Affiliation: Albany Medical College
- Immediate translation of Formin DIAPH1 mRNA after its exiting the nucleus is required for its perinuclear localization in fibroblastsGuoning Liao
Center for Cell Biology and Cancer Research, Albany Medical College, Albany, New York, United States of America
PLoS ONE 8:e68190. 2013..Furthermore, a correlation of DIAPH1 mRNA and DIAPH1 protein localization has been demonstrated using a new method to quantify the intracellular distribution of protein. ..
- Interactions of elongation factor 1alpha with F-actin and beta-actin mRNA: implications for anchoring mRNA in cell protrusionsGang Liu
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, New York, New York 10461, USA
Mol Biol Cell 13:579-92. 2002..Taken together, these results implicate EF1alpha in the anchoring of beta-actin mRNA to the protrusion in crawling cells...
- A quantitative evaluation of peroxidase inhibitors for tyramide signal amplification mediated cytochemistry and histochemistryG Liu
Center for Cell Biology and Cancer Research, Albany Medical College, 47 New Scotland Avenue MC 165, Albany, NY 12208, USA
Histochem Cell Biol 126:283-91. 2006..Our results recommend the use of HCl and caution the use of phenylhydrazine, glucose oxidase, NaN(3) and H(2)O(2) as potent peroxidase inhibitors...
- Localization of all seven messenger RNAs for the actin-polymerization nucleator Arp2/3 complex in the protrusions of fibroblastsLisa A Mingle
Center for Cell Biology and Cancer Research, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
J Cell Sci 118:2425-33. 2005..In addition, myosin inhibitors significantly inhibit Arp2 mRNA localization in chicken embryo fibroblasts, suggesting a myosin motor dependent mechanism for Arp2/3-complex mRNA localization...
- The activation domains, the proline-rich domain, and the C-terminal basic domain in p53 are necessary for acetylation of histones on the proximal p21 promoter and interaction with p300/CREB-binding proteinGang Liu
Department of Cell Biology, The University of Alabama, Birmingham, Alabama 35294, USA
J Biol Chem 278:17557-65. 2003....
- Regulation of RNA-polymerase-II-dependent transcription by N-WASP and its nuclear-binding partnersXiaoyang Wu
Department of Molecular Medicine, Cornell University, Ithaca, NY 14853, USA
Nat Cell Biol 8:756-63. 2006..Based on these results, we propose a nuclear function for N-WASP in transcriptional regulation...
- Aminopyridine carboxamides as c-Jun N-terminal kinase inhibitors: targeting the gatekeeper residue and beyondGang Liu
Metabolic Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064 6101, USA
Bioorg Med Chem Lett 16:5723-30. 2006..The syntheses of analogues and the impact of structural modification on in vitro potency and cellular activity are described...
- Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studiesMei Liu
Metabolic Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064 6098, USA
Bioorg Med Chem Lett 17:668-72. 2007..SAR studies led to the discovery of potent JNK1 inhibitors with good enzymatic activity as well as cellular potency represented by compound 2b. Kinase selectivity profile and the crystal structure of 2b are also described...
- Adamantyl-substituted retinoid-related molecules bind small heterodimer partner and modulate the Sin3A repressorLulu Farhana
John D Dingell Veterans Affairs Medical Center, 4646 John R Street, Detroit, MI 48201, USA
Cancer Res 67:318-25. 2007..These results suggest that AHPN/3-Cl-AHPC and their analogues are SHP ligands and their induction of apoptosis is mediated by their binding to the SHP receptor...
- Panning and identification of a colon tumor binding peptide from a phage display peptide libraryYangde Zhang
National Key Laboratory of Nanobiological Technology, Changsha, Hunan, China
J Biomol Screen 12:429-35. 2007..These studies suggest that peptide CP15 may be a promising lead candidate in the development of a useful colon tumor diagnostic and targeted drug delivery agent...
- The tyrosine degradation gene hppD is transcriptionally activated by HpdA and repressed by HpdR in Streptomyces coelicolor, while hpdA is negatively autoregulated and repressed by HpdRHaihua Yang
State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Science, Beijing 100101, China
Mol Microbiol 65:1064-77. 2007..These results suggested that the transcription of hppD is subject to coarse and fine control by a complex regulatory system...
- Structure-activity relationships of 3,4-dihydro-1H-quinazolin-2-one derivatives as potential CDK5 inhibitorsRobert M Rzasa
Department of Chemistry Research and Discovery, Amgen Inc, One Amgen Center Drive, Thousand Oaks, CA 91320 1789, USA
Bioorg Med Chem 15:6574-95. 2007..In this investigation we present our synthetic studies toward this series of compounds and discuss their biological relevance as CDK5 inhibitors...
- Micro-magnetic resonance imaging of avian embryosXiaojing Li
Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, UK
J Anat 211:798-809. 2007..The work with the living quail embryos lays the foundations for using micro-magnetic resonance imaging as an experimental tool to follow the consequences of such manipulations over time...
- A nano-combinatorial library strategy for the discovery of nanotubes with reduced protein-binding, cytotoxicity, and immune responseHongyu Zhou
St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
Nano Lett 8:859-65. 2008..Our results demonstrated the general utility of the nanocombinatorial library approach in nanomedicine and nanotoxicity research...
- An enzyme-based E-DNA sensor for sequence-specific detection of femtomolar DNA targetsGang Liu
Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China
J Am Chem Soc 130:6820-5. 2008..By using this new strategy, we demonstrate that the prototype E-DNA sensor has been able to detect as low as femtomolar DNA targets with excellent differentiation ability for even single mismatches...
- PAI-1 inhibits neutrophil efferocytosisYoung Jun Park
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Proc Natl Acad Sci U S A 105:11784-9. 2008..Our data therefore indicate that PAI-1 serves as a novel "don't eat me" signal for viable and apoptotic neutrophils...
- High mobility group protein-1 inhibits phagocytosis of apoptotic neutrophils through binding to phosphatidylserineGang Liu
Department of Medicine, University of Alabama, Birmingham, AL 35294, USA
J Immunol 181:4240-6. 2008..These findings demonstrate that HMGB1 can modulate phagocytosis of apoptotic neutrophils and suggest an alternative mechanism by which HMGB1 is involved in enhancing inflammatory responses...
- The ferredoxin reductase gene is regulated by the p53 family and sensitizes cells to oxidative stress-induced apoptosisGang Liu
Department of Cell Biology, UAB Comprehensive Cancer Center, The University of Alabama at Birmingham, Birmingham, Alabama, AL 35294, USA
Oncogene 21:7195-204. 2002....
- Molecular cloning of a novel rat gene Tsarg1, a member of the DnaJ/HSP40 protein familyHong Mei Yang
Human Reproductive and Stem Cell Engineering Institute, Central South University, Changsha, P R China
DNA Seq 16:166-72. 2005..The results of RT-PCR and Northern blot analysis showed that Tsarg1 was specifically expressed in rat testis, which probably inhibits rat testis spermatogenic cell apoptosis...
- Discovery of a potent, selective protein tyrosine phosphatase 1B inhibitor using a linked-fragment strategyBruce G Szczepankiewicz
Metabolic Disease Research, Global Pharmaceutical Research and Development Organization, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064, USA
J Am Chem Soc 125:4087-96. 2003..The modular approach to drug design described in this work should be applicable for the design of potent and selective inhibitors of other therapeutically relevant protein tyrosine phosphatases...
- Potent, selective inhibitors of protein tyrosine phosphatase 1BZhili Xin
Metabolic Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064 6098, USA
Bioorg Med Chem Lett 13:1887-90. 2003....
- Fragment screening and assembly: a highly efficient approach to a selective and cell active protein tyrosine phosphatase 1B inhibitorGang Liu
Metabolic Disease Research and Advanced Technology, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064 6098, USA
J Med Chem 46:4232-5. 2003....
- DeltaNp73beta is active in transactivation and growth suppressionGang Liu
Department of Cell Biology, The University of Alabama at Birmingham, 1530 3rd Avenue, Birmingham, AL 35294 0005, USA
Mol Cell Biol 24:487-501. 2004..However, unlike DeltaNp73beta, DeltaNp73alpha is inactive in suppressing cell growth. Our data, together with others' previous findings, suggest that DeltaNp73beta may have distinct functions under certain cellular circumstances...
- Molecular cloning of TSARG6 gene related to apoptosis in human spermatogenic cellsGang Liu
Human Reproductive and Stem Cell Engineering Institute, Central South University, Changsha 410078, China
Acta Biochim Biophys Sin (Shanghai) 36:93-8. 2004..8 kb. Based upon all these observations, it is considered that we cloned a new gene which probably inhibited human testis spermatogenesis apoptosis...
- Determinants of retinoid X receptor transcriptional antagonismClaudio N Cavasotto
Cancer Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
J Med Chem 47:4360-72. 2004..The antagonist also blocked activation of RAR subtypes alpha and beta by 9-cis-RA but not that of RARgamma...
- Inhibition of protein tyrosine phosphatase 1B as a potential treatment of diabetes and obesityZhonghua Pei
Metabolic Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
Curr Pharm Des 10:3481-504. 2004....
- A pathway-specific transcriptional regulatory gene for nikkomycin biosynthesis in Streptomyces ansochromogenes that also influences colony developmentGang Liu
State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Science, Beijing 100080, China
Mol Microbiol 55:1855-66. 2005..These results suggested that sanG encodes a transcriptional activator important for nikkomycin biosynthesis that, unusually, also has pleiotropic effects on secondary metabolism and development...
- The C-terminal sterile alpha motif and the extreme C terminus regulate the transcriptional activity of the alpha isoform of p73Gang Liu
Department of Cell Biology, The University of Alabama, Birmingham, 35294, USA
J Biol Chem 280:20111-9. 2005..Finally, we showed that both inhibitory domains suppress the ability of p73 to interact with the transcriptional coactivators p300/CBP that are necessary for the initiation of transcription...
- Structure-activity relationship studies on tetralin carboxamide growth hormone secretagogue receptor antagonistsHongyu Zhao
Metabolic Disease Research, Global Pharmaceutical Research and Development, R4MC, AP 10, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 6098, USA
Bioorg Med Chem Lett 15:1825-8. 2005..It was found that certain 2-alkoxycarbonylamino substituted tetralin carboxamides are potent, selective, and orally bioavailable GHS-R antagonists...
- Solid-phase synthesis and antibacterial evaluations of N-demethylvancomycin derivativesNian Huan Yao
Chinese Academy of Medical Sciences and Peking Union Medical College, Institute of Materia Medica, 1 Xian Nong Tan Street, Beijing 100050, PR China
Bioorg Med Chem Lett 15:2325-9. 2005..Biological evaluation of these compounds indicated that bulky hydrophobic substituent on vancosamine of N-demethylvancomycin can increase antibacterial activity against vancomycin-resistant Enterococcus faecalis...
- The interaction between ADAM 22 and 14-3-3zeta: regulation of cell adhesion and spreadingPeng cheng Zhu
State Key Laboratory of Genetic Engineering, Institute of Genetics, Fudan University School of Life Science, 200433, Shanghai, PR China
Biochem Biophys Res Commun 301:991-9. 2003....
- Identification of novel Ah receptor agonists using a high-throughput green fluorescent protein-based recombinant cell bioassayScott R Nagy
Department of Environmental Toxicology, University of California, Davis 95616, USA
Biochemistry 41:861-8. 2002..Overall, these results have not only allowed the identification of novel activators of the AhR but also demonstrate the utility of the recombinant H1G1.1c3 cell bioassay for high-throughput chemical screening...
- Arp2/3 mRNA localization and directional cell migrationGang Liu; Fiscal Year: 2008..unreadable] [unreadable]..