Research Topics
| H K KimelbergSummaryAffiliation: Albany Medical College Country: USA Publications
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Detail Information
Publications
Acutely isolated astrocytes as models to probe astrocyte functionsH K Kimelberg
Division of Neurosurgery, Albany Medical College, NY 12208, USA
Neurochem Int 36:359-67. 2000....- Freshly isolated astrocytes from rat hippocampus show two distinct current patterns and different [K(+)](o) uptake capabilitiesM Zhou
Center for Neuropharmacology and Neuroscience and Division of Neurosurgery, Albany Medical College, Albany, New York 12208, USA
J Neurophysiol 84:2746-57. 2000..ORAs show abundant outward potassium currents with more depolarized RMP. Thus VRAs and ORAs may cooperate in vivo for uptake and release of K(+), respectively... - Neuroprotective activity of tamoxifen in permanent focal ischemiaHarold K Kimelberg
Center for Neuropharmacology and Neuroscience, and Division of Neurosurgery, Albany Medical College, Albany, New York 12208, USA
J Neurosurg 99:138-42. 2003..In this study the authors tested whether similar protective effects are found in a rat model of permanent focal ischemia (permanent middle cerebral artery [MCA] occlusion)... - Freshly isolated hippocampal CA1 astrocytes comprise two populations differing in glutamate transporter and AMPA receptor expressionM Zhou
Center for Neuropharmacology and Neuroscience and Division of Neurosurgery, Albany Medical College, Albany, New York 12208, USA
J Neurosci 21:7901-8. 2001..This heterogeneity implies that GFAP+ astrocytes may participate in or modulate glutamate synaptic transmission differently... - Sodium channel currents in rat hippocampal NG2 glia: characterization and contribution to resting membrane potentialM Xie
Neural and Vascular Biology, Ordway Research Institute, 150 New Scotland Avenue, Albany, NY 12208, USA
Neuroscience 150:853-62. 2007..14 at RMP which is approximately threefold higher than astrocytes (0.05). These results indicate that a TTX sensitive I(Na) component in NG2 glia contributes significantly to the depolarized NG2 glia RMP in the developing brain... - Developmental expression of metabotropic P2Y(1) and P2Y(2) receptors in freshly isolated astrocytes from rat hippocampusY Zhu
Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York, USA
J Neurochem 77:530-41. 2001.... - Tamoxifen inhibits nitrotyrosine formation after reversible middle cerebral artery occlusion in the ratK Osuka
Division of Neurosurgery, Albany Medical College, Albany 12208, USA
J Neurochem 76:1842-50. 2001.... - Current methods and approaches to studying astrocytes: a forum position paperH K Kimelberg
Department of Pharmacology and Neurosciences, Neuroscience and Neuropharmacology Research Group and Division of Neurosurgery, Albany Medical College, NY 12208, USA
Neurotoxicology 20:703-12; discussion 719-22. 1999..Different and alternative systems to primary astrocyte cultures are described and critically evaluated in this article... 
DCPIB, a specific inhibitor of volume regulated anion channels (VRACs), reduces infarct size in MCAo and the release of glutamate in the ischemic cortical penumbraYonghua Zhang
Neural and Vascular Biology Theme, Ordway Research Institute, Albany, New York 12208, USA
Exp Neurol 210:514-20. 2008..v. These experiments support the hypothesis that EAA released via VRACs contributes to later ischemic-induced damage...- Neuroprotection by tamoxifen in focal cerebral ischemia is not mediated by an agonist action at estrogen receptors but is associated with antioxidant activityYonghua Zhang
Neural and Vascular Biology Theme, Ordway Research Institute, 150 New Scotland Avenue, Albany, NY 12208, USA
Exp Neurol 204:819-27. 2007..These data are consistent with at least part of tamoxifen's marked neuroprotection in focal cerebral ischemic injury being due to its antioxidant activity but not by an acute action on estrogen receptors (212 words)... - Anion channels in astrocytes: biophysics, pharmacology, and functionHarold K Kimelberg
Neural and Vascular Biology Theme, Ordway Research Institute, Albany, New York 12208, USA
Glia 54:747-57. 2006..However, the identity of these channels in astrocytes, as in all other cells, remains elusive. The potential involvement of VRACs in pathological states such as stroke, metastasis, and spreading depression is also discussed... - Neuroprotection by pyrroloquinoline quinone (PQQ) in reversible middle cerebral artery occlusion in the adult ratYonghua Zhang
Neural and Vascular Biology, Ordway Research Institute, 150 New Scotland Avenue, Albany, NY 12208, USA
Brain Res 1094:200-6. 2006..Thus, PQQ is neuroprotective when given as a single administration at least 3 h after initiation of rMCAo. These data indicate that PQQ may be a useful neuroprotectant in stroke therapy... - Pharmacological comparison of swelling-activated excitatory amino acid release and Cl- currents in cultured rat astrocytesIskandar F Abdullaev
Ordway Research Institute, Albany, NY 12208, USA
J Physiol 572:677-89. 2006..Taken together, our data suggest that (i) astrocytic volume-dependent EAA release is largely mediated by the VRAC, and (ii) the ClC-2, ClC-3, ClC-4, ClC-5, VDAC, CaCC, MDR-1 and CFTR gene products do not contribute to EAA permeability... - Hydrogen peroxide potentiates volume-sensitive excitatory amino acid release via a mechanism involving Ca2+/calmodulin-dependent protein kinase IIRENEE E HASKEW-LAYTON
Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
J Biol Chem 280:3548-54. 2005..These data demonstrate that H2O2 strongly up-regulates astrocytic volume-sensitive EAA release via a CaMKII-dependent mechanism and in this way may potently promote pathological EAA release and brain damage in ischemia... - ATP regulates anion channel-mediated organic osmolyte release from cultured rat astrocytes via multiple Ca2+-sensitive mechanismsAlexander A Mongin
Center for Neuropharmacology and Neuroscience, Albany Medical College, New York 12208, USA
Am J Physiol Cell Physiol 288:C204-13. 2005..Ca(2+)-dependent organic osmolyte release via VRACs may contribute to the physiological functions of these channels in the brain, including astrocyte-to-neuron intercellular communication... - Increased release of excitatory amino acids by the actions of ATP and peroxynitrite on volume-regulated anion channels (VRACs) in astrocytesHarold K Kimelberg
Neural and Vascular Biology Theme, Ordway Research Institute, Inc, 150 New Scotland Ave, Albany, NY 12208, USA
Neurochem Int 45:511-9. 2004..Thus, the enhancement of cell volume-dependent release of excitatory amino acids from astrocytes can be physiological or pathological and its magnitude depends on the degree of the cell volume increase... - Volume activated anion channel and astrocytic cellular edema in traumatic brain injury and strokeHarold K Kimelberg
Neural and Vascular Biology Theme, Ordway Research Institute, 150 New Scotland Avenue, Albany, NY 12208, USA
Adv Exp Med Biol 559:157-67. 2004 - Volume-regulated anion channels are the predominant contributors to release of excitatory amino acids in the ischemic cortical penumbraPaul J Feustel
Center for Neuropharmacology and Neuroscience, MC136, Albany Medical College, Albany, New York, USA
Stroke 35:1164-8. 2004.... - ATP potently modulates anion channel-mediated excitatory amino acid release from cultured astrocytesAlexander A Mongin
Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
Am J Physiol Cell Physiol 283:C569-78. 2002..Moderate cell swelling and ATP may serve as two cooperative signals in bidirectional neuron-astrocyte communication in vivo... - Peroxynitrite enhances astrocytic volume-sensitive excitatory amino acid release via a src tyrosine kinase-dependent mechanismRenée E Haskew
Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
J Neurochem 82:903-12. 2002..This modulation may contribute to EAA-mediated neuronal damage in ischemia and other pathological conditions favoring cell swelling and ONOO- production... - Inhibition of release of taurine and excitatory amino acids in ischemia and neuroprotectionHarold K Kimelberg
Center for Neuropharmacology and Neuroscience and Division of Neurosurgery Albany Medical College, Albany, New York, USA
Neurochem Res 29:267-74. 2004..Although tamoxifen cannot therefore be used as a test of the "VRAC-excitotxicity" hypothesis it may prove successful for translation of basic stroke research to the clinic because of its multiple targets... - Tamoxifen as a powerful neuroprotectant in experimental stroke and implications for human stroke therapyHarold K Kimelberg
Neural and Vascular Biology, Ordway Research Institute, 150 New Scotland Ave, Albany, NY 12208, USA
Recent Pat CNS Drug Discov 3:104-8. 2008..Differences that may make tamoxifen still desirable and the problem of predicting clinical efficacy from successful animal studies are discussed... - Oxygen and glucose deprivation-induced changes in astrocyte membrane potential and their underlying mechanisms in acute rat hippocampal slicesMinjie Xie
Department of Neural and Vascular Biology, Ordway Research Institute, Albany, NY 12208, USA
J Cereb Blood Flow Metab 28:456-67. 2008.... - Electrophysiologically "complex" glial cells freshly isolated from the hippocampus are immunopositive for the chondroitin sulfate proteoglycan NG2Gary P Schools
Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
J Neurosci Res 73:765-77. 2003.... - Is autocrine ATP release required for activation of volume-sensitive chloride channels?Alexander A Mongin
J Neurophysiol 90:2791-2; author reply 2792-3. 2003 - Development of gap junctions in hippocampal astrocytes: evidence that whole cell electrophysiological phenotype is an intrinsic property of the individual cellGary P Schools
Neural and Vascular Biology Theme, Ordway Research Institute, Inc, Albany, NY 12208, USA
J Neurophysiol 96:1383-92. 2006.... - Cellular expression of P2Y and beta-AR receptor mRNAs and proteins in freshly isolated astrocytes and tissue sections from the CA1 region of P8-12 rat hippocampusYingzi Zhu
Center for Neuropharmacology and Neuroscience, USA
Brain Res Dev Brain Res 148:77-87. 2004..These data show that astrocytes in situ express, and to a large extent likely co-express, beta-AR and P2Y receptors... - Development of GLAST(+) astrocytes and NG2(+) glia in rat hippocampus CA1: mature astrocytes are electrophysiologically passiveMin Zhou
Neural and Vascular Biology, Ordway Research Inst, 150 New Scotland Ave, Albany, NY 12208, USA
J Neurophysiol 95:134-43. 2006..While most glia in the NG2 lineage preserve a certain amount of voltage-gated ion conductances, mature GLAST(+) astrocytes are electrophysiologically passive... - Behavioral and histological neuroprotection by tamoxifen after reversible focal cerebral ischemiaYonghua Zhang
Neural and Vascular Biology Theme, Ordway Research Institute, Albany, NY 12208, USA
Exp Neurol 196:41-6. 2005..If these results are extrapolatable to human stroke, these data indicate that tamoxifen may be a useful neuroprotectant... - Astrocytic swelling in cerebral ischemia as a possible cause of injury and target for therapyHarold K Kimelberg
Neural and Vascular Biology, Ordway Research Institute, Albany, New York 12208, USA
Glia 50:389-97. 2005..The question, however, of whether neuroprotection by tamoxifen can be solely attributed to VRAC inhibition in astrocytes has yet to be resolved... - The role of hypotheses in current research, illustrated by hypotheses on the possible role of astrocytes in energy metabolism and cerebral blood flow: from Newton to nowHarold K Kimelberg
Neural and Vascular Biology Theme, Ordway Research Institute, Albany, New York 12208, USA
J Cereb Blood Flow Metab 24:1235-9. 2004 - The problem of astrocyte identityHarold K Kimelberg
Neural and Vascular Biology Theme, Ordway Research Institute Inc, Center for Medical Science, 150 New Scotland Avenue, Albany, NY 12208, USA
Neurochem Int 45:191-202. 2004..This approach will no doubt be perfected with time but at present an acceptable, practical definition of what constitutes the class of astrocytes remains elusive...