Research Topics
Species | ALEXANDER MONGINSummaryAffiliation: Albany Medical College Country: USA Publications
Research Grants
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Detail Information
Publications
DCPIB, the proposed selective blocker of volume-regulated anion channels, inhibits several glutamate transport pathways in glial cellsNicole H Bowens
Center for Neuropharmacology and Neuroscience, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
Mol Pharmacol 83:22-32. 2013..Overall, our data demonstrate that DCPIB influences several glutamate transport pathways and that its effects on VRAC in vivo should be verified using additional pharmacological controls...- Selective vulnerability of synaptic signaling and metabolism to nitrosative stressAlexander A Mongin
Center for Neuropharmacology and Neuroscience, Albany Medical College, New York 12208, USA
Antioxid Redox Signal 17:992-1012. 2012..RECENT ADVANCES: Recent work in the field focused on the ability of NO and RNS to yield protein modifications, including the S-nitrosation of cysteine residues, which, in many instances, impact cellular functions and viability... - A simple method for measuring intracellular activities of glutamine synthetase and glutaminase in glial cellsAlexander A Mongin
Center for Neuropharmacology and Neuroscience, Albany Medical College, New York 12208, USA
Am J Physiol Cell Physiol 301:C814-22. 2011..Overall, this paper describes optimized conditions and pharmacological controls for measuring GS and GLNase activities in intact glial cells... 
ATP regulates anion channel-mediated organic osmolyte release from cultured rat astrocytes via multiple Ca2+-sensitive mechanismsAlexander A Mongin
Center for Neuropharmacology and Neuroscience, Albany Medical College, New York 12208, USA
Am J Physiol Cell Physiol 288:C204-13. 2005..Ca(2+)-dependent organic osmolyte release via VRACs may contribute to the physiological functions of these channels in the brain, including astrocyte-to-neuron intercellular communication...- Hydrogen peroxide potentiates volume-sensitive excitatory amino acid release via a mechanism involving Ca2+/calmodulin-dependent protein kinase IIRENEE E HASKEW-LAYTON
Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
J Biol Chem 280:3548-54. 2005..These data demonstrate that H2O2 strongly up-regulates astrocytic volume-sensitive EAA release via a CaMKII-dependent mechanism and in this way may potently promote pathological EAA release and brain damage in ischemia... - ATP potently modulates anion channel-mediated excitatory amino acid release from cultured astrocytesAlexander A Mongin
Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
Am J Physiol Cell Physiol 283:C569-78. 2002..Moderate cell swelling and ATP may serve as two cooperative signals in bidirectional neuron-astrocyte communication in vivo... - Peroxynitrite enhances astrocytic volume-sensitive excitatory amino acid release via a src tyrosine kinase-dependent mechanismRenée E Haskew
Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
J Neurochem 82:903-12. 2002..This modulation may contribute to EAA-mediated neuronal damage in ischemia and other pathological conditions favoring cell swelling and ONOO- production... - Activation of microglia with zymosan promotes excitatory amino acid release via volume-regulated anion channels: the role of NADPH oxidasesTimothy J Harrigan
Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
J Neurochem 106:2449-62. 2008..Taken together, these data suggest that the anion channel VRAC may contribute to microglial glutamate release and that its activity is regulated by endogenous ROS originating from NOX4... - Two distinct modes of hypoosmotic medium-induced release of excitatory amino acids and taurine in the rat brain in vivoRENEE E HASKEW-LAYTON
Center of Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York, USA
PLoS ONE 3:e3543. 2008..Taken together, our findings indicate that different transport mechanisms and/or distinct cellular sources mediate hypoosmotic medium-induced release of the excitatory amino acids and taurine in vivo... - Pharmacological comparison of swelling-activated excitatory amino acid release and Cl- currents in cultured rat astrocytesIskandar F Abdullaev
Ordway Research Institute, Albany, NY 12208, USA
J Physiol 572:677-89. 2006..Taken together, our data suggest that (i) astrocytic volume-dependent EAA release is largely mediated by the VRAC, and (ii) the ClC-2, ClC-3, ClC-4, ClC-5, VDAC, CaCC, MDR-1 and CFTR gene products do not contribute to EAA permeability... - Is autocrine ATP release required for activation of volume-sensitive chloride channels?Alexander A Mongin
J Neurophysiol 90:2791-2; author reply 2792-3. 2003 - Salt-sensing mechanisms in blood pressure regulation and hypertensionSergei N Orlov
Department of Medicine and Centre Hospitalier de l Université de Montréal, Montreal, Quebec, Canada
Am J Physiol Heart Circ Physiol 293:H2039-53. 2007....
Research Grants
- Oxidative Stress and Pathological Glutamate Release in StrokeAlexander A Mongin; Fiscal Year: 2010..The present project will study previously unrecognized mechanisms of brain damage and seek to develop new pharmacological agents for stroke treatment. ..
- Defects of Neurotransmission in Ischemia and ReperfusionALEXANDER MONGIN; Fiscal Year: 2007....
- Oxidative Stress and Pathological Glutamate Release in StrokeALEXANDER MONGIN; Fiscal Year: 2009..The present project will study previously unrecognized mechanisms of brain damage and seek to develop new pharmacological agents for stroke treatment. ..