Affiliation: Albany Medical College
- Cat's claw inhibits TNFalpha production and scavenges free radicals: role in cytoprotectionM Sandoval
Department of Pediatrics and Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 12208, USA
Free Radic Biol Med 29:71-8. 2000..The primary mechanism for cat's claw anti-inflammatory actions appears to be immunomodulation via suppression of TNFalpha synthesis...
- Sangre de grado Croton palanostigma induces apoptosis in human gastrointestinal cancer cellsManuel Sandoval
Center for Cardiovascular Sciences and Department of Pediatrics, Albany Medical College, 47 New Scotland Avenue MC 8, Albany, NY 12208, USA
J Ethnopharmacol 80:121-9. 2002..The induction of apoptosis and microtubule damage in AGS, HT29 and T84 cells suggest that sangre de grado should be evaluated further as a potential source of anti-cancer agents...
- Anti-inflammatory and antioxidant activities of cat's claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid contentM Sandoval
Albany Medical College, Center for Cardiovascular Sciences and Deapertment of Pediatrics, NY 12208, USA
Phytomedicine 9:325-37. 2002..guianensis is more potent. In conclusion, the presence of oxindole or pentacyclic alkaloids did not influence the antioxidant and anti-inflammatory properties of cat's claw...
- Treatment of gastric ulcers and diarrhea with the Amazonian herbal medicine sangre de gradoM J Miller
Department of Pediatrics and Center for Cardiovascular Sciences, Albany Medical College, New York 12208, USA
Am J Physiol Gastrointest Liver Physiol 279:G192-200. 2000..We conclude that sangre de grado is a potent, cost-effective treatment for gastrointestinal ulcers and distress via antimicrobial, anti-inflammatory, and sensory afferent-dependent actions...
- Inhibition of neurogenic inflammation by the Amazonian herbal medicine sangre de gradoM J Miller
Department of Pediatrics, Albany Medical College, Albany, New York, New York 12208, USA
J Invest Dermatol 117:725-30. 2001..Subjects reported relief within minutes. We conclude that sangre de grado is a potent inhibitor of sensory afferent nerve mechanisms and supports its ethnomedical use for disorders characterized by neurogenic inflammation...
- Nitric Oxide. III. A molecular prelude to intestinal inflammationM J Miller
Department of Pediatrics, Albany Medical College, Albany, New York 12208, USA
Am J Physiol 276:G795-9. 1999..Thus, whereas iNOS may be a marker for the proinflammatory actions of NO, the species that mediate tissue injury/dysfunction in inflammation are likely to be nitrogen oxides other than NO...
- Dietary antioxidants protect gut epithelial cells from oxidant-induced apoptosisM J Miller
Center for Cardiovascular Sciences, Albany Medical College, Albany, New York, USA
BMC Complement Altern Med 1:11. 2001..The potential of ascorbic acid and two botanical decoctions, green tea and cat's claw, to limit cell death in response to oxidants were evaluated in vitro...
- Efficacy and safety of freeze-dried cat's claw in osteoarthritis of the knee: mechanisms of action of the species Uncaria guianensisJ Piscoya
Universidad Nacional Mayor de San Marcos, Facultad de Medicina, Lima, Peru
Inflamm Res 50:442-8. 2001..The species, U guianensis and U tomentosa are equiactive. They are effective antioxidants, but their anti-inflammatory properties may result from their ability to inhibit TNFalpha and to a lesser extent PGE2 production...