Research Topics
Genomes and Genes | DAVID JOURD'HEUILSummaryAffiliation: Albany Medical College Country: USA Publications
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Publications
Oxidative and drug-induced alterations in brush border membrane hemileaflet fluidity, functional consequences for glucose transportD JOURD'HEUIL
Center for Cardiovascular Sciences, Albany Medical College, NY 12208, USA
Biochim Biophys Acta 1510:342-53. 2001..On the basis of these experiments, we propose that previous studies that reported coincidental alteration in membrane fluidity and glucose transport cannot be interpreted on the basis of bulk fluidity or hemileaflet fluidity...- Reaction of superoxide and nitric oxide with peroxynitrite. Implications for peroxynitrite-mediated oxidation reactions in vivoD JOURD'HEUIL
Center for Cardiovascular Sciences, Albany Medical College, Albany, New York 12208, USA
J Biol Chem 276:28799-805. 2001..The physiological implications of these findings are discussed... - Increased nitric oxide-dependent nitrosylation of 4,5-diaminofluorescein by oxidants: implications for the measurement of intracellular nitric oxideDAVID JOURD'HEUIL
Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 12208, USA
Free Radic Biol Med 33:676-84. 2002..Our findings indicate that DAF-2 fluorometric assays are quantitatively difficult to interpret in cells and in solution when oxidants and (*) NO are co-generated... - Oxidation and nitrosation of thiols at low micromolar exposure to nitric oxide. Evidence for a free radical mechanismDAVID JOURD'HEUIL
Center for Cardiovascular Sciences, Albany Medical College, 47 New Scotland Avenue MC8, Albany, NY 12208, USA
J Biol Chem 278:15720-6. 2003..Nitrosothiol formation in vivo depends not only on the availability of .NO and O2 but also on the degree of oxidative stress by affecting the steady-state concentration of thiyl radicals... 
Redox-sensitivity and site-specificity of S- and N- denitrosation in proteinsFrances L Jourd'heuil
Center for Cardiovascular Sciences, Albany Medical College, Albany, New York, United States of America
PLoS ONE 5:e14400. 2010..In this study, we characterized a redox-based mechanism by which N-nitroso-tryptophan residues in proteins may be denitrosated...- Cytoglobin is expressed in the vasculature and regulates cell respiration and proliferation via nitric oxide dioxygenationKatharine E Halligan
Center for Cardiovascular Sciences, Albany Medical College, Albany, New York 12208
J Biol Chem 284:8539-47. 2009..These results indicate that cytoglobin contributes to cell-mediated NO dioxygenation and represents an important NO sink in the vascular wall... - Regulation of smooth muscle by inducible nitric oxide synthase and NADPH oxidase in vascular proliferative diseasesRoman Ginnan
Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 12208, USA
Free Radic Biol Med 44:1232-45. 2008..Overall, the integration of nonphagocytic NADPH oxidase with cytokine signaling in general and in vascular smooth muscle in particular is poorly understood and merits further investigation... - Interplay between calcium and reactive oxygen/nitrogen species: an essential paradigm for vascular smooth muscle signalingMohamed Trebak
Center for Cardiovascular Sciences, Albany Medical College, New York, USA
Antioxid Redox Signal 12:657-74. 2010..In this review, we summarize and highlight current experimental evidence supporting the idea that cross-talk between Ca(2+) and ROS/RNS may represent a well-integrated signaling network in vascular smooth muscle... - Activation of microglia with zymosan promotes excitatory amino acid release via volume-regulated anion channels: the role of NADPH oxidasesTimothy J Harrigan
Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
J Neurochem 106:2449-62. 2008..Taken together, these data suggest that the anion channel VRAC may contribute to microglial glutamate release and that its activity is regulated by endogenous ROS originating from NOX4... - PKC-delta mediates activation of ERK1/2 and induction of iNOS by IL-1beta in vascular smooth muscle cellsRoman Ginnan
Center for Cardiovascular Sciences, MC 8, Albany Medical College, Albany, NY 12208, USA
Am J Physiol Cell Physiol 290:C1583-91. 2006..Taken together, we have outlined a novel transduction pathway implicating PKC-delta as a critical component of the IL-1-dependent activation of ERK in VSM cells... - Redox control of G(1)/S cell cycle regulators during nitric oxide-mediated cell cycle arrestQi Lu
Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 12208, USA
J Cell Physiol 212:827-39. 2007..Together, our results demonstrate that GSH serves as an important component of cellular protective mechanisms against NO-derived nitrosative stress to regulate DNA damage checkpoint... - Essential role for STIM1/Orai1-mediated calcium influx in PDGF-induced smooth muscle migrationJonathan M Bisaillon
Center for Cardiovascular Sciences, Albany Medical College, NY 12208, USA
Am J Physiol Cell Physiol 298:C993-1005. 2010.... - NADPH oxidase 4 is required for interleukin-1β-mediated activation of protein kinase Cδ and downstream activation of c-jun N-terminal kinase signaling in smooth muscleRoman Ginnan
Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 12208, USA
Free Radic Biol Med 54:125-34. 2013..Our study positions PKCδ as an important redox-sensitive mediator of IL-1β-dependent signaling and downstream activation of inflammatory mediators in VSM cells... - Selective vulnerability of synaptic signaling and metabolism to nitrosative stressAlexander A Mongin
Center for Neuropharmacology and Neuroscience, Albany Medical College, New York 12208, USA
Antioxid Redox Signal 17:992-1012. 2012..RECENT ADVANCES: Recent work in the field focused on the ability of NO and RNS to yield protein modifications, including the S-nitrosation of cysteine residues, which, in many instances, impact cellular functions and viability... - iNOS regulation by calcium/calmodulin-dependent protein kinase II in vascular smooth muscleRachel J Jones
Center for Cardiovascular Sciences, Albany Medical College, 43 New Scotland Ave, Albany, NY 12208, USA
Am J Physiol Heart Circ Physiol 292:H2634-42. 2007..The results suggest that CaMKIIdelta(2) may be an important regulator of iNOS trafficking and activity in VSMCs... - Long-lasting inhibition of presynaptic metabolism and neurotransmitter release by protein S-nitrosylationAlena Rudkouskaya
Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY 12208, USA
Free Radic Biol Med 49:757-69. 2010..A similar mechanism may contribute to the long-term suppression of neuronal communication during nitrosative stress in vivo... 
Xanthine oxidase-mediated denitrosation of N-nitroso-tryptophan by superoxide and uric acidKimberley Viles
Center for Cardiovascular Sciences, Albany Medical College, Albany, NY, USA
Nitric Oxide 28:57-64. 2013..Site-specificity of this reaction may possibly be used in combination with the tri-iodide-based chemiluminescence assay to discern between nitrosated Trp, S-nitrosothiols, and nitrosylated heme proteins...- Effects of low-dose fluticasone propionate/salmeterol combination therapy on exhaled nitric oxide and nitrite/nitrate in breath condensates from patients with mild persistent asthmaM Asghar Pasha
Division of Allergy and Immunology, Albany Medical College, Albany, NY, USA
J Asthma 50:64-70. 2013..Thus, we evaluated AHR, exhaled nitric oxide (FE(NO)), and nitrite and nitrate in exhaled breath condensates (EBCs) from mild persistent asthmatic patients treated with a low-dose FSC (100/50)... - Catalase potentiates interleukin-1beta-induced expression of nitric oxide synthase in rat vascular smooth muscle cellsBenjamin J Guikema
Center for Cardiovascular Sciences, Albany Medical College, 47 New Scotland Avenue MC8, Albany, NY 12208, USA
Free Radic Biol Med 38:597-605. 2005..The present results outline a novel role for H2O2 in suppressing signaling pathways leading to gene expression such as iNOS in VSMC in response to cytokines...
Research Grants
- Mechanisms of Nitric Oxide Mediated Cell InjuryDAVID JOURD HEUIL; Fiscal Year: 2005....