DAVID JOURD'HEUIL

Summary

Affiliation: Albany Medical College
Country: USA

Publications

  1. ncbi request reprint Oxidative and drug-induced alterations in brush border membrane hemileaflet fluidity, functional consequences for glucose transport
    D JOURD'HEUIL
    Center for Cardiovascular Sciences, Albany Medical College, NY 12208, USA
    Biochim Biophys Acta 1510:342-53. 2001
  2. ncbi request reprint Reaction of superoxide and nitric oxide with peroxynitrite. Implications for peroxynitrite-mediated oxidation reactions in vivo
    D JOURD'HEUIL
    Center for Cardiovascular Sciences, Albany Medical College, Albany, New York 12208, USA
    J Biol Chem 276:28799-805. 2001
  3. ncbi request reprint Increased nitric oxide-dependent nitrosylation of 4,5-diaminofluorescein by oxidants: implications for the measurement of intracellular nitric oxide
    DAVID JOURD'HEUIL
    Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 12208, USA
    Free Radic Biol Med 33:676-84. 2002
  4. ncbi request reprint Oxidation and nitrosation of thiols at low micromolar exposure to nitric oxide. Evidence for a free radical mechanism
    DAVID JOURD'HEUIL
    Center for Cardiovascular Sciences, Albany Medical College, 47 New Scotland Avenue MC8, Albany, NY 12208, USA
    J Biol Chem 278:15720-6. 2003
  5. pmc Redox-sensitivity and site-specificity of S- and N- denitrosation in proteins
    Frances L Jourd'heuil
    Center for Cardiovascular Sciences, Albany Medical College, Albany, New York, United States of America
    PLoS ONE 5:e14400. 2010
  6. pmc Cytoglobin is expressed in the vasculature and regulates cell respiration and proliferation via nitric oxide dioxygenation
    Katharine E Halligan
    Center for Cardiovascular Sciences, Albany Medical College, Albany, New York 12208
    J Biol Chem 284:8539-47. 2009
  7. ncbi request reprint Manganese superoxide dismutase protects from TNF-alpha-induced apoptosis by increasing the steady-state production of H2O2
    Jaya Dasgupta
    Center for Immunology and Microbial Disease, Albany Medical College, NY 12208, USA
    Antioxid Redox Signal 8:1295-305. 2006
  8. pmc NADPH oxidase 4 is required for interleukin-1β-mediated activation of protein kinase Cδ and downstream activation of c-jun N-terminal kinase signaling in smooth muscle
    Roman Ginnan
    Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 12208, USA
    Free Radic Biol Med 54:125-34. 2013
  9. pmc Regulation of smooth muscle by inducible nitric oxide synthase and NADPH oxidase in vascular proliferative diseases
    Roman Ginnan
    Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 12208, USA
    Free Radic Biol Med 44:1232-45. 2008
  10. pmc Interplay between calcium and reactive oxygen/nitrogen species: an essential paradigm for vascular smooth muscle signaling
    Mohamed Trebak
    Center for Cardiovascular Sciences, Albany Medical College, New York, USA
    Antioxid Redox Signal 12:657-74. 2010

Research Grants

  1. Mechanisms of Nitric Oxide Mediated Cell Injury
    DAVID JOURD HEUIL; Fiscal Year: 2005

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Oxidative and drug-induced alterations in brush border membrane hemileaflet fluidity, functional consequences for glucose transport
    D JOURD'HEUIL
    Center for Cardiovascular Sciences, Albany Medical College, NY 12208, USA
    Biochim Biophys Acta 1510:342-53. 2001
    ..On the basis of these experiments, we propose that previous studies that reported coincidental alteration in membrane fluidity and glucose transport cannot be interpreted on the basis of bulk fluidity or hemileaflet fluidity...
  2. ncbi request reprint Reaction of superoxide and nitric oxide with peroxynitrite. Implications for peroxynitrite-mediated oxidation reactions in vivo
    D JOURD'HEUIL
    Center for Cardiovascular Sciences, Albany Medical College, Albany, New York 12208, USA
    J Biol Chem 276:28799-805. 2001
    ..The physiological implications of these findings are discussed...
  3. ncbi request reprint Increased nitric oxide-dependent nitrosylation of 4,5-diaminofluorescein by oxidants: implications for the measurement of intracellular nitric oxide
    DAVID JOURD'HEUIL
    Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 12208, USA
    Free Radic Biol Med 33:676-84. 2002
    ..Our findings indicate that DAF-2 fluorometric assays are quantitatively difficult to interpret in cells and in solution when oxidants and (*) NO are co-generated...
  4. ncbi request reprint Oxidation and nitrosation of thiols at low micromolar exposure to nitric oxide. Evidence for a free radical mechanism
    DAVID JOURD'HEUIL
    Center for Cardiovascular Sciences, Albany Medical College, 47 New Scotland Avenue MC8, Albany, NY 12208, USA
    J Biol Chem 278:15720-6. 2003
    ..Nitrosothiol formation in vivo depends not only on the availability of .NO and O2 but also on the degree of oxidative stress by affecting the steady-state concentration of thiyl radicals...
  5. pmc Redox-sensitivity and site-specificity of S- and N- denitrosation in proteins
    Frances L Jourd'heuil
    Center for Cardiovascular Sciences, Albany Medical College, Albany, New York, United States of America
    PLoS ONE 5:e14400. 2010
    ..In this study, we characterized a redox-based mechanism by which N-nitroso-tryptophan residues in proteins may be denitrosated...
  6. pmc Cytoglobin is expressed in the vasculature and regulates cell respiration and proliferation via nitric oxide dioxygenation
    Katharine E Halligan
    Center for Cardiovascular Sciences, Albany Medical College, Albany, New York 12208
    J Biol Chem 284:8539-47. 2009
    ..These results indicate that cytoglobin contributes to cell-mediated NO dioxygenation and represents an important NO sink in the vascular wall...
  7. ncbi request reprint Manganese superoxide dismutase protects from TNF-alpha-induced apoptosis by increasing the steady-state production of H2O2
    Jaya Dasgupta
    Center for Immunology and Microbial Disease, Albany Medical College, NY 12208, USA
    Antioxid Redox Signal 8:1295-305. 2006
    ..These findings indicate that increases in the intracellular steady-state production of H(2)O(2) by SOD2 can block the activation of key processes fundamental to the process of programmed cell death...
  8. pmc NADPH oxidase 4 is required for interleukin-1β-mediated activation of protein kinase Cδ and downstream activation of c-jun N-terminal kinase signaling in smooth muscle
    Roman Ginnan
    Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 12208, USA
    Free Radic Biol Med 54:125-34. 2013
    ..Our study positions PKCδ as an important redox-sensitive mediator of IL-1β-dependent signaling and downstream activation of inflammatory mediators in VSM cells...
  9. pmc Regulation of smooth muscle by inducible nitric oxide synthase and NADPH oxidase in vascular proliferative diseases
    Roman Ginnan
    Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 12208, USA
    Free Radic Biol Med 44:1232-45. 2008
    ..Overall, the integration of nonphagocytic NADPH oxidase with cytokine signaling in general and in vascular smooth muscle in particular is poorly understood and merits further investigation...
  10. pmc Interplay between calcium and reactive oxygen/nitrogen species: an essential paradigm for vascular smooth muscle signaling
    Mohamed Trebak
    Center for Cardiovascular Sciences, Albany Medical College, New York, USA
    Antioxid Redox Signal 12:657-74. 2010
    ..In this review, we summarize and highlight current experimental evidence supporting the idea that cross-talk between Ca(2+) and ROS/RNS may represent a well-integrated signaling network in vascular smooth muscle...
  11. ncbi request reprint PKC-delta mediates activation of ERK1/2 and induction of iNOS by IL-1beta in vascular smooth muscle cells
    Roman Ginnan
    Center for Cardiovascular Sciences, MC 8, Albany Medical College, Albany, NY 12208, USA
    Am J Physiol Cell Physiol 290:C1583-91. 2006
    ..Taken together, we have outlined a novel transduction pathway implicating PKC-delta as a critical component of the IL-1-dependent activation of ERK in VSM cells...
  12. pmc Activation of microglia with zymosan promotes excitatory amino acid release via volume-regulated anion channels: the role of NADPH oxidases
    Timothy J Harrigan
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
    J Neurochem 106:2449-62. 2008
    ..Taken together, these data suggest that the anion channel VRAC may contribute to microglial glutamate release and that its activity is regulated by endogenous ROS originating from NOX4...
  13. ncbi request reprint Chemical considerations and biological selectivity of protein nitrosation: implications for NO-mediated signal transduction
    Benjamin Guikema
    Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 12208, USA
    Antioxid Redox Signal 7:593-606. 2005
    ....
  14. pmc Essential role for STIM1/Orai1-mediated calcium influx in PDGF-induced smooth muscle migration
    Jonathan M Bisaillon
    Center for Cardiovascular Sciences, Albany Medical College, NY 12208, USA
    Am J Physiol Cell Physiol 298:C993-1005. 2010
    ....
  15. ncbi request reprint Redox control of G(1)/S cell cycle regulators during nitric oxide-mediated cell cycle arrest
    Qi Lu
    Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 12208, USA
    J Cell Physiol 212:827-39. 2007
    ..Together, our results demonstrate that GSH serves as an important component of cellular protective mechanisms against NO-derived nitrosative stress to regulate DNA damage checkpoint...
  16. ncbi request reprint Detection of nitrosothiols and other nitroso species in vitro and in cells
    DAVID JOURD'HEUIL
    Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 12208, USA
    Methods Enzymol 396:118-31. 2005
    ..They also provide the means to characterize and identify proteins that may represent specific targets for nitrosation reactions...
  17. doi request reprint Effects of low-dose fluticasone propionate/salmeterol combination therapy on exhaled nitric oxide and nitrite/nitrate in breath condensates from patients with mild persistent asthma
    M Asghar Pasha
    Division of Allergy and Immunology, Albany Medical College, Albany, NY, USA
    J Asthma 50:64-70. 2013
    ..Thus, we evaluated AHR, exhaled nitric oxide (FE(NO)), and nitrite and nitrate in exhaled breath condensates (EBCs) from mild persistent asthmatic patients treated with a low-dose FSC (100/50)...
  18. pmc Selective vulnerability of synaptic signaling and metabolism to nitrosative stress
    Alexander A Mongin
    Center for Neuropharmacology and Neuroscience, Albany Medical College, New York 12208, USA
    Antioxid Redox Signal 17:992-1012. 2012
    ..RNS cause irreversible or poorly reversible damage to brain cells...
  19. pmc Long-lasting inhibition of presynaptic metabolism and neurotransmitter release by protein S-nitrosylation
    Alena Rudkouskaya
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY 12208, USA
    Free Radic Biol Med 49:757-69. 2010
    ..A similar mechanism may contribute to the long-term suppression of neuronal communication during nitrosative stress in vivo...
  20. ncbi request reprint iNOS regulation by calcium/calmodulin-dependent protein kinase II in vascular smooth muscle
    Rachel J Jones
    Center for Cardiovascular Sciences, Albany Medical College, 43 New Scotland Ave, Albany, NY 12208, USA
    Am J Physiol Heart Circ Physiol 292:H2634-42. 2007
    ..The results suggest that CaMKIIdelta(2) may be an important regulator of iNOS trafficking and activity in VSMCs...
  21. doi request reprint Xanthine oxidase-mediated denitrosation of N-nitroso-tryptophan by superoxide and uric acid
    Kimberley Viles
    Center for Cardiovascular Sciences, Albany Medical College, Albany, NY, USA
    Nitric Oxide 28:57-64. 2013
    ..Site-specificity of this reaction may possibly be used in combination with the tri-iodide-based chemiluminescence assay to discern between nitrosated Trp, S-nitrosothiols, and nitrosylated heme proteins...
  22. ncbi request reprint Catalase potentiates interleukin-1beta-induced expression of nitric oxide synthase in rat vascular smooth muscle cells
    Benjamin J Guikema
    Center for Cardiovascular Sciences, Albany Medical College, 47 New Scotland Avenue MC8, Albany, NY 12208, USA
    Free Radic Biol Med 38:597-605. 2005
    ..The present results outline a novel role for H2O2 in suppressing signaling pathways leading to gene expression such as iNOS in VSMC in response to cytokines...

Research Grants5

  1. Mechanisms of Nitric Oxide Mediated Cell Injury
    DAVID JOURD HEUIL; Fiscal Year: 2005
    ....