D W Metzger

Summary

Affiliation: Albany Medical College
Country: USA

Publications

  1. pmc Immune dysfunction and bacterial coinfections following influenza
    Dennis W Metzger
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
    J Immunol 191:2047-52. 2013
  2. pmc Differing effects of interleukin-10 on cutaneous and pulmonary Francisella tularensis live vaccine strain infection
    Dennis W Metzger
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York, USA
    Infect Immun 81:2022-7. 2013
  3. pmc Interleukin-12 as an adjuvant for induction of protective antibody responses
    Dennis W Metzger
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
    Cytokine 52:102-7. 2010
  4. pmc Intranasal vaccination with pneumococcal surface protein A and interleukin-12 augments antibody-mediated opsonization and protective immunity against Streptococcus pneumoniae infection
    B P Arulanandam
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York 12208, USA
    Infect Immun 69:6718-24. 2001
  5. ncbi request reprint Mucosal immunopathogenesis of Francisella tularensis
    Dennis W Metzger
    Center for Immunology and Microbial Disease, MC 151, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    Ann N Y Acad Sci 1105:266-83. 2007
  6. ncbi request reprint Immune responses to tissue-engineered extracellular matrix used as a bioscaffold
    Dennis W Metzger
    Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    Ann N Y Acad Sci 961:335-6. 2002
  7. ncbi request reprint IgA immunodeficiency leads to inadequate Th cell priming and increased susceptibility to influenza virus infection
    B P Arulanandam
    Center for Immunology and Microbial Disease Research, Albany Medical College, Albany, NY 12208, USA
    J Immunol 166:226-31. 2001
  8. ncbi request reprint Fc receptor-mediated phagocytosis makes a significant contribution to clearance of influenza virus infections
    V C Huber
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
    J Immunol 166:7381-8. 2001
  9. ncbi request reprint Intranasal interleukin-12 is a powerful adjuvant for protective mucosal immunity
    B P Arulanandam
    Center for Immunology, Albany Medical College, Albany, NY 12208, USA
    J Infect Dis 180:940-9. 1999
  10. pmc Inactivated Francisella tularensis live vaccine strain protects against respiratory tularemia by intranasal vaccination in an immunoglobulin A-dependent fashion
    Shawn D Baron
    Center for Immunology and Microbial Disease, MC 151, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    Infect Immun 75:2152-62. 2007

Research Grants

  1. Annual Conference on Tularemia
    DENNIS METZGER; Fiscal Year: 2007
  2. Immunology and Microbial Disease Training Grant
    DENNIS METZGER; Fiscal Year: 2006
  3. Mucosal Immunopathogenesis of Franscisella Tularensis
    DENNIS METZGER; Fiscal Year: 2007
  4. REGULATION OF B CELL FUNCTION BY INTERLEUKIN 12
    DENNIS METZGER; Fiscal Year: 2007
  5. The Upstate New York Immunology Conference
    DENNIS METZGER; Fiscal Year: 2007
  6. Otitis media-associated pneumococcal genes
    Honggao Yan; Fiscal Year: 2010
  7. REGULATION OF B CELL FUNCTION BY INTERLEUKIN 12
    DENNIS METZGER; Fiscal Year: 2009
  8. REGULATION OF B CELL FUNCTION BY INTERLEUKIN 12
    Dennis W Metzger; Fiscal Year: 2010
  9. REGULATION OF B CELL FUNCTION BY INTERLEUKIN 12
    DENNIS METZGER; Fiscal Year: 2006
  10. REGULATION OF B CELL FUNCTION BY INTERLEUKIN 12
    DENNIS METZGER; Fiscal Year: 2000

Collaborators

Detail Information

Publications48

  1. pmc Immune dysfunction and bacterial coinfections following influenza
    Dennis W Metzger
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
    J Immunol 191:2047-52. 2013
    ....
  2. pmc Differing effects of interleukin-10 on cutaneous and pulmonary Francisella tularensis live vaccine strain infection
    Dennis W Metzger
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York, USA
    Infect Immun 81:2022-7. 2013
    ..Taken together, these findings suggest that differentially regulating expression of the IL-10 pathway in various tissues could ultimately have prophylactic and therapeutic benefits for protection against tularemia...
  3. pmc Interleukin-12 as an adjuvant for induction of protective antibody responses
    Dennis W Metzger
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
    Cytokine 52:102-7. 2010
    ..Studies examining the efficacy of IL-12-mediated effects on protective antibody response in the mouse model are summarized in this review...
  4. pmc Intranasal vaccination with pneumococcal surface protein A and interleukin-12 augments antibody-mediated opsonization and protective immunity against Streptococcus pneumoniae infection
    B P Arulanandam
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York 12208, USA
    Infect Immun 69:6718-24. 2001
    ..These findings demonstrate the effectiveness of combining PspA and IL-12 at mucosal sites to achieve optimal antibody-mediated opsonization and killing of S. pneumoniae...
  5. ncbi request reprint Mucosal immunopathogenesis of Francisella tularensis
    Dennis W Metzger
    Center for Immunology and Microbial Disease, MC 151, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    Ann N Y Acad Sci 1105:266-83. 2007
    ....
  6. ncbi request reprint Immune responses to tissue-engineered extracellular matrix used as a bioscaffold
    Dennis W Metzger
    Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    Ann N Y Acad Sci 961:335-6. 2002
  7. ncbi request reprint IgA immunodeficiency leads to inadequate Th cell priming and increased susceptibility to influenza virus infection
    B P Arulanandam
    Center for Immunology and Microbial Disease Research, Albany Medical College, Albany, NY 12208, USA
    J Immunol 166:226-31. 2001
    ..Collectively, these results provide evidence that a major role of IgA is to facilitate presentation of Ag to mucosal T cells. IL-12 treatment can overcome IgA deficiency by providing adequate T cell priming during vaccination...
  8. ncbi request reprint Fc receptor-mediated phagocytosis makes a significant contribution to clearance of influenza virus infections
    V C Huber
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
    J Immunol 166:7381-8. 2001
    ..We conclude that Fc receptor-mediated phagocytosis plays a pivotal role in clearance of respiratory virus infections...
  9. ncbi request reprint Intranasal interleukin-12 is a powerful adjuvant for protective mucosal immunity
    B P Arulanandam
    Center for Immunology, Albany Medical College, Albany, NY 12208, USA
    J Infect Dis 180:940-9. 1999
    ..These findings show for the first time that soluble IL-12 delivered in serves as a powerful respiratory adjuvant for protective antiviral immunity...
  10. pmc Inactivated Francisella tularensis live vaccine strain protects against respiratory tularemia by intranasal vaccination in an immunoglobulin A-dependent fashion
    Shawn D Baron
    Center for Immunology and Microbial Disease, MC 151, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    Infect Immun 75:2152-62. 2007
    ..These results are the first results to demonstrate that IgA-mediated protection against lethal respiratory tularemia occurs after mucosal vaccination with inactivated F. tularensis LVS...
  11. pmc IL-12 can alleviate Th17-mediated allergic lung inflammation through induction of pulmonary IL-10 expression
    D M Durrant
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York, USA
    Mucosal Immunol 3:301-11. 2010
    ..We conclude that Th17-mediated allergic lung inflammation that becomes dominant in the absence of effective IFN-gamma signaling can be effectively suppressed by IL-12 through an IL-10-dependent mechanism...
  12. ncbi request reprint Prophylactic and therapeutic use of antibodies for protection against respiratory infection with Francisella tularensis
    Girish S Kirimanjeswara
    Center for Immunology and Microbial Disease, Albany Medical College, 47 New Scotland Avenue Albany, NY 12208, USA
    J Immunol 179:532-9. 2007
    ..Thus, this study provides the first evidence for the therapeutic use of Abs in Francisella-infected individuals...
  13. pmc Utilization of Fc receptors as a mucosal vaccine strategy against an intracellular bacterium, Francisella tularensis
    Deepak B Rawool
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
    J Immunol 180:5548-57. 2008
    ..tularensis, a category A biothreat agent. In summary, these studies show for the first time the use of FcRs as a highly effective vaccination strategy against a highly virulent mucosal intracellular pathogen...
  14. ncbi request reprint Xenogeneic extracellular matrix grafts elicit a TH2-restricted immune response
    A J Allman
    Center for Immunology and Microbial Disease, MC 151, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    Transplantation 71:1631-40. 2001
    ..CONCLUSIONS: Porcine extracellular matrix elicits an immune response that is predominately Th2-like, consistent with a remodeling reaction rather than rejection...
  15. pmc Increased protection against pneumococcal disease by mucosal administration of conjugate vaccine plus interleukin-12
    Joyce M Lynch
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York 12208, USA
    Infect Immun 71:4780-8. 2003
    ..We conclude that i.n vaccination in the presence of IL-12 is able to enhance systemic and mucosal immune responses to pneumococci and efficiently protect against both invasive infection and bacterial carriage...
  16. doi request reprint Humoral and cell-mediated immunity to the intracellular pathogen Francisella tularensis
    Girish S Kirimanjeswara
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
    Immunol Rev 225:244-55. 2008
    ..tularensis. Thus, novel vaccine approaches should be designed to induce robust antibody and cell-mediated immune responses to this pathogen...
  17. pmc Superoxide dismutase B gene (sodB)-deficient mutants of Francisella tularensis demonstrate hypersensitivity to oxidative stress and attenuated virulence
    Chandra Shekhar Bakshi
    Center for Immunology and Microbial Disease, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208 3479, USA
    J Bacteriol 188:6443-8. 2006
    ..The sodB(Ft) mutant also was significantly attenuated for virulence in mice. Thus, this study has identified sodB as an important F. tularensis virulence factor...
  18. pmc Intranasal interleukin-12 treatment for protection against respiratory infection with the Francisella tularensis live vaccine strain
    Nathalie S Duckett
    Center for Immunology and Microbial Disease MC 151, Albany Medical College, 47 New Scotland Ave, Albany, NY 12208, USA
    Infect Immun 73:2306-11. 2005
    ..These results demonstrate that exogenous IL-12 delivered intranasally can prevent respiratory tularemia through a mechanism that is at least partially dependent upon the expression of IFN-gamma and CD8 T cells...
  19. ncbi request reprint Fcgamma-receptor signaling augments the LPS-stimulated increase in serum tumor necrosis factor-alpha levels
    M L Refici
    Center for Cardiovascular Sciences, Albany Medical College, 47 New Scotland Ave, Albany, NY 12208, USA
    Am J Physiol Regul Integr Comp Physiol 280:R1037-44. 2001
    ..These results indicate that FcgammaR signaling primarily mediates the augmented serum TNF-alpha response to LPS caused by EIgG...
  20. ncbi request reprint An important role for polymeric Ig receptor-mediated transport of IgA in protection against Streptococcus pneumoniae nasopharyngeal carriage
    Keer Sun
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
    J Immunol 173:4576-81. 2004
    ..The results demonstrate the critical role of secretory IgA in protection against pneumococcal nasal colonization and suggest that directed targeting to mucosal tissues will be needed for effective vaccination in humans...
  21. ncbi request reprint Early activation of NK cells after lung infection with the intracellular bacterium, Francisella tularensis LVS
    Maria C Lopez
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
    Cell Immunol 232:75-85. 2004
    ..The results indicate that IFN-gamma is secreted in response to respiratory infection with F. tularensis LVS, and that NK cells are the early responders responsible for IFN-gamma secretion...
  22. ncbi request reprint Intranasal vaccination of neonatal mice with polysaccharide conjugate vaccine for protection against pneumococcal otitis media
    Albert Sabirov
    Center for Immunology and Microbial Disease, Albany Medical College MC 151, 47 New Scotland Ave, Albany, NY 12208, USA
    Vaccine 24:5584-92. 2006
    ..n. vaccination of neonatal mice in the presence of IL-12 is able to enhance IFN-gamma dependent ME mucosal and systemic immune responses to pneumococci and efficiently protect against both OM and invasive infection...
  23. pmc Contribution of citrulline ureidase to Francisella tularensis strain Schu S4 pathogenesis
    Manish Mahawar
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208 3479, USA
    J Bacteriol 191:4798-806. 2009
    ..To conclude, this study demonstrates that ctu contributes to intracellular survival, in vivo growth, and pathogenesis. However, ctu is not an absolute requirement for the virulence of F. tularensis Schu S4 in mice...
  24. pmc Identification of Francisella tularensis live vaccine strain CuZn superoxide dismutase as critical for resistance to extracellularly generated reactive oxygen species
    Amanda A Melillo
    Center for Immunology and Microbial Disease, MC 151, Albany Medical College, 47 New Scotland Ave, Albany, NY 12208, USA
    J Bacteriol 191:6447-56. 2009
    ..To conclude, this study demonstrates that SodB and SodC act to confer protection against host-derived oxidants and contribute to intramacrophage survival and virulence of F. tularensis in mice...
  25. pmc Adaptation of Francisella tularensis to the mammalian environment is governed by cues which can be mimicked in vitro
    Karsten R O Hazlett
    Center for Immunology and Microbial Disease, Center for Cardiovascular Sciences, Albany Medical College, 47 New Scotland Avenue, Albany, New York 12208, USA
    Infect Immun 76:4479-88. 2008
    ..Cumulatively, our findings provide compelling evidence that growth in BHI yields bacteria which recapitulate the phenotype of Francisella organisms that have emerged from macrophages...
  26. pmc An improved vaccine for prevention of respiratory tularemia caused by Francisella tularensis SchuS4 strain
    Chandra Shekhar Bakshi
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
    Vaccine 26:5276-88. 2008
    ..Collectively, this study describes an improved live vaccine candidate against respiratory tularemia that has an attenuated virulence and enhanced protective efficacy than the LVS...
  27. pmc Analysis of murine genetic predisposition to pneumococcal infection reveals a critical role of alveolar macrophages in maintaining the sterility of the lower respiratory tract
    Keer Sun
    Center for Immunology and Microbial Disease, MC 151, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    Infect Immun 79:1842-7. 2011
    ....
  28. ncbi request reprint Delivery of IL-12 intranasally leads to reduced IL-12-mediated toxicity
    Victor C Huber
    Center for Immunology and Microbial Disease, Albany Medical College, 47 New Scotland Avenue, MC 151, Albany, NY 12208, USA
    Int Immunopharmacol 3:801-9. 2003
    ..e., serum IgG2a). Thus, IL-12 can be delivered safely and effectively by the i.n. route, a finding which may allow IL-12 to fulfill its clinical potential...
  29. ncbi request reprint Azithromycin modulates murine immune responses to pneumococcal conjugate vaccine and inhibits nasal clearance of bacteria
    Aracelis D Fernandez
    Center for Immunology and Microbial Disease and Department of Pediatrics, Albany Medical College, Albany, New York 12208, USA
    J Infect Dis 190:1762-6. 2004
    ..The results demonstrate that azithromycin can be inhibitory with regard to protective immune responsiveness...
  30. pmc Intranasal vaccination of infant mice induces protective immunity in the absence of nasal-associated lymphoid tissue
    Albert Sabirov
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY, USA
    Vaccine 26:1566-76. 2008
    ..n. vaccination. In addition, in the young mice CLN play a more important role than NALT for induction of protective mucosal and systemic antibody responses following i.n. immunization...
  31. doi request reprint Inhibition of pulmonary antibacterial defense by interferon-gamma during recovery from influenza infection
    Keer Sun
    Center for Immunology and Microbial Disease, Albany Medical College, 47 New Scotland Avenue, Albany, New York 12208, USA
    Nat Med 14:558-64. 2008
    ..Thus, IFN-gamma, although probably facilitating induction of specific anti-influenza adaptive immunity, suppresses innate protection against extracellular bacterial pathogens in the lung...
  32. ncbi request reprint The Th2-restricted immune response to xenogeneic small intestinal submucosa does not influence systemic protective immunity to viral and bacterial pathogens
    Amy J Allman
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York 12208, USA
    Tissue Eng 8:53-62. 2002
    ..Therefore, SIS implantation does not increase susceptibility to viral or bacterial pathogenic agents...
  33. pmc A detrimental effect of interleukin-10 on protective pulmonary humoral immunity during primary influenza A virus infection
    Keer Sun
    Center for Immunology and Microbial Disease, MC 151, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    J Virol 84:5007-14. 2010
    ..Our results show that an absence of IL-10 at the time of primary infection leads to enhanced local virus-specific antibody production and, thus, increased protection against influenza A virus infection...
  34. pmc Development of allergen-induced airway inflammation in the absence of T-bet regulation is dependent on IL-17
    Douglas M Durrant
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
    J Immunol 183:5293-300. 2009
    ..These findings indicate that IL-17 is a key mediator of airway inflammation in the absence of T-bet. The results of this study suggest a possible target for therapeutic intervention of human asthma...
  35. pmc Interleukin-12 promotes gamma interferon-dependent neutrophil recruitment in the lung and improves protection against respiratory Streptococcus pneumoniae infection
    Keer Sun
    Center for Immunology and Microbial Disease, MC 151, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    Infect Immun 75:1196-202. 2007
    ..The findings show that IL-12 and IFN-gamma can mediate a protective effect against respiratory infection caused by extracellular bacterial pathogens...
  36. ncbi request reprint Matrix metalloproteinase 9 activity enhances host susceptibility to pulmonary infection with type A and B strains of Francisella tularensis
    Meenakshi Malik
    Center for Immunology and Microbial Disease, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    J Immunol 178:1013-20. 2007
    ....
  37. pmc Intranasal vaccination using interleukin-12 and cholera toxin subunit B as adjuvants to enhance mucosal and systemic immunity to human immunodeficiency virus type 1 glycoproteins
    Diana I Albu
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York 12208, USA
    J Virol 77:5589-97. 2003
    ....
  38. pmc Exogenous interleukin-12 protects against lethal infection with coxsackievirus B4
    Daniel M Potvin
    Department of Biomedical Sciences, School of Public Health, State University of New York at Albany, Albany, New York 12237, USA
    J Virol 77:8272-9. 2003
    ..The data suggest that IL-12 treatment during CVB4-V infection is able to suppress the immunopathological mechanisms that lead to chronic disease...
  39. ncbi request reprint Mucosal B cell deficiency in IgA-/- mice abrogates the development of allergic lung inflammation
    Paul M Arnaboldi
    Center for Immunology and Microbial Disease, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    J Immunol 175:1276-85. 2005
    ..The results indicate that Ag-specific B cells are required at mucosal surfaces for induction of inflammation and likely function as major APCs in the lung for soluble protein Ags...
  40. ncbi request reprint Natural anti-galactose alpha1,3 galactose antibodies delay, but do not prevent the acceptance of extracellular matrix xenografts
    Roberta H Raeder
    Center for Immunology and Microbial Disease, Albany Medical College, NY 12208, USA
    Transpl Immunol 10:15-24. 2002
    ..We conclude that, in contrast to xenotransplantation of whole organs, naturally-occurring anti-alpha gal antibodies do not influence the ability of xenogeneic extracellular matrices to serve as bioscaffolds for tissue remodeling...
  41. pmc Intranasal administration of an inactivated Yersinia pestis vaccine with interleukin-12 generates protective immunity against pneumonic plague
    Devender Kumar
    Center for Immunology and Microbial Disease, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    Clin Vaccine Immunol 18:1925-35. 2011
    ..In summary, the results demonstrate the safety, immunogenicity, and protective efficacy of i.n. administered iYp plus IL-12 in a mouse model of pneumonic plague...
  42. ncbi request reprint Immune response to engineered tissues and cells: breakout session summary
    David M Harlan
    National Institute of Diabetes, Digestive and Kidney Diseases NIH, Building 10, Room 11S210, 10 Center Drive, Bethesda, MD 20892, USA
    Ann N Y Acad Sci 961:350-1. 2002
  43. pmc Generation and characterization of an attenuated mutant in a response regulator gene of Francisella tularensis live vaccine strain (LVS)
    Wendy L Sammons-Jackson
    Department of Molecular Medicine, College of Medicine, University of South Florida, Tampa, Florida 33612, USA
    DNA Cell Biol 27:387-403. 2008
    ..tularensis. Further, a mutant in FTL0552 or the comparable locus in SchuS4 (FTT1557c) may be an alternative candidate vaccine for tularemia...
  44. ncbi request reprint Immune response to small intestinal submucosa (surgisis) implant in humans: preliminary observations
    Luca Ansaloni
    Unit of General Surgery, University of Bologna, Sant Orsola Malpighi Hospital, Bologna, Italy
    J Invest Surg 20:237-41. 2007
    ..Thus, this study showed that in a small series of patients the SIS elicits an antibody response without clinical rejection of the xenograft and minimal postoperative complications...
  45. pmc Mouse models for the study of mucosal vaccination against otitis media
    Albert Sabirov
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY, United States
    Vaccine 26:1501-24. 2008
    ..In addition, we discuss various mucosal vaccine antigens, mucosal adjuvants and mucosal delivery systems...
  46. ncbi request reprint Immunological concerns with bioengineering approaches
    David M Harlan
    National Institute of Diabetes, Digestive and Kidney Diseases NIH, Building 10, Room 11S210, 10 Center Drive, Bethesda, MD 20892, USA
    Ann N Y Acad Sci 961:323-30. 2002
  47. ncbi request reprint Effects of cyclic pressure on bone marrow cell cultures
    Jiro Nagatomi
    Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180 3590, USA
    J Biomech Eng 124:308-14. 2002
    ....

Research Grants30

  1. Annual Conference on Tularemia
    DENNIS METZGER; Fiscal Year: 2007
    ..Funds requested in this application will be used primarily to allow new investigators with limited resources (e.g., R21 recipients) as well as trainees, to participate in these meetings. ..
  2. Immunology and Microbial Disease Training Grant
    DENNIS METZGER; Fiscal Year: 2006
    ....
  3. Mucosal Immunopathogenesis of Franscisella Tularensis
    DENNIS METZGER; Fiscal Year: 2007
    ..The results of these studies will ultimately be used to evaluate new mucosal vaccination strategies and new vaccine candidates against human respiratory infection with F. tularensis. ..
  4. REGULATION OF B CELL FUNCTION BY INTERLEUKIN 12
    DENNIS METZGER; Fiscal Year: 2007
    ..The ultimate goal is to exploit the information obtained in order to understand the requirements for induction of protective pulmonary immunity and to design effective mucosal vaccine adjuvants for use in humans. ..
  5. The Upstate New York Immunology Conference
    DENNIS METZGER; Fiscal Year: 2007
    ..This year's topics will be: Advances in Biotechnology, Immune Regulation, Biodefense and Emerging Diseases, The Immune Response to Infection, and Strategies in Immunotherapy. ..
  6. Otitis media-associated pneumococcal genes
    Honggao Yan; Fiscal Year: 2010
    ..pneumoniae. The bacterial genes identified in this project can be targeted to treat and prevent S. pneumoniae disease by disarming the immune evasion arsenals of S. pneumoniae through novel anti-bacterial drugs and vaccines. ..
  7. REGULATION OF B CELL FUNCTION BY INTERLEUKIN 12
    DENNIS METZGER; Fiscal Year: 2009
    ..The ultimate goal is to exploit the information obtained in order to understand the requirements for induction of protective pulmonary immunity and to design effective mucosal vaccine adjuvants for use in humans. ..
  8. REGULATION OF B CELL FUNCTION BY INTERLEUKIN 12
    Dennis W Metzger; Fiscal Year: 2010
    ..The ultimate goal is to exploit the information obtained in order to understand the requirements for induction of protective pulmonary immunity and to design effective mucosal vaccine adjuvants for use in humans. ..
  9. REGULATION OF B CELL FUNCTION BY INTERLEUKIN 12
    DENNIS METZGER; Fiscal Year: 2006
    ..The results of this study will provide important insight into the roles of IL-12 and IgA in controlling immunity, and could have immediate impact on human health. ..
  10. REGULATION OF B CELL FUNCTION BY INTERLEUKIN 12
    DENNIS METZGER; Fiscal Year: 2000
    ..Current vaccines are of only limited effectiveness. Thus, the use of IL-12 as a vaccine adjuvant may provide a novel approach for protection against these diseases and could have immediate impact on human health. ..
  11. IMMUNE RESPONSES TO SMALL INTESTINAL SUBMUCOSA
    DENNIS METZGER; Fiscal Year: 2001
    ..The results will provide important insight into the mechanisms responsible for successful xenogeneic transplantation and could lead to targeted cytokine therapies to prevent tissue rejection. ..
  12. CYTOKINE CONTROL OF RESPIRATORY IMMUNITY
    DENNIS METZGER; Fiscal Year: 2001
    ..Thus, the application of IL-12 as a mucosal vaccine adjuvant may provide a novel approach for protection against respiratory diseases and could have immediate impact on human health. ..
  13. REGULATION OF B CELL FUNCTION BY INTERLEUKIN 12
    DENNIS METZGER; Fiscal Year: 2002
    ..The results of this study will provide important insight into the roles of IL-12 and IgA in controlling immunity, and could have immediate impact on human health. ..
  14. The Upstate New York Immunology Conference
    DENNIS METZGER; Fiscal Year: 2003
    ..abstract_text> ..
  15. Effect of Influenza Infection on Alveolar Macrophage Function
    Dennis W Metzger; Fiscal Year: 2010
    ..The results obtained from this study will provide a comprehensive model for understanding microbial interactions in the pulmonary tract and thus provide important insight into the development of effective therapeutics for human use. ..