ALEXANDER MONGIN

Summary

Affiliation: Albany Medical College
Country: USA

Publications

  1. pmc DCPIB, the proposed selective blocker of volume-regulated anion channels, inhibits several glutamate transport pathways in glial cells
    Nicole H Bowens
    Center for Neuropharmacology and Neuroscience, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    Mol Pharmacol 83:22-32. 2013
  2. pmc Selective vulnerability of synaptic signaling and metabolism to nitrosative stress
    Alexander A Mongin
    Center for Neuropharmacology and Neuroscience, Albany Medical College, New York 12208, USA
    Antioxid Redox Signal 17:992-1012. 2012
  3. pmc A simple method for measuring intracellular activities of glutamine synthetase and glutaminase in glial cells
    Alexander A Mongin
    Center for Neuropharmacology and Neuroscience, Albany Medical College, New York 12208, USA
    Am J Physiol Cell Physiol 301:C814-22. 2011
  4. ncbi request reprint ATP regulates anion channel-mediated organic osmolyte release from cultured rat astrocytes via multiple Ca2+-sensitive mechanisms
    Alexander A Mongin
    Center for Neuropharmacology and Neuroscience, Albany Medical College, New York 12208, USA
    Am J Physiol Cell Physiol 288:C204-13. 2005
  5. ncbi request reprint Hydrogen peroxide potentiates volume-sensitive excitatory amino acid release via a mechanism involving Ca2+/calmodulin-dependent protein kinase II
    RENEE E HASKEW-LAYTON
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
    J Biol Chem 280:3548-54. 2005
  6. ncbi request reprint ATP potently modulates anion channel-mediated excitatory amino acid release from cultured astrocytes
    Alexander A Mongin
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
    Am J Physiol Cell Physiol 283:C569-78. 2002
  7. ncbi request reprint Peroxynitrite enhances astrocytic volume-sensitive excitatory amino acid release via a src tyrosine kinase-dependent mechanism
    Renée E Haskew
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
    J Neurochem 82:903-12. 2002
  8. pmc Activation of microglia with zymosan promotes excitatory amino acid release via volume-regulated anion channels: the role of NADPH oxidases
    Timothy J Harrigan
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
    J Neurochem 106:2449-62. 2008
  9. pmc Two distinct modes of hypoosmotic medium-induced release of excitatory amino acids and taurine in the rat brain in vivo
    RENEE E HASKEW-LAYTON
    Center of Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York, USA
    PLoS ONE 3:e3543. 2008
  10. pmc Pharmacological comparison of swelling-activated excitatory amino acid release and Cl- currents in cultured rat astrocytes
    Iskandar F Abdullaev
    Ordway Research Institute, Albany, NY 12208, USA
    J Physiol 572:677-89. 2006

Research Grants

Collaborators

Detail Information

Publications12

  1. pmc DCPIB, the proposed selective blocker of volume-regulated anion channels, inhibits several glutamate transport pathways in glial cells
    Nicole H Bowens
    Center for Neuropharmacology and Neuroscience, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    Mol Pharmacol 83:22-32. 2013
    ..Overall, our data demonstrate that DCPIB influences several glutamate transport pathways and that its effects on VRAC in vivo should be verified using additional pharmacological controls...
  2. pmc Selective vulnerability of synaptic signaling and metabolism to nitrosative stress
    Alexander A Mongin
    Center for Neuropharmacology and Neuroscience, Albany Medical College, New York 12208, USA
    Antioxid Redox Signal 17:992-1012. 2012
    ..RECENT ADVANCES: Recent work in the field focused on the ability of NO and RNS to yield protein modifications, including the S-nitrosation of cysteine residues, which, in many instances, impact cellular functions and viability...
  3. pmc A simple method for measuring intracellular activities of glutamine synthetase and glutaminase in glial cells
    Alexander A Mongin
    Center for Neuropharmacology and Neuroscience, Albany Medical College, New York 12208, USA
    Am J Physiol Cell Physiol 301:C814-22. 2011
    ..Overall, this paper describes optimized conditions and pharmacological controls for measuring GS and GLNase activities in intact glial cells...
  4. ncbi request reprint ATP regulates anion channel-mediated organic osmolyte release from cultured rat astrocytes via multiple Ca2+-sensitive mechanisms
    Alexander A Mongin
    Center for Neuropharmacology and Neuroscience, Albany Medical College, New York 12208, USA
    Am J Physiol Cell Physiol 288:C204-13. 2005
    ..Ca(2+)-dependent organic osmolyte release via VRACs may contribute to the physiological functions of these channels in the brain, including astrocyte-to-neuron intercellular communication...
  5. ncbi request reprint Hydrogen peroxide potentiates volume-sensitive excitatory amino acid release via a mechanism involving Ca2+/calmodulin-dependent protein kinase II
    RENEE E HASKEW-LAYTON
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
    J Biol Chem 280:3548-54. 2005
    ..These data demonstrate that H2O2 strongly up-regulates astrocytic volume-sensitive EAA release via a CaMKII-dependent mechanism and in this way may potently promote pathological EAA release and brain damage in ischemia...
  6. ncbi request reprint ATP potently modulates anion channel-mediated excitatory amino acid release from cultured astrocytes
    Alexander A Mongin
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
    Am J Physiol Cell Physiol 283:C569-78. 2002
    ..Moderate cell swelling and ATP may serve as two cooperative signals in bidirectional neuron-astrocyte communication in vivo...
  7. ncbi request reprint Peroxynitrite enhances astrocytic volume-sensitive excitatory amino acid release via a src tyrosine kinase-dependent mechanism
    Renée E Haskew
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
    J Neurochem 82:903-12. 2002
    ..This modulation may contribute to EAA-mediated neuronal damage in ischemia and other pathological conditions favoring cell swelling and ONOO- production...
  8. pmc Activation of microglia with zymosan promotes excitatory amino acid release via volume-regulated anion channels: the role of NADPH oxidases
    Timothy J Harrigan
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
    J Neurochem 106:2449-62. 2008
    ..Taken together, these data suggest that the anion channel VRAC may contribute to microglial glutamate release and that its activity is regulated by endogenous ROS originating from NOX4...
  9. pmc Two distinct modes of hypoosmotic medium-induced release of excitatory amino acids and taurine in the rat brain in vivo
    RENEE E HASKEW-LAYTON
    Center of Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York, USA
    PLoS ONE 3:e3543. 2008
    ..Taken together, our findings indicate that different transport mechanisms and/or distinct cellular sources mediate hypoosmotic medium-induced release of the excitatory amino acids and taurine in vivo...
  10. pmc Pharmacological comparison of swelling-activated excitatory amino acid release and Cl- currents in cultured rat astrocytes
    Iskandar F Abdullaev
    Ordway Research Institute, Albany, NY 12208, USA
    J Physiol 572:677-89. 2006
    ..Taken together, our data suggest that (i) astrocytic volume-dependent EAA release is largely mediated by the VRAC, and (ii) the ClC-2, ClC-3, ClC-4, ClC-5, VDAC, CaCC, MDR-1 and CFTR gene products do not contribute to EAA permeability...
  11. ncbi request reprint Is autocrine ATP release required for activation of volume-sensitive chloride channels?
    Alexander A Mongin
    J Neurophysiol 90:2791-2; author reply 2792-3. 2003
  12. ncbi request reprint Salt-sensing mechanisms in blood pressure regulation and hypertension
    Sergei N Orlov
    Department of Medicine and Centre Hospitalier de l Université de Montréal, Montreal, Quebec, Canada
    Am J Physiol Heart Circ Physiol 293:H2039-53. 2007
    ....

Research Grants4

  1. Oxidative Stress and Pathological Glutamate Release in Stroke
    Alexander A Mongin; Fiscal Year: 2010
    ..The present project will study previously unrecognized mechanisms of brain damage and seek to develop new pharmacological agents for stroke treatment. ..
  2. Defects of Neurotransmission in Ischemia and Reperfusion
    ALEXANDER MONGIN; Fiscal Year: 2007
    ....
  3. Oxidative Stress and Pathological Glutamate Release in Stroke
    ALEXANDER MONGIN; Fiscal Year: 2009
    ..The present project will study previously unrecognized mechanisms of brain damage and seek to develop new pharmacological agents for stroke treatment. ..