G Liu

Summary

Affiliation: Albany Medical College
Country: USA

Publications

  1. pmc Immediate translation of Formin DIAPH1 mRNA after its exiting the nucleus is required for its perinuclear localization in fibroblasts
    Guoning Liao
    Center for Cell Biology and Cancer Research, Albany Medical College, Albany, New York, United States of America
    PLoS ONE 8:e68190. 2013
  2. pmc Interactions of elongation factor 1alpha with F-actin and beta-actin mRNA: implications for anchoring mRNA in cell protrusions
    Gang Liu
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, New York, New York 10461, USA
    Mol Biol Cell 13:579-92. 2002
  3. pmc A quantitative evaluation of peroxidase inhibitors for tyramide signal amplification mediated cytochemistry and histochemistry
    G Liu
    Center for Cell Biology and Cancer Research, Albany Medical College, 47 New Scotland Avenue MC 165, Albany, NY 12208, USA
    Histochem Cell Biol 126:283-91. 2006
  4. pmc Localization of all seven messenger RNAs for the actin-polymerization nucleator Arp2/3 complex in the protrusions of fibroblasts
    Lisa A Mingle
    Center for Cell Biology and Cancer Research, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    J Cell Sci 118:2425-33. 2005
  5. ncbi request reprint The activation domains, the proline-rich domain, and the C-terminal basic domain in p53 are necessary for acetylation of histones on the proximal p21 promoter and interaction with p300/CREB-binding protein
    Gang Liu
    Department of Cell Biology, The University of Alabama, Birmingham, Alabama 35294, USA
    J Biol Chem 278:17557-65. 2003
  6. ncbi request reprint Regulation of RNA-polymerase-II-dependent transcription by N-WASP and its nuclear-binding partners
    Xiaoyang Wu
    Department of Molecular Medicine, Cornell University, Ithaca, NY 14853, USA
    Nat Cell Biol 8:756-63. 2006
  7. ncbi request reprint Aminopyridine carboxamides as c-Jun N-terminal kinase inhibitors: targeting the gatekeeper residue and beyond
    Gang Liu
    Metabolic Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064 6101, USA
    Bioorg Med Chem Lett 16:5723-30. 2006
  8. ncbi request reprint Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies
    Mei Liu
    Metabolic Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064 6098, USA
    Bioorg Med Chem Lett 17:668-72. 2007
  9. pmc Adamantyl-substituted retinoid-related molecules bind small heterodimer partner and modulate the Sin3A repressor
    Lulu Farhana
    John D Dingell Veterans Affairs Medical Center, 4646 John R Street, Detroit, MI 48201, USA
    Cancer Res 67:318-25. 2007
  10. ncbi request reprint Panning and identification of a colon tumor binding peptide from a phage display peptide library
    Yangde Zhang
    National Key Laboratory of Nanobiological Technology, Changsha, Hunan, China
    J Biomol Screen 12:429-35. 2007

Collaborators

  • Robert H Singer
  • Philip J Hajduk
  • Claudio N Cavasotto
  • Susan E Nozell
  • Michael Denison
  • Robert Liddington
  • B Liu
  • Yubo Sun
  • Thorsten K Oost
  • Cheryll Tickle
  • Bruce G Szczepankiewicz
  • Zhonghua Pei
  • Zhili Xin
  • Guoning Liao
  • Cele Abad-Zapatero
  • James M Trevillyan
  • Young Jun Park
  • Hongyu Zhou
  • Mei Liu
  • Robert M Rzasa
  • Yangde Zhang
  • Xiaojing Li
  • Haihua Yang
  • Lulu Farhana
  • Hing L Sham
  • Xiaoyang Wu
  • Nataly N Okuhama
  • Hong Mei Yang
  • Lisa A Mingle
  • Hongyu Zhao
  • Nian Huan Yao
  • Thomas H Lubben
  • Kit S Lam
  • Peng cheng Zhu
  • Charles W Hutchins
  • Scott R Nagy
  • Guangbo Qu
  • Xia Zhao
  • Bin Zhang
  • Bing Yan
  • Qiu Zhang
  • Yuyan Chen
  • Emmanuel F Lorne
  • Qingxin Mu
  • Yuko Tsuruta
  • Edward Abraham
  • Sulian Gao
  • Jing Wang
  • Jaroslaw Zmijewski
  • Ningning Gao
  • Yuehan Xing
  • Aifeng Liu
  • Linqi Wang
  • Zeben Xia
  • Xiaoling Xiong
  • Matthew Towers
  • David D Moore
  • Andrew Bain
  • Jia Liu
  • Sheng Ou
  • Jiji Chen
  • Suzanne Duce
  • Elizabeth H Fry
  • Duosha Hu
  • Jiwei Wang
  • Seaneen Tenent
  • Deanna L Haasch
  • Lifeng Ren
  • Matthew R Kaller
  • Jingfeng Zhao
  • Yuqing Tian
  • Rebecca J Gum
  • Li Wang
  • Neema Jaberi
  • Laura McDonald
  • Ruth Mahood
  • Ella Magal
  • Huarong Tan
  • Hui Ling Wang
  • Yifeng Pan
  • Katy Schmidt
  • Jill E Clampit
  • Sanyi Wang
  • Joseph A Fontana
  • Craig Cunningham
  • Timothy D Osslund
  • Kevin Beattie
  • Vincent J Santora
  • Sandy Chudek
  • Mark H Norman

Detail Information

Publications32

  1. pmc Immediate translation of Formin DIAPH1 mRNA after its exiting the nucleus is required for its perinuclear localization in fibroblasts
    Guoning Liao
    Center for Cell Biology and Cancer Research, Albany Medical College, Albany, New York, United States of America
    PLoS ONE 8:e68190. 2013
    ..Furthermore, a correlation of DIAPH1 mRNA and DIAPH1 protein localization has been demonstrated using a new method to quantify the intracellular distribution of protein. ..
  2. pmc Interactions of elongation factor 1alpha with F-actin and beta-actin mRNA: implications for anchoring mRNA in cell protrusions
    Gang Liu
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, New York, New York 10461, USA
    Mol Biol Cell 13:579-92. 2002
    ..Taken together, these results implicate EF1alpha in the anchoring of beta-actin mRNA to the protrusion in crawling cells...
  3. pmc A quantitative evaluation of peroxidase inhibitors for tyramide signal amplification mediated cytochemistry and histochemistry
    G Liu
    Center for Cell Biology and Cancer Research, Albany Medical College, 47 New Scotland Avenue MC 165, Albany, NY 12208, USA
    Histochem Cell Biol 126:283-91. 2006
    ..Our results recommend the use of HCl and caution the use of phenylhydrazine, glucose oxidase, NaN(3) and H(2)O(2) as potent peroxidase inhibitors...
  4. pmc Localization of all seven messenger RNAs for the actin-polymerization nucleator Arp2/3 complex in the protrusions of fibroblasts
    Lisa A Mingle
    Center for Cell Biology and Cancer Research, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    J Cell Sci 118:2425-33. 2005
    ..In addition, myosin inhibitors significantly inhibit Arp2 mRNA localization in chicken embryo fibroblasts, suggesting a myosin motor dependent mechanism for Arp2/3-complex mRNA localization...
  5. ncbi request reprint The activation domains, the proline-rich domain, and the C-terminal basic domain in p53 are necessary for acetylation of histones on the proximal p21 promoter and interaction with p300/CREB-binding protein
    Gang Liu
    Department of Cell Biology, The University of Alabama, Birmingham, Alabama 35294, USA
    J Biol Chem 278:17557-65. 2003
    ....
  6. ncbi request reprint Regulation of RNA-polymerase-II-dependent transcription by N-WASP and its nuclear-binding partners
    Xiaoyang Wu
    Department of Molecular Medicine, Cornell University, Ithaca, NY 14853, USA
    Nat Cell Biol 8:756-63. 2006
    ..Based on these results, we propose a nuclear function for N-WASP in transcriptional regulation...
  7. ncbi request reprint Aminopyridine carboxamides as c-Jun N-terminal kinase inhibitors: targeting the gatekeeper residue and beyond
    Gang Liu
    Metabolic Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064 6101, USA
    Bioorg Med Chem Lett 16:5723-30. 2006
    ..The syntheses of analogues and the impact of structural modification on in vitro potency and cellular activity are described...
  8. ncbi request reprint Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies
    Mei Liu
    Metabolic Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064 6098, USA
    Bioorg Med Chem Lett 17:668-72. 2007
    ..SAR studies led to the discovery of potent JNK1 inhibitors with good enzymatic activity as well as cellular potency represented by compound 2b. Kinase selectivity profile and the crystal structure of 2b are also described...
  9. pmc Adamantyl-substituted retinoid-related molecules bind small heterodimer partner and modulate the Sin3A repressor
    Lulu Farhana
    John D Dingell Veterans Affairs Medical Center, 4646 John R Street, Detroit, MI 48201, USA
    Cancer Res 67:318-25. 2007
    ..These results suggest that AHPN/3-Cl-AHPC and their analogues are SHP ligands and their induction of apoptosis is mediated by their binding to the SHP receptor...
  10. ncbi request reprint Panning and identification of a colon tumor binding peptide from a phage display peptide library
    Yangde Zhang
    National Key Laboratory of Nanobiological Technology, Changsha, Hunan, China
    J Biomol Screen 12:429-35. 2007
    ..These studies suggest that peptide CP15 may be a promising lead candidate in the development of a useful colon tumor diagnostic and targeted drug delivery agent...
  11. ncbi request reprint The tyrosine degradation gene hppD is transcriptionally activated by HpdA and repressed by HpdR in Streptomyces coelicolor, while hpdA is negatively autoregulated and repressed by HpdR
    Haihua Yang
    State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Science, Beijing 100101, China
    Mol Microbiol 65:1064-77. 2007
    ..These results suggested that the transcription of hppD is subject to coarse and fine control by a complex regulatory system...
  12. ncbi request reprint Structure-activity relationships of 3,4-dihydro-1H-quinazolin-2-one derivatives as potential CDK5 inhibitors
    Robert M Rzasa
    Department of Chemistry Research and Discovery, Amgen Inc, One Amgen Center Drive, Thousand Oaks, CA 91320 1789, USA
    Bioorg Med Chem 15:6574-95. 2007
    ..In this investigation we present our synthetic studies toward this series of compounds and discuss their biological relevance as CDK5 inhibitors...
  13. pmc Micro-magnetic resonance imaging of avian embryos
    Xiaojing Li
    Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, UK
    J Anat 211:798-809. 2007
    ..The work with the living quail embryos lays the foundations for using micro-magnetic resonance imaging as an experimental tool to follow the consequences of such manipulations over time...
  14. doi request reprint A nano-combinatorial library strategy for the discovery of nanotubes with reduced protein-binding, cytotoxicity, and immune response
    Hongyu Zhou
    St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nano Lett 8:859-65. 2008
    ..Our results demonstrated the general utility of the nanocombinatorial library approach in nanomedicine and nanotoxicity research...
  15. doi request reprint An enzyme-based E-DNA sensor for sequence-specific detection of femtomolar DNA targets
    Gang Liu
    Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China
    J Am Chem Soc 130:6820-5. 2008
    ..By using this new strategy, we demonstrate that the prototype E-DNA sensor has been able to detect as low as femtomolar DNA targets with excellent differentiation ability for even single mismatches...
  16. pmc PAI-1 inhibits neutrophil efferocytosis
    Young Jun Park
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Proc Natl Acad Sci U S A 105:11784-9. 2008
    ..Our data therefore indicate that PAI-1 serves as a novel "don't eat me" signal for viable and apoptotic neutrophils...
  17. pmc High mobility group protein-1 inhibits phagocytosis of apoptotic neutrophils through binding to phosphatidylserine
    Gang Liu
    Department of Medicine, University of Alabama, Birmingham, AL 35294, USA
    J Immunol 181:4240-6. 2008
    ..These findings demonstrate that HMGB1 can modulate phagocytosis of apoptotic neutrophils and suggest an alternative mechanism by which HMGB1 is involved in enhancing inflammatory responses...
  18. ncbi request reprint The ferredoxin reductase gene is regulated by the p53 family and sensitizes cells to oxidative stress-induced apoptosis
    Gang Liu
    Department of Cell Biology, UAB Comprehensive Cancer Center, The University of Alabama at Birmingham, Birmingham, Alabama, AL 35294, USA
    Oncogene 21:7195-204. 2002
    ....
  19. ncbi request reprint Molecular cloning of a novel rat gene Tsarg1, a member of the DnaJ/HSP40 protein family
    Hong Mei Yang
    Human Reproductive and Stem Cell Engineering Institute, Central South University, Changsha, P R China
    DNA Seq 16:166-72. 2005
    ..The results of RT-PCR and Northern blot analysis showed that Tsarg1 was specifically expressed in rat testis, which probably inhibits rat testis spermatogenic cell apoptosis...
  20. ncbi request reprint Discovery of a potent, selective protein tyrosine phosphatase 1B inhibitor using a linked-fragment strategy
    Bruce G Szczepankiewicz
    Metabolic Disease Research, Global Pharmaceutical Research and Development Organization, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064, USA
    J Am Chem Soc 125:4087-96. 2003
    ..The modular approach to drug design described in this work should be applicable for the design of potent and selective inhibitors of other therapeutically relevant protein tyrosine phosphatases...
  21. ncbi request reprint Potent, selective inhibitors of protein tyrosine phosphatase 1B
    Zhili Xin
    Metabolic Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064 6098, USA
    Bioorg Med Chem Lett 13:1887-90. 2003
    ....
  22. ncbi request reprint Fragment screening and assembly: a highly efficient approach to a selective and cell active protein tyrosine phosphatase 1B inhibitor
    Gang Liu
    Metabolic Disease Research and Advanced Technology, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064 6098, USA
    J Med Chem 46:4232-5. 2003
    ....
  23. pmc DeltaNp73beta is active in transactivation and growth suppression
    Gang Liu
    Department of Cell Biology, The University of Alabama at Birmingham, 1530 3rd Avenue, Birmingham, AL 35294 0005, USA
    Mol Cell Biol 24:487-501. 2004
    ..However, unlike DeltaNp73beta, DeltaNp73alpha is inactive in suppressing cell growth. Our data, together with others' previous findings, suggest that DeltaNp73beta may have distinct functions under certain cellular circumstances...
  24. ncbi request reprint Molecular cloning of TSARG6 gene related to apoptosis in human spermatogenic cells
    Gang Liu
    Human Reproductive and Stem Cell Engineering Institute, Central South University, Changsha 410078, China
    Acta Biochim Biophys Sin (Shanghai) 36:93-8. 2004
    ..8 kb. Based upon all these observations, it is considered that we cloned a new gene which probably inhibited human testis spermatogenesis apoptosis...
  25. ncbi request reprint Determinants of retinoid X receptor transcriptional antagonism
    Claudio N Cavasotto
    Cancer Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    J Med Chem 47:4360-72. 2004
    ..The antagonist also blocked activation of RAR subtypes alpha and beta by 9-cis-RA but not that of RARgamma...
  26. ncbi request reprint Inhibition of protein tyrosine phosphatase 1B as a potential treatment of diabetes and obesity
    Zhonghua Pei
    Metabolic Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Curr Pharm Des 10:3481-504. 2004
    ....
  27. ncbi request reprint A pathway-specific transcriptional regulatory gene for nikkomycin biosynthesis in Streptomyces ansochromogenes that also influences colony development
    Gang Liu
    State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Science, Beijing 100080, China
    Mol Microbiol 55:1855-66. 2005
    ..These results suggested that sanG encodes a transcriptional activator important for nikkomycin biosynthesis that, unusually, also has pleiotropic effects on secondary metabolism and development...
  28. ncbi request reprint The C-terminal sterile alpha motif and the extreme C terminus regulate the transcriptional activity of the alpha isoform of p73
    Gang Liu
    Department of Cell Biology, The University of Alabama, Birmingham, 35294, USA
    J Biol Chem 280:20111-9. 2005
    ..Finally, we showed that both inhibitory domains suppress the ability of p73 to interact with the transcriptional coactivators p300/CBP that are necessary for the initiation of transcription...
  29. ncbi request reprint Structure-activity relationship studies on tetralin carboxamide growth hormone secretagogue receptor antagonists
    Hongyu Zhao
    Metabolic Disease Research, Global Pharmaceutical Research and Development, R4MC, AP 10, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 6098, USA
    Bioorg Med Chem Lett 15:1825-8. 2005
    ..It was found that certain 2-alkoxycarbonylamino substituted tetralin carboxamides are potent, selective, and orally bioavailable GHS-R antagonists...
  30. ncbi request reprint Solid-phase synthesis and antibacterial evaluations of N-demethylvancomycin derivatives
    Nian Huan Yao
    Chinese Academy of Medical Sciences and Peking Union Medical College, Institute of Materia Medica, 1 Xian Nong Tan Street, Beijing 100050, PR China
    Bioorg Med Chem Lett 15:2325-9. 2005
    ..Biological evaluation of these compounds indicated that bulky hydrophobic substituent on vancosamine of N-demethylvancomycin can increase antibacterial activity against vancomycin-resistant Enterococcus faecalis...
  31. ncbi request reprint The interaction between ADAM 22 and 14-3-3zeta: regulation of cell adhesion and spreading
    Peng cheng Zhu
    State Key Laboratory of Genetic Engineering, Institute of Genetics, Fudan University School of Life Science, 200433, Shanghai, PR China
    Biochem Biophys Res Commun 301:991-9. 2003
    ....
  32. ncbi request reprint Identification of novel Ah receptor agonists using a high-throughput green fluorescent protein-based recombinant cell bioassay
    Scott R Nagy
    Department of Environmental Toxicology, University of California, Davis 95616, USA
    Biochemistry 41:861-8. 2002
    ..Overall, these results have not only allowed the identification of novel activators of the AhR but also demonstrate the utility of the recombinant H1G1.1c3 cell bioassay for high-throughput chemical screening...