Dale Tang; Fiscal Year: 2007
    ..The knowledge obtained from these studies may disclose new biological targets for the development of more effective pharmacological treatment of pulmonary diseases such as asthma. ..