MICHELLE LENNARTZ

Summary

Affiliation: Albany Medical College
Country: USA

Publications

  1. ncbi A role for PKC-epsilon in Fc gammaR-mediated phagocytosis by RAW 264.7 cells
    Elaine C Larsen
    Centers for Cell Biology and Cancer Research, Albany Medical College, Albany, NY 12208, USA
    J Cell Biol 159:939-44. 2002
  2. ncbi Ligation of macrophage Fcγ receptors recapitulates the gene expression pattern of vulnerable human carotid plaques
    Michelle R Lennartz
    Center for Cell Biology and Cancer Research, Albany Medical College, Albany, New York, United States of America
    PLoS ONE 6:e21803. 2011
  3. ncbi Differential effect of Fc gamma receptor ligation on LPS-stimulated TNF-alpha secretion by hepatic, splenic, and peritoneal macrophages
    Daniel J Loegering
    Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 12208, USA
    Inflammation 26:305-10. 2002
  4. ncbi Signaling pathways for Fc gamma receptor-stimulated tumor necrosis factor-alpha secretion and respiratory burst in RAW 264.7 macrophages
    Daniel J Loegering
    Center for Cardiovascular Sciences, Albany Medical College, Albany, New York 12208, USA
    Inflammation 28:23-31. 2004
  5. ncbi Francisella tularensis LVS grown in macrophages has reduced ability to stimulate the secretion of inflammatory cytokines by macrophages in vitro
    Daniel J Loegering
    Center for Cardiovascular Sciences, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    Microb Pathog 41:218-25. 2006
  6. ncbi Role of PKC isoforms in the Fc(gamma)R-mediated inhibition of LPS-stimulated IL-12 secretion by macrophages
    Van Fronhofer
    Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208-3479, USA
    J Leukoc Biol 79:408-15. 2006
  7. ncbi Targeting of protein kinase C-epsilon during Fcgamma receptor-dependent phagocytosis requires the epsilonC1B domain and phospholipase C-gamma1
    Keylon L Cheeseman
    Center for Cell Biology and Cancer Research, Albany Medical College, Albany, NY 12208, USA
    Mol Biol Cell 17:799-813. 2006
  8. ncbi Multiplexed cytokine detection in microliter microdialysis samples obtained from activated cultured macrophages
    Xiaoping Ao
    Department of Chemistry and Chemical Biology and Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, 110 Eighth Street, Troy, NY 12180-3590, USA
    J Pharm Biomed Anal 40:915-21. 2006
  9. ncbi Isoform-specific membrane targeting mechanism of Rac during Fc gamma R-mediated phagocytosis: positive charge-dependent and independent targeting mechanism of Rac to the phagosome
    Takehiko Ueyama
    Laboratory of Molecular Pharmacology, Biosignal Research Center, Kobe University, Kobe, Japan
    J Immunol 175:2381-90. 2005
  10. ncbi Superoxide production at phagosomal cup/phagosome through beta I protein kinase C during Fc gamma R-mediated phagocytosis in microglia
    Takehiko Ueyama
    Laboratory of Molecular Pharmacology, Biosignal Research Center, Kobe University, Kobe, Japan
    J Immunol 173:4582-9. 2004

Research Grants

  1. Protein Kinase C in Macrophage Activation
    MICHELLE LENNARTZ; Fiscal Year: 2006
  2. Role of Protein Kinase C in Macrophage Activation
    Michelle R Lennartz; Fiscal Year: 2010
  3. Role of Protein Kinase C in Macrophage Activation
    Michelle R Lennartz; Fiscal Year: 2010

Collaborators

  • Daniel J Loegering
  • Xiangdan Wang
  • Takehiko Ueyama
  • Naoaki Saito
  • Yasuhito Shirai
  • Julie A Stenken
  • Van Fronhofer
  • Keylon L Cheeseman
  • Xiaoping Ao
  • Toshihiro Kobayashi
  • Hideki Sumimoto
  • Elaine C Larsen
  • Lindsay A Flax
  • Tanya M Michaud
  • Demin Wang
  • Kaori Kashiwagi
  • Mika Eto
  • Keiichiro Kami
  • Ryu Takeya
  • Toshihiko Tatsuno
  • Shigeto Hayashi
  • Makoto Sawada
  • Yukiko Noda
  • Norio Sakai
  • Kyoko Rikitake
  • Tomoko Yamasaki
  • Harumichi Seguchi
  • Christer Larsson
  • Pamela M Brannock
  • Peter B Weber

Detail Information

Publications12

  1. ncbi A role for PKC-epsilon in Fc gammaR-mediated phagocytosis by RAW 264.7 cells
    Elaine C Larsen
    Centers for Cell Biology and Cancer Research, Albany Medical College, Albany, NY 12208, USA
    J Cell Biol 159:939-44. 2002
    ..These results demonstrate a role for PKC- epsilon in Fc gammaR-mediated phagocytosis that is independent of its effects on actin assembly...
  2. ncbi Ligation of macrophage Fcγ receptors recapitulates the gene expression pattern of vulnerable human carotid plaques
    Michelle R Lennartz
    Center for Cell Biology and Cancer Research, Albany Medical College, Albany, New York, United States of America
    PLoS ONE 6:e21803. 2011
    ..That ligation of FcγR recapitulates the pattern of gene expression in vulnerable plaques suggests that the FcγR → macrophage activation pathway may play a greater role in human plaque vulnerability than previously appreciated...
  3. ncbi Differential effect of Fc gamma receptor ligation on LPS-stimulated TNF-alpha secretion by hepatic, splenic, and peritoneal macrophages
    Daniel J Loegering
    Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 12208, USA
    Inflammation 26:305-10. 2002
    ..Thus, the ability of FcgammaR ligation to influence TNF-alpha secretion may be specific to the tissue source of the macrophages...
  4. ncbi Signaling pathways for Fc gamma receptor-stimulated tumor necrosis factor-alpha secretion and respiratory burst in RAW 264.7 macrophages
    Daniel J Loegering
    Center for Cardiovascular Sciences, Albany Medical College, Albany, New York 12208, USA
    Inflammation 28:23-31. 2004
    ..Thus, interferon-gamma treated RAW 264.7 cells are a model of inflammatory macrophages and are well suited for further study of these signaling pathways...
  5. ncbi Francisella tularensis LVS grown in macrophages has reduced ability to stimulate the secretion of inflammatory cytokines by macrophages in vitro
    Daniel J Loegering
    Center for Cardiovascular Sciences, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    Microb Pathog 41:218-25. 2006
    ..tularensis that is associated with decreased stimulation of cytokine secretion, inhibition of LPS-stimulated secretion of inflammatory cytokines by macrophages and increased lethality in mice...
  6. ncbi Role of PKC isoforms in the Fc(gamma)R-mediated inhibition of LPS-stimulated IL-12 secretion by macrophages
    Van Fronhofer
    Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208-3479, USA
    J Leukoc Biol 79:408-15. 2006
    ..Down-regulation of PKC-alpha had no effect on LPS-stimulated IL-12p40 secretion. The results suggest a negative role for PKC-delta and a positive role for PKC-epsilon in the regulation of LPS-stimulated IL-12p40 secretion...
  7. ncbi Targeting of protein kinase C-epsilon during Fcgamma receptor-dependent phagocytosis requires the epsilonC1B domain and phospholipase C-gamma1
    Keylon L Cheeseman
    Center for Cell Biology and Cancer Research, Albany Medical College, Albany, NY 12208, USA
    Mol Biol Cell 17:799-813. 2006
    ..Together, these results support a model in which PI-PLC-gamma1 provides DAG that binds to epsilonC1B, facilitating PKC-epsilon localization to phagosomes for efficient IgG-mediated phagocytosis...
  8. ncbi Multiplexed cytokine detection in microliter microdialysis samples obtained from activated cultured macrophages
    Xiaoping Ao
    Department of Chemistry and Chemical Biology and Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, 110 Eighth Street, Troy, NY 12180-3590, USA
    J Pharm Biomed Anal 40:915-21. 2006
    ..These results demonstrate that microdialysis sampling can be used for collection of selected cytokines with improved temporal resolution...
  9. ncbi Isoform-specific membrane targeting mechanism of Rac during Fc gamma R-mediated phagocytosis: positive charge-dependent and independent targeting mechanism of Rac to the phagosome
    Takehiko Ueyama
    Laboratory of Molecular Pharmacology, Biosignal Research Center, Kobe University, Kobe, Japan
    J Immunol 175:2381-90. 2005
    ..In addition to this mechanism, Rac2 has a positive charge-independent mechanism in which Rac2 initially targets to endomembranes and then these endomembranes fuse to the phagosome...
  10. ncbi Superoxide production at phagosomal cup/phagosome through beta I protein kinase C during Fc gamma R-mediated phagocytosis in microglia
    Takehiko Ueyama
    Laboratory of Molecular Pharmacology, Biosignal Research Center, Kobe University, Kobe, Japan
    J Immunol 173:4582-9. 2004
    ..This study also suggests that DGKbeta plays a prominent role in regulation of O(2)(-) production during FcgammaR-mediated phagocytosis...
  11. ncbi Interleukin-6 collection through long-term implanted microdialysis sampling probes in rat subcutaneous space
    Xiangdan Wang
    Department of Chemistry and Chemical Biology and Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, 110 Eighth Street, Troy, New York 12180 3590, USA
    Anal Chem 79:1816-24. 2007
    ....
  12. ncbi Multiplexed cytokine detection of interstitial fluid collected from polymeric hollow tube implants--a feasibility study
    Xiangdan Wang
    Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, 110 Eighth Street, Troy, NY 12180 3590, USA
    Cytokine 43:15-9. 2008
    ....

Research Grants9

  1. Protein Kinase C in Macrophage Activation
    MICHELLE LENNARTZ; Fiscal Year: 2006
    ..Defining the mechanisms by which PKC transduces the phagocytic signal is critical to our understanding of host defense and the defects that result in autoimmune diseases. ..
  2. Role of Protein Kinase C in Macrophage Activation
    Michelle R Lennartz; Fiscal Year: 2010
    ..Understanding membrane remodeling using phagocytosis as a model system will advance our knowledge of the innate immune system and may be applicable to other cell processes, including tumor metastasis and wound healing. ..
  3. Role of Protein Kinase C in Macrophage Activation
    Michelle R Lennartz; Fiscal Year: 2010
    ..Understanding membrane remodeling using phagocytosis as a model system will advance our knowledge of the innate immune system and may be applicable to other cell processes, including tumor metastasis and wound healing. ..